scholarly journals ABO blood group antigen therapy: a potential new strategy against solid tumors

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Qiong Luo ◽  
Mingxin Pan ◽  
Hao Feng ◽  
Lei Wang
Keyword(s):  
Blood Group ◽  
Killer Cell ◽  
Membrane Attack Complex ◽  
Blood Group Antigen ◽  
Control Group ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Blood Group A ◽  
Group A

AbstractThe economic burden of tumors is increasing, so there is an urgent need to develop new therapies for their treatment. Killing tumors by activating complement is an effective strategy for the treatment. We used the ABO blood group system and the corresponding antibodies to activate the killer cell capacity of the complement system. After the construction of a mouse model containing blood group A antibodies and inoculating colorectal cancer and breast cancer cells into the axillae of the mice, intratumoural injection using a lentivirus carrying a blood group antigen as a drug significantly reduced the tumor volume of the mice. Compared with the control group, the content of the C5b-9 complement membrane attack complex in the tumors of mice treated with the blood group A antigen was significantly increased, and the proportion of NK cells was also significantly increased. In vitro cell-based experiments proved that tumor cells expressing blood group A antigens showed significantly inhibited cell proliferation when added to serum containing blood group A antibodies. These results all prove that the ABO blood group antigen may become a powerful tool for the treatment of tumors in patients.

scholarly journals ABO Blood Group. Related Investigations and Their Association with Defined Pathologies

2007 ◽  
Vol 7 ◽  
pp. 1151-1154 ◽  
Author(s):  
Ursula Jesch ◽  
P. Christian Endler ◽  
Beatrix Wulkersdorfer ◽  
Heinz Spranger
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Chi Square ◽  
Ulcus Ventriculi ◽  
Group System ◽  
Blood Group A ◽  
Chi Square Test ◽  
Group A ◽  
Group Sex

The ABO blood group system was discovered by Karl Landsteiner in 1901. Since then, scientists have speculated on an association between different pathologies and the ABO blood group system. The aim of this pilot study was to determine the significance between different blood types of the ABO blood group system and certain pathologies. We included 237 patients with known diagnosis, blood group, sex, and age in the study. As a statistical method, the Chi-square test was chosen. In some cases, a significant association between the blood groups and defined diseases could be determined. Carriers of blood group O suffered from ulcus ventriculi and gastritis (X21 = 78.629, p <0.001), colitis ulcerosa and duodenitis (X21 = 5.846, p < 0.016), whereas male patients carrying blood group A tended to contract different types of tumours. In patients with intestinal tumours, females with blood group A were more likely to develop the pathology, whereas in males, the blood group O dominated. The development of cholelithiasis was found, above all, in patients with blood group O, which differed from other research where a correlation between this pathology and blood group A was found.

scholarly journals Correlation between CT chest severity score (CT-SS) and ABO blood group system in Egyptian patients with COVID-19

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Mohamed G. Mansour ◽  
Ahmed S. Abdelrahman ◽  
Emad H. Abdeldayem
Keyword(s):  
Blood Group ◽  
Severity Score ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Moderate Severity ◽  
Group System ◽  
Blood Group A ◽  
Egyptian Patients ◽  
Group A ◽  
The Mean

Abstract Background The 2019 coronavirus disease (COVID-19) has become a global health crisis. CT chest is considered as an important investigation for early diagnosis as well as assessment of severity of COVID-19 pneumonia. Several articles reported that there is a correlation between ABO blood group system and susceptibility as well as prognosis of the disease. In our study we correlated the CT severity score (CT-SS) and the ABO blood group in patients with COVID-19 infection. This study involved 547 symptomatic patients with pathologically proven COVID-19 infection (positive PCR); non contrast CT chest was done for all cases and CT severity score (CT-SS) was calculated followed by its correlation with the patients’ ABO blood group. Aim of the work was to evaluate the relation between CT-SS and the ABO blood groups in Egyptian patients with COVID-19 infection. Results The mean CT-SS in patients with blood group A patients (n = 153; 28%) was 13.7 (moderate severity), while in patients with blood group O (n = 227; 41.5%) the mean CT-SS was 6.7 (mild severity). In blood group B patients (n = 139; 25.4%) the mean CT-SS was 9.1 (mild to moderate severity) and in blood group AB patients (n = 28; 5.1%) the mean CT-SS was 9.7 (mild to moderate severity). Conclusion COVID-19 patients with blood group A are more prone to aggressive CT findings (higher CT-SS) and consequently may be susceptible to increased risk of mortality compared to the patients with other blood groups; however, patients with blood group O are suggested to have the least CT-SS and appear to be relatively protected.

