scholarly journals Recent trends in global insecticide use for disease vector control and potential implications for resistance management

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Henk van den Berg ◽  
Haroldo Sergio da Silva Bezerra ◽  
Samira Al-Eryani ◽  
Emmanuel Chanda ◽  
Bhupender N. Nagpal ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Vector Control ◽  
Chagas Disease ◽  
Pyrethroid Resistance ◽  
Resistance Management ◽  
Insecticide Treated Nets ◽  
Vector Borne Diseases ◽  
Control Programs ◽  
Disease Vector ◽  
Vector Borne

AbstractInsecticides have played a major role in the prevention, control, and elimination of vector-borne diseases, but insecticide resistance threatens the efficacy of available vector control tools. A global survey was conducted to investigate vector control insecticide use from 2010 to 2019. Out of 140 countries selected as sample for the study, 87 countries responded. Also, data on ex-factory deliveries of insecticide-treated nets (ITNs) were analyzed. Insecticide operational use was highest for control of malaria, followed by dengue, leishmaniasis and Chagas disease. Vector control relied on few insecticide classes with pyrethroids the most used overall. Results indicated that IRS programs have been slow to react to detection of pyrethroid resistance, while proactive resistance management using insecticides with unrelated modes of action was generally weak. The intensive use of recently introduced insecticide products raised concern about product stewardship regarding the preservation of insecticide susceptibility in vector populations. Resistance management was weakest for control of dengue, leishmaniasis or Chagas disease. Therefore, it will be vital that vector control programs coordinate on insecticide procurement, planning, implementation, resistance monitoring, and capacity building. Moreover, increased consideration should be given to alternative vector control tools that prevent the development of insecticide resistance.

scholarly journals Co-occurrence of kdr mutations V1016I and F1534C in pyrethroid-resistant Aedes aegypti (Diptera: Culicidae) populations from Costa Rica

2019 ◽  
Author(s):  
Aryana Zardkoohi ◽  
David Castañeda ◽  
Carmen Castillo ◽  
Juan C Lol ◽  
Francisco Lopez ◽  
...  
Keyword(s):  
Costa Rica ◽  
Aedes Aegypti ◽  
Insecticide Resistance ◽  
Vector Control ◽  
Resistance Management ◽  
Management Plan ◽  
Costa Rican ◽  
Mosquito Vector ◽  
Control Programs ◽  
Control And Prevention

AbstractAedes aegypti (Linnaeus, 1762) is considered the most important mosquito vector species for several arboviruses (e.g., dengue, chikungunya, Zika) in Costa Rica. The main strategy for the control and prevention of Aedes-borne diseases relies on insecticide-based vector control. However, the emergence of insecticide resistance in the mosquito populations present a big threat for the prevention actions. The characterization of the mechanisms driving the insecticide resistance in Ae. aegypti are vital for decision making in vector control programs. Therefore, we analyzed the voltage-gated sodium channel gene for the presence of the V1016I and F1534C kdr mutations in pyrethroid-resistant Ae. aegypti populations from Puntarenas and Limon provinces, Costa Rica. The CDC bottle bioassays showed that both Costa Rican Ae. aegypti populations were resistant to permethrin and deltamethrin. In the case of kdr genotyping, results revealed the co-occurrence of V1016I and F1534C mutations in permethrin and deltamethrin-resistant populations, as well as the fixation of the 1534C allele. Therefore, our findings make an urgent call to expand the knowledge about the insecticide resistance status and mechanisms in the Costa Rican populations of Ae. aegypti which must be a priority to develop an effective resistance management plan.

scholarly journals Phenotypic and molecular analysis of insecticide resistance in Aedes albopictus populations from Greece

2020 ◽  
Author(s):  
Sofia Balaska ◽  
Emmanouil Alexandros Fotakis ◽  
Ilias Kioulos ◽  
Linda Grigoraki ◽  
Spyridoula Mpellou ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Vector Control ◽  
Molecular Analysis ◽  
Aedes Albopictus ◽  
Pyrethroid Resistance ◽  
Disease Outbreaks ◽  
Control Methods ◽  
Resistance Mutations ◽  
Control Programs ◽  
Southern European Countries

