scholarly journals Relationship between serum total testosterone and prostate volume in aging men

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bo-Wen Xia ◽  
Si-Cong Zhao ◽  
Zong-Ping Chen ◽  
Chao Chen ◽  
Tian-Shu Liu ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Prostate Volume ◽  
Serum Testosterone ◽  
Total Testosterone ◽  
Related Factors ◽  
Testosterone Levels ◽  
Aging Men ◽  
Low Testosterone ◽  
The Relationship ◽  
Relevant Factors

AbstractTotal testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs. 24.06 ± 6.77 P = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all P < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (P = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.

Relationship between serum total testosterone and prostate volume in aging men

2021 ◽  
Author(s):  
Bo-Wen Xia ◽  
Si-Cong Zhao ◽  
Zong-Ping Chen ◽  
Chao Chen ◽  
Tian-Shu Liu ◽  
...  
Keyword(s):  
Testosterone Level ◽  
Prostate Volume ◽  
Serum Testosterone ◽  
Total Testosterone ◽  
Related Factors ◽  
Testosterone Levels ◽  
Aging Men ◽  
Low Testosterone ◽  
The Relationship ◽  
Relevant Factors

Abstract Objectives Total testosterone levels decline with age, while prostate volume and the prevalence of benign prostatic hyperplasia increase with age. We sought to investigate the correlation of serum testosterone levels with prostate volume in aging men. Materials and methods We analyzed clinical data obtained from 416 ostensibly healthy men who underwent routine health check-ups and recruited and collected data from these subjects 4 years later. We analyzed the correlation between prostate volume and relevant factors, as well as the correlation between changes in prostate volume and low testosterone over a 4-year period. Results Men with low testosterone had significantly larger prostate volume than those in the normal testosterone group (26.86 ± 8.75 vs 24.06 ± 6.77 p = 0.02), and subjects with low testosterone had significantly higher levels of obesity-related factors, including waist circumference, body mass index, and insulin (all p < 0.001). After adjustment for age, testosterone level was negatively correlated with prostate volume (p = 0.004), and prostate volume and 4-year changes in prostate volume were associated with low testosterone. With increased testosterone level, prostate volume showed a significant linear decreasing trend. Conclusion These findings provide evidence of the relationship between testosterone and prostate volume. Additional large studies are needed to confirm these preliminary results.

scholarly journals SHBG and total testosterone levels in men with adult onset hypogonadism: what are we overlooking?

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Stephen J. Winters
Keyword(s):  
Testosterone Level ◽  
Clinical Condition ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Total Testosterone ◽  
Male Hypogonadism ◽  
Adult Onset ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
The Relationship

Abstract Background Adult onset male hypogonadism (AOH) is a common clinical condition whose diagnosis and management are controversial, and is often characterized by a low level of SHBG, but our understanding of why testosterone levels are low when SHBG is low is incomplete. Methods This retrospective chart review was performed to compare the relationship between SHBG and testosterone in the plasma of men presenting for evaluation of AOH with a cohort of men treated chronically with transdermal testosterone. Results The level of SHBG was < 30 nmol/L in 73% of men who presented for evaluation of AOH, and was inversely proportional to BMI in both the untreated and the testosterone-treated men. As in previous populations, the level of SHBG was highly positively correlated (r = 0.71, p < 0.01) with the total testosterone level in untreated men presenting for evaluation of AOH, but no relationship was found between the level of SHBG and total testosterone among men who were being treated with a transdermal testosterone preparation. Conclusions These findings further support the idea that SHBG regulates testicular negative feedback either directly or by modulating the entry of testosterone or estradiol into cells in the hypothalamus and/or pituitary to control gonadotropin synthesis and secretion which explains in part the low testosterone levels in men with AOH. Trial registration Not applicable

scholarly journals Association of plasma total testosterone level and metabolic syndrome in adult males

2019 ◽  
Vol 9 (3) ◽  
pp. e27-e27
Author(s):  
Alireza Hejrati ◽  
Amir Ziaee ◽  
Mohammad Pourmahmudian ◽  
Elham Bayani ◽  
Mehrnaz Ghavamipour ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Testosterone Level ◽  
Density Lipoprotein ◽  
Serum Testosterone ◽  
Plasma Testosterone ◽  
Adult Males ◽  
Plasma Testosterone Level ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
The Relationship

