scholarly journals Factors associated with inflamm-aging in institutionalized older people

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leônidas de Oliveira Neto ◽  
Vagner Deuel de O. Tavares ◽  
Pedro Moraes Dutra Agrícola ◽  
Larissa Praça de Oliveira ◽  
Márcia Cristina Sales ◽  
...  
Keyword(s):  
Older People ◽  
Oldest Old ◽  
Bivariate Analysis ◽  
Older Individuals ◽  
Factors Associated ◽  
Risk Of Death ◽  
Health Related ◽  
Inflammatory State ◽  
Unit Of Measurement ◽  
Institutionalized Older People

AbstractThe increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80 years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80 years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.

scholarly journals Inflammaging: Analysis of a Risk Profile for Gerontocide by COVID-19 in Brazil

2020 ◽  
Author(s):  
Leônidas de Oliveira Neto ◽  
Vagner Deuel de Oliveira Tavares ◽  
Pedro Moraes Dutra Agrícola ◽  
Larissa Praça de Oliveira ◽  
Márcia Cristina Sales ◽  
...  
Keyword(s):  
Oldest Old ◽  
Bivariate Analysis ◽  
Institutionalized Elderly ◽  
Elderly Individuals ◽  
Factors Associated ◽  
Risk Of Death ◽  
Health Related ◽  
Inflammatory State ◽  
Unit Of Measurement ◽  
Relative Risk Of Death

Abstract Introduction: The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized elderly individuals, few studies have proposed verifying the factors associated with this condition in this population to pandemic COVID-19.Objective: To verify the factors associated with inflamm-aging in institutionalized elderly.Methodology: A total of 187 elderly individuals (≥ 60 years old) living in the nursing homes of Natal/RN were included in the study. After cluster analysis was used to identify 3 groups according to their inflammatory state, an analysis of sarcopenia and anthropometric, biochemical, sociodemographic and health-related variables was performed. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p <0.20 in the bivariate analysis.Results: IL-6, TNFα and Zinc. Low-density lipids (LDL), high-density lipids (HDL) and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1% and 0.9%, respectively, while oldest old (≥80 years old) had 84.9% chance of presenting inflamm-aging in relation to no oldest old (<80 years).Conclusion: The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death from COVID-19.

Influence of nutritional status on health-related quality of life of non-institutionalized older people

2013 ◽  
Vol 18 (4) ◽  
pp. 359-364 ◽  
Author(s):  
Susana Jiménez-Redondo ◽  
B. Beltran De Miguel ◽  
J. Gavidia Banegas ◽  
L. Guzman Mercedes ◽  
J. Gomez-Pavon ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nutritional Status ◽  
Older People ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Institutionalized Older People

scholarly journals Dementia and road traffic accidents among non-institutionalized older people in Denmark: A Danish register-based nested case-control study

2018 ◽  
Vol 47 (2) ◽  
pp. 221-228 ◽  
Author(s):  
Jindong Ding Petersen ◽  
Volkert Dirk Siersma ◽  
René Depont Christensen ◽  
Maria Munch Storsveen ◽  
Connie Thurøe Nielsen ◽  
...  
Keyword(s):  
Older People ◽  
Traffic Accidents ◽  
Road Traffic ◽  
Conditional Logistic Regression ◽  
Geographic Location ◽  
Source Population ◽  
Older Individuals ◽  
Road Traffic Accidents ◽  
People With Dementia ◽  
Institutionalized Older People