Abstract Background: Aedes albopictus has a well-established presence in southern European countries, associated with recent disease outbreaks (e.g. Chikungunya). Development of insecticide resistance in the vector is a major concern as it’s control mainly relies on the use of biocides. Data on the specie’s resistance status is essential for efficient and sustainable control. Methods: We investigated the insecticide resistance status of several Ae. albopictus populations from Greece. Bioassays were performed against diflubenzuron (DFB), B. thuringiensis var. israelensis (Bti), deltamethrin and malathion. Molecular analysis of known insecticide resistance loci was performed, i.e. voltage-gated sodium channel (VGSC) mutations associated with pyrethroid resistance; presence and frequency of carboxylesterases 3 (CCEae3a) and 6 (CCEae6a) gene amplification associated with organophosphate (OP) resistance and; chitin synthase-1 (CHS-1) for the possible presence of DFB resistance mutations. Results: Bioassays showed full susceptibility to DFB, Bti and deltamethrin, but resistance against the OP malathion. VGSC analysis revealed a widespread distribution of mutations F1534C (in all populations, with allelic frequencies between 6.6% - 68.3%), and I1532T (in 6 populations), but absence of V1016G. CCE gene amplifications were recorded in 8 out of 11 populations. Co-presence of mutation F1534C and CCEae3a amplification was reported in a subgroup of samples. No mutations at the CHS locus I1043 were detected. Conclusions: The results indicate: (i) the suitability of larvicides DFB and Bti for Ae. albopictus control in Greece, (ii) a possible incipient pyrethroid resistance due to the presence of kdr mutations and (iii) a possible reduced efficacy of OPs, in a scenario of re-introducing them for vector control. The study highlights the need for systematic resistance monitoring for developing and implementing appropriate evidence-based control programs. Key words: diagnostic, arbovirus, mosquito tiger, insecticide resistance, vector control, Europe

scholarly journals Bioassay and molecular monitoring of insecticide resistance status in Aedes albopictus populations from Greece, to support evidence-based vector control

2020 ◽  
Author(s):  
Sofia Balaska ◽  
Emmanouil Alexandros Fotakis ◽  
Ilias Kioulos ◽  
Linda Grigoraki ◽  
Spyridoula Mpellou ◽  
...  
Keyword(s):  
Insecticide Resistance ◽  
Vector Control ◽  
Aedes Albopictus ◽  
Pyrethroid Resistance ◽  
Disease Outbreaks ◽  
Evidence Based ◽  
Resistance Mutations ◽  
Molecular Monitoring ◽  
Allelic Frequencies ◽  
Control Programs

Abstract Background: Aedes albopictus has a well-established presence in southern European countries, associated with recent disease outbreaks (e.g. Chikungunya). Development of insecticide resistance in the vector is a major concern as its control mainly relies on the use of biocides. Data on the species’ resistance status is essential for efficient and sustainable control. To date the insecticide resistance status of Ae. albopictus populations from Greece against major insecticides used in vector control remains largely unknown. Methods: We investigated the insecticide resistance status of nineteen Ae. albopictus populations from 11 regions of Greece. Bioassays were performed against diflubenzuron (DFB), B. thuringiensis var. israelensis (Bti), deltamethrin and malathion. Known insecticide resistance loci were molecularly analysed, i.e. voltage-gated sodium channel (VGSC) mutations associated with pyrethroid resistance; presence and frequency of carboxylesterases 3 (CCEae3a) and 6 (CCEae6a) gene amplification associated with organophosphate (OP) resistance and; chitin synthase-1 (CHS-1) for the possible presence of DFB resistance mutations. Results: Bioassays showed full susceptibility to DFB, Bti and deltamethrin, but resistance against the OP malathion (range of mortality: 55.30-91.40%). VGSC analysis revealed a widespread distribution of mutations F1534C (in all populations, with allelic frequencies between 6.6% - 68.3%), and I1532T (in 6 populations; allelic frequencies below 22.70%), but absence of V1016G. CCE gene amplifications were recorded in 8 out of 11 populations (overall frequency: 33%). Co-presence of mutation F1534C and CCEae3a amplification was reported in 39 of the 156 samples commonly analysed. No mutations at the CHS-1 locus I1043 were detected. Conclusions: The results indicate: (i) the suitability of larvicides DFB and Bti for Ae. albopictus control in Greece, (ii) possible incipient pyrethroid resistance due to the presence of kdr mutations and (iii) possible reduced efficacy of OPs, in a scenario of re-introducing them for vector control. The study highlights the need for systematic resistance monitoring for developing and implementing appropriate evidence-based control programs.

scholarly journals MONITORING AND MAPPING OF INSECTICIDE RESISTANCE IN MALARIA VECTOR, ANOPHELES SACHAROVI IN IRAN (1997-2020)