Introduction: Low testosterone level has strongly been correlated with body fat accumulation and abdominal obesity in men. Objectives: This study aimed to evaluate testosterone level in men with and without metabolic syndrome to determine the relationship between testosterone and metabolic syndrome. Patients and Methods: This case-control study was conducted on 172 cases of metabolic syndrome and 172 participants as a control group in Rasoul Akram hospital, Tehran, Iran. Demographic characteristics, fasting blood sugar (FBS), high-density lipoprotein (HDL), low-density lipoprotein (LDL), cholesterol, triglyceride (TG), and testosterone levels were recorded. SPSS version 21.0 and SAS version 9.1 were used for statistical analysis. Level of significance was considered 0.05. Results: The mean age of the two groups were 45.1±9.3 years and 41.5 ±11.2 years, respectively. There was a significant difference in serum testosterone levels between both groups and low testosterone levels were associated with metabolic syndrome (P<0.001). Serum testosterone levels showed a significant negative correlation with age in the metabolic syndrome group (r= -0.16, P=0.02). The relationship between metabolic syndrome and total plasma testosterone level using logistic regression model showed that, by increasing the total plasma testosterone level, the odds ratio for metabolic syndrome was 0.076 (95% CI: 0.027-0.216; P< 0.001). Conclusion: According to the results, low level of testosterone was related to the presence of metabolic syndrome in adult males. Future studies can investigate diagnostic value of testosterone level in this syndrome.

scholarly journals The decline of serum testosterone levels in community-dwelling men over 70 years of age: descriptive data and predictors of longitudinal changes

2008 ◽  
Vol 159 (4) ◽  
pp. 459-468 ◽  
Author(s):  
B Lapauw ◽  
S Goemaere ◽  
H Zmierczak ◽  
I Van Pottelbergh ◽  
A Mahmoud ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Community Dwelling ◽  
Sex Hormone Binding Globulin ◽  
Total Testosterone ◽  
Elderly Men ◽  
Related Factors ◽  
Longitudinal Changes ◽  
Testosterone Levels ◽  
Testosterone Production ◽  
Healthy Elderly

ObjectiveThis study was designed to assess longitudinal changes in serum testosterone levels, explore relationships with aging, genetic-, health-, and lifestyle-related factors, and investigate predictors of changes in healthy elderly men.DesignPopulation-based, longitudinal, 4-year observational study in 221 community-dwelling men aged 71–86 years at baseline.MethodsHormone levels assessed by immunoassay, anthropometry, questionnaires on general health, and genetic polymorphisms. Predictors of changes in testosterone levels explored using linear mixed-effects modeling for longitudinal analyses.ResultsTotal testosterone (TT), free testosterone, and bioavailable testosterone (BioT) levels decreased with aging, decreases in BioT being most marked. No changes in sex hormone-binding globulin (SHBG) or estradiol (E2), while LH and FSH levels increased during follow-up. Subjects who gained weight displayed a greater decline in TT levels, mainly due to decreasing SHBG levels. However, baseline body composition was not predictive of subsequent changes in testosterone levels. Baseline E2 (P=0.023 to 0.004), LH (P=0.046 to 0.005), and FSH (P<0.002) levels were independently positively associated with a faster decline in testosterone fractions, although only FSH remained significant when adjusting for baseline testosterone (P=0.041–0.035). Carriers of a ‘TA’ haplotype of the estrogen receptor α gene (ERα) PvuII and XbaI polymorphisms displayed a slower decline of TT and BioT (P=0.041–0.007).ConclusionsIn elderly men with already low serum testosterone levels, a further decline was observed, independent of baseline age. The identification of FSH levels as a predictor of this decline appears to reflect the testicular mechanisms of aging-related changes in testosterone production, whereas associations with E2 and ERα polymorphisms are suggestive of estrogen-related processes, possibly related to changes in the neuroendocrine regulation of testosterone production.

scholarly journals COVID-19 may cause Erectile Dysfunction (ED) and the high level of testosterone is associated with poor prognosis

2021 ◽  
Author(s):  
kadir karkin ◽  
ergün alma ◽  
Hakan Erçil ◽  
keremhan gözükara ◽  
ferhat ortaoğlu ◽  
...  
Keyword(s):  
Intensive Care ◽  
Erectile Dysfunction ◽  
Testosterone Level ◽  
Age Groups ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Age Group ◽  
Testosterone Levels ◽  
High Level ◽  
The Relationship

We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Between April-December 2020, 70 patients who admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for any reason before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. This questionnaire was arranged to present the first month before COVID-19 and after COVID-19. The patients were registered as 20-40 age group 1, 40-60 age group 2 and 60 years and above group 3. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated. It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all three groups were statisticaly and significantly different compared to the period before COVID-19 (p <0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p <0.05). Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease. Keywords COVID-19, erectile dysfunction, testosterone What’s already known about this topic? The relationship between Erectile Dysfunction (ED) and COVID-19 develops due to vasculogenic and hormonal causes which were caused by the primary disease. What does this article add? We showed with this study that COVID-19 causes ED in all age groups, reduces testosterone levels seriously. Moreover, we also presented that the higher the testosterone levels during COVID-19, the more severe the disease progresses.

scholarly journals Erectile dysfunction and testosterone levels prior to COVID-19 disease: What is the relationship?

