TRANSFORMATION OF ECONOMIC PROCESSES ON THE BASIS OF DIGITALISATION

The main task of our study is to justify the primary directions of transformation of economic processes on the basis of digitalisation. Nowadays, the digitalisation of the economy in the global economic environment is considered a priority model of global innovation development. Institutional factors are particularly important in the conditions of transformation of economic processes on the basis of digitalisation. They form the fundamental parameters of the long-term functioning of economic systems. It is determined that the role of institutional factors in ensuring economic development is multifaceted as they affect its duration and quality. These factors can be divided into formal and informal. We have systematised the influence of formal and informal institutional factors on the transformation of economic processes. It is found that the inability of the Ukrainian institutional system to ensure effective economic development demonstrates the institutional traps. Negative manifestations of this system hinder the positive directions for the transformation of economic processes, modernisation of the economy, and competitiveness. It is justified that the transformation of management economic processes should be based on the implementation of the proposed system of principles, the use of which will identify and solve a set of problems of social development of the region, which meets the challenges of our time. To create an effective system of interaction between corporate and regional participants, it is necessary to link their goals, to harmonise them with the goals of socio-economic development of the region. This is where digitalisation can help. It is determined that in modern conditions, the problems of the digital sector affect the competitiveness of the economy, as the lag in obtaining and processing relevant data, the inability to use digital resources are accompanied by the loss of former market positions. From the standpoint of the theory of asymmetry of international trade, the digital dependence of one country on another leads to an increase in the gap in economic development between these countries. The rapid development of information and computer technologies and the active Internet penetration into all spheres of human life have led to the transformation of economic processes according to the level of digitalisation. The development and dissemination of key technologies underlying the digital economy have a decisive impact on the transformation of globalisation: they directly affect the production of goods and services, human resources, investment in human and physical capital, foreign direct investment, international technology transfer, industrial innovation. In essence, all this directly affects the efficiency of production, performance, competitiveness, and economic growth – from individual market participants to countries, regions, and the world economy as a whole.

Performance Evaluation of Regression Analysis Algorithms in Predicting the Enrollment of Basic Education

The use of Linear Regression in predicting enrolment has been shown to be beneficial, although it varies with various datasets and attributes; varying weights of the correlation of the attributes can be discarded if they do not impact the prediction. Data collecting had grown since prior investigations, resulting in a more complicated dataset with many varieties. As a result of the data being created by multiple clerks, cleaning and combining proved tough; nonetheless, the fundamental parameters remain intact. Different algorithms were examined but Linear Regression obtained the highest accuracy with a 12.398 percentage for the absolute error and a root mean squared of 26.936 to create a tangible model to anticipate the enrolment of Region IVA CALABARZON in the Philippines. This demonstrates that it was 2.067 percentage points more than the prior research.

Application of artificial intelligence in a real-world research for predicting the risk of liver metastasis in T1 colorectal cancer

Background Liver is the most common metastatic site of colorectal cancer (CRC) and liver metastasis (LM) determines subsequent treatment as well as prognosis of patients, especially in T1 patients. T1 CRC patients with LM are recommended to adopt surgery and systematic treatments rather than endoscopic therapy alone. Nevertheless, there is still no effective model to predict the risk of LM in T1 CRC patients. Hence, we aim to construct an accurate predictive model and an easy-to-use tool clinically. Methods We integrated two independent CRC cohorts from Surveillance Epidemiology and End Results database (SEER, training dataset) and Xijing hospital (testing dataset). Artificial intelligence (AI) and machine learning (ML) methods were adopted to establish the predictive model. Results A total of 16,785 and 326 T1 CRC patients from SEER database and Xijing hospital were incorporated respectively into the study. Every single ML model demonstrated great predictive capability, with an area under the curve (AUC) close to 0.95 and a stacking bagging model displaying the best performance (AUC = 0.9631). Expectedly, the stacking model exhibited a favorable discriminative ability and precisely screened out all eight LM cases from 326 T1 patients in the outer validation cohort. In the subgroup analysis, the stacking model also demonstrated a splendid predictive ability for patients with tumor size ranging from one to50mm (AUC = 0.956). Conclusion We successfully established an innovative and convenient AI model for predicting LM in T1 CRC patients, which was further verified in the external dataset. Ultimately, we designed a novel and easy-to-use decision tree, which only incorporated four fundamental parameters and could be successfully applied in clinical practice.