scholarly journals Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality

2021 ◽  
Author(s):  
Uzma Ishaq ◽  
Asmara Malik ◽  
Jahanzeb Malik ◽  
Asad Mehmood ◽  
Azhar Qureshi ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Blood Group ◽  
Cox Regression ◽  
Survival Function ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Acute Phase Reactants ◽  
Blood Group A ◽  
Group A

AbstractBackground and objectiveThe ABO blood group system has been associated with infectious and noninfectious disease, including dengue, hepatitis B virus (HBV), and severe respiratory syndrome coronavirus (SARS), etc. Coronavirus disease 2019 (COVID-19) is the ongoing pandemic with multitude of manifestations and association of ABO blood group in South-East Asian population needs to be explored.MethodsIt was a retrospective study of patients with real time polymerase chain reaction (RT-PCR) diagnosis of COVID-19 at Advanced Diagnostics and Liver Center between April 2020 to January 2021. Blood group A, B, O, and AB were identified in every participant, irrespective of their RH type and allotted groups 1, 2,3, and 4, respectively. Cox regression and logistic regression were used for inferential statistics.ResultsThe cohort included 1067 patients: 521 (48.8%) of blood group O, 295 (27.6%) of blood group B, 202 (18.9%) of blood group A, and 49 (4.5%) of blood group AB. The majority of the patients were males 712 (66.7%) with an average body mass index (BMI) of 27.45 ± 3.53. Patients with AB blood group stayed a median (IQR) of 14 (5, 27) days while A blood group cohort stayed 13 (6,27) days and overall 10.6% COVID-19-related mortality was observed at our center, with 13.9% in blood group A as the majority of COVID-19 deaths. Regarding severity of COVID-19 disease, there was a trend towards critical disease in blood group A and O (n=83, 41.1%; n=183, 35.1%; OR, 11.34 (95% CI, 46.79-53.22); p<0.001). Logistic regression demonstrates blood group O and AB as predictors for severe COVID-19 disease (O: OR: 0.438 (95% CI: 0.168-1.139) p=0.090; AB: OR: 0.415 (95% CI: 0.165-1.046) p=0.062) and cause-specific hazards ratio (HR) for survival function was 3.206 (p=0.361) among all blood groups.ConclusionAlthough the prevalence of blood group O was higher in this cohort, hospital stay, severity of disease, and mortality were associated with blood group A. Further studies are needed for understanding the underlying mechanism behind the association of blood groups with COVID-19.

scholarly journals ABO blood group A transferase and its codon 69 substitution enzymes synthesize FORS1 antigen of FORS blood group system

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Miyako Yamamoto ◽  
Maria Cristina Tarasco ◽  
Emili Cid ◽  
Hidetomo Kobayashi ◽  
Fumiichiro Yamamoto
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Group System ◽  
Blood Group A ◽  
Group A

scholarly journals ABO Blood Group System: Its Association with Anthropometric Indices among Young Adults of Yoruba Ethnicity

2019 ◽  
pp. 1-7
Author(s):  
M. A. Asafa ◽  
O. Ogunlade ◽  
R. A. Bolarinwa ◽  
L. A. Bisiriyu ◽  
O. A. Eluwole ◽  
...  
Keyword(s):  
Young Adults ◽  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Anthropometric Indices ◽  
Blood Group A ◽  
Group A ◽  
The Mean ◽  
Apparently Healthy