2021 ◽  
Vol 93 (4) ◽  
pp. 460-464
Author(s):  
Kadir Karkin ◽  
Ergün Alma
Keyword(s):  
Intensive Care ◽  
Erectile Dysfunction ◽  
Testosterone Level ◽  
Premature Ejaculation ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Testosterone Levels ◽  
Disease Prognosis ◽  
Before And After ◽  
The Relationship

Objective: We aimed to investigate the relationship between COVID-19 and Erectile Dysfunction (ED) and the effect of serum testosterone level on the disease prognosis. Methods: Between April-December 2020, 70 patients who were admitted with a complaint of ED after having COVID-19 and whose serum testosterone level was checked for varicocele, premature ejaculation, and infertility reasons before COVID-19. The patients filled the International Index of Erectile Function (IIEF-5) and their testosterone level was checked. The questionnaire was arranged to assess the first month before COVID-19 and after COVID-19. Testosterone levels of the patients before and after COVID-19 were compared. The relationship between testosterone levels and hospitalization in the intensive care was evaluated.Results: It was revealed that testosterone levels and IIEF-5 scores after COVID-19 in all patients were statisticaly and significantly different compared to the period before COVID-19 (p < 0.05). Testosterone levels of patients in need of intensive care were significantly higher than those without any need of intensive care (p < 0.05).Conclusions: Our study has presented that COVID-19 may cause ED and high testosterone levels increase the rate of hospitalization in the intensive care by intensifying the disease.

scholarly journals Relationship between Serum Testosterone and Nocturia in Men without Benign Prostate Enlargement

2016 ◽  
Vol 9 (1) ◽  
pp. 167-167
Author(s):  
S. Jeh ◽  
◽  
D. Seo ◽  
S. Choi ◽  
S. Kam ◽  
...  
Keyword(s):  
Flow Rate ◽  
Testosterone Level ◽  
Prostate Volume ◽  
Specific Antigen ◽  
Multivariate Logistic Regression Analysis ◽  
Serum Testosterone ◽  
Total Testosterone ◽  
Urinary Flow ◽  
Prostate Enlargement ◽  
Benign Prostate

Objective: To clarify the relationship between serum total testosterone and nocturia in males without an enlarged prostate. Design and Method: Among the 1029 male patients who visited our clinic for health screening from January 2010 to July 2014, 596 patients without benign prostate enlargement (BPE) were analyzed. To evaluate the effect of serum total testosterone on prevalence of nocturia and number of nocturia episodes, multivariate analyses were performed including the covariates of age, International Prostate Symptom Score (IPSS), International Index of Erectile Function (IIEF) score, body mass index, prostate specific antigen, prostate volume and maximal urinary flow rate. Results: Mean prostate volume was 21.70±4.34 ml and prevalence of nocturia (over 1 times/night) was 22.1%. Multivariate logistic regression analysis revealed positive associations of age (OR 1.048, P = 0.005), total IPSS (OR 1.217, P <0.001) and testosterone level (OR 1.115, P = 0.041) with the prevalence of nocturia. Although the mean testosterone level was progressively elevated as the number of nocturia episodes increased, no consistent association with the number of nocturia episodes was seen for testosterone after adjusting for age, IPSS, IIEF score and maximal urine flow rate. Conclusions: Serum total testosterone level is significantly positively associated with the prevalence of nocturia. Therefore, in men without enlarged prostate, testosterone seems to have an opposing role in the etiology of nocturia.

scholarly journals Comparison of Basal Serum Testosterone Levels between Male Athletes and Martial Artists

2018 ◽  
Vol 6 (11) ◽  
Author(s):  
Roberto Arjona-Luna
Keyword(s):  
Martial Arts ◽  
Serum Testosterone ◽  
Total Serum ◽  
Control Group ◽  
Total Testosterone ◽  
Male Athletes ◽  
Testosterone Levels ◽  
Biological Stress ◽  
Significant Difference ◽  
The Relationship

