scholarly journals A new novel method for assessing intracranial pressure using non-invasive fundus images: a pilot study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mikkel Schou Andersen ◽  
Christian Bonde Pedersen ◽  
Frantz Rom Poulsen
Keyword(s):  
Pilot Study ◽  
Intracranial Pressure ◽  
Fundus Images ◽  
Non Invasive ◽  
New Novel ◽  
Novel Method

scholarly journals A Novel Method to Assess Antimicrobial Susceptibility in Commensal Oropharyngeal Neisseria—A Pilot Study

Antibiotics ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 100
Author(s):  
Jolein Gyonne Elise Laumen ◽  
Saïd Abdellati ◽  
Christophe Van Dijck ◽  
Delphine Martiny ◽  
Irith De Baetselier ◽  
...  
Keyword(s):  
Pilot Study ◽  
Antimicrobial Susceptibility ◽  
Neisseria Species ◽  
Oral Rinse ◽  
Non Invasive ◽  
Simple Protocol ◽  
Surveillance Programs ◽  
Invasive Method ◽  
Novel Method ◽  
Commensal Neisseria

Commensal Neisseria provide a reservoir of resistance genes that can be transferred to the pathogens Neisseria gonorrhoeae and N. meningitidis in the human oropharynx. Surveillance programs are thus needed to monitor resistance in oropharyngeal commensal Neisseria, but currently the isolation and antimicrobial susceptibility testing of these commensals is laborious, complex and expensive. In addition, the posterior oropharyngeal/tonsillar swab, which is commonly used to sample oropharyngeal Neisseria, is poorly tolerated by many individuals. We evaluated an alternative non-invasive method to isolate oropharyngeal commensal Neisseria and to detect decreased susceptibility to azithromycin using selective media (LBVT.SNR) with and without azithromycin (2 µg/mL). In this pilot study, we compared paired posterior oropharyngeal/tonsillar swabs and oral rinse-and-gargle samples from 10 participants and demonstrated that a similar Neisseria species diversity and number of colonies were isolated from both sample types. Moreover, the proportion of Neisseria colonies that had a decreased susceptibility to azithromycin was similar in the rinse samples compared to the swabs. This pilot study has produced encouraging data that a simple protocol of oral rinse-and-gargle and culture on plates selective for commensal Neisseria with and without a target antimicrobial can be used as a surveillance tool to monitor antimicrobial susceptibility in commensal oropharyngeal Neisseria. Larger studies are required to validate these findings.

Ultrasound non-invasive intracranial pressure assessment in paediatric neurocritical care: a pilot study

2019 ◽  
Vol 36 (1) ◽  
pp. 117-124 ◽  
Author(s):  
Chiara Robba ◽  
Danilo Cardim ◽  
Marek Czosnyka ◽  
Francisco Abecasis ◽  
Stefano Pezzato ◽  
...  
Keyword(s):  
Pilot Study ◽  
Intracranial Pressure ◽  
Neurocritical Care ◽  
Non Invasive

scholarly journals Mean intracranial pressure monitoring by a non-invasive audiological technique: a pilot study.

1989 ◽  
Vol 52 (5) ◽  
pp. 610-612 ◽  
Author(s):  
A Reid ◽  
R J Marchbanks ◽  
D E Bateman ◽  
A M Martin ◽  
A P Brightwell ◽  
...  
Keyword(s):  
Pilot Study ◽  
Intracranial Pressure ◽  
Intracranial Pressure Monitoring ◽  
Pressure Monitoring ◽  
Non Invasive

Non-Invasive Distinction of Non-Alcoholic Fatty Liver Disease using Urinary Volatile Organic Compound Analysis: Early Results

2015 ◽  
Vol 24 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Ramesh P. Arasaradnam ◽  
Michael McFarlane ◽  
Emma Daulton ◽  
Erik Westenbrink ◽  
Nicola O’Connell ◽  
...  
Keyword(s):  
Liver Disease ◽  
Pilot Study ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Diagnostic Methods ◽  
Screening Methods ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Volatile Organic ◽  
Alcoholic Fatty Liver Disease