Introduction: The ABO blood group system is unique in immunology and haematology because it is the only system in which antibodies are consistently and predictably present in the serum of normal individuals whose red cells lack the antigens. Several epidemiological studies have reported that the distribution of different ABO blood groups vary markedly among the populations of different geographical areas reflecting racial differences. Aims: The aim of this study was to determine the association between ABO blood group and anthropometric indices among apparently healthy young adults of Yoruba ethnicity. Study Design: This is a cross-sectional descriptive study. Place and Duration of Study: The study was carried out at Department of Physiological Sciences and University Health Centre, Obafemi Awolowo University, Ile-Ife between May 2016 to June 2017. Methodology: Eighty apparently healthy young adults who were purposely selected participated in the study after screening for the ABO blood groups following the standard protocol. They were divided into four equal groups; 20 in each of blood groups A, B, AB and O who were age- and sex - matched. The weight (kg) and height (cm) of the participants were measured following standard protocol. Body mass index (BMI) and body surface area (BSA) were estimated from weight and height using Quetelex and Mosteller formulae respectively. Chi-square was used to compare grouped data while the comparison of means of parameters among the four blood groups was done using Analysis of Variance (ANOVA). A p-value of < 0.05 was taken statistically significant. Results: Out of the total 80 participants, 15% were males. The mean ± SD of height(m) of participants with blood groups A, B, O and AB were 1.65 ± 0.06, 1.63 ± 0.08, 1.62 ± 0.08 and 1.63 ± 0.08 (F= 0.349, p= 0.790) respectively. The mean ± SD of weight(kg) of the participants with blood group A,B, O and AB were 56.15 ± 8.71, 56.00 ± 11.21, 57.10 ± 12.73 and 58.05 ± 10.35 (F= 0.154, p= 0.927) respectively. The mean ± SD of BMI in kg/m2 for blood groups A, B, O and AB were 20.74 ± 3.22, 20.86 ± 2.91, 21.79 ± 5.10 and 21.91 ± 4.21 (F= 0.472, p= 0.703) respectively while the mean ± SD of BSA (m2) for blood group A, B, O and AB were 1.60 ± 0.12, 1.59 ± 0.19, 1.60 ± 0.18 and 1.62 ± 0.15 (F= 0.098, p= 0.961) respectively. Conclusion: AB Blood group may be predisposed to metabolic syndrome due to the higher mean of weight, BSA and BMI found in this group.

scholarly journals ABO groups can play a role in susceptibility and severity of COVID-19

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Samra ◽  
M. Habeb ◽  
R. Nafae
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Infection Group ◽  
Mechanically Ventilated ◽  
Blood Group A ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
The Relationship ◽  
Seriously Ill

Abstract Background A few people infected by the coronavirus become seriously ill, while others show little to no signs of the symptoms, or are asymptomatic. Recent researches are pointing to the fact that the ABO blood group might play an important role in a person’s susceptibility and severity of COVID-19 infection. Aim of the study: try to understand the relationship between ABO groups and COVID-19 (susceptibility and severity). Results A total of (507) patients were included in this study. The study population was divided based on the ABO blood group into types A+, A−, B+, AB, O+, and O−. Blood group A was associated with high susceptibility of infection: group A, 381 (75.1%); and less common in group O, 97 (19.2%), group B, 18 (3.5%), and group AB, 11 (2.2%). The severity of COVID-19 infection was common in non-blood group O where (20 (7.1%), 4 (26.7%), 2 (11%), and 1 (9%) in type A+, A−, B+, and AB, respectively), while in type O 3.1%. And mechanically ventilated patients were 22 (5.9%), 2 (13.4%), 2 (11.1%), and 1 (1%). Mortality was high in blood groups A and B, 16 (4.37%) and 1 (5.5%), respectively, while in blood group O, it was 1%. Conclusion The incidence, severity, and mortality of COVID-19 were common in non-blood group O. While blood group O was protected against COVID-19.

