scholarly journals Inferring a causal relationship between ceramide levels and COVID-19 respiratory distress

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mehran M. Khodadoust
Keyword(s):  
Respiratory Distress ◽  
Causal Relationship ◽  
Respiratory Symptoms ◽  
Fold Increase ◽  
Plasma Samples ◽  
Total Plasma ◽  
Lipidomic Analysis ◽  
Distress Symptoms ◽  
Concentration Dependency ◽  
Total Plasma Concentration

AbstractA causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is inferred. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging to the ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis led to the demonstration of concentration dependency for severe COVID-19 respiratory symptoms in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) were shown to be increased by 48-, 40-, and 33-fold, respectively, in infected plasma samples and to 116-, 91- and 50-fold, respectively, in plasma samples with respiratory distress. Hence, monitoring plasma ceramide concentration, can be a valuable tool for measuring effects of therapies on COVID-19 respiratory distress patients.

scholarly journals Ceramide Levels and Covid-19 Respiratory Distress, a Causal Relationship

2021 ◽  
Author(s):  
Mehran Khodadoust
Keyword(s):  
Respiratory Distress ◽  
Causal Relationship ◽  
Fold Increase ◽  
Plasma Samples ◽  
Total Plasma ◽  
Lipidomic Analysis ◽  
Distress Symptoms ◽  
Concentration Dependency ◽  
Ceramide Synthesis ◽  
Total Plasma Concentration

Abstract A causal relationship between plasma ceramide concentration and Covid-19 patients with respiratory distress symptoms is presented. In this study, plasma samples of 52 individuals infected with Covid-19 were utilized in a lipidomic analysis. Lipids belonging to ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis lead to demonstration of concentration dependency, for severe Covid-19 respiratory symptoms, in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) are shown to be increased by 48, 40, and 33–folds respectively in infected plasma samples, and to 116, 91 and 50-folds in plasma samples with respiratory distress. Hence, monitoring of plasma ceramide concentration, targeting ceramide synthesis, its salvage and its regulatory mechanisms, are validated approach towards enhancing survival from Covid-19 respiratory distress.

scholarly journals Ceramide Levels and Covid-19 Respiratory Distress, a Causal Relationship

2021 ◽  
Author(s):  
Mehran Khodadoust
Keyword(s):  
Respiratory Distress ◽  
Causal Relationship ◽  
Fold Increase ◽  
Plasma Samples ◽  
Total Plasma ◽  
Lipidomic Analysis ◽  
Distress Symptoms ◽  
Concentration Dependency ◽  
Ceramide Synthesis ◽  
Total Plasma Concentration

Abstract A causal relationship between plasma ceramide concentration and Covid-19 patients with respiratory distress symptoms is presented. Hence, monitoring of plasma ceramide concentration, targeting ceramide synthesis, its salvage and its regulatory mechanisms, are validated approach towards enhancing survival from Covid-19 respiratory distress. In this study, plasma samples of 52 individuals infected with Covid-19 were utilized in a lipidomic analysis. Lipids belonging to ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis lead to demonstration of concentration dependency, for severe Covid-19 respiratory symptoms, in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) are shown to be increased by 48, 40, and 33–folds respectively in infected plasma samples, and to 116, 91 and 50-folds in plasma samples with respiratory distress.

scholarly journals Ceramide Levels and COVID-19 Respiratory Distress, a Causal Relationship

2021 ◽  
Author(s):  
Mehran Khodadoust
Keyword(s):  
Respiratory Distress ◽  
Causal Relationship ◽  
Fold Increase ◽  
Plasma Samples ◽  
Total Plasma ◽  
Lipidomic Analysis ◽  
Distress Symptoms ◽  
Concentration Dependency ◽  
Ceramide Synthesis ◽  
Total Plasma Concentration

Abstract A causal relationship between plasma ceramide concentration and respiratory distress symptoms in COVID-19 patients is presented. In this study, plasma samples of 52 individuals infected with COVID-19 were utilized in a lipidomic analysis. Lipids belonging to the ceramide class exhibited a 400-fold increase in total plasma concentration in infected patients. Further analysis led to the demonstration of concentration dependency for severe COVID-19 respiratory symptoms in a subclass of ceramides. The subclasses Cer(d18:0/24:1), Cer(d18:1/24:1), and Cer(d18:1/22:0) were shown to be increased by 48-, 40-, and 33-fold, respectively, in infected plasma samples and to 116-, 91- and 50-fold, respectively, in plasma samples with respiratory distress. Hence, monitoring plasma ceramide concentration, targeting ceramide synthesis, its salvage and its regulatory mechanisms are validated approaches towards enhancing survival from COVID-19 respiratory distress.

