scholarly journals Inflammaging: Analysis of a Risk Profile for Gerontocide by COVID-19 in Brazil

2020 ◽  
Author(s):  
Leônidas de Oliveira Neto ◽  
Vagner Deuel de Oliveira Tavares ◽  
Pedro Moraes Dutra Agrícola ◽  
Larissa Praça de Oliveira ◽  
Márcia Cristina Sales ◽  
...  
Keyword(s):  
Oldest Old ◽  
Bivariate Analysis ◽  
Institutionalized Elderly ◽  
Elderly Individuals ◽  
Factors Associated ◽  
Risk Of Death ◽  
Health Related ◽  
Inflammatory State ◽  
Unit Of Measurement ◽  
Relative Risk Of Death

Abstract Introduction: The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized elderly individuals, few studies have proposed verifying the factors associated with this condition in this population to pandemic COVID-19.Objective: To verify the factors associated with inflamm-aging in institutionalized elderly.Methodology: A total of 187 elderly individuals (≥ 60 years old) living in the nursing homes of Natal/RN were included in the study. After cluster analysis was used to identify 3 groups according to their inflammatory state, an analysis of sarcopenia and anthropometric, biochemical, sociodemographic and health-related variables was performed. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p <0.20 in the bivariate analysis.Results: IL-6, TNFα and Zinc. Low-density lipids (LDL), high-density lipids (HDL) and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1% and 0.9%, respectively, while oldest old (≥80 years old) had 84.9% chance of presenting inflamm-aging in relation to no oldest old (<80 years).Conclusion: The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death from COVID-19.

scholarly journals Factors associated with inflamm-aging in institutionalized older people

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Leônidas de Oliveira Neto ◽  
Vagner Deuel de O. Tavares ◽  
Pedro Moraes Dutra Agrícola ◽  
Larissa Praça de Oliveira ◽  
Márcia Cristina Sales ◽  
...  
Keyword(s):  
Older People ◽  
Oldest Old ◽  
Bivariate Analysis ◽  
Older Individuals ◽  
Factors Associated ◽  
Risk Of Death ◽  
Health Related ◽  
Inflammatory State ◽  
Unit Of Measurement ◽  
Institutionalized Older People

AbstractThe increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80 years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80 years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.

Factors associated with sarcopenia in institutionalized elderly

2020 ◽  
Author(s):  
Leônidas de Oliveira Neto ◽  
Larissa Praça de Oliveira ◽  
Pedro Moraes Dutra Agrícola ◽  
Vagner Deuel de Oliveira Tavares ◽  
Igor Conterato Gomes ◽  
...  
Keyword(s):  
Muscle Mass ◽  
The Elderly ◽  
Chi Square ◽  
Institutionalized Elderly ◽  
Elderly Individuals ◽  
Factors Associated ◽  
Knee Height ◽  
Qualitative Variables ◽  
Health Related ◽  
Chi Square Test

ABSTRACT Background The diagnosis of sarcopenia is based on the analysis of strength, functionality and muscle mass. The objective was to verify the factors associated with sarcopenia in institutionalized elderly. Methods In total, 219 elderly individuals (≥60 years old) living in long-term institutions in Natal/RN were included in the study. After defining the elderly as sarcopenic or non-sarcopenic, anthropometric, biochemical, sociodemographic and health-related were analyzed. The Student t-test and Mann–Whitney test were used to analyze the quantitative, while the chi-square test was used for the qualitative variables. Finally, Poisson regression was used to provide prevalence ratios for those variables that presented differences in the bivariate analyses. Results Physical capacity and anthropometry were associated with sarcopenia. For each 1 cm of knee height, the elderly presented 2.71% more chance of not having sarcopenia, and eutrophic or overweight individuals (according to BMI) presented 37.71 and 91.81% chances, respectively, of not presenting sarcopenia. Elderly individuals who ambulate have a 30.08% chance of not being considered sarcopenic. In addition, biochemical and anthropometric indicators demonstrated a relationship of sarcopenia with malnutrition. Conclusion Sarcopenia is associated with a loss of body mass, not only selective muscle mass, and greater physical inability to ambulate.

scholarly journals Analysis of the Characteristics of Chronic Energy Deficiency in Pregnant Women during the Covid 19 Pandemic

2021 ◽  
Vol 7 (2) ◽  
pp. 170-175
Author(s):  
Hardianti Mukkadas ◽  
I Made Cristian B ◽  
Wa Ode Salma
Keyword(s):  
Pregnant Women ◽  
Health Center ◽  
Bivariate Analysis ◽  
P Value ◽  
Cross Sectional ◽  
Causal Factors ◽  
Energy Deficiency ◽  
Factors Associated ◽  
Risk Of Death ◽  
Chronic Energy Deficiency

