scholarly journals Ultra-broadband axicon transducer for optoacoustic endoscopy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zakiullah Ali ◽  
Christian Zakian ◽  
Vasilis Ntziachristos

AbstractImage performance in optoacoustic endoscopy depends markedly on the design of the transducer employed. Ideally, high-resolution performance is required over an expanded depth of focus. Current optoacoustic focused transducers achieve lateral resolutions in the range of tens of microns in the mesoscopic regime, but their depth of focus is limited to hundreds of microns by the nature of their spherical geometry. We designed an ultra-broadband axicon detector with a 2 mm central aperture and investigated whether the imaging characteristics exceeded those of a spherical detector of similar size. We show a previously undocumented ability to achieve a broadband elongated pencil-beam optoacoustic sensitivity with an axicon detection geometry, providing approximately 40 μm-lateral resolution maintained over a depth of focus of 950 μm—3.8 times that of the reference spherical detector. This performance could potentially lead to optoacoustic endoscopes that can visualize optical absorption deeper and with higher resolution than any other optical endoscope today.

Sensors ◽  
2019 ◽  
Vol 19 (2) ◽  
pp. 378 ◽  
Author(s):  
Daniel Tarrazó-Serrano ◽  
Sergio Castiñeira-Ibáñez ◽  
Oleg Minin ◽  
Pilar Candelas ◽  
Constanza Rubio ◽  
...  

The image performance of acoustic and ultrasound sensors depends on several fundamental parameters such as depth of focus or lateral resolution. There are currently two different types of acoustic diffractive lenses: those that form a diffraction-limited spot with a shallow depth of focus (zone plates) and lenses that form an extended focus (quasi-Bessel beams). In this paper, we investigate a pupil-masked Soret zone plate, which allows the tunability of a normalized angular spectrum. It is shown that the depth of focus and the lateral resolution can be modified, without changing the lens structure, by choosing the size of the pupil mask. This effect is based on the transformation of spherically-converging waves into quasi-conical waves, due to the apodization of the central part of the zone plate. The theoretical analysis is verified with both numerical simulations and experimental measurements. A Soret zone plate immersed in water with D/2F = 2.5 and F = 4.5 λ changes its depth of focus from 2.84 λ to 5.9 λ and the lateral resolution increases from 0.81 λ to 0.64 λ at a frequency of 250 kHz, by modifying the pupil mask dimensions of the Soret zone plate.


Author(s):  
A. V. Crewe

The high resolution STEM is now a fact of life. I think that we have, in the last few years, demonstrated that this instrument is capable of the same resolving power as a CEM but is sufficiently different in its imaging characteristics to offer some real advantages.It seems possible to prove in a quite general way that only a field emission source can give adequate intensity for the highest resolution^ and at the moment this means operating at ultra high vacuum levels. Our experience, however, is that neither the source nor the vacuum are difficult to manage and indeed are simpler than many other systems and substantially trouble-free.


1961 ◽  
Vol 14 (3) ◽  
pp. 403 ◽  
Author(s):  
T Krishnan ◽  
NR Labrum

A study of the brightness distribution on the Sun at 21-cm wavelength on April 8, 1959, is described. High resolution observations were made of the partial eclipse on that day with a simple radiometer of high sensitivity. The brightness distribution of the uneclipsed Sun at the same wavelength was obtained using a cross-grating interferometer, which enabled the bright regions to be located accurately.


1969 ◽  
Vol 1 (5) ◽  
pp. 216-217
Author(s):  
A. E. Le Marne ◽  
P. A. Shaver

In a current programme at the Molonglo Radio Observatory using the high-resolution pencil beam of the instrument (∼3′ arc) an attempt is being made to extend the measured spectra of known planetary nebulae down to 408 MHz. Of 23 such planetaries already investigated, 14 have been detected. The main results will be given elsewhere; here it is proposed to discuss in detail only the well-known planetary nebula IC 418.


2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Lauren L. Levy ◽  
Peter M. Vila ◽  
Richard W. Park ◽  
Richard Schwarz ◽  
Alexandros D. Polydorides ◽  
...  

Background. High-resolution optical imaging provides real-time visualization of mucosa in the upper aerodigestive tract (UADT) which allows non-invasive discrimination of benign and neoplastic epithelium. The high-resolution microendoscope (HRME) utilizes a fiberoptic probe in conjunction with a tissue contrast agent to display nuclei and cellular architecture. This technology has broad potential applications to intraoperative margin detection and early cancer detection. Methods. Our group has created an extensive image collection of both neoplastic and normal epithelium of the UADT. Here, we present and describe imaging characteristics of benign, dysplastic, and malignant mucosa in the oral cavity, oropharynx, larynx, and esophagus. Results. There are differences in the nuclear organization and overall tissue architecture of benign and malignant mucosa which correlate with histopathologic diagnosis. Different anatomic subsites also display unique imaging characteristics. Conclusion. HRME allows discrimination between benign and neoplastic mucosa, and familiarity with the characteristics of each subsite facilitates correct diagnosis.


The Analyst ◽  
2016 ◽  
Vol 141 (7) ◽  
pp. 2150-2154 ◽  
Author(s):  
L. Hartmanová ◽  
I. Lorencová ◽  
M. Volný ◽  
P. Fryčák ◽  
V. Havlíček ◽  
...  

Nanoelectrospray directed at the surface (desorption nanoelectrospray) coupled with a high resolution mass spectrometer represents a new tool for mass spectrometry imaging.


2012 ◽  
Vol 116 (30) ◽  
pp. 16161-16166 ◽  
Author(s):  
Shin G. Chou ◽  
Paul E. Stutzman ◽  
Shuangzhen Wang ◽  
Edward J. Garboczi ◽  
William F. Egelhoff ◽  
...  

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