scholarly journals Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Sakiko Minami ◽  
Norihiro Nagai ◽  
Misa Suzuki ◽  
Toshihide Kurihara ◽  
Hideki Sonobe ◽  
...  
Keyword(s):  
Steady State ◽  
Visual Function ◽  
Signal To Noise Ratio ◽  
Disease Diagnosis ◽  
Retinal Nerve Fibre Layer ◽  
Healthy Adults ◽  
Visual Evaluation ◽  
Pattern Electroretinography ◽  
Highly Sensitive ◽  
Nerve Fibre Layer

AbstractWe aimed to establish a highly sensitive method for measuring visual function using spatial-sweep steady-state pattern electroretinography (swpPERG). Overall, 35 eyes of 35 healthy adults (18 men; mean age, 32.3 years) were examined using swpPERG, and the data were recorded using spatial-patterned and contrast-reversed stimuli of size 1 (thickest) to 6. Data were converted into frequency-domain using a Fourier transform and expressed by signal-to-noise ratio (SNR). The number of participants who showed SNR ≥ 1 was significantly lesser at stimulus sizes 5 and 6 compared with those at greater stimulus sizes. Among the data with SNR ≥ 1, SNRs were negatively correlated with age at stimulus size 5 (r = −0.500, P = 0.029), and positively correlated with macular volume evaluated by optical coherence tomography (OCT) within a 6-mm circle diameter from the fovea of the retinal nerve fibre layer at size 4 (r = 0.409, P = 0.025) and of the ganglion cell layer at size 5 (r = 0.567, P = 0.011). We found that SNRs of swpPERG, recorded using the EvokeDx system, were correlated with age and macular morphology in participants without diagnosed eye diseases. The system detected subtle differences in retinal function, which may help in early disease diagnosis and visual evaluation in neuroprotective interventions in the future.

Is retinal nerve fibre layer thickness correlated with visual function in individuals having optic neuritis?

2021 ◽  
pp. 1-7
Author(s):  
Abbas Ali Yekta ◽  
Sara Sorouh ◽  
Amir Asharlous ◽  
Ali Mirzajani ◽  
Ebrahim Jafarzadehpur ◽  
...  
Keyword(s):  
Optic Neuritis ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Visual Function ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Temporal retinal nerve fibre layer thinning in cluster headache patients detected by optical coherence tomography

Cephalalgia ◽  
2015 ◽  
Vol 35 (11) ◽  
pp. 946-958 ◽  
Author(s):  
Carina Ewering ◽  
Nazmiye Haşal ◽  
Florian Alten ◽  
Christoph R Clemens ◽  
Nicole Eter ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Cluster Headache ◽  
Nerve Fibre ◽  
Visual Function ◽  
Retinal Nerve Fibre Layer ◽  
Optical Coherence ◽  
Healthy Individuals ◽  
Oxygen Inhalation ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Background The exact pathophysiology of cluster headache (CH) is still not fully clarified. Various studies confirmed changes in ocular blood flow during CH attacks. Furthermore, vasoconstricting medication influences blood supply to the eye. We investigated the retina of CH patients for structural retinal alterations with optical coherence tomography (OCT), and how these changes correlate to headache characteristics, oxygen use and impaired visual function. Methods Spectral domain OCT of 107 CH patients – 67 episodic, 35 chronic, five former chronic sufferers – were compared to OCT from 65 healthy individuals. Visual function tests with Sloan charts and a substantial ophthalmologic examination were engaged. Results Reduction of temporal and temporal-inferior retinal nerve fibre layer (RNFL) thickness was found in both eyes for CH patients with a predominant thinning on the headache side in the temporal-inferior area. Chronic CH patients revealed thinning of the macula compared to episodic suffers and healthy individuals. Bilateral thinning of temporal RNFL was also found in users of 100% oxygen compared to non-users and healthy controls. Visual function did not differ between patients and controls. Discussion Our OCT findings show a systemic effect causing temporal retinal thinning in both eyes of CH patients possibly due to attack-inherent or medication-induced frequent bilateral vessel diameter changes. The temporal retina with its thinly myelinated parvo-cellular axons and its more susceptible vessels for the vasoconstricting influence of oxygen inhalation seems to be predisposed for tissue damage-causing processes related to CH.

