scholarly journals State-specific projection of COVID-19 infection in the United States and evaluation of three major control measures

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Shi Chen ◽  
Qin Li ◽  
Song Gao ◽  
Yuhao Kang ◽  
Xun Shi
Keyword(s):  
United States ◽  
New York ◽  
Compartmental Model ◽  
Spatial Interaction ◽  
The United States ◽  
State Policies ◽  
Control Measures ◽  
Specific Information ◽  
Social Distancing ◽  
Infected People

AbstractMost models of the COVID-19 pandemic in the United States do not consider geographic variation and spatial interaction. In this research, we developed a travel-network-based susceptible-exposed-infectious-removed (SEIR) mathematical compartmental model system that characterizes infections by state and incorporates inflows and outflows of interstate travelers. Modeling reveals that curbing interstate travel when the disease is already widespread will make little difference. Meanwhile, increased testing capacity (facilitating early identification of infected people and quick isolation) and strict social-distancing and self-quarantine rules are most effective in abating the outbreak. The modeling has also produced state-specific information. For example, for New York and Michigan, isolation of persons exposed to the virus needs to be imposed within 2 days to prevent a broad outbreak, whereas for other states this period can be 3.6 days. This model could be used to determine resources needed before safely lifting state policies on social distancing.

scholarly journals State-specific Projection of COVID-19 Infection in the United States and Evaluation of Three Major Control Measures

2020 ◽  
Author(s):  
Shi Chen ◽  
Qin Li ◽  
Song Gao ◽  
Yuhao Kang ◽  
Xun Shi
Keyword(s):  
United States ◽  
New York ◽  
Compartmental Model ◽  
Spatial Interaction ◽  
The United States ◽  
State Policies ◽  
Control Measures ◽  
Specific Information ◽  
Social Distancing ◽  
Infected People

ABSTRACTMost models of the COVID-19 pandemic in the United States do not consider geographic variation and spatial interaction. In this research, we developed a travel-network-based susceptible-exposed-infectious-removed (SEIR) mathematical compartmental model system that characterizes infections by state and incorporates inflows and outflows of interstate travelers. Modeling reveals that curbing interstate travel when the disease is already widespread will make little difference. Meanwhile, increased testing capacity (facilitating early identification of infected people and quick isolation) and strict social-distancing and self-quarantine rules are most effective in abating the outbreak. The modeling has also produced state-specific information. For example, for New York and Michigan, isolation of persons exposed to the virus needs to be imposed within 2 days to prevent a broad outbreak, whereas for other states this period can be 3.6 days. This model could be used to determine resources needed before safely lifting state policies on social distancing.

scholarly journals Socioeconomic Disparities in Social Distancing During the COVID-19 Pandemic in the United States: Observational Study (Preprint)

2020 ◽  
Author(s):  
Romain Garnier ◽  
Jan R Benetka ◽  
John Kraemer ◽  
Shweta Bansal
Keyword(s):  
United States ◽  
Black People ◽  
The United States ◽  
Control Measures ◽  
Mobility Patterns ◽  
Poverty Level ◽  
Social Distancing ◽  
Mobility Data ◽  
Black Populations ◽  
The Impact

BACKGROUND Eliminating disparities in the burden of COVID-19 requires equitable access to control measures across socio-economic groups. Limited research on socio-economic differences in mobility hampers our ability to understand whether inequalities in social distancing are occurring during the SARS-CoV-2 pandemic. OBJECTIVE We aimed to assess how mobility patterns have varied across the United States during the COVID-19 pandemic and to identify associations with socioeconomic factors of populations. METHODS We used anonymized mobility data from tens of millions of devices to measure the speed and depth of social distancing at the county level in the United States between February and May 2020, the period during which social distancing was widespread in this country. Using linear mixed models, we assessed the associations between social distancing and socioeconomic variables, including the proportion of people in the population below the poverty level, the proportion of Black people, the proportion of essential workers, and the population density. RESULTS We found that the speed, depth, and duration of social distancing in the United States are heterogeneous. We particularly show that social distancing is slower and less intense in counties with higher proportions of people below the poverty level and essential workers; in contrast, we show that social distancing is intensely adopted in counties with higher population densities and larger Black populations. CONCLUSIONS Socioeconomic inequalities appear to be associated with the levels of adoption of social distancing, potentially resulting in wide-ranging differences in the impact of the COVID-19 pandemic in communities across the United States. These inequalities are likely to amplify existing health disparities and must be addressed to ensure the success of ongoing pandemic mitigation efforts.

