scholarly journals The Development of Severe Neonatal Alloimmune Thrombocytopenia due to Anti-HPA-1a Antibodies Is Correlated to MaternalABOGenotypes

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Maria Therese Ahlen ◽  
Anne Husebekk ◽  
Mette Kjær Killie ◽  
Jens Kjeldsen-Kragh ◽  
Martin L. Olsson ◽  
...  
Keyword(s):  
Relative Risk ◽  
Pregnant Women ◽  
Blood Group ◽  
Lower Risk ◽  
Abo Blood Group ◽  
Severe Thrombocytopenia ◽  
Blood Group A ◽  
Group A ◽  
Alloimmune Thrombocytopenia ◽  
Design And Methods

Background. Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995–2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies.Design and Methods. A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated.Results. We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25–0.75).Conclusion. The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternalABOtypes, and this study indicates that the observation is due to genetic properties on the maternal side.

The Development of Severe Anti-HPA 1a-Related Neonatal Alloimmune Thrombocytopenia Is Influenced by the Maternal ABO Type.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 2093-2093 ◽  
Author(s):  
Maria T. Ahlen ◽  
Mette K. Killie ◽  
Anne Husebekk ◽  
Jens Kjeldsen-Kragh ◽  
Martin L. Olsson ◽  
...  
Keyword(s):  
Relative Risk ◽  
Blood Group ◽  
Intervention Program ◽  
Swedish Population ◽  
Allele Distribution ◽  
Blood Group A ◽  
Abo Incompatibility ◽  
Norwegian Population ◽  
Group A ◽  
Alloimmune Thrombocytopenia

Abstract About 100 000 pregnant women were included in a screening and intervention program aimed to reduce morbidity and mortality related to neonatal alloimmune thrombocytopenia (NAIT). NAIT due to HPA 1a immunization have many features in common with hemolytic disease of the newborn (HDN) caused by RhD immunization. Platelets express blood group A and B antigens, and as described in HDN, ABO incompatibility between mother and fetus could possibly protect against immunization against HPA 1a. The aim of the study was to describe the ABO distribution among the immunized mothers and examine whether ABO status of the mother influenced the severity of thrombocytopenia in the newborn. ABO typing of HPA 1a immunized women was routinely performed by serological methods during the screening. ABO genotyping resolving the major alleles (A1, A2, B, O1, O1v or O2 alleles) of the women and their newborns was performed by PCR-RFLP methods. The ABO distribution among the immunized HPA 1a negative women was found to be similar to the normal distribution in the Norwegian population, which may indicate that the ABO type does not influence the immunization mechanism. However, we find that HPA 1a immunized women of blood group A have a higher risk of delivering a child with severe NAIT (platelet count < 50×109/L) than women with blood group O. Twenty percent of the immunized women with blood group O gave birth to children with severe NAIT, compared to 46% among the immunized blood group A mothers, resulting in a relative risk of 0.43 (95% CI 0.25–0.76). The ABO type of the newborn was not found to influence development of severe NAIT. The O1/O1v allele distribution among the immunized women with blood group O resembles the distribution reported for a Swedish population. However, only 2/22 (9.1%) pregnancies among the O1v negative blood group O mothers resulted in a newborn with severe NAIT, compared to 10/34 (29.4%) among the O1v-positive blood group O women, resulting in a relative risk of 0.31 (95% CI 0.07–1.28). The observation that the immune response against HPA 1a may have different consequences depending on the ABO blood group of the mother is interesting. O1v, also termed O02, constitutes a separate but ancient allelic lineage at the ABO locus and we are now in the process of examining if our observation is related to linkage disequilibrium between the ABO gene and one or more pregnancy-related immunoregulatory genes.

scholarly journals ABO groups can play a role in susceptibility and severity of COVID-19

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
S. Samra ◽  
M. Habeb ◽  
R. Nafae
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Infection Group ◽  
Mechanically Ventilated ◽  
Blood Group A ◽  
Group A ◽  
Study Population ◽  
Group B ◽  
The Relationship ◽  
Seriously Ill

Abstract Background A few people infected by the coronavirus become seriously ill, while others show little to no signs of the symptoms, or are asymptomatic. Recent researches are pointing to the fact that the ABO blood group might play an important role in a person’s susceptibility and severity of COVID-19 infection. Aim of the study: try to understand the relationship between ABO groups and COVID-19 (susceptibility and severity). Results A total of (507) patients were included in this study. The study population was divided based on the ABO blood group into types A+, A−, B+, AB, O+, and O−. Blood group A was associated with high susceptibility of infection: group A, 381 (75.1%); and less common in group O, 97 (19.2%), group B, 18 (3.5%), and group AB, 11 (2.2%). The severity of COVID-19 infection was common in non-blood group O where (20 (7.1%), 4 (26.7%), 2 (11%), and 1 (9%) in type A+, A−, B+, and AB, respectively), while in type O 3.1%. And mechanically ventilated patients were 22 (5.9%), 2 (13.4%), 2 (11.1%), and 1 (1%). Mortality was high in blood groups A and B, 16 (4.37%) and 1 (5.5%), respectively, while in blood group O, it was 1%. Conclusion The incidence, severity, and mortality of COVID-19 were common in non-blood group O. While blood group O was protected against COVID-19.

