scholarly journals Serum estradiol level according to dose and formulation of oral estrogens in postmenopausal women

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Soo-Min Kim ◽  
Sung Eun Kim ◽  
Dong-Yun Lee ◽  
DooSeok Choi
Keyword(s):  
Postmenopausal Women ◽  
Cross Sectional Study ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Cross Sectional ◽  
Serum Estradiol Level ◽  
Estrogen Dose ◽  
Conjugated Estrogen ◽  
Estradiol Levels ◽  
Different Doses

AbstractThis study was performed to evaluate serum estradiol level in postmenopausal women using oral menopausal hormone therapy (MHT) with different doses and formulations of estrogens. A total of 344 postmenopausal women who received oral MHT was included in this cross-sectional study. Serum estradiol level was compared according to formulation (estradiol hemihydrate [EH] or valerate [EV], conjugated estrogen [CE]) and dose (estradiol 1 or 2 mg, CE 0.45 or 0.625 mg) of the estrogens. Mean age and years since menopause were 56.9 and 7.9 years, respectively. Mean duration of MHT was 27.4 months. Since serum estradiol levels were not significantly different at either dose, EH and EV at the same dose were combined for comparisons: estradiol 1 mg and 2 mg. The serum estradiol level with estradiol 2 mg (107.6 pg/mL) was significantly higher by 60% than with estradiol 1 mg (65.8 pg/mL) or CE 0.45 mg (60.1 pg/mL), and it was also significantly higher than with CE 0.625 mg (76.8 pg/mL). Our findings suggest that serum estradiol level is not directly proportional to estrogen dose. In terms of serum concentration, CE 0.45 mg is equivalent to estradiol 1 mg.

scholarly journals The Relationship Between Musculoskeletal Pains, Serum Estradiol Level and Climacteric Symptoms in Postmenopausal Women

2020 ◽  
Author(s):  
Neda Mohamadzade ◽  
Shahideh Jahanian Sadatmahalleh ◽  
Saeideh Ziaei ◽  
Narges Zaeemzadeh ◽  
Anoshirvan Kazemnejad
Keyword(s):  
Postmenopausal Women ◽  
Musculoskeletal Pain ◽  
Rating Scale ◽  
Personal Data ◽  
Cross Sectional Study ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Climacteric Symptoms ◽  
Cross Sectional ◽  
Serum Estradiol Level

Abstract Background: Due to the decrease of estrogen levels in postmenopausal females, menopause can be associated with musculoskeletal pains. This study was designed to assess the possible association between musculoskeletal pains, serum estradiol level, and climacteric symptoms in postmenopausal women.Methods: This cross-sectional study was conducted on 307 postmenopausal females selected by convenience sampling method. Data collection procedure lasted from October 2016 to September 2018. The required data were collected using the Menopause Rating Scale (MRS), Örebro Musculoskeletal Pain Questionnaire (ÖMPQ), and a questionnaire containing personal data. The blood sample was taken to measure the estradiol level. Results: There was a direct relationship between musculoskeletal pains and menopause symptoms (p<0.001), age (p=0.03), parity (p=0.01), and BMI (p=0.03) and an indirect association between musculoskeletal pain and marriage age (p=0.009), age of first pregnancy (0.017), estradiol level (p<0.001) and education level (p=0.002). The regression analysis results showed that menopause symptoms were the strongest predictor of musculoskeletal pains among all the variables.Conclusions: The findings of the present study showed that although various parameters are associated with musculoskeletal pains, climacteric symptoms are the most important predictive parameters of musculoskeletal pains.