2021 ◽  
Vol 5 (2) ◽  
pp. 75-79
Author(s):  
H. Vatandoost ◽  
AA. Hanafi -Bojd ◽  
F. Nikpoor
Keyword(s):  
Insecticide Resistance ◽  
Vector Control ◽  
Malaria Vector ◽  
Web Of Science ◽  
World Health ◽  
African Region ◽  
Vector Borne Diseases ◽  
Control Decision ◽  
Vector Borne ◽  
Health Organization

Malaria is the main vector borne diseases worldwide. According to the recent record of World Health Organization, 228 million cases have been reported in 2018 mainly in in African region. One of the main important measures for vector control is using insecticides. Monitoring and mapping of insecticide resistance is the main measure for appropriate decision. All the date published about resistant status of Anopheles sacharovi were searched on Pubmed, Elsevier, Springer, Web of Science, Iranmedex, Majiran, google scholar, etc. The results showed that there is widespread, resistance/tolerance to different groups of insecticides in the country. Monitoring and mapping as well as detection of mechanisms of insecticide resistance is appropriate for vector control decision. The results of resistant of this malaria vector to different WHO insecticides will provide an appropriate guideline for the Ministry of health and Medical Education of the country for appropriate vector control.

scholarly journals The Role of the Private Sector in Supporting Malaria Control in Resource Development Settings

2020 ◽  
Vol 222 (Supplement_8) ◽  
pp. S701-S708
Author(s):  
Robert T Jones ◽  
Lucy S Tusting ◽  
Hugh M P Smith ◽  
Sylvester Segbaya ◽  
Michael B Macdonald ◽  
...  
Keyword(s):  
Private Sector ◽  
Vector Control ◽  
Malaria Control ◽  
Local Resident ◽  
Vector Borne Diseases ◽  
The Public ◽  
Control Programs ◽  
Large Numbers ◽  
Industrial Operations ◽  
Vector Borne

Abstract Industrial operations of the private sector, such as extraction, agriculture, and construction, can bring large numbers of people into new settlement areas and cause environmental change that promotes the transmission of vector-borne diseases. Industry-related workers and communities unduly exposed to infection risk typically lack the knowledge and means to protect themselves. However, there is a strong business rationale for protecting local resident employees through integrated vector control programs, as well as an ethical responsibility to care for these individuals and the affected communities. We discuss the role and challenges of the private sector in developing malaria control programs, which can include extensive collaborations with the public sector that go on to form the basis of national vector control programs or more broadly support local healthcare systems.

scholarly journals Management of insecticides for use in disease vector control: Lessons from six countries in Asia and the Middle East

2021 ◽  
Vol 15 (4) ◽  
pp. e0009358
Author(s):  
Henk van den Berg ◽  
Raman Velayudhan ◽  
Rajpal S. Yadav
Keyword(s):  
Visceral Leishmaniasis ◽  
Insecticide Resistance ◽  
Vector Control ◽  
Resistance Management ◽  
Action Planning ◽  
Lessons Learned ◽  
Malaria Vectors ◽  
National Guidelines ◽  
Control Programs ◽  
Multi Stakeholder

Interventions to control the vectors of human diseases, notably malaria, leishmaniasis and dengue, have relied mainly on the action of chemical insecticides. However, concerns have been raised regarding the management of insecticides in vector-borne disease-endemic countries. Our study aimed to analyze how vector control insecticides are managed in selected countries to extract lessons learned. A qualitative analysis of the situation of vector control insecticides management was conducted in six countries. Multi-stakeholder meetings and key informer interviews were conducted on aspects covering the pesticide lifecycle. Findings were compared and synthesized to extract lessons learned. Centrally executed guidelines and standards on the management of insecticides offered direction and control in most malaria programs, but were largely lacking from decentralized dengue programs, where practices of procurement, application, safety, storage, and disposal were variable between districts. Decentralized programs were better at facilitating participation of stakeholders and local communities and securing financing from local budgets. However, little coordination existed between malaria, visceral leishmaniasis and dengue programs within countries. Entomological capacity was concentrated in malaria programs at central level, while dengue and visceral leishmaniasis programs were missing out on expertise. Monitoring systems for insecticide resistance in malaria vectors were rarely used for dengue or visceral leishmaniasis vectors. Strategies for insecticide resistance management, where present, did not extend across programs or sectors in most countries. Dengue programs in most countries continued to rely on space spraying which, considering the realities on the ground, call for revision of international guidelines. Vector control programs in the selected countries were confronted with critical shortcomings in the procurement, application, safety measures, storage, and disposal of vector control insecticides, with implications for the efficiency, effectiveness, and safety of vector control. Further international support is needed to assist countries in situation analysis, action planning and development of national guidelines on vector control insecticide management.