scholarly journals Association of ABO blood group with fracture pattern and mortality in hip fracture patients

2014 ◽  
Vol 96 (6) ◽  
pp. 442-445 ◽  
Author(s):  
CE Uzoigwe ◽  
RP Smith ◽  
A Khan ◽  
D Aghedo ◽  
M Venkatesan
Keyword(s):  
Hip Fracture ◽  
Blood Group ◽  
Femoral Fracture ◽  
Intertrochanteric Fracture ◽  
Proximal Femoral Fracture ◽  
Fracture Pattern ◽  
Abo Blood Group ◽  
Blood Group A ◽  
Fracture Configuration ◽  
Group A

Introduction The mechanism of falling has been proposed as the exclusive explanation for hip fracture pattern. Evidence exists that other genetic factors also influence proximal femoral fracture configuration. The ABO blood group serotype has been associated with other pathologies but any role in hip fracture has yet to be definitively characterised. Methods Our National Hip Fracture Database was interrogated over a four-year period. All patients had their blood group retrieved, and this was compared with hip fracture pattern and mortality rates. Confounding factors were accounted for using logistic regression and the Cox proportional hazards model. Results A total of 2,987 consecutive patients presented to our institution. Those with blood group A were significantly more likely to sustain intracapsular fractures than ‘non-A’ individuals (p=0.009). The blood group distribution of patients with intracapsular fractures was identical to that of the national population of England. However, blood group A was less common in patients with intertrochanteric fractures than in the general population (p=0.0002). Even after correction for age and sex, blood group A was associated with a decrease in the odds of suffering an intertrochanteric fracture to 80% (p=0.002). Blood group A had inferior survivorship correcting for age, sex and hip fracture pattern (hazard ratio: 1.14, p=0.035). This may be due to associated increased prevalence of co-morbid disease in this cohort. Conclusions Blood group is an independent predictor of hip fracture pattern, with group A patients more likely to sustain an intracapsular fracture and non-A individuals more likely to sustain an intertrochanteric fracture. The determinants of fracture pattern are likely to be related to complex interactions at a molecular level based on genetic susceptibility. The mechanism of fall may not be the only aetiological determinant of proximal femoral fracture configuration.

scholarly journals Frequency of ABO and Rhesus blood groups in Saudi healthy blood donors versus non-Saudi in a retrospective study in Makkah City

2021 ◽  
Vol 1 (1) ◽  
pp. 2-13
Author(s):  
Amal z. Moustafa ◽  
Mohammed S. Aldosari ◽  
Talat A. AL-Bukhari ◽  
Younis A. Allohibi ◽  
Shirin H . Teama ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Blood Group ◽  
Blood Donors ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Sri Lankan ◽  
Blood Storage ◽  
Blood Group A ◽  
Group A ◽  
Makkah City

Purpose: to assess the frequency of ABO and Rh blood groups among Saudi and non-Saudi healthy blood donors and to compare between them. Methods: A retrospective study was conducted; in Makkah City, Saudi Arabia. It included 15,365 participants of 44 nationalities who have attended the blood bank of King Abdul Aziz Hospital. The collected data were age, sex, nationality, ABO, and Rhesus blood groups.  Results: 46.8 % of the participants were O, 28.8 % A, 19.5 % B, and 4.9% AB. The nationalities with a higher frequency of blood group O were Saudi, Mauritanian, Yemeni, Thai, Malian, Sudanese, Jordanian, Indian, Moroccan, Somali, Malaysian, Indonesian, Myanmar, Nigerian, Pakistani, Bangladeshi, Algerian, Djibouti, Burkinabe, Eritrean, Ghanaian, Bahraini, Bosnian, Canadian, Gambian, Iraqi, and Sri Lankan. Those with a higher frequency of blood group A were Turkish, Palestinian, Syrian, Lebanese, Egyptian, Afghan, Chadian, French, Tunisian, Cameroonian, Ethiopian, and British.  Those with a higher frequency of B were Nigerien, American, Nepalese, and two nationalities with higher AB frequency Filipino and Chinese. 91.6 % of all populations were Rh-positive, and 8.4% were Rh-negative. The Saudi participants were like some nationalities and differed from others. Conclusion:  In Makkah city, the higher frequency of ABO blood group in Saudi and non -Saudi people is O followed by A, then B, and AB.  The Rh-positive is predominant, and 8.4% of the participants are negative. The ABO and Rh blood groups' identifications are essential for providing suitable blood storage for individuals in need.