Pregnant women who experience chronic energy deficiency (KEK) tend to give birth to LBW babies and have a greater risk of death. Objective: This study was to analyze the factors associated with the incidence of KEK in pregnant women. Methods: The study was conducted for 2 months, in 2020 at Anggaberi Health Center and Soropia Health Center in Konawe district. Design: cross sectional, quantitative data collection and secondary data. The research sample was pregnant women who were registered in the maternal cohort data, which were taken randomly as many as 115 people. Univariate data analysis was carried out descriptively to see the distribution of the values ​​of the causal factors, bivariate analysis was carried out to analyze the relationship between the causal factors and the incidence of KEK through statistics, namely Chi-square test and cross tabulation with a significance value of 0.05. The results of the study found that the factors associated with the incidence of KEK were age (p-value = 0.000), education level (p-value = 0.000), employment status (p-value = 0.000), and pregnancy weight (p-value = 0.000 ). The incidence of KEK is more likely in mothers who have characteristics such as age < 20 years and > 35 years, low education, not working and low pregnant weight. Therefore, it is hoped that an increase in food security at the family level can be socialized through providing information to preconception women through counseling, flip-charts and posters.

scholarly journals Factors Influencing Mood Disorders and Health Related Quality of Life in Adults With Glioma: A Longitudinal Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Antonella Leonetti ◽  
Guglielmo Puglisi ◽  
Marco Rossi ◽  
Luca Viganò ◽  
Marco Conti Nibali ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mood Disorders ◽  
Cognitive Deficits ◽  
Bivariate Analysis ◽  
Health Related Quality ◽  
Factors Associated ◽  
The Third ◽  
Related Quality ◽  
Health Related

ObjectiveAt present, it is not clear whether Mood Disorders (MD) and poor Health Related Quality of Life (HRQoL) in the glioma population correlate with features of the tumor, or rather with secondary symptoms associated with treatment. The aim of this study was to assess the prevalence of MD and decline in HRQoL in glioma patients, and to determine the main factors associated with these two variables.Methods80 patients affected by lower-grade gliomas (LGGs) and 65 affected by high-grade gliomas (HGGs) were evaluated, from admission up to 12 months after surgery, for MD, HRQoL, clinical characteristics, and cognitive functions. Independent factors associated with MD and low HRQoL were identified by using bivariate analysis.ResultsData showed that prevalence of low HRQoL was comparable in both groups during all the time points assessed (pre, 1, 3, 6 and 12 months after surgery). In contrast at 6 months following surgery, HGGs showed a higher prevalence of MD compared to LGGs;. Bivariate analysis revealed that factors associated with MD and HRQoL in LGGs and HGGs were different over the course of the disease. In LGGs, from the pre-operative period to one year post surgery, MD and low HRQOL were associated with the occurrence of cognitive deficits and, from the third month after surgery onward, they were also associated with the effect exerted by adjuvant treatments. In HGGs, MD were associated with cognitive deficits at 3 and 6 months after surgery, along with older age (65-75 years); HRQoL, in its Physical component in particular, was associated with older age only from 6 months after surgery.ConclusionFactors associated with MD and low HRQoL were different in LGGs and HGGs over the course of the disease. In LGGs the effect of adjuvant treatments was prominent in determining the prevalence of both MD and poor HRQoL from the third month after surgery onward. In HGGs, MD and HRQoL were associated with age, at 3 and 6 months after surgery. In both, the occurrence of cognitive deficits was significantly associated with MD.

Factors associated with oral health-related quality of life in institutionalized elderly

2006 ◽  
Vol 64 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Alexander J. Hassel ◽  
Ulrich Koke ◽  
Marc Schmitter ◽  
Peter Rammelsberg
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Health Related Quality ◽  
Institutionalized Elderly ◽  
Factors Associated ◽  
Related Quality ◽  
Health Related

scholarly journals Physical, nutritional and psychological states interfere with health related quality of life of institutionalized elderly