scholarly journals Public Health Interventions’ Effect on Hospital Use in Patients With COVID-19: Comparative Study (Preprint)

2020 ◽  
Author(s):  
Xiaofeng Wang ◽  
Rui Ren ◽  
Michael W Kattan ◽  
Lara Jehi ◽  
Zhenshun Cheng ◽  
...  
Keyword(s):  
Public Health ◽  
United States ◽  
New York ◽  
New York State ◽  
The United States ◽  
Health Interventions ◽  
Public Health Interventions ◽  
Social Distancing ◽  
Transmission Rates ◽  
Hospital Use

BACKGROUND Different states in the United States had different nonpharmaceutical public health interventions during the COVID-19 pandemic. The effects of those interventions on hospital use have not been systematically evaluated. The investigation could provide data-driven evidence to potentially improve the implementation of public health interventions in the future. OBJECTIVE We aim to study two representative areas in the United States and one area in China (New York State, Ohio State, and Hubei Province), and investigate the effects of their public health interventions by time periods according to key interventions. METHODS This observational study evaluated the numbers of infected, hospitalized, and death cases in New York and Ohio from March 16 through September 14, 2020, and Hubei from January 26 to March 31, 2020. We developed novel Bayesian generalized compartmental models. The clinical stages of COVID-19 were stratified in the models, and the effects of public health interventions were modeled through piecewise exponential functions. Time-dependent transmission rates and effective reproduction numbers were estimated. The associations of interventions and the numbers of required hospital and intensive care unit beds were studied. RESULTS The interventions of social distancing, home confinement, and wearing masks significantly decreased (in a Bayesian sense) the case incidence and reduced the demand for beds in all areas. Ohio’s transmission rates declined before the state’s “stay at home” order, which provided evidence that early intervention is important. Wearing masks was significantly associated with reducing the transmission rates after reopening, when comparing New York and Ohio. The centralized quarantine intervention in Hubei played a significant role in further preventing and controlling the disease in that area. The estimated rates that cured patients become susceptible in all areas were small (<0.0001), which indicates that they have little chance to get the infection again. CONCLUSIONS The series of public health interventions in three areas were temporally associated with the burden of COVID-19–attributed hospital use. Social distancing and the use of face masks should continue to prevent the next peak of the pandemic.

scholarly journals Quantifying human mobility behaviour changes during the COVID-19 outbreak in the United States

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yixuan Pan ◽  
Aref Darzi ◽  
Aliakbar Kabiri ◽  
Guangchen Zhao ◽  
Weiyu Luo ◽  
...  
Keyword(s):  
United States ◽  
Real Time ◽  
Human Mobility ◽  
The United States ◽  
Control Measures ◽  
Social Distancing ◽  
First Case ◽  
Mobility Behaviour ◽  
Novel Coronavirus ◽  
Behaviour Changes

AbstractSince the first case of the novel coronavirus disease (COVID-19) was confirmed in Wuhan, China, social distancing has been promoted worldwide, including in the United States, as a major community mitigation strategy. However, our understanding remains limited in how people would react to such control measures, as well as how people would resume their normal behaviours when those orders were relaxed. We utilize an integrated dataset of real-time mobile device location data involving 100 million devices in the contiguous United States (plus Alaska and Hawaii) from February 2, 2020 to May 30, 2020. Built upon the common human mobility metrics, we construct a Social Distancing Index (SDI) to evaluate people’s mobility pattern changes along with the spread of COVID-19 at different geographic levels. We find that both government orders and local outbreak severity significantly contribute to the strength of social distancing. As people tend to practice less social distancing immediately after they observe a sign of local mitigation, we identify several states and counties with higher risks of continuous community transmission and a second outbreak. Our proposed index could help policymakers and researchers monitor people’s real-time mobility behaviours, understand the influence of government orders, and evaluate the risk of local outbreaks.