Aim: We used register-based data to estimate the effect of all-type dementia on road traffic accidents (RTAs) risk, combined with comorbidities or sedative medicines, among non-institutionalized older people in Denmark. Methods: The source population was all residents in Denmark aged 65 years and older, alive as of January 1, 2008 ( n = 853,228). Cases were those who had any type of RTA in 2009–2014. Each case was matched for age, sex and geographic location to 4–6 controls. All-type dementia was ascertained using the International Classification of Diseases version 10 (ICD-10) diagnosis supplemented with prescribed medicine records. Eight chronic diseases were selected to assess comorbidities. Four types of medicines were categorized as sedative medicines for analysis. Conditional logistic regression with adjustment for education and marital status as well as either the number of comorbidities or sedative medications use was performed using STATA software. Results: Older people with dementia had lower RTAs risk compared to their controls (odds ratio = 0.43, 95% confidence interval (0.32–0.60), p < 0.001). Significant interaction was observed between dementia and the number of comorbidities for RTAs estimation. Conclusions: The significantly lower RTAs risk for older individuals with dementia observed in our study may be due to people with dementia living at home having a lower frequency of outdoor activities; that is, less exposure to traffic. However, this, together with the interaction between dementia and comorbidities as well as sedative medications, should be investigated further.

scholarly journals Analysis of the Characteristics of Chronic Energy Deficiency in Pregnant Women during the Covid 19 Pandemic

2021 ◽  
Vol 7 (2) ◽  
pp. 170-175
Author(s):  
Hardianti Mukkadas ◽  
I Made Cristian B ◽  
Wa Ode Salma
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Bivariate Analysis ◽  
P Value ◽  
Cross Sectional ◽  
Causal Factors ◽  
Energy Deficiency ◽  
Factors Associated ◽  
Risk Of Death ◽  
Chronic Energy Deficiency

Pregnant women who experience chronic energy deficiency (KEK) tend to give birth to LBW babies and have a greater risk of death. Objective: This study was to analyze the factors associated with the incidence of KEK in pregnant women. Methods: The study was conducted for 2 months, in 2020 at Anggaberi Health Center and Soropia Health Center in Konawe district. Design: cross sectional, quantitative data collection and secondary data. The research sample was pregnant women who were registered in the maternal cohort data, which were taken randomly as many as 115 people. Univariate data analysis was carried out descriptively to see the distribution of the values ​​of the causal factors, bivariate analysis was carried out to analyze the relationship between the causal factors and the incidence of KEK through statistics, namely Chi-square test and cross tabulation with a significance value of 0.05. The results of the study found that the factors associated with the incidence of KEK were age (p-value = 0.000), education level (p-value = 0.000), employment status (p-value = 0.000), and pregnancy weight (p-value = 0.000 ). The incidence of KEK is more likely in mothers who have characteristics such as age < 20 years and > 35 years, low education, not working and low pregnant weight. Therefore, it is hoped that an increase in food security at the family level can be socialized through providing information to preconception women through counseling, flip-charts and posters.

scholarly journals Enforced Social Isolation and Risk of Death in Elderly People in Cyprus

2020 ◽  
Author(s):  
Marios Kyriazis
Keyword(s):  
Older People ◽  
Elderly People ◽  
Social Isolation ◽  
Direct Contact ◽  
Social Cognitive ◽  
Older Individuals ◽  
Potential Minimum ◽  
Risk Of Death ◽  
Health Authorities ◽  
Isolation Period

AbstractSocial isolation is associated with a higher risk of death in older people. The quarantine and social distancing measures due to Covid-19 imposed in Cyprus from the beginning of the pandemic, aim to isolate individuals from direct contact with others. This has resulted in vulnerable older people being isolated at their places of residence for several weeks, while the recommendation by some experts is a potential minimum isolation period of three to four months. The risk of death from causes other than those related to Covid-19, increases in such individuals, and it is due to the effects of social isolation. We estimate that in the next year, there will be an increase in the death numbers of such older people in Cyprus, reaching a minimum 200 extra deaths a year, for every three months of isolation. The health authorities must develop a program of support for these older individuals to include medical, social, cognitive, physical and psychological elements. Examples of such support are given here.

scholarly journals Factors Influencing Mood Disorders and Health Related Quality of Life in Adults With Glioma: A Longitudinal Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Antonella Leonetti ◽  
Guglielmo Puglisi ◽  
Marco Rossi ◽  
Luca Viganò ◽  
Marco Conti Nibali ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mood Disorders ◽  
Cognitive Deficits ◽  
Bivariate Analysis ◽  
Health Related Quality ◽  
Factors Associated ◽  
The Third ◽  
Related Quality ◽  
Health Related

