scholarly journals Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses D

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tatiana P. de Paula ◽  
Juliano S. R. Moreira ◽  
Luiza F. Sperb ◽  
Maria Elisa P. Muller ◽  
Thais Steemburgo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Single Dose ◽  
Blood Pressure Monitoring ◽  
Hypovitaminosis D ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Before And After

AbstractObservational and experimental data reinforce the concept that vitamin D is associated with the pathogenesis of arterial hypertension. We investigated the effect of a single dose of 100,000 IU of cholecalciferol, in office blood pressure (BP), and 24-h ambulatory blood pressure monitoring (ABPM) in patients with type 2 diabetes mellitus (DM), hypertension, and hypovitaminosis D. Forty-three patients were randomized to a placebo or cholecalciferol group. BP was assessed by office measurements and 24-h ABPM, before and after intervention. At week 8, a greater decrease in median ABPM values was observed in cholecalciferol supplementation than in the placebo group for systolic 24-h (− 7.5 vs. − 1; P = 0.02), systolic daytime (− 7 vs. − 1; P = 0.007), systolic nighttime (− 7.0 vs. 3; P = 0.009), diastolic 24-h (− 3.5 vs. − 1; P = 0.037), and daytime DBP (− 5 vs. 0; P = 0.01). Office DBP was also reduced after vitamin D supplementation. A single dose of vitamin D3 improves BP in patients with type 2 diabetes, hypertension, and vitamin D insufficiency, regardless of vitamin D normalization. Vitamin D supplementation could be a valuable tool to treat patients with type 2 DM, hypertension, and hypovitaminosis D.Trial registration: Clinicaltrials.gov NCT 02204527.

High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients

2020 ◽  
Vol 16 ◽  
Author(s):  
Natércia Neves Marques de Queiroz ◽  
Franciane Trindade Cunha de Melo ◽  
Fabrício de Souza Resende ◽  
Luísa Corrêa Janaú ◽  
Norberto Jorge Kzan de Souza Neto ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Vitamin D ◽  
Blood Pressure Monitoring ◽  
Vitamin D Supplementation ◽  
High Dose ◽  
Before And After ◽  
Patients With Diabetes ◽  
Morning Blood Pressure ◽  
Cholecalciferol Supplementation ◽  
Lipids Profile

Background: Vitamin D (VD) deficiency has been related to several endocrine metabolic and cardiovascular diseases. Effect of VD supplementation on blood pressure (BP) in patients with diabetes is controversial. Objective: The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood pressure of normotensive type 1 diabetes mellitus (T1DM) patients by 24-hour ambulatory blood pressure monitoring (ABPM). Methods: We performed a clinical trial including 35 T1DM normotensive patients, who received doses of 4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent 24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before and after VD supplementation. Results and discussion: We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in other pressoric markers. Besides, we noticed a relation between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05). Conclusion: Our study suggests an association between supplementation of high doses of vitamin D and the reduction of morning blood pressure in normotensive T1DM patients.

scholarly journals Vitamin D in Type 2 Diabetes: Genetic Susceptibility and the Response to Supplementation

2020 ◽  
Vol 52 (07) ◽  
pp. 492-499
Author(s):  
Marissa Penna-Martinez ◽  
Klaus Badenhoop ◽  
Edith Klahold ◽  
Franziska Bruns ◽  
Christian Seidl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Insufficiency ◽  
Vitamin D Metabolism ◽  
Risk Alleles ◽  
Before And After ◽  
Cholecalciferol Supplementation ◽  
The Impact

