scholarly journals A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yan Hu ◽  
Sheng Hu ◽  
Shangwen Zhang ◽  
Siyi Dong ◽  
Jie Hu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Double Layer ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Inner Core ◽  
Synthetic Polymer ◽  
Ph Sensitive ◽  
Sustained Drug Delivery ◽  
Potential Applications ◽  
Sensitive Property

AbstractA new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was formed by physical crosslinking with pH-sensitive property. The synthetic polymer out-layer with enhanced stability was introduced by chemical crosslinking to eliminate the expansion of inner core and the diffusion of inner content. The physicochemical structure of the double-layer hydrogels was characterized. The drug-release results demonstrated that the sustained-release effect of the hydrogels for different model drugs could be regulated by changing the composition or thickness of the hydrogel layer. The significant sustained-release effect for BSA and indomethacin indicated that the bilayer hydrogel can be developed into a novel sustained delivery system for bioactive substance or drugs with potential applications in drugs and functional foods.

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

scholarly journals Sustained drug delivery system in fish and the potential for use of PLGA microparticles: a review

2019 ◽  
Vol 64 (No. 7) ◽  
pp. 287-293
Author(s):  
J Matejkova ◽  
P Podhorec
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Hormonal Treatment ◽  
The United States ◽  
Pharmaceutical Products ◽  
European Medicines Agency ◽  
Sustained Drug Delivery ◽  
Plga Microparticles

Many fish species display some form of reproductive disorder in captivity. Captive fish reared in conditions outside the natural spawning environment show a failure of the pituitary to release the maturational gonadotropin luteinizing hormone thus necessitating administration of the hormone to induce spawning. A controlled sustained-release delivery system can conquer the issue of short half-life of gonadotropin releasing hormone (GnRH) in blood and avoid the necessity of using re-injections. Sustained release of GnRHa can induce long-term enhancement in semen production and multiple spawning in species with asynchronous or multiple batch group synchronous ovarian physiology. The most recent development is the incorporation of GnRHa into microparticles of biodegradable polymers that release the drug during a certain period of time ranging from days to weeks. The most attractive polymeric candidate used as a carrier for administering a pharmaceutical products is poly(lactic-co-glycolic acid); (PLGA). PLGA has excellent biodegradability and biocompatibility and is generally recognised as safe by international regulatory agencies including the European Medicines Agency and the United States Food and Drug Administration. This review describes methods of hormonal treatment in fish, highlights the advantage of sustained drug delivery system and discusses the potential of PLGA microparticles as a tool for achieving successful reproduction.

Bio-inspired fabrication and potential applications of hierarchically porous CaCO3 hollow nanospheres

2016 ◽  
Vol 40 (8) ◽  
pp. 6874-6880 ◽  
Author(s):  
Xiaoming Ma ◽  
Yucong Zhu ◽  
Ping Yang ◽  
Zipeng Wei ◽  
Peng Liu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Anticancer Drug ◽  
Ph Sensitive ◽  
Hollow Nanospheres ◽  
Delivery Vehicle ◽  
Hierarchically Porous ◽  
Potential Applications

Hierarchically porous CaCO3 hollow nanospheres are developed as an efficient pH-sensitive and sustained release anticancer drug (DOX) delivery vehicle.

Magnetic/pH-sensitive double-layer microrobots for drug delivery and sustained release

2020 ◽  
Vol 19 ◽  
pp. 100583 ◽  
Author(s):  
Weinan Chen ◽  
Mengmeng Sun ◽  
Xinjian Fan ◽  
Hui Xie
Keyword(s):  
Drug Delivery ◽  
Sustained Release ◽  
Double Layer ◽  
Ph Sensitive

SUSTAINED RELEASE MULTIPARTICULATE GASTRORETENTIVE DELIVERY SYSTEM OF CINNARIZINE

INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (07) ◽  
pp. 31-38
Author(s):  
Gurudev Kruthi ◽  
◽  
B. V. Basavaraj ◽  
S. Bharath ◽  
R. Deveswaran ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Delivery System ◽  
Polymer Concentration ◽  
Entrapment Efficiency ◽  
Ir Studies ◽  
Sustained Drug Delivery ◽  
Release Studies ◽  
Drug Entrapment Efficiency

The main aim of the present work was to formulate and evaluate sustained release multiparticulate gastroretentive delivery system of cinnarizine. The microspheres were prepared by solvent evaporation method by using Eudragit RS 100 as a polymer in varying ratios. The prepared microspheres were evaluated for drug – polymer compatibility studies, micromeritic properties, drug entrapment efficiency, in vitro buoyancy and drug release studies. The mean particle size increased with increase in polymer concentration, ranging between 60.33 μm to 144.88 μm. FT IR studies showed that the drug and polymer were compatible with each other. The entrapment efficiency decreased with increase in the polymer concentration with values of 50%, 33.3% and 25% respectively. The microspheres floated upto 9 h over the surface of the gastric buffer medium and the buoyancy percentage was found to be in the range of 64.3 – 76.2%. In vitro drug release studies showed that the prepared microspheres exhibited prolonged drug release upto 62.89% for more than 9 h. The mechanism of drug release was found to be a combination of both peppas and matrix kinetics. Thus the developed floating microspheres of cinnarizine may be used as sustained drug delivery system for increasing the therapeutic efficacy with an improved patient compliance.

An Update on Recent Advances in Cubosome: A Novel Drug Delivery System

2021 ◽  
Vol 21 ◽  
Author(s):  
Madhukar Garg ◽  
Anju Goyal ◽  
Sapna Kumari
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Lipid Bilayers ◽  
Delivery System ◽  
Liquid Crystalline ◽  
Three Dimensional ◽  
Biologically Active ◽  
Potential Applications ◽  
Health Related ◽  
Novel Drug

: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three dimensional honeycombs like structure provided with two internal aqueous channels for incorporation of number of biologically active ingredients. In contrast liposomes they provide large surface area for incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as method of choice in the sustained release, controlled release and targeted release dosage forms as new drug delivery system for the better release of the drugs. As lot of advancement in the new form of dosage form has bring the novel avenues in drug delivery mechanisms so it was matter of worth to compile the latest updates on the various aspects of mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health related benefits.

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