scholarly journals Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point

2011 ◽  
Vol 96 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Gadi Wollstein ◽  
Larry Kagemann ◽  
Richard A Bilonick ◽  
Hiroshi Ishikawa ◽  
Lindsey S Folio ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Visual Function ◽  
Retinal Nerve Fibre Layer ◽  
Tipping Point ◽  
Fibre Layer ◽  
Function Loss ◽  
Nerve Fibre Layer

Visual function and retinal nerve fibre layer degeneration in patients with Alzheimer disease: correlations with severity of dementia

2014 ◽  
Vol 93 (6) ◽  
pp. e507-e508 ◽  
Author(s):  
Maria P. Bambo ◽  
Elena Garcia-Martin ◽  
Sofia Otin ◽  
Juan Pinilla ◽  
José M. Larrosa ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Nerve Fibre ◽  
Visual Function ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer ◽  
Severity Of Dementia

scholarly journals Recent Advances in Quenchbody, a Fluorescent Immunosensor

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1223
Author(s):  
Jinhua Dong ◽  
Hiroshi Ueda
Keyword(s):  
Fluorescence Intensity ◽  
Fluorescent Dyes ◽  
Antibody Fragment ◽  
Disease Diagnosis ◽  
Disease Biomarkers ◽  
Highly Sensitive ◽  
Physiologically Active Substances ◽  
New Type ◽  
Antigen Antibody ◽  
Active Substances

The detection of viruses, disease biomarkers, physiologically active substances, drugs, and chemicals is of great significance in many areas of our lives. Immunodetection technology is based on the specificity and affinity of antigen–antibody reactions. Compared with other analytical methods such as liquid chromatography coupled with mass spectrometry, which requires a large and expensive instrument, immunodetection has the advantages of simplicity and good selectivity and is thus widely used in disease diagnosis and food/environmental monitoring. Quenchbody (Q-body), a new type of fluorescent immunosensor, is an antibody fragment labeled with fluorescent dyes. When the Q-body binds to its antigen, the fluorescence intensity increases. The detection of antigens by changes in fluorescence intensity is simple, easy to operate, and highly sensitive. This review comprehensively discusses the principle, construction, application, and current progress related to Q-bodies.

scholarly journals Interphotoreceptor coupling: an evolutionary perspective

2021 ◽  
Author(s):  
Lorenzo Cangiano ◽  
Sabrina Asteriti
Keyword(s):  
Visual Information ◽  
Signal To Noise Ratio ◽  
Electrical Coupling ◽  
Physiological Role ◽  
Cellular Processes ◽  
Contact Points ◽  
Highly Sensitive ◽  
The Many ◽  
The Impact

AbstractIn the vertebrate retina, signals generated by cones of different spectral preference and by highly sensitive rod photoreceptors interact at various levels to extract salient visual information. The first opportunity for such interaction is offered by electrical coupling of the photoreceptors themselves, which is mediated by gap junctions located at the contact points of specialised cellular processes: synaptic terminals, telodendria and radial fins. Here, we examine the evolutionary pressures for and against interphotoreceptor coupling, which are likely to have shaped how coupling is deployed in different species. The impact of coupling on signal to noise ratio, spatial acuity, contrast sensitivity, absolute and increment threshold, retinal signal flow and colour discrimination is discussed while emphasising available data from a variety of vertebrate models spanning from lampreys to primates. We highlight the many gaps in our knowledge, persisting discrepancies in the literature, as well as some major unanswered questions on the actual extent and physiological role of cone-cone, rod-cone and rod-rod communication. Lastly, we point toward limited but intriguing evidence suggestive of the ancestral form of coupling among ciliary photoreceptors.

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