AbstractVariants of vitamin D metabolism-genes may predispose to type 2 diabetes (T2D). This study investigated the impact of these variants on disease susceptibility, Vitamin D, parathyroid hormone, C-peptide and HbA1c levels before and after cholecalciferol supplementation in patients with T2D.Twelve polymorphisms within CYP2R1, CYP27B1, DBP, VDR and CYP24A1 were genotyped in 553 T2D patients and 916 controls. In addition 65 patients receiving either cholecalciferol or placebo were analyzed during 6 months intervention and 6 months follow-up.T2D risk alleles are VDR rs7975232 “G” (pc=0.031), rs1544410 “G” (pc=0.027) and CYP2R1 rs10741657 “A” (pc=0.016). Patients with genotypes CYP27B1 rs10877012 “CC” (pc=4x10-5), DBP rs7041 “GG” (pc=0.003), rs4588 “CC” (pc = 3x10-4), CYP24A1 rs2585426 “CG” (pc=0.006) and rs2248137 “CG” (pc=0.001) showed lower 25(OH)D3 and DBP rs4588 “CC” lower 1,25(OH)2D3 levels (pc=0.005). Whereas DBP rs4588 “CC” (pc=0.009), CYP27B1 rs10877012 “AC” (pc=0.059), VDR rs7975323 “AG” (pc=0.033) and rs1544410 “GG” (pc=0.013) are associated with higher 25(OH)D3 levels at 6 months’ follow-up. Significant PTH suppression was detected for CYP2R1 “AG“ (pc=0.002), DBP rs4588 “CC” (pc<0.001), VDR rs110735810 “CT” (pc<0.001) and CYP24A1 rs2248137 “GG” (pc=0.021).Genetic variants of the vitamin D system predispose to type 2 diabetes and regulate – partially - vitamin D metabolism, concentrations and the vitamin D status. Vitamin D insufficiency is a T2D risk factor. The response to cholecalciferol supplementation can be measured as 25(OH)D3 increment and PTH suppression. This process is regulated by genes of the vitamin D system conferring modest T2D risk.

scholarly journals Prospective Evaluation of Vitamin D Supplementation on Peripheral Neuropathy in Type 2 Diabetes Mellitus -A Review

2021 ◽  
pp. 260-266
Author(s):  
Faisal Suliman Algaows ◽  
Fatema Abdullah Althkerallah ◽  
Norah Abdulmohsen Alsuwailem ◽  
Amnah Abdulnasser Mawlan Ahmed ◽  
Razan Fahad Alwagdani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
Vitamin D Levels

Diabetic neuropathy is a long-term consequence of diabetes that can cause significant morbidity and a decline in quality of life in many individuals. Low vitamin D levels, in addition to causing rickets in infants and chondrosteoma in adults, may have a role in the development of DM and its underlying disorders, according to a growing body of evidence. Vitamin D deficiency has been linked to type 1 or type 2 diabetes, as well as the microvascular and macrovascular problems that come with it. Vitamin D insufficiency has been linked to diabetic peripheral neuropathy (DPN) as an independent risk factor. Vitamin D, both topical and oral, has been shown to considerably improve DPN symptoms and pain.

Association of plasma vitamin D status with lifestyle patterns and ambulatory blood pressure monitoring parameters in patients with type 2 diabetes and hypertension

2018 ◽  
Vol 139 ◽  
pp. 139-146 ◽  
Author(s):  
Juliano Soares Rabello Moreira ◽  
Tatiana Pedroso de Paula ◽  
Luiza Ferreira Sperb ◽  
Maria Elisa Peinado Miller ◽  
Mirela Jobim Azevedo ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Plasma Vitamin ◽  
Vitamin D Status ◽  
Pressure Monitoring ◽  
Lifestyle Patterns

scholarly journals Hypovitaminosis D and effect of vitamin D supplementation in type 2 diabetes mellitus: a rural population based study

2019 ◽  
Vol 6 (4) ◽  
pp. 1293
Author(s):  
Sathiyanarayanan Janakiraman ◽  
Girija Subramanian
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Supplementation ◽  
Vitamin D Levels ◽  
Short Period ◽  
Before And After ◽  
The Mean

Background: Deficiency of Vitamin D in general population and its association with various disease conditions have been studied worldwide. Type 2 Diabetes mellitus is increasing at an alarming rate in Indian subcontinent, contributing to increased morbidity and mortality. This study aimed to estimate level of Vitamin D and its association with patients with type 2 diabetes mellitus of rural origin. This study objective was to estimate the Vitamin D level of patients with Type 2 Diabetes mellitus and the effect of Vitamin D supplementation on glycemic statusMethods: This study was conducted at the Department of General medicine for a period of 1 year. Eighty patients with type 2 Diabetes mellitus were recruited in the study and baseline parameters of glycemic control and Vitamin D levels were assessed. Only 36 patients complied with the recommendation and evaluated further.Results: All the patients included in the study had insufficient or deficient levels of Vitamin D. The mean vitamin D levels before and after supplementation were 17.75±6.30 and 29.33±6.34 respectively. The mean plasma HbA1c level before and after supplementation were 7.78 and 7.30 respectively. Patients after vitamin D replacement showed significant improvement in their glycaemic status.Conclusions: Vitamin D supplementation of 2000 IU/day had shown to improve the glycaemic status. The beneficial effect of Vitamin D on diabetes was evident in a short period of supplementation.