There are reports about the relationship between testosterone levels and aggressiveness in animals and humans. The practice of martial arts requires high levels of pain tolerance, fear control and of course, enough aggressiveness to overcome psychological and biological stress. Therefore, the objective of the present study was to identify the relationship between basal testosterone levels and martial arts practice by comparing total serum testosterone values between male athletes and martial artists. In this cross-sectional study, the total testosterone between a control group of 15 male athletes and 15 male martial artists was compared. The participants had the following inclusion criteria: healthy men between 18 and 35 years old, not obese, with at least 1 year of continuous training, 3 to 5 sessions per week with a duration from 60 to 90 min at a moderate to high intensity, non smokers, alcohol free, and free from exogenous testosterone or testosterone precursors. Blood samples were recolected between 8:00 to 10:00 am and the laboratory results were obtained by chemiluminescence. The testosterone levels mean of the martial artist's group was 6.44 (±1.17) ng/mL and the athlete's control group had a mean of 6.09 (±1.32) ng/mL. Comparing values with the Student´s t-test showed no statistically significant difference, with a p value of 0.45. There is no significant difference of basal total testosterone levels between male martial artists and athletes, and it seems there is no direct relationship between testosterone levels and martial arts practice. Further investigation on the physiologic responses produced by the practice of combat sports is a growing necessity.

Why Do We Need New Markers for Male Hypogonadism and How Seminal Proteomics Might Solve the Problem?

2020 ◽  
Vol 27 (12) ◽  
pp. 1186-1191
Author(s):  
Giuseppe Grande ◽  
Domenico Milardi ◽  
Silvia Baroni ◽  
Andrea Urbani ◽  
Alfredo Pontecorvi
Keyword(s):  
Serum Testosterone ◽  
Clinical Syndrome ◽  
Testosterone Replacement ◽  
Total Testosterone ◽  
Male Hypogonadism ◽  
Grey Zone ◽  
Testosterone Levels ◽  
Normal Number ◽  
Replacement Treatment

Male hypogonadism is “a clinical syndrome that results from failure of the testis to produce physiological concentrations of testosterone and/or a normal number of spermatozoa due to pathology at one or more levels of the hypothalamic– pituitary–testicular axis”. The diagnostic protocol of male hypogonadism includes accurate medical history, physical exam, as well as hormone assays and instrumental evaluation. Basal hormonal evaluation of serum testosterone, LH, and FSH is important in the evaluation of diseases of the hypothalamus-pituitary-testis axis. Total testosterone levels < 8 nmol/l profoundly suggest the diagnosis of hypogonadism. An inadequate androgen status is moreover possible if the total testosterone levels are 8-12 nmol/L. In this “grey zone” the diagnosis of hypogonadism is debated and the appropriateness for treating these patients with testosterone should be fostered by symptoms, although often non-specific. Up to now, no markers of androgen tissue action can be used in clinical practice. The identification of markers of androgens action might be useful in supporting diagnosis, Testosterone Replacement Treatment (TRT) and clinical follow-up. The aim of this review is to analyze the main findings of recent studies in the field of discovering putative diagnostic markers of male hypogonadism in seminal plasma by proteomic techniques. The identified proteins might represent a “molecular androtest” useful as a seminal fingerprint of male hypogonadism, for the diagnosis of patients with moderate grades of testosterone reduction and in the follow-up of testosterone replacement treatment.

scholarly journals Normogonadotropic hypogonadism in men with obesity

2009 ◽  
Vol 6 (3) ◽  
pp. 39-42 ◽  
Author(s):  
L V Savel'eva ◽  
R V Rozhivanov ◽  
B O Shurdumova ◽  
V V Fadeev
Keyword(s):  
Testosterone Level ◽  
Healthy Subjects ◽  
Immunoreactive Insulin ◽  
Homa Index ◽  
Obese Patients ◽  
Functional Disorder ◽  
Testosterone Levels ◽  
Significant Difference ◽  
Low Testosterone ◽  
Index Calculation

Objective: to evaluate the preavalence and characteristics of hypogonadism in obese man. Research and Methods: Thestudy was performed in 31 obese man (aged 33 [22;44], BMI 40 [34,4;44,0]. Measurements during the study: chemistry panel, testosteroa and LH levels, immunoreactive insulin, HOMA index calculation. Statistically significant difference w as considered as p < 0,05. Results. Hypogonadism preavalence was 80,6%. The hypogonadism prevalence and testosterone level was more depended on age and obesity but less on duration. 100 % risk of hypogonadism w as observed in heavily obese patients. There w as no increase of LH levels. In man with low testosterone lev els HOMA index w as significantly higher со mpared to healthy subjects. Conclusion: The prevalence of normogonadotropic hypogonadism in obese men is extremely high and it represents an evidence of functional disorder of hypophyseal gonadal system. Thedecrease of testosterone levels is age-coinciding, but it is more pronounced in obese nan.

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