PHYSICAL DISORDERS AFTER HYSTERECTOMY DEPEND ON MRS AND SERUM ESTRADIOL LEVELS

2016 ◽  
pp. 41-45
Author(s):  
Lam Huong Le
Keyword(s):  
Key Words ◽  
Cross Sectional Study ◽  
Sexual Disorders ◽  
Serum Estradiol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Total Hysterectomy ◽  
Physical Disorders ◽  
The Relationship ◽  
Estradiol Levels

Objectives: To study the relationship between serum estradiol and physical disorders after hysterectomy. Methods: A descriptive cross sectional study on 151 women after total hysterectomy from 12/2008 to 11/2010 at Hue Cental Hospial. Results: Serious disorders in total hysterectomy group include: physical disorders (34.78%), maternal disorders (71.74%), sexual disorders (58.70%). There were significant differences these disorders between total hysterectomy group and hysterectomy with/without accessiory remove group, as well as menopause group. Conclusion: Serum estradiol levels was inversely correlated with physical disorders, martenal disorders, sexual disorders and other disorders. Key words: hysterectomy, serum estradiol

The Association Between Serum Estradiol Level and Hearing Sensitivity in Postmenopausal Women

2002 ◽  
Vol 99 (5, Part 1) ◽  
pp. 726-730 ◽  
Author(s):  
Sung Hoon Kim ◽  
Byung Moon Kang ◽  
Hee Dong Chae ◽  
Chung Hoon Kim
Keyword(s):  
Postmenopausal Women ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Serum Estradiol Level ◽  
Hearing Sensitivity

scholarly journals The Occurrence of Glaucoma and Association with Serum Estradiol Level in Postmenopausal Women

2013 ◽  
Vol 19 (2) ◽  
pp. 106 ◽  
Author(s):  
Gyun-Ho Jeon ◽  
Hyun-Jin Cho ◽  
Sungwook Chun ◽  
Yong-Il Ji ◽  
Chul-Hoi Jeong ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Estradiol Level ◽  
Serum Estradiol ◽  
Serum Estradiol Level

scholarly journals CORRELATION BETWEEN PHYTOESTROGENS INTAKE WITH TELOMERE LENGTH IN MINANGKABAU PREMENOPAUSAL WOMEN

2018 ◽  
Vol 11 (11) ◽  
pp. 499
Author(s):  
Desmawati Desmawati ◽  
Delmi Sulastri ◽  
Yuniar Lestari ◽  
Jamsari Jamsari
Keyword(s):  
Telomere Length ◽  
Significant Positive Correlation ◽  
Venous Blood ◽  
Premenopausal Women ◽  
Cross Sectional Study ◽  
Estradiol Level ◽  
Sectional Study ◽  
Cross Sectional ◽  
Food Frequency ◽  
Estradiol Levels

Objective: This study aimed to investigate the correlation between phytoestrogens intake with telomere length in premenopausal Minangkabau ethnicity women.Methods: This cross-sectional study was conducted in Padang city, to 113 premenopausal Minangkabau ethnic 40–54 years old. Food intake data were obtained by an interview by trained enumerators using semi-quantitative food frequency questionnaire. Telomere examination was done from 3 ml of venous blood. Telomere length examination by modification of O’Callaghan and Fenech method. Estradiol level was measured by the ELISA technique.Results: This research indicated an average telomere length was 554.79±426.81 bp, estradiol level was 149.47±52.26 pg/ml, and phytoestrogens intake was 37.95±32.25 mg/day. There were the differences between phytoestrogens intake and telomere length based on estradiol levels. Then, there was no significant correlation between phytoestrogens intake and telomere length.Conclusion: There is no significant positive correlation between phytoestrogens intake and telomere length of premenopausal women in the Minangkabau ethnic.

scholarly journals Correction to: Low serum estradiol levels are related to Mycobacterium avium complex lung disease: a cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yoshifumi Uwamino ◽  
Tomoyasu Nishimura ◽  
Yasunori Sato ◽  
Eiko Tamizu ◽  
Takanori Asakura ◽  
...  
Keyword(s):  
Lung Disease ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Complex ◽  
Cross Sectional Study ◽  
Serum Estradiol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Estradiol Levels ◽  
Low Serum

scholarly journals Low serum estradiol levels are related to Mycobacterium avium complex lung disease: a cross-sectional study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Yoshifumi Uwamino ◽  
Tomoyasu Nishimura ◽  
Yasunori Sato ◽  
Eiko Tamizu ◽  
Takanori Asakura ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Confidence Interval ◽  
Postmenopausal Women ◽  
Mycobacterium Avium ◽  
Cross Sectional Study ◽  
Healthy Controls ◽  
Serum Estradiol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Low Serum