scholarly journals P1037EFFECT OF VITAMIN D SUPPLEMENTATION ON PROTEINURIA, LIPID STATUS, GLICOREGULATION, C-REACTIVE PROTEIN, VEGF-A, TGF-BETA1 AND NEPHRIN IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Marijana Petroviä‡ ◽  
Stanko Petrovic ◽  
Katarina Obrencevic ◽  
Tamara Dragovic ◽  
Nemanja Rancic ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Insufficiency ◽  
Vitamin D Supplementation ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tgf Β1

Abstract Background and Aims: Vitamin D insufficiency/deficiency is often present in patients with Type-2 diabetes mellitus and could present a risk factor for rapid progression of diabetic nephropathy and higher incidence of cardiovascular events. The aim of this study was to examine the influence of vitamin D supplementation on glucoregulation, inflammation, cholesterol, triglycerides, albuminuria and biomarkers of renal injury – nephrin, VEGF-A and TGF- β1 in patients with Type-2 diabetes mellitus and vitamin D insufficiency/deficiency. Method: We included 90 patients with Type-2 diabetes mellitus and vitamin D insufficiency/deficiency in this prospective, cohort study. Patients are divided in 3 equal groups: 30 patients with normal albuminuria, 30 with microalbuminuria and 30 with macroalbuminuria. Therapy included 6 months of supplementation with cholecalciferol drops: first 2 months with 20000 IU twice weekly, than if vitamin D level remained below normal range, we procedeed with same dose next 4 months. If the level of vitamin D normalized, we proceeded with 5000 IU twice weekly. At the beginning and at the end of the study we measured levels of albumin, hemoglobin, serum iron, urea, creatinine, fasting blood glucose, hemoglobin A1c, calcium, phosphorus, total cholesterol, triglycerides, C-reactive protein, intact parathyroid hormone, and urine analysis: 24-hour urine protein, albumin/creatinine ratio and creatinine clearance. Biomarkers are measured in serum and urine. Levels of calcium, phosphorus and vitamin D are also checked 2 months after beginning of therapy due to possible correction of cholecalciferol dose. Results are analysed according to the vitamin D level at the beginning and at the end of the study. Results: The lowest level of vitamin D, before therapy, is found in patients with macroalbuminuria, while at the end of the study we found significantly higher level of vitamin D in all three groups. After 6 months of therapy we found significant decrease of 24-hour urine protein, total cholesterol, triglycerides, hemoglobin A1c and VEGF-A in urine, in all three groups, and C-reactive protein in patients with normal albuminuria and microalbuminuria, nephrin in urine in patients with microalbuminuria and TGF- β1 in urine in patients with macroalbuminuria. Conclusion: vitamin D supplementation with high-dose cholecalciferol in patients with Type-2 diabetes mellitus (with or without albuminuria) decreases C-reactive protein, hemoglobin A1c, total cholesterol, triglycerides in serum, and albumin/creatinine ratio, 24-hour urine protein, VEGF-A, TGF- β1 and nephrin in urine.

scholarly journals Study on the correlation between Vitamin D and HbA1c in type 2 diabetes mellitus

2021 ◽  
Vol 9 (4) ◽  
pp. 219-224
Author(s):  
Dr. A Ponnambalam ◽  
◽  
Dr. M Arun ◽  
Dr. G. Prabhu ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Hypovitaminosis D ◽  
Vitamin D Supplementation ◽  
Type 2 Dm ◽  
Vitamin D Levels

Background: Type 2 diabetes mellitus (DM) is associated with increased morbidity and mortalitydue to the development of complications, especially due to poor glycemic control. Besides its role incalcium homeostasis, Vitamin D has been involved in the pathophysiology as well as glycemiccontrol of type 2 DM. Methods: 100 patients diagnosed with type 2 DM were included. Vitamin Dlevels along with glycosylated haemoglobin were measured in all the individuals. Results: Vitamin Ddeficiency was observed in 48% of the patients. Vitamin D levels were not associated with markersof glycemic control (HbA1c). Conclusions: Hypovitaminosis D was observed nearly in half of thepatients with type 2 diabetes, suggesting a potential for vitamin D supplementation in type 2 DMpatients.

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