2020 ◽  
Author(s):  
Ilky Pollansky Silva e Farias ◽  
Luiza Almeida Souto Montenegro ◽  
Rayssa Lucena Wanderley ◽  
Jannerson Cesar Xavier de Pontes ◽  
Antonio Carlos Pereira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Status ◽  
Capital City ◽  
Health Related Quality ◽  
Institutionalized Elderly ◽  
Factors Associated ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Abstract Purpose Nursing home elders experience many problems that may influence their quality of life, in example of cognitive, mental, nutritional and physical disabilities. Concerning about elders’ wellbeing may help them living with dignity. This study aimed to investigate factors associated with Health-Related Quality of Life (HRQoL) of institutionalized elders in a capital city of Brazilian Northeast. Methods A cross-sectional study was conducted with 193 institutionalized elders living in the metropolitan region of João Pessoa (Brazil). The following variables were tested regarding their association with the elders’ HRQoL: Socio-demographic characteristics; Performance of daily-living activities, Frailty status, Cognitive status, Nutritional status, Self-perception of oral health and Depression status. Hierarchical multiple linear and logistic regressions analyses were performed in order to assess the impact of each independent variable on HRQoL, considering a significance level of 5%. Results The mean (SD) and the median of HRQoL of institutionalized elders were 62.69(15.24) and 62, respectively. Elderly were mostly (72.02%) female, being those with 80 years and over the more frequent (54.92%). Dependence on daily activities (OR=2.06, 95%CI=1.32-3.23), frailty (OR=1.68, 95%CI=1.15-2.45) and depression (OR=2.22, 95%CI=1.51-3.27) were statistically associated with poor HRQoL (p<0.05). Other variables have no significance within the adjusted model. Conclusions Dependent, frail and depressed institutionalized elderly presented a greater chance to have a worse HRQoL. It is necessary to plan and implement actions that would reduce the factors associated with the low quality of life of institutionalized elderly.

scholarly journals Physical, nutritional and psychological states interfere with health related quality of life of institutionalized elderly

2019 ◽  
Author(s):  
Ilky Pollansky Silva e Farias ◽  
Luiza Almeida Souto Montenegro ◽  
Rayssa Lucena Wanderley ◽  
Jannerson Cesar Xavier de Pontes ◽  
Antonio Carlos Pereira ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nursing Home Residents ◽  
Cognitive Status ◽  
Health Related Quality ◽  
Institutionalized Elderly ◽  
Factors Associated ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Abstract Purpose Nursing home residents experience many problems that may influence their quality of life, in example of cognitive, mental, nutritional and physical disabilities. Concerning about elders’ wellbeing may help them living with dignity. This study aimed to investigate factors associated with Health-Related Quality of Life (HRQoL) of institutionalized elderly in a capital city of Brazilian Northeast.Methods A cross-sectional study was conducted with 193 institutionalized elderly living in the metropolitan region of João Pessoa (Brazil). A theoretical-conceptual model was build to guide the multiple regression analysis. The following variables were tested regarding their association with the residents’ HRQoL: 1) socio-demographic characteristics; 2) data associated with general health (Performance of daily-living activities, Frailty status, Cognitive status, Nutritional status, Self-perception of oral health and Depression status). Multiple linear and logistic regressions analyses were performed in order to assess the impact of each independent variable on HRQoL, considering a significance level of 5%.Results The mean ± SD and the median of HRQoL among institutionalized elderly people were 62.69 ± 15.24 and 62, respectively. Elderly were mostly (72.02%) female, being those with 80 years and over the more frequent (54.92%). Dependence on daily activities (OR=2.06, 95%CI=1.32-3.23), frailty (OR=1.68, 95%CI=1.15-2.45) and depression (OR=2.22, 95%CI=1.51-3.27) were statistically associated with poor HRQoL (p<0.05).Conclusions Dependent, frail and depressed institutionalized elderly presented a greater chance to have a worse HRQoL. It is necessary to plan and implement actions that would reduce the factors associated with the low quality of life of institutionalized elderly.

scholarly journals Factors associated with urinary tract infection in a Nursing Home

2021 ◽  
Vol 74 (suppl 2) ◽  
Author(s):  
João Luis Almeida da Silva ◽  
Cassiane Dezoti da Fonseca ◽  
Eniva Miladi Fernandes Stumm ◽  
Roseanne Montargil Rocha ◽  
Myria Ribeiro da Silva ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Nursing Home ◽  
Urinary Tract ◽  
Tract Infection ◽  
Demographic Data ◽  
Bivariate Analysis ◽  
Institutionalized Elderly ◽  
Factors Associated ◽  
Modifiable Factors ◽  
Tract Infections

ABSTRACT Objective: to analyze the factors associated with urinary tract infection occurrence in institutionalized elderly. Methods: this is a cross-sectional, analytical, quantitative study with 116 elderly people from a Nursing Home. Urinary tract infection diagnosis was carried out through urine culture and clinical assessment. Demographic data and associated factors were obtained from medical records. Statistical analysis included bivariate analysis and logistic regression models. Results: the factors associated with urinary tract infection (p<0.05) were being female; wheelchair user; diaper use; diuretic use; urinary and bowel incontinence; type 1 diabetes; benign prostatic hyperplasia; dehydration. Conclusion: this study revealed that it is important to consider non-modifiable factors such as sex and clinical comorbidities; however, dehydration, a modifiable factor, increased the chances of developing urinary tract infections by 40 times among institutionalized elderly and demands greater attention from the health team.