Aquatic Therapy for Persons with Neuromuscular Diseases – A Scoping Review

Background: Aquatic exercise is among the most common physical activity modalities performed by people with disabilities. Objective: The present paper reviews currently-available research on aquatic therapy (AT) for persons with neuromuscular diseases (NMD). Methods: A scoping review of the existing literature was conducted on PubMed, Embase, Medline, Scopus, Web of Science, SPORTdiscus, CINAHL and Lilacs from the earliest date available until October 2020. It follows the methodological framework for conducting a scoping review proposed by the Joanna Briggs Institute. Results: A total of 28 articles were analyzed and the study parameters grouped by the topography of NMD; most of the studies (n = 16) addressed myopathies. A considerable increase in the number of studies was found over time, and heterogeneity was identified across and within AT interventions for persons with NMD; hence, to allow more effective interpretation of study results, there is a need to standardize the fundamental parameters and procedures for aquatic therapy. Conclusions: This scoping review provides a comprehensive outline of available literature; the findings could serve as a starting point for clinical studies on the effects of AT on persons with NMD, and encourage a more coherent approach to their design.

Our Third Skin

<p>It can be argued that there is an absence of reverence between contemporary architecture that governs our urban environment and the human body. Current architectural forms are unwittingly unresponsive to the dynamic flow of human action thus realising a denaturalisation of the human body’s transformations. The natural body deliberately expresses itself through reactive and interactive dynamic fluctuations whilst planar verticality and horizontality are qualities that commonly delineate the revered contemporary architecture of our lived realities. This thesis explored the human body as both a metaphorical and literal site. Provoking an investigation into how the body responds to the surface of architecture in an attempt to redefine how the design of architecture can better respond to the body as an active controller for defining space and generating form. This notion elicits the exploration of the relationship between; body and space, body and surface, body and form. By actively trying to understand the fundamental parameters of interior architecture that enhance our experience of being, this thesis is a commentary on how principles of interior architecture can be extracted and adapted to thrive within the ubiquitous realities of the urban environment. This is an effort to return form back to something more intimately attuned to the body’s stature. The motivation of this thesis was to create a design methodology that transitions from concept, to design and reach its realisation – where material enables the abstract intellect of form to be thought. With each phase propelled by the aspiration to better understand the relationship between the biological body and architecture. Following the framework of body space, interaction, and form, the methodology of the thesis has been developed at three scales of immediacy, maturing from the wearable to the inhabitable. The first level of immediacy considered and intuitively explores the body as a ‘site’. By using the biological body and the scale of the body to understand the body as a vessel that both contains and occupies space. The second level of immediacy and scale increased and responded to the intimate expressions of the self upon the surface of architecture. An investigation into how the anatomy of the body responds to the planar and static nature of surface. Actualising an experiential surface that departs from being a flat rigid surface and becomes suppler like an epidermis. Such an architecture that excites and transforms the body that is subject to it. As the methodology manifests the possibility of using the body as a design generative, the third and last level of immediacy is an amalgamation and development upon the previous analyses. The existential dialect between the surface of the body and the surface of architecture generates the contours of a ‘vertical somatic topography’. Site and material are introduced to shift the ephemeral form to reach physical conception through a series of scale models. The chosen site’s organisation and behaviour of material(s) directed and balanced the variations of form. The form creates a new immersive spatial condition that entices passer-byers to rediscover an omitted space in the city. The antithetical form of the installation deconstructs and disturbs the space in which it is presented imposing an affective reaction between body and surface - counteracting the sensory deprivation and suggests a space to slow, ingest, interact, and confer yourself in a moment of realisation of the surrounding architecture’s immobility and insensitivity to the ever dynamic natural body.</p>