School Nurses on the Front Lines of Medicine: Take a BREATH: The Approach to a Student With Respiratory Distress

2017 ◽  
Vol 33 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Morgann Loaec ◽  
Robert P. Olympia
Keyword(s):  
Emergency Department ◽  
Respiratory Distress ◽  
Respiratory Symptoms ◽  
School Setting ◽  
School Nurses ◽  
Initial Assessment ◽  
Level Of Care ◽  
Primary Health ◽  
Life Threatening

Students presenting with varying degrees of respiratory symptoms and distress occur commonly in the school setting. It is important to develop a differential diagnosis for respiratory distress, to initiate stabilization of the student with life-threatening symptoms, and to triage these students to an appropriate level of care (back to the classroom, home with their guardian with follow up at their primary health care provider’s office, or directly to the closest emergency department via Emergency Medical Services). This article describes the initial assessment and management of a student presenting with respiratory distress.

scholarly journals PROBLEMS FINDING IMPORTED CASE LEPTOSPIROSIS (CLINICAL OBSERVATION)

2017 ◽  
Vol 22 (1) ◽  
pp. 36-41
Author(s):  
M. A Nikulina ◽  
V. M Granitov ◽  
S. F Tanashkin ◽  
E. V Volchkova ◽  
E. A Nemilostiva
Keyword(s):  
Infectious Diseases ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Adult Respiratory Distress Syndrome ◽  
Respiratory Symptoms ◽  
Clinical Case ◽  
Distress Syndrome ◽  
Clinical Observation ◽  
Tropical Regions ◽  
Imported Case

Leptospirosis can be up to 20-40% of infectious diseases such as malaria, dengue fever and many others occurring in tropical regions. There is presented the description of the clinical case of leptospirosis in a patient arrived from Vietnam. The severity of the patient's disease is associated with an increase in respiratory symptoms and disease caused by the development of adult respiratory distress syndrome, which can occur not less than in 19.0% of patients, mostly in men and lead to the death in 14.2% of patients. Thus, after arrival from tropical countries patients with fever, signs of organ (respiratory, renal, hepatic, etc.) failure are to be tested for leptospirosis.

Long-Term Performance and Stability of Molecular Shotgun Lipidomic Analysis of Human Plasma Samples

2013 ◽  
Vol 85 (18) ◽  
pp. 8757-8763 ◽  
Author(s):  
Laura A. Heiskanen ◽  
Matti Suoniemi ◽  
Hung Xuan Ta ◽  
Kirill Tarasov ◽  
Kim Ekroos
Keyword(s):  
Human Plasma ◽  
Plasma Samples ◽  
Lipidomic Analysis ◽  
Human Plasma Samples ◽  
Long Term Performance ◽  
Term Performance

Un suono che inganna: quando sospettare il doppio arco aortico

2021 ◽  
Vol 24 (4) ◽  
pp. 109-113
Author(s):  
Virginia Giannone ◽  
Manuela Goia ◽  
Elisabetta Bignamini
Keyword(s):  
Respiratory Distress ◽  
Respiratory Symptoms ◽  
Vascular Ring ◽  
Male Infant ◽  
Chest Ct ◽  
Tracheal Compression ◽  
Contrast Enhanced ◽  
Precise Diagnosis ◽  
Vascular Structures ◽  
Chest Ct Scan

The article describes a case of a 10-month-old male infant presenting with respiratory distress, laryngotracheitis and double aortic arch (DAA). Tracheal compression by vascular structures in infants is uncommon and may be masked by nonspecific respiratory symptoms. DAA is the most common vascular ring. Doctors should think about a congenital vascular ring due to DAA in children with repeated episodes of laryngitis, hissing breath, cough and dyspnoea when other common aetiologies are excluded. A precise diagnosis can be made through the contrast-enhanced chest CT scan.

scholarly journals Quantifying Oxidized Lipids in Oven Fried and Deep Fried Potatoes: A Three-Way Analysis by LOI, Chemical Assays, and Lipidomics