scholarly journals Differential Effects of Intervention Timing on COVID-19 Spread in the United States

2020 ◽  
Author(s):  
Sen Pei ◽  
Sasikiran Kandula ◽  
Jeffrey Shaman
Keyword(s):  
United States ◽  
Disease Transmission ◽  
Metropolitan Areas ◽  
Human Mobility ◽  
The United States ◽  
Aggressive Response ◽  
Control Measures ◽  
County Level ◽  
Social Distancing ◽  
Us Counties

Assessing the effects of early non-pharmaceutical interventions1-5 on COVID-19 spread in the United States is crucial for understanding and planning future control measures to combat the ongoing pandemic6-10. Here we use county-level observations of reported infections and deaths11, in conjunction with human mobility data12 and a metapopulation transmission model13,14, to quantify changes of disease transmission rates in US counties from March 15, 2020 to May 3, 2020. We find significant reductions of the basic reproductive numbers in major metropolitan areas in association with social distancing and other control measures. Counterfactual simulations indicate that, had these same control measures been implemented just 1-2 weeks earlier, a substantial number of cases and deaths could have been averted. Specifically, nationwide, 61.6% [95% CI: 54.6%-67.7%] of reported infections and 55.0% [95% CI: 46.1%-62.2%] of reported deaths as of May 3, 2020 could have been avoided if the same control measures had been implemented just one week earlier. We also examine the effects of delays in re-implementing social distancing following a relaxation of control measures. A longer response time results in a stronger rebound of infections and death. Our findings underscore the importance of early intervention and aggressive response in controlling the COVID-19 pandemic.

scholarly journals Socio-economic disparities in social distancing during the COVID-19 pandemic in the United States

2020 ◽  
Author(s):  
Romain Garnier ◽  
Jan R. Benetka ◽  
John Kraemer ◽  
Shweta Bansal
Keyword(s):  
United States ◽  
Black People ◽  
The United States ◽  
Control Measures ◽  
Mobility Patterns ◽  
Poverty Level ◽  
Social Distancing ◽  
Mobility Data ◽  
Black Populations ◽  
The Impact

AbstractImportanceEliminating disparities in the burden of COVID-19 requires equitable access to control measures across socio-economic groups. Limited research on socio-economic differences in mobility hampers our ability to understand whether inequalities in social distancing are occurring during the SARS-CoV-2 pandemic.ObjectiveTo assess how mobility patterns have varied across the United States during the COVID-19 pandemic, and identify associations with socio-economic factors of populations.Design, Setting, and ParticipantsWe used anonymized mobility data from tens of millions of devices to measure the speed and depth of social distancing at the county level between February and May 2020. Using linear mixed models, we assessed the associations between social distancing and socio-economic variables, including the proportion of people below the poverty level, the proportion of Black people, the proportion of essential workers, and the population density.Main outcomes and ResultsWe find that the speed, depth, and duration of social distancing in the United States is heterogeneous. We particularly show that social distancing is slower and less intense in counties with higher proportions of people below the poverty level and essential workers; and in contrast, that social distancing is intense in counties with higher population densities and larger Black populations.Conclusions and relevanceSocio-economic inequalities appear to be associated with the levels of adoption of social distancing, potentially resulting in wide-ranging differences in the impact of COVID-19 in communities across the United States. This is likely to amplify existing health disparities, and needs to be addressed to ensure the success of ongoing pandemic mitigation efforts.

scholarly journals Effects of New York’s Executive Order on Face Mask Use on COVID-19 Infections and Mortality: A Modeling Study