Our Third Skin

<p>It can be argued that there is an absence of reverence between contemporary architecture that governs our urban environment and the human body. Current architectural forms are unwittingly unresponsive to the dynamic flow of human action thus realising a denaturalisation of the human body’s transformations. The natural body deliberately expresses itself through reactive and interactive dynamic fluctuations whilst planar verticality and horizontality are qualities that commonly delineate the revered contemporary architecture of our lived realities. This thesis explored the human body as both a metaphorical and literal site. Provoking an investigation into how the body responds to the surface of architecture in an attempt to redefine how the design of architecture can better respond to the body as an active controller for defining space and generating form. This notion elicits the exploration of the relationship between; body and space, body and surface, body and form. By actively trying to understand the fundamental parameters of interior architecture that enhance our experience of being, this thesis is a commentary on how principles of interior architecture can be extracted and adapted to thrive within the ubiquitous realities of the urban environment. This is an effort to return form back to something more intimately attuned to the body’s stature. The motivation of this thesis was to create a design methodology that transitions from concept, to design and reach its realisation – where material enables the abstract intellect of form to be thought. With each phase propelled by the aspiration to better understand the relationship between the biological body and architecture. Following the framework of body space, interaction, and form, the methodology of the thesis has been developed at three scales of immediacy, maturing from the wearable to the inhabitable. The first level of immediacy considered and intuitively explores the body as a ‘site’. By using the biological body and the scale of the body to understand the body as a vessel that both contains and occupies space. The second level of immediacy and scale increased and responded to the intimate expressions of the self upon the surface of architecture. An investigation into how the anatomy of the body responds to the planar and static nature of surface. Actualising an experiential surface that departs from being a flat rigid surface and becomes suppler like an epidermis. Such an architecture that excites and transforms the body that is subject to it. As the methodology manifests the possibility of using the body as a design generative, the third and last level of immediacy is an amalgamation and development upon the previous analyses. The existential dialect between the surface of the body and the surface of architecture generates the contours of a ‘vertical somatic topography’. Site and material are introduced to shift the ephemeral form to reach physical conception through a series of scale models. The chosen site’s organisation and behaviour of material(s) directed and balanced the variations of form. The form creates a new immersive spatial condition that entices passer-byers to rediscover an omitted space in the city. The antithetical form of the installation deconstructs and disturbs the space in which it is presented imposing an affective reaction between body and surface - counteracting the sensory deprivation and suggests a space to slow, ingest, interact, and confer yourself in a moment of realisation of the surrounding architecture’s immobility and insensitivity to the ever dynamic natural body.</p>

Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids

Medical research in the recent years has achieved significant progress due to the increasing prominence of organoid technology. Various developed tissue organoids bridge the limitations of conventional 2D cell culture and animal models by recapitulating in vivo cellular complexity. Current 3D cardiac organoid cultures have shown their utility in modelling key developmental hallmarks of heart organogenesis, but the complexity of the organ demands a more versatile model that can investigate more fundamental parameters, such as structure, organization and compartmentalization of a functioning heart. This review will cover the prominence of cardiac organoids in recent research, unpack current in vitro 3D models of the developing heart and look into the prospect of developing physiologically appropriate cardiac organoids with translational applicability. In addition, we discuss some of the limitations of existing cardiac organoid models in modelling embryonic development of the heart and manifestation of cardiac diseases.

The First Retrieval of a Substellar Subdwarf: A Cloud-free SDSS J125637.13–022452.4

We present the first retrieval analysis of a substellar subdwarf, SDSS J125637.13−022452.4 (SDSS J1256−0224), using the Brewster retrieval code base. We find SDSS J1256−0224 is best fit by a cloud-free model with an ion (neutral H, H−, and electron) abundance corresponding to Fe / H ion = − 1.5 . However, this model is indistinguishable from a cloud-free model with Fe / H ion = − 2.0 and a cloud-free model with Fe / H ion = − 1.5 assuming a subsolar carbon-to-oxygen ratio. We are able to constrain abundances for H2O, FeH, and CrH, with an inability to constrain any carbon-bearing species likely due to the low metallicity of SDSS J1256−0224. We also present an updated spectral energy distribution (SED) and semiempirical fundamental parameters. Our retrieval- and SED-based fundamental parameters agree with the Baraffe low-metallicity evolutionary models. From examining our “rejected” models (those with ΔBIC > 45), we find that we are able to retrieve gas abundances consistent with those of our best fitting model. We find the cloud in these poorer fitting “cloudy” models is either pushed to the bottom of the atmosphere or made optically thin.

Design of a dual-band antenna for energy harvesting application

This report presents an investigation on how to improve the current dual-band antenna to enhance the better result of the antenna parameters for energy harvesting application. Besides that, to develop a new design and validate the antenna frequencies that will operate at 2.4 GHz and 5.4 GHz. At 5.4 GHz, more data can be transmitted compare to 2.4 GHz. However, 2.4 GHz has long distance of radiation, so it can be used when far away from the antenna module compare to 5 GHz that has short distance in radiation. The development of this project includes the scope of designing and testing of antenna using computer simulation technology (CST) 2018 software and vector network analyzer (VNA) equipment. In the process of designing, fundamental parameters of antenna are being measured and validated, in purpose to identify the better antenna performance.