scholarly journals Management of insecticides for use in disease vector control: a global survey

2020 ◽  
Author(s):  
Henk van den Berg ◽  
Haroldo Sergio da Silva Bezerra ◽  
Emmanuel Chanda ◽  
Samira Al-Eryani ◽  
Bhupender Nath Nagpal ◽  
...  
Keyword(s):  
Vector Control ◽  
Management Practices ◽  
Critical Role ◽  
Worker Safety ◽  
External Support ◽  
Vector Borne Diseases ◽  
Global Survey ◽  
Pesticide Management ◽  
Country Level ◽  
Vector Borne

Abstract Background: Vector control plays a critical role in the prevention, control and elimination of vector-borne diseases, and interventions of vector control continue to depend largely on the action of chemical insecticides. A global survey was conducted on the management practices of vector control insecticides at country level to identify gaps to inform future strategies on pesticide management, seeking to improve efficacy of interventions and reduce the side effects of chemicals used on health and the environment.Methods: A survey by questionnaire on the management practices of vector control insecticides was disseminated among all WHO Member States. Data were analysed using descriptive statistics.Results: Responses were received from 94 countries, or a 48% response rate . Capacity for insecticide resistance monitoring was established in 68-80% of the countries in most regions, often with external support; however, this capacity was largely lacking from the European & Others Region. Procurement of vector control insecticides was in 50-75% of countries taking place by agencies other than the central-level procuring agency, over which the central authorities lacked control, for example, to select the product or assure product quality. Moreover, some countries experienced problems with estimating the correct amounts for procurement, especially for emergency purposes. Large fractions of countries across regions showed shortcomings in worker safety, pesticide storage practices, and pesticide waste disposal. Shortcomings were most pronounced in countries of the European & Others region, which has long been relatively free from mosquito-borne diseases but have recently faced challenges of re-emerging vector-borne diseases.Conclusions: Critical shortcomings in the management of vector control insecticides are common in countries across regions, with risks of adverse pesticide effects on health and the environment. Advocacy and resource mobilization are needed at regional and country level to address these challenges.

scholarly journals Ecosystem approaches to controlling of vector-borne diseases: dengue and Chagas disease

2009 ◽  
Vol 25 (suppl 1) ◽  
pp. S4-S4 ◽  
Author(s):  
Maria Glória Teixeira ◽  
Ana Boischio ◽  
Maria da Conceição N. Costa
Keyword(s):  
Chagas Disease ◽  
Vector Borne Diseases ◽  
Vector Borne ◽  
Ecosystem Approaches

scholarly journals POTENSI TRIATOMA SP DALAM PENYEBARAN PENYAKIT TULAR VEKTOR EMERGING DI INDONESIA

2019 ◽  
Vol 11 (2) ◽  
pp. 131-138
Author(s):  
Risqa Novita
Keyword(s):  
Allergic Reaction ◽  
Southeast Asia ◽  
Chagas Disease ◽  
Early Warning System ◽  
Warning System ◽  
Emerging Diseases ◽  
Laboratory Research ◽  
Tropical Country ◽  
Vector Borne Diseases ◽  
Vector Borne

The era of globalization allows migration fastly, so we do not have boundary of a country. This led to an increase of the infectious diseases. Indonesia also have an impact on this globalization by highly migration. Indonesia is a tropical country and has diversity of vectors that can transmit various tropical diseases. One of a vector  which transmitted vector borne diseases is a bug Triatoma. Triatoma lives near the people’s house and in the bed. One of the species of Triatoma which found in indonesia is Triatoma rubrifasciata which is vector of Chagas disease and Leprosy and can cause allergic reaction of the skin after the bite. Triatoma infection in Southeast Asia, including in Indonesia has not been widely reported. This condition should make us to be alert on the disease emerging or re emerging diseases that can be caused by Triatoma . This article aims to study Triatoma as a vector of emerging and potentially re emerging diseases in Indonesia, which are Chagas, skin allergic reaction after bite and Leprosy. Methods. Literature review by look in google scholar and pubmed, by search using keywords: emerging parasitic, vector borne diseases, Triatoma in Southeast Asia. Inclusion criterias are research articles, laboratory research, case report, and systematic surveillance. Based on the literatures, tracing data that Indonesia has a chance to be  the cases of Chagas disease, Skin allergic reaction of Triatoma and Leprosy. It is supposed to made the vigilance on  make a early warning system, so our public health coud be achieved highest.

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