2020 ◽  
Author(s):  
Mingwang Shen ◽  
Jian Zu ◽  
Christopher K. Fairley ◽  
José A. Pagán ◽  
Bart Ferket ◽  
...  
Keyword(s):  
United States ◽  
New York ◽  
New York City ◽  
Compartmental Model ◽  
Mental Hygiene ◽  
Face Mask ◽  
The United States ◽  
Executive Order ◽  
Department Of Health ◽  
Control And Prevention

ABSTRACTBackgroundNew York City (NYC) was the epicenter of the COVID-19 pandemic in the United States. On April 17, 2020, the State of New York implemented an Executive Order that requires all people in New York to wear a face mask or covering in public settings where social distancing cannot be maintained. It is unclear how this Executive Order has affected the spread of COVID-19 in NYC.MethodsA dynamic compartmental model of COVID-19 transmission among NYC residents was developed to assess the effect of the Executive Order on face mask use on infections and deaths due to COVID-19 in NYC. Data on daily and cumulative COVID-19 infections and deaths were obtained from the NYC Department of Health and Mental Hygiene.ResultsThe Executive Order on face mask use is estimated to avert 99,517 (95% CIs: 72,723-126,312) COVID-19 infections and 7,978 (5,692-10,265) deaths in NYC. If the Executive Order was implemented one week earlier (on April 10), the averted infections and deaths would be 111,475 (81,593-141,356) and 9,017 (6,446-11,589), respectively. If the Executive Order was implemented two weeks earlier (on April 3 when the Centers for Disease Control and Prevention recommended face mask use), the averted infections and deaths would be 128,598 (94,373-162,824) and 10,515 (7,540-13,489), respectively.ConclusionsNew York’s Executive Order on face mask use is projected to have significantly reduced the spread of COVID-19 in NYC. Implementing the Executive Order at an earlier date would avert even more COVID-19 infections and deaths.

scholarly journals Public Health Interventions’ Effect on Hospital Use in Patients With COVID-19: Comparative Study

10.2196/25174 ◽  
2020 ◽  
Vol 6 (4) ◽  
pp. e25174
Author(s):  
Xiaofeng Wang ◽  
Rui Ren ◽  
Michael W Kattan ◽  
Lara Jehi ◽  
Zhenshun Cheng ◽  
...  
Keyword(s):  
Public Health ◽  
United States ◽  
New York ◽  
New York State ◽  
The United States ◽  
Health Interventions ◽  
Public Health Interventions ◽  
Social Distancing ◽  
Transmission Rates ◽  
Hospital Use

Background Different states in the United States had different nonpharmaceutical public health interventions during the COVID-19 pandemic. The effects of those interventions on hospital use have not been systematically evaluated. The investigation could provide data-driven evidence to potentially improve the implementation of public health interventions in the future. Objective We aim to study two representative areas in the United States and one area in China (New York State, Ohio State, and Hubei Province), and investigate the effects of their public health interventions by time periods according to key interventions. Methods This observational study evaluated the numbers of infected, hospitalized, and death cases in New York and Ohio from March 16 through September 14, 2020, and Hubei from January 26 to March 31, 2020. We developed novel Bayesian generalized compartmental models. The clinical stages of COVID-19 were stratified in the models, and the effects of public health interventions were modeled through piecewise exponential functions. Time-dependent transmission rates and effective reproduction numbers were estimated. The associations of interventions and the numbers of required hospital and intensive care unit beds were studied. Results The interventions of social distancing, home confinement, and wearing masks significantly decreased (in a Bayesian sense) the case incidence and reduced the demand for beds in all areas. Ohio’s transmission rates declined before the state’s “stay at home” order, which provided evidence that early intervention is important. Wearing masks was significantly associated with reducing the transmission rates after reopening, when comparing New York and Ohio. The centralized quarantine intervention in Hubei played a significant role in further preventing and controlling the disease in that area. The estimated rates that cured patients become susceptible in all areas were small (<0.0001), which indicates that they have little chance to get the infection again. Conclusions The series of public health interventions in three areas were temporally associated with the burden of COVID-19–attributed hospital use. Social distancing and the use of face masks should continue to prevent the next peak of the pandemic.

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