scholarly journals Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulfate

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Johannes G. Keller ◽  
Uschi M. Graham ◽  
Johanna Koltermann-Jülly ◽  
Robert Gelein ◽  
Lan Ma-Hock ◽  
...  
Keyword(s):  
Barium Sulfate ◽  
Flow Cells ◽  
Inhaled Nanoparticles

scholarly journals Author Correction: Predicting dissolution and transformation of inhaled nanoparticles in the lung using abiotic flow cells: The case of barium sulphate

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Johannes G. Keller ◽  
Uschi M. Graham ◽  
Johanna Koltermann-Jülly ◽  
Robert Gelein ◽  
Lan Ma-Hock ◽  
...  
Keyword(s):  
Barium Sulphate ◽  
Flow Cells ◽  
Inhaled Nanoparticles

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Investigations on the Nature of Hemophilia A

1963 ◽  
Vol 09 (01) ◽  
pp. 030-052 ◽  
Author(s):  
Eberhard Mammen
Keyword(s):  
Factor Viii ◽  
Human Plasma ◽  
Barium Sulfate ◽  
Freeze Drying ◽  
Room Temperature ◽  
Hemophilia A ◽  
Normal Human Plasma ◽  
Normal Human ◽  
And Storage ◽  
Prothrombin Activation

SummaryIn this paper an inhibitor is described that is found in hemophilic plasma and serum different from any till now described inhibitor. The inhibitor only inhibits prothrombin activation in the “intrinsic clotting systems”. This inhibitor is probably not present in normal human plasma or serum. It is destroyed by ether and freeze drying, is labile to acid and storage at room temperature. It is stable upon dialysis and has not been adsorbed on barium sulfate, aluminum hydroxide or kaolin. It precipitates at 50% v/v saturation with alcohol. The nature of this inhibitor seems to be a protein or lipoprotein.Factor VIII was isolated from hemophilic plasma. The amount isolated was the same as from normal plasma and the activity properties were not different. Hemophiliacs have normal amounts of factor VIII.

“In vitro” Neutralization with Oxalate Ion of the Anticoagulant Effect of Heparin

1961 ◽  
Vol 05 (02) ◽  
pp. 314-318 ◽  
Author(s):  
W. O Cruz ◽  
L Meis ◽  
C. P Dietrich
Keyword(s):  
Calcium Oxalate ◽  
Aluminium Hydroxide ◽  
Barium Sulfate ◽  
Anticoagulant Effect ◽  
Normal Plasma ◽  
Oxalate Ion

SummaryHeparinized blood or plasma coagulates if, after addition of oxalate, recalcification follows. Of the decalcifying agents only oxalate ion has been suitable for demonstrating this phenomenon. Oxalate seem to accomplish two different roles connected with this effect: a fundamental one, i. e., to sensitize a heparinlipoprotein complex to the action of an anti-heparin factor found in normal plasma or serum and a secondary one, related to its capacity to adsorb this antiheparin factor. The latter is removable by centrifugation. This anti-heparin oxalate factor, which is able to counteract the action of heparin after previous addition of oxalate, was found in sequestrened, Dowex 50 resin plasma or in serum, but is not active in citrated plasma. This factor was removed from plasma by adsorption with barium sulfate, aluminium hydroxide or calcium oxalate and was eluted from these adsorbants after incubation with saline.

A Simple Method for Preparing Fibrinogen

1966 ◽  
Vol 16 (01/02) ◽  
pp. 198-206 ◽  
Author(s):  
W Straughn ◽  
R. H Wagner
Keyword(s):  
Barium Sulfate ◽  
Caproic Acid ◽  
Aminobutyric Acid ◽  
Gamma Aminobutyric Acid ◽  
Human Fibrinogen ◽  
Simple Method ◽  
High Yields ◽  
Marked Stability

SummaryA simple new procedure is reported for the isolation of canine, bovine, porcine, and human fibrinogen. Two molar β-alanine is used to precipitate fibrinogen from barium sulfate adsorbed plasma. The procedure is characterized by dependability and high yields. The material is 95% to 98% clottable protein but still contains impurities such as plasminogen and fibrin-stabilizing factor. Plasminogen may be removed by adsorption with charcoal. The fibrinogen preparations exhibit marked stability to freezing, lyophilization, and dialysis. Epsilon-amino-n-caproic acid and gamma-aminobutyric acid which were also studied have the property of precipitating proteins from plasma but lack the specificity for fibrinogen found with β-alanine.