Abstract Background The risk factors for Mycobacterium avium complex lung disease (MAC-LD) are not well known. We hypothesized that low serum estradiol (E2) levels are related to MAC-LD as most patients with MAC-LD are postmenopausal women. Methods This cross-sectional study compared patients with MAC-LD and healthy controls. Study subjects were postmenopausal women aged 65 years or younger. Serum testosterone, dehydroepiandrosterone sulfate (DHEA-S), and E2 levels were measured and categorized as high or low based on median levels. We performed multivariate analysis, receiver operating characteristic (ROC) curve analysis, and age- and body mass index (BMI)-matched subgroup analysis to evaluate the association between low serum E2 levels and MAC-LD. Additionally, using blood samples obtained for other clinical studies, the levels of sex steroid hormones were compared between age- and BMI-matched MAC-LD and bronchiectasis female patients without non-tuberculosis mycobacterial infections (non-NTM BE). Results Forty-two patients with MAC-LD and 91 healthy controls were included. The median E2 (2.20 pg/mL vs. 15.0 pg/mL, p < 0.001), testosterone (0.230 ng/L vs. 0.250 ng/L, p = 0.005), and DHEA-S (82.5 μg/dL vs. 114.0 μg/dL, p < 0.001) levels were lower in the MAC-LD group than in the control group. Multivariate analysis revealed that low serum E2 (adjusted odds ratio = 34.62, 95% confidence interval = 6.02–199.14) was independently related to MAC-LD, whereas low DHEA-S and testosterone were not. ROC analysis illustrated a strong relationship between low serum E2 levels and MAC-LD (area under the curve = 0.947, 95% confidence interval = 0.899–0.995). Even the age- and BMI-matched subgroup analysis of 17 MAC-LD patients and 17 healthy controls showed lower serum E2 in MAC-LD patients than in healthy controls. Additionally, serum E2 levels of 20 MAC-LD patients were lower than plasma E2 levels of 11 matched non-NTM BE patients (1.79 pg/mL vs. 11.0 pg/mL, p < 0.001). Conclusions Low serum E2 levels were strongly related to MAC-LD in postmenopausal women.

Phytoestrogen Intake Correlate with Blood Pressure in Minangkabau Premenopausal People

2018 ◽  
Vol 24 (8) ◽  
pp. 6211-6213
Author(s):  
Desmawati ◽  
Delmi Sulastri ◽  
Yusrawati ◽  
Jamsari
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
Sitting Position ◽  
Serum Estradiol ◽  
Sectional Study ◽  
Cross Sectional ◽  
Correlation Test ◽  
Elisa Kit ◽  
The Subject ◽  
Estradiol Levels

Prevalence of hypertension increases in the premenopausal phase due to changes in estrogen levels. Phytoestrogens is known as estrogens like estrogen derived from plants. This study aims to elucidate the correlation of phytoestrogen intake with blood pressure in Minangkabau premenopausal people. A cross-sectional study was conducted in Minangkabau premenopausal people, aged 40–55 years old at Padang City in West Sumatera, Indonesia. Phytoestrogen intake examined to 76 subject by using food frequenty questionnaire (FFQ) that contain 200 kinds of food. Data were analyzed by using correlation test with significant levels p < 0.05. Blood pressure was measured in a sitting position after the subject rests for 10 minutes. Serum estradiol was measured by ELISA tecnique using E2 (estradiol) ELISA KIT from Elabscience. This study show that mean systolic blood pressure (SBP) is 119.74±16.1 mmHg and diastolic blood pressure (DBP) is 76.32±11.1 mmHg. Mean of phytoestrogens intake is 32.66±26.63 mg. The correlation test showed that there was a significant correlation between phytoestrogen intake with SBP (r=−0.255; p=0.26) and DBP (r=−0.246; p=0.032). Whereas serum estradiol levels did not show significant correlation with both SBP and DBP (r=−0.177; p=0.125 and r=−0.204: p=0.077) respectively. Phytoestrogens intake has significant correlation with blood pressure in Minangkabau premenopausal people.

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