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 789-789
Author(s):  
Traycie Williams ◽  
Paul Plummer ◽  
Mandy Blackburn ◽  
Timothy Garrett ◽  
Vasilis Vasiliou ◽  
...  
Keyword(s):  
Lipid Oxidation ◽  
Fold Increase ◽  
Oxidized Lipids ◽  
Walnut Oil ◽  
Lipidomic Analysis ◽  
Funding Sources ◽  
Relative Value ◽  
Conjugated Triene ◽  
Fried Potatoes ◽  
Good Agreement

Abstract Objectives Standard chemical methods that determine oxidized lipids in foods are laborious and require toxic chemicals. Our goal was to develop a mathematical lipid oxidation index (LOI) to predict oxidized lipid content of oven fried (OF) and deep fried (DF) potatoes and compare it to standard chemical assays and redox lipidomic analyses. Methods We calculated the LOI value of each recipe using a mathematical formula which consisted of the parameters of 16 nutrients, time and temperature. Next, we OF and DF potatoes in soy, olive, and walnut oils and then extracted oil from the cooked potatoes using the modified Hara and Radin method. We assayed samples of each oil to quantify the conjugated diene (CD), conjugated triene (CT), peroxide (PV), acid (AV), and p-Anisidine (p-Ad) values. In addition, aliquots of each oil sample were sent to collaborators to determine the relative value of oxidized lipids by mass spectrometry and lipidomic informatics. Results Overall, the chemical assays demonstrated that oven frying promoted significantly more oxidation than deep frying. Potatoes OF in walnut oil had greater mean CD (24.1 ± 0.44 vs 19.45 ± 0.06), CT (16.43 ± 0.25 vs 15.67 ± 0.12), AV (0.29 ± 0.01 vs 0.14 ± 0.003), PV (361 ± 7.6 vs 200 ± 6.06), and p-Ad (0.50 ± 0.03 vs 0.14 ± 0.01) when compared to DF potatoes (P ≤ 0.05). This increase in lipid oxidation was not consistent for potatoes prepared with soy and olive oils. LOI predicted a two-fold increase in lipid oxidation in OF potatoes as compared to DF potatoes no matter the type of oil (soy: 308 vs 150; olive: 319 vs; walnut: 330 vs 161). Finally, lipidomic analysis revealed a similar trend in the relative amounts of total oxidized lipids in OF potatoes (soy oil: 24% vs 12%; olive oil: 22% vs 7%; walnut oil 31% vs 17%) and was used to tentatively annotate over 3000 unique oxidized lipids. Conclusions This preliminary study demonstrates that two of the three methods, LOI and lipidomic analysis, are in good agreement in quantifying lipid oxidation in OF and DF potatoes. However, the suboptimal agreement of the chemical assays suggests that the parameters of LOI require further examination. Funding Sources MP is funded by a grant from the Research Dietetic Practice Group (RDPG)/Sugar Association. TW is funded by the Regina Myers McClain Foundation at UCM for his work as a research assistant.

scholarly journals Acute neonatal respiratory distress caused by a lingual thyroid: the role of nasendoscopy and medical treatment

2015 ◽  
Vol 129 (4) ◽  
pp. 403-405 ◽  
Author(s):  
L Lane ◽  
S Prudon ◽  
T Cheetham ◽  
S Powell
Keyword(s):  
Case Report ◽  
Thyroid Gland ◽  
Respiratory Distress ◽  
Neonatal Screening ◽  
Surgical Procedure ◽  
Respiratory Symptoms ◽  
Lingual Thyroid ◽  
Thyroxine Therapy ◽  
Neonatal Respiratory Distress

AbstractBackground:A lingual thyroid is a known cause of oropharyngeal obstruction in the neonate. It can be asymptomatic, or present as stridor, dysphonia, dysphagia or dyspnoea with faltering growth. The therapeutic options include surgical resection.Case report:A 6-day-old female neonate, born at 36 weeks gestation, presented with stridulous breathing and poor feeding. Although the cause was initially thought to be laryngomalacia, nasendoscopy revealed a lingual thyroid. The baby had deranged thyroid function, as detected on neonatal screening, but this result was not available until a later date. Despite being symptomatic, the patient was managed medically; thyroxine therapy was associated with resolution of the respiratory symptoms.Conclusion:Nasendoscopy provides valuable information about an ectopic thyroid gland. Thyroid replacement therapy may help to suppress the size of the ectopic gland and ultimately prevent an unnecessary surgical procedure.

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