Unstable Cathode Potential in Alkaline Flow Cells for CO2 Electroreduction Driven by Gas Evolution

2021 ◽  
Author(s):  
Kevin Krause ◽  
ChungHyuk Lee ◽  
Jason K. Lee ◽  
Kieran F. Fahy ◽  
Hisan W. Shafaque ◽  
...  
Keyword(s):  
Gas Evolution ◽  
Cathode Potential ◽  
Flow Cells ◽  
Co2 Electroreduction

scholarly journals Crystallization Behavior and Mechanical Properties of Poly(ε-caprolactone) Reinforced with Barium Sulfate Submicron Particles

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2368
Author(s):  
Hegoi Amestoy ◽  
Paul Diego ◽  
Emilio Meaurio ◽  
Jone Muñoz ◽  
Jose-Ramon Sarasua
Keyword(s):  
Barium Sulfate ◽  
Thermal Studies ◽  
Polarized Light ◽  
Optical Microscope ◽  
Submicron Particles ◽  
Degree Of Crystallinity ◽  
Scanning Calorimetry ◽  
Nucleation Effect ◽  
Crystal Fraction ◽  
Light Optical Microscope

Poly(ε-caprolactone) (PCL) was mixed with submicron particles of barium sulfate to obtain biodegradable radiopaque composites. X-ray images comparing with aluminum samples show that 15 wt.% barium sulfate (BaSO4) is sufficient to present radiopacity. Thermal studies by differential scanning calorimetry (DSC) show a statistically significant increase in PCL degree of crystallinity from 46% to 52% for 25 wt.% BaSO4. Non-isothermal crystallization tests were performed at different cooling rates to evaluate crystallization kinetics. The nucleation effect of BaSO4 was found to change the morphology and quantity of the primary crystals of PCL, which was also corroborated by the use of a polarized light optical microscope (PLOM). These results fit well with Avrami–Ozawa–Jeziorny model and show a secondary crystallization that contributes to an increase in crystal fraction with internal structure reorganization. The addition of barium sulfate particles in composite formulations with PCL improves stiffness but not strength for all compositions due to possible cavitation effects induced by debonding of reinforcement interphase.

scholarly journals Screening for Effects of Inhaled Nanoparticles in Cell Culture Models for Prolonged Exposure

Nanomaterials ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 606
Author(s):  
Claudia Meindl ◽  
Kristin Öhlinger ◽  
Verena Zrim ◽  
Thomas Steinkogler ◽  
Eleonore Fröhlich
Keyword(s):  
Prolonged Exposure ◽  
A549 Cells ◽  
Cytokine Release ◽  
Transient Effects ◽  
Particle Uptake ◽  
Particle Accumulation ◽  
Low Concentrations ◽  
Culture Models ◽  
20 Nm ◽  
Inhaled Nanoparticles

Respiratory exposure of humans to environmental and therapeutic nanoparticles repeatedly occurs at relatively low concentrations. To identify adverse effects of particle accumulation under realistic conditions, monocultures of Calu-3 and A549 cells and co-cultures of A549 and THP-1 macrophages in the air–liquid interphase culture were exposed repeatedly to 2 µg/cm2 20 nm and 200 nm polystyrene particles with different functionalization. Particle accumulation, transepithelial electrical resistance, dextran (3–70 kDa) uptake and proinflammatory cytokine secretion were determined over 28 days. Calu-3 cells showed constant particle uptake without any change in barrier function and cytokine release. A549 cells preferentially ingested amino- and not-functionalized particles combined with decreased endocytosis. Cytokine release was transiently increased upon exposure to all particles. Carboxyl-functionalized demonstrated higher uptake and higher cytokine release than the other particles in the A549/THP-1 co-cultures. The evaluated respiratory cells and co-cultures ingested different amounts and types of particles and caused small (partly transient) effects. The data suggest that the healthy cells can adapt to low doses of non-cytotoxic particles.

Sign in / Sign up

Export Citation Format

Share Document