scholarly journals Prevalence and association of malaria with ABO blood group and hemoglobin levels in individuals visiting Mekaneeyesus Primary Hospital, Estie District, northwest Ethiopia: A cross-sectional study

2020 ◽  
Author(s):  
Balaynesh Tazebew ◽  
Abaineh Munshea Abitew ◽  
Endalkachew Nibret
Keyword(s):  
Logistic Regression ◽  
Blood Group ◽  
Cross Sectional Study ◽  
Abo Blood Group ◽  
Insect Vector ◽  
Sectional Study ◽  
Cross Sectional ◽  
Blood Group A ◽  
Primary Hospital ◽  
Group A

Abstract Background Malaria continues to be a major health problem in developing sub-Saharan countries including Ethiopia. Malaria is a complex disease and its local characteristics are determined by a variety of geographical, environmental, insect vector, host, and parasite factors.Methods A hospital based cross-sectional study was conducted to determine the prevalence of malaria and its possible association with hemoglobin level and ABO blood group among individuals attending Mekaneeyesus Primary Hospital, Estie District, northwestern Ethiopia. Socio-demographic variables and relevant data were collected from 390 randomly selected individuals through structured questionnaire. Then, thick and thin smears were prepared from finger pricked blood samples, stained, and examined microscopically for detection and identification of malaria parasites. ABO blood group and hemoglobin levels of the same subjects were also determined. The data generated were entered into a computer and analyzed for descriptive and logistic regression models using SPSS version 23.0. Variables with p-value < 0.05 in multivariable logistic regression were considered as explanatory variables.Results The overall prevalence of malaria was 8.5%; Plasmodium vivax (5.6%) was the most predominant, followed by P. falciparum (2.3%), and mixed infection of the two species (0.5%). In multivariate logistic regression analysis, being male (AOR = 3.48), under-five years of age (AOR = 72.84), rural residence (AOR = 2.64), and failing to use bed net (AOR =4.65) were significantly associated with the risk of malaria infection. Most (14.6%) of malaria positives cases were among individuals with blood group “A”, while the least number of cases were among subjects with blood group “O”. Individuals with blood group “A” were about four times more likelihood of getting malaria as compared to individuals with blood group “O” (AOR= 3.74). The prevalence of anemia was 23% and significantly associated with malaria (p<0.05).Conclusions Malaria in the study area is still higher than the average prevalence at country level. Therefore special attention should be given to the prevention and control strategies with the objective of increasing the awareness of local community towards malaria.

Normal Human Serum Contains Natural Antibodies Reactive With Autologous ABO Blood Group Antigens

Blood ◽  
1999 ◽  
Vol 93 (12) ◽  
pp. 4418-4424 ◽  
Author(s):  
Sergio H. Spalter ◽  
Srini V. Kaveri ◽  
Emmanuelle Bonnin ◽  
Jean-Claude Mani ◽  
Jean-Pierre Cartron ◽  
...  
Keyword(s):  
Human Serum ◽  
Blood Group ◽  
Autologous Blood ◽  
Natural Antibodies ◽  
Normal Human Serum ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Blood Group A ◽  
Group A ◽  
Normal Human

Abstract It is widely accepted that the serum of healthy individuals contains natural antibodies only against those blood group A or B antigens that are not expressed on the individual’s red blood cells. The mechanisms involved in tolerance to autologous blood group antigens remain unclear. In the present study, we show that IgM and IgG antibodies reactive with autologous blood group antigens are present in the immunoglobulin fraction of normal human serum. Natural IgG anti-A antibodies purified by affinity chromatography from IgG of individuals of blood group A exhibited an affinity for A trisaccharide antigen in the micromolar range and agglutinated A red cells at sixfold higher concentrations than those required for agglutination with affinity-purified anti-A IgG of individuals of blood group B. Whereas autoantibodies reactive with self A and B antigens are readily detected in purified IgG and IgM fractions, their expression is restricted in whole serum as a result of complementary interactions between variable regions of antibodies. These observations suggest that tolerance to autologous ABO blood group antigens is dependent on peripheral control of antibody autoreactivity.

scholarly journals Factor VIII and Factor VIII Related Antigen in Normal Pregnancy

1977 ◽  
Author(s):  
G. O. S. de Melo
Keyword(s):  
Factor Viii ◽  
Pregnant Women ◽  
Blood Group ◽  
Normal Pregnancy ◽  
Clear Tendency ◽  
Factor Viii Related Antigen ◽  
Blood Group A ◽  
Significant Difference ◽  
Group A ◽  
In Pregnancy