ObjectiveAt present, it is not clear whether Mood Disorders (MD) and poor Health Related Quality of Life (HRQoL) in the glioma population correlate with features of the tumor, or rather with secondary symptoms associated with treatment. The aim of this study was to assess the prevalence of MD and decline in HRQoL in glioma patients, and to determine the main factors associated with these two variables.Methods80 patients affected by lower-grade gliomas (LGGs) and 65 affected by high-grade gliomas (HGGs) were evaluated, from admission up to 12 months after surgery, for MD, HRQoL, clinical characteristics, and cognitive functions. Independent factors associated with MD and low HRQoL were identified by using bivariate analysis.ResultsData showed that prevalence of low HRQoL was comparable in both groups during all the time points assessed (pre, 1, 3, 6 and 12 months after surgery). In contrast at 6 months following surgery, HGGs showed a higher prevalence of MD compared to LGGs;. Bivariate analysis revealed that factors associated with MD and HRQoL in LGGs and HGGs were different over the course of the disease. In LGGs, from the pre-operative period to one year post surgery, MD and low HRQOL were associated with the occurrence of cognitive deficits and, from the third month after surgery onward, they were also associated with the effect exerted by adjuvant treatments. In HGGs, MD were associated with cognitive deficits at 3 and 6 months after surgery, along with older age (65-75 years); HRQoL, in its Physical component in particular, was associated with older age only from 6 months after surgery.ConclusionFactors associated with MD and low HRQoL were different in LGGs and HGGs over the course of the disease. In LGGs the effect of adjuvant treatments was prominent in determining the prevalence of both MD and poor HRQoL from the third month after surgery onward. In HGGs, MD and HRQoL were associated with age, at 3 and 6 months after surgery. In both, the occurrence of cognitive deficits was significantly associated with MD.

scholarly journals Factors Associated With Low Handgrip Strength In Older People: Data Of The Study Of Chronic Diseases (EDOC-I)

2020 ◽  
Author(s):  
Cledir de Araújo Amaral ◽  
Thatiana Lameira Maciel Amaral ◽  
Gina Torres Rego Monteiro ◽  
Mauricio Teixeira Leite de Vasconcellos ◽  
Margareth Crisostomo Portela
Keyword(s):  
Older People ◽  
Chronic Diseases ◽  
Handgrip Strength ◽  
Age Groups ◽  
Health Assessment ◽  
Sample Survey ◽  
Older Individuals ◽  
Cross Sectional ◽  
Factors Associated ◽  
Important Health

Abstract Background Handgrip strength (HGS) is an important health biomarker, whose low scores have been shown to be associated with morbimortality. This study aimed to analyze the factors associated with low HGS in older persons in Rio Branco, Acre, Brazil. Methods The study was carried out with data from the Study of Chronic Diseases (EDOC-I) – Older People, a cross-sectional household PAPI probability sample survey performed with 1,016 people aged over 60 residing in Rio Branco in 2014. The low HGS was defined by the 20th percentile of the maximum HGS by sex and age group. Associations between variables of health status (psychological and physical) and low HGS, by sex, were estimated using logistic regression, expressed by adjusted ORs (aOR). Results Older individuals had lower median HGS than younger individuals (-6.0 kg among men and -2.6 kg among women). Women aged over 80 years had, on average, the lower quintile of HGS compared to women of the previous age groups. Factors independently associated with low HGS in men and women, respectively, were low weigh in body mass index [(aOR = 2.80; 95%CI: 1.19, 6.61) and (aOR = 2.61; 95%CI: 1.46, 4.66)], anemia [(aOR= 4.15; 95%CI: 2.09, 8.21) and (aOR = 1.80; 95%CI: 1.06, 3.06)] and diabetes as a risk factor in men (aOR 1.95; 95%CI: 1.00, 3.81). There was a higher chance of low HGS in men with partners (aOR = 2.44; 95%CI: 1.32, 4.51), smokers or former smokers (aOR = 3.25; 95%CI: 1.25, 8.44), with current self-assessment of health worse than the 12 previous months (aOR = 2.21; 95%CI: 1.14, 4.30) and dependence in activities of daily living (aOR = 2.92; 95%CI: 1.35, 6.30). Only among women, there was an increased chance of low HGS associated with altered waist-to-hip ratio (aOR = 1.79; 95%CI: 1.02, 3.12), insomnia (aOR = 1.83; 95%CI: 1.10, 3.03) and physical activity from displacement/occupation (aOR = 1.75; 95%CI: 1.08, 2.84). Conclusion Factors associated with low HGS are not common to sex and the inclusion of HGS as a component of health assessment seems to be a promising strategy for disease prevention and health promotion.