Background & Aims: Non-Alcoholic Fatty Liver Disease (NAFLD) is the commonest cause of chronic liver disease in the western world. Current diagnostic methods including Fibroscan have limitations, thus there is a need for more robust non-invasive screening methods. The gut microbiome is altered in several gastrointestinal and hepatic disorders resulting in altered, unique gut fermentation patterns, detectable by analysis of volatile organic compounds (VOCs) in urine, breath and faeces. We performed a proof of principle pilot study to determine if progressive fatty liver disease produced an altered urinary VOC pattern; specifically NAFLD and Non-Alcoholic Steatohepatitis (NASH).Methods: 34 patients were recruited: 8 NASH cirrhotics (NASH-C); 7 non-cirrhotic NASH; 4 NAFLD and 15 controls. Urine was collected and stored frozen. For assay, the samples were defrosted and aliquoted into vials, which were heated to 40±0.1°C and the headspace analyzed by FAIMS (Field Asymmetric Ion Mobility Spectroscopy). A previously used data processing pipeline employing a Random Forrest classification algorithm and using a 10 fold cross validation method was applied.Results: Urinary VOC results demonstrated sensitivity of 0.58 (0.33 - 0.88), but specificity of 0.93 (0.68 - 1.00) and an Area Under Curve (AUC) 0.73 (0.55 -0.90) to distinguish between liver disease and controls. However, NASH/NASH-C was separated from the NAFLD/controls with a sensitivity of 0.73 (0.45 - 0.92), specificity of 0.79 (0.54 - 0.94) and AUC of 0.79 (0.64 - 0.95), respectively.Conclusions: This pilot study suggests that urinary VOCs detection may offer the potential for early non-invasive characterisation of liver disease using 'smell prints' to distinguish between NASH and NAFLD.

Bee Markers: A Novel Method for Non-Invasive Short Term Marking of Bats

2020 ◽  
Vol 21 (2) ◽  
pp. 465 ◽  
Author(s):  
Lucinda Kirkpatrick ◽  
Grzegorz Apoznański ◽  
Luc De Bruyn ◽  
Ralf Gyselings ◽  
Tomasz Kokurewicz
Keyword(s):  
Short Term ◽  
Non Invasive ◽  
Novel Method

scholarly journals Study on the nonlinear vibration of embedded carbon nanotube via the Hamiltonian-based method

2021 ◽  
pp. 146134842110327
Author(s):  
Kang-Jia Wang ◽  
Guo-Dong Wang
Keyword(s):  
Carbon Nanotubes ◽  
Carbon Nanotube ◽  
Nonlinear Vibration ◽  
Elastic Medium ◽  
Numerical Results ◽  
Frequency Property ◽  
New Novel ◽  
Novel Method

This article mainly studies the vibration of the carbon nanotubes embedded in elastic medium. A new novel method called the Hamiltonian-based method is applied to determine the frequency property of the nonlinear vibration. Finally, the effectiveness and reliability of the proposed method is verified through the numerical results. The obtained results in this work are expected to be helpful for the study of the nonlinear vibration.

scholarly journals Non-Invasive Intracranial Pressure Evaluation in an Emergency Room – Point-of-Care Ultrasonography

2016 ◽  
Vol 38 (04) ◽  
pp. 279-283
Author(s):  
Daniel Damiani ◽  
Durval Damiani
Keyword(s):  
Intracranial Pressure ◽  
Randomized Trials ◽  
Point Of Care ◽  
Current Data ◽  
Point Of Care Ultrasound ◽  
Medical Specialties ◽  
Non Invasive ◽  
Nerve Sheath ◽  
Invasive Method ◽  
Point Of Care Ultrasonography

AbstractPoint-of-care ultrasound is modifying conducts in emergency care. The various medical specialties, in addition to traditional indications in cases of multiple trauma, are using this technique for rapid diagnosis at the bedside without patient mobilization and without radiation. Point-of-care ultrasound in neurocritical patients, through its transorbital window, can estimate the intracranial pressure by a non-invasive method. Through the measurement of the diameter of the optic nerve sheath 3 mm posterior to the retina, the intracranial pressure is estimated if the value of the diameter is > 5 mm, as it has been verified in other studies. The present article describes the most current data on this topic, and it also highlights the need for more multicentric and randomized trials to determine the correct cut-off points that represent the high sensibility and specificity of the method.

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