Factor VIII and factor VIII related antigen were found to change proportionately during normal pregnancy. There was a clear tendency for levels of activity and antigen to increase as the duration of the pregnancy advanced. In the pregnant women studied a significant difference was observed in factor VIII levels between Blood Group A and Blood Group O. A similar difference was found in factor VIII related antigen levels. Age, weight and previous use of contraceptives seems to have no influence on factor VIII and factor VIII related antigen values in pregnancy.

scholarly journals The association of ABO blood group with indices of disease severity and multiorgan dysfunction in COVID-19

2020 ◽  
Vol 4 (20) ◽  
pp. 4981-4989 ◽  
Author(s):  
Ryan L. Hoiland ◽  
Nicholas A. Fergusson ◽  
Anish R. Mitra ◽  
Donald E. G. Griesdale ◽  
Dana V. Devine ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Critically Ill ◽  
Blood Group ◽  
Inflammatory Cytokines ◽  
Abo Blood Group ◽  
Icu Admission ◽  
Blood Group A ◽  
Increased Risk ◽  
Group A ◽  
Underlying Mechanisms

Abstract Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities of COVID-19. We conducted a multicenter retrospective analysis and nested prospective observational substudy of critically ill patients with COVID-19. We collected data pertaining to age, sex, comorbidities, dates of symptom onset, hospital admission, intensive care unit (ICU) admission, mechanical ventilation, continuous renal replacement therapy (CRRT), standard laboratory parameters, and serum inflammatory cytokines. National (N = 398 671; P = .38) and provincial (n = 62 246; P = .60) ABO blood group distributions did not differ from our cohort (n = 95). A higher proportion of COVID-19 patients with blood group A or AB required mechanical ventilation (P = .02) and CRRT (P = .004) and had a longer ICU stay (P = .03) compared with patients with blood group O or B. Blood group A or AB also had an increased probability of requiring mechanical ventilation and CRRT after adjusting for age, sex, and presence of ≥1 comorbidity. Inflammatory cytokines did not differ between patients with blood group A or AB (n = 11) vs O or B (n = 14; P &gt; .10 for all cytokines). Collectively, our data indicate that critically ill COVID-19 patients with blood group A or AB are at increased risk for requiring mechanical ventilation, CRRT, and prolonged ICU admission compared with patients with blood group O or B. Further work is needed to understand the underlying mechanisms.

scholarly journals CLINICAL EVALUATION OF TRIPLE AND QUADRUPLE HELICOBACTER PYLORI ERADICATION THERAPY IN PEPTIC ULCER PATIENTS WITH DIFFERENT ABO BLOOD GROUP PHENOTYPES

2018 ◽  
Vol 11 (7) ◽  
pp. 460
Author(s):  
Manal Khalid Abdulridha ◽  
Rana Hussein Kutaif ◽  
Yassir Mustafa Kamal ◽  
Akram Ajeel Najeeb
Keyword(s):  
Peptic Ulcer ◽  
Triple Therapy ◽  
Blood Group ◽  
Eradication Rate ◽  
Abo Blood Group ◽  
Quadruple Therapy ◽  
Blood Group A ◽  
Group A ◽  
H Pylori ◽  
Group B

Objective: This study aimed to examine the pathological changes in gastric mucosa of Helicobacter pylori-infected peptic ulcer patients carrying different ABO phenotypes and to study the response to the 14 days’ standard triple therapy and 10 days’ quadruple therapy in peptic ulcer patients according to their ABO phenotypes.Methods: Interventional prospective randomized-controlled open-label study was performed on newly diagnosed patients with PUD. The H. pylori-positive patients were allocated into two major study groups in which they are subdivided according to ABO blood group phenotypes: Group 1 received standard H. pylori eradication triple therapy and Group 2 received standard H. pylori eradication quadruple regimen. Patients were monitored after 2 months for successful H. pylori eradication.Results: Chronic active gastritis was significantly high in patients carrying blood Group O phenotype (81.25%), while the atrophic gastritis and intestinal metaplasia were significantly high in patients carrying blood Group A phenotype (25.00% and 16.67%), respectively. 14 days’ triple therapy showed significantly lower eradication rate in H. pylori-infected peptic ulcer patients carrying blood Group O phenotype (p<0.01), meanwhile higher response was found among patients with blood Group B. 10 days’ quadruple therapy produced a significant high eradication rate in H. pylori-infected patients carrying blood Group O than those with blood Group A (p<0.01), but still both showed lower response compared to that in patients carrying blood Group B and AB phenotypes. Elderly patients showed significantly less healing efficacy than younger patients (p<0.01), and the least healing rate was noticed in female patients after both regimens.Conclusion: Lower eradication rate in H. pylori-infected was noticed in peptic ulcer patients carrying blood Group O mainly than those with other blood groups and particularly those with duodenal Ulceri. 10 days’ quadruple therapy showed significant higher eradication rate in H. pylori infection and a better ulcer healing efficacy.

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