Risk of Death Associated With Use of PPIs in Three Cohorts of Institutionalized Older People in Finland

2012 ◽  
Vol 13 (5) ◽  
pp. 488.e9-488.e13 ◽  
Author(s):  
Mariko Teramura-Grönblad ◽  
J. Simon Bell ◽  
Minna M. Pöysti ◽  
Timo E. Strandberg ◽  
Jouko V. Laurila ◽  
...  
Keyword(s):  
Older People ◽  
Risk Of Death ◽  
Institutionalized Older People

scholarly journals Anticholinergic and sedative drug burden in community-dwelling older people: a national database study

BMJ Open ◽  
2018 ◽  
Vol 8 (7) ◽  
pp. e022500 ◽  
Author(s):  
Catherine J Byrne ◽  
Caroline Walsh ◽  
Caitriona Cahir ◽  
Cristín Ryan ◽  
David J Williams ◽  
...  
Keyword(s):  
Older People ◽  
Community Dwelling ◽  
National Database ◽  
Older Individuals ◽  
Patient Factors ◽  
Claims Database ◽  
Database Study ◽  
Factors Associated ◽  
Pharmacy Claims ◽  
Sedative Effects

ObjectivesThe Drug Burden Index (DBI) tool quantifies individual exposure to anticholinergic and sedative medications. The DBI has been internationally validated against adverse health outcomes in older people. DBI exposure has not been reported in the Irish older population. This study aimed to: (1) develop a list of drugs with clinically significant anticholinergic and/or sedative effects (DBI medications) relevant to Ireland; (2) examine, using the DBI formula, the prevalence of exposure to DBI medications in Irish older people and (3) explore patient factors associated DBI exposure.DesignA cross-sectional national pharmacy claims database study.SettingCommunity setting using the General Medical Services (GMS) scheme pharmacy claims database maintained by the Health Service Executive Primary Care Reimbursement Services.ParticipantsIrish older individuals (aged ≥65 years) enrolled in the GMS scheme and dispensed at least one prescription item in 2016 (n=428 516).Main outcome measuresPrevalence of exposure to DBI medications and patient factors associated with DBI exposure.Results282 874 (66%) of the GMS population aged ≥65 years were exposed to at least one DBI medication in 2016. Prevalence of exposure to DBI medications was significantly higher in females than males (females 71.6% vs males 58.7%, adjusted OR 1.65, 95% CI 1.63 to 1.68). Prevalence of DBI exposure increased progressively with the number of chronic drugs used, rising from 42.7% of those prescribed 0–4 chronic drugs to 95.4% of those on ≥12 chronic drugs (adjusted OR 27.8, 95% CI 26.7 to 29.0). The most frequently used DBI medications were codeine/paracetamol combination products (20.1% of patients), tramadol (11.5%), zopiclone (9.5%), zolpidem (8.5%), pregabalin (7.9%) and alprazolam (7.8%).ConclusionsThe majority of older people in Ireland are exposed to medications with anticholinergic and/or sedative effects, particularly females and those with multiple comorbidities. The high use of low-dose codeine/paracetamol combination products, Z-drugs and benzodiazepines, suggests there are opportunities for deprescribing.

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