Unusual Inheritance in the ABO Blood Group System: A Group O Child from A Group A(2)B Mother

Vox Sanguinis ◽  
1978 ◽  
Vol 35 (3) ◽  
pp. 176-180
Author(s):  
Maria Dolores Valdes ◽  
Caroline Zoes ◽  
Alice Froker
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group System ◽  
Group System ◽  
System A ◽  
Group A

scholarly journals The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to MaternalABOGenotypes

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Maria Therese Ahlen ◽  
Anne Husebekk ◽  
Mette Kjær Killie ◽  
Jens Kjeldsen-Kragh ◽  
Martin L. Olsson ◽  
...  
Keyword(s):  
Relative Risk ◽  
Pregnant Women ◽  
Blood Group ◽  
Lower Risk ◽  
Abo Blood Group ◽  
Severe Thrombocytopenia ◽  
Blood Group A ◽  
Group A ◽  
Alloimmune Thrombocytopenia ◽  
Design And Methods

Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995–2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies.Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated.Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25–0.75).Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternalABOtypes, and this study indicates that the observation is due to genetic properties on the maternal side.

Transcriptional Profile of Carbohydrate Blood Group Genes in Erythroid Versus Neutrophil Differentiation of Human CD34+ Cells In Vitro.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4242-4242
Author(s):  
Josefina H. Dykes ◽  
Britt Thuresson ◽  
Louise Edvardsson ◽  
Tor Olofsson ◽  
Martin L. Olsson
Keyword(s):  
Gene Expression ◽  
Blood Group ◽  
Erythroid Differentiation ◽  
Surface Expression ◽  
Blood Groups ◽  
Blood Group A ◽  
Cd34 Cells ◽  
Group A ◽  
Neutrophil Differentiation

Abstract Carbohydrate blood groups and their corresponding antibodies are clinically important, known to be involved in conditions such as hemolytic transfusion reactions, hemolytic disease of the newborn and spontaneous abortion. However, little is understood about the developmental changes in expression of carbohydrate blood groups during hematopoiesis, with preceding studies mainly focusing on protein-based blood group molecules. We have previously identified the carbohydrate blood group A antigen as the earliest, specific marker for definitive erythroid commitment, in preference to other suggested candidates such as Kell or Glycophorin C [Br J Haematol2004;127:451–63]. With regard to this lineage-restriction point we mapped the gene expression of some clinically important carbohydrate blood group systems during erythroid versus neutrophil differentiation in vitro. Human bone marrow CD34+ cells from healthy donors, carrying the blood group A1 allele and functional secretor (FUT2) and Lewis (FUT3) genes, were cultured in vitro towards erythroid or neutrophil development and sorted on a flow cytometer into subpopulations according to their surface expression of blood group A antigen/CD117 and CD15/CD33. Sorted cells were cultured in clonogenic assays in methylcellulose or analyzed by TaqMan real-time reverse transcriptase PCR for gene expression of a number of carbohydrate blood group glycosyltransferases. Surface expression of the blood group A antigen coincided with commitment to erythroid differentiation and the expression of CD15 with neutrophil/monocytic differentiation. In gene expression studies the ABO, H (FUT1), I (IGnT) and Pk (A4GALT) genes were all expressed in freshly isolated and sorted CD34+ cells. The ABO and the H genes were up-regulated in erythroid differentiation and silenced in neutrophil differentiation. The ABO gene expression was markedly decreased in late stages of erythroid maturation. The I gene was expressed both during erythroid and neutrophil development with an increased expression in late erythroid differentiation. The Pk gene retained a low expression throughout neutrophil differentiation and was up-regulated several-fold during erythroid differentiation. There was no detectable expression of FUT3 and the gene suggested being responsible for biosynthesis of the Sda antigen, GALGT2, in either erythroid or neutrophil differentiation. Our data support the identification of the blood group A antigen as an early and specific marker for definitive erythroid differentiation. In mature cells of the myeloid lineage, the results of the gene expression studies are compatible with previous findings of gene and/or surface expression of the I and Pk blood groups but not of ABO and H. The marked increase in expression of the Pk gene during erythroid differentiation may well agree with the fact that the Pk antigen is the precursor structure of globoside, the most abundant neutral glycolipid in the erythrocyte membrane. The absence of hematopoietic FUT3 expression in Lewis gene positive individuals was expected whilst the relevance of undetectable GALGT2 expression in hematopoietic differentiation is uncertain. The role of the GALGT2 gene in surface expression of Sda has not been definitively proven and the molecular basis of different Sda phenotype variants is unknown. In conclusion, our data extend previous findings of carbohydrate blood group distribution, primarily obtained from mature blood cells and leukemic cell lines, to normal human hematopoiesis.

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