Characteristics of Physician Relocation Following Hurricane Katrina

2009 ◽  
Vol 95 (1) ◽  
pp. 6-12
Author(s):  
Kusuma Madamala ◽  
Claudia R. Campbell ◽  
Edbert B. Hsu ◽  
Yu-Hsiang Hsieh ◽  
James James
Keyword(s):  
Hurricane Katrina ◽  
Gulf Coast ◽  
General Medicine ◽  
The United States ◽  
Lessons Learned ◽  
Bivariate Analysis ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Factors Associated ◽  
The Impact

ABSTRACT Introduction: On Aug. 29, 2005, Hurricane Katrina made landfall along the Gulf Coast of the United States, resulting in the evacuation of more than 1.5 million people, including nearly 6000 physicians. This article examines the relocation patterns of physicians following the storm, determines the impact that the disaster had on their lives and practices, and identifies lessons learned. Methods: An Internet-based survey was conducted among licensed physicians reporting addresses within Federal Emergency Management Agency-designated disaster zones in Louisiana and Mississippi. Descriptive data analysis was used to describe respondent characteristics. Multivariate logistic regression was performed to identify the factors associated with physician nonreturn to original practice. For those remaining relocated out of state, bivariate analysis with x2 or Fisher exact test was used to determine factors associated with plans to return to original practice. Results: A total of 312 eligible responses were collected. Among disaster zone respondents, 85.6 percent lived in Louisiana and 14.4 percent resided in Mississippi before the hurricane struck. By spring 2006, 75.6 percent (n = 236) of the respondents had returned to their original homes, whereas 24.4 percent (n = 76) remained displaced. Factors associated with nonreturn to original employment included family or general medicine practice (OR 0.42, 95 percent CI 0.17–1.04; P = .059) and severe or complete damage to the workplace (OR 0.24, 95 percent CI 0.13–0.42; P &lt; .001). Conclusions: A sizeable proportion of physicians remain displaced after Hurricane Katrina, along with a lasting decrease in the number of physicians serving in the areas affected by the disaster. Programs designed to address identified physician needs in the aftermath of the storm may give confidence to displaced physicians to return.

scholarly journals POS1260 FACTORS ASSOCIATED WITH SEVERE SARS-COV-2 INFECTION IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES IN MADRID: RESULTS FROM REUMA-COVID SORCOM REGISTRY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 914-914
Author(s):  
A. Boteanu ◽  
A. García Fernández ◽  
N. De la Torre ◽  
M. Pavia Pascual ◽  
O. Sanchez Pernaute ◽  
...  
Keyword(s):  
High Risk ◽  
Rheumatic Diseases ◽  
Connective Tissue Diseases ◽  
Severe Infection ◽  
Pulmonary Involvement ◽  
Inflammatory Rheumatic Diseases ◽  
Factors Associated ◽  
Risk Of Death ◽  
Cardiovascular Comorbidities ◽  
Male Sex

Background:Patients with inflammatory rheumatic diseases (IRD) infected with SARS-CoV-2 may be at risk to develop a severe course of COVID-19 due to the immune dysregulation or the influence of immunomodulating drugs on the course of the infection. For a better understanding of SARS-CoV-2 infections in patients with IRD and due to the high incidence of COVID-19 in Madrid from the beginning of this pandemic infection in Spain, the Society of Rheumatology from Madrid (SORCOM) established a registry (REUMA-COVID SORCOM) shortly after the beginning of the pandemic in Spain.Objectives:To determine factors associated with severity of infection with SARS-CoV-2 in patients with inflammatory rheumatic diseases in MadridMethods:The REUMA-COVID SORCOM registry is a multicenter, retrospective, observational cohort study conducted in Madrid, a SORCOM initiative. All rheumatology departments from Madrid were invited to participate. The study includes patients with IRD presenting with a confirmed or highly suspected diagnosis of COVID-19 between March 1, 2020, and November 10, 2020. We consider severe infection death or need of hospitalization. Inclusion criteria was having an IRD and at least 1 of the following 4 criteria: (1) a biologically confirmed COVID-19 diagnosis based on a positive result of a SARS-CoV-2 polymerase chain reaction (PCR) test on a nasopharyngeal swab; (2) Detection of IgM or IgG anti SARS-CoV2 in a symptomatic or asymptomatic patients (3)typical thoracic computed tomography (CT) abnormalities (ground-glass opacities) in epidemic areas; (4) COVID19–typical symptoms in an epidemic zone of COVID-19.Results:As of November 10, 2020, 417 patients with IRD were included in the REUMA-COVID SORCOM registry. 5 patients were discharged for incomplete data. Of 412 patients (mean age 57 years, 87.4% Caucasian race, 66.3% female) 174 need hospitalization (42.2%) and 33 patients died (18.4% mortality in hospitalized patients). 82.3% had comorbidities. 234 (56.8%) patients were classified as inflammatory arthropathy, 133 (32.3%) had connective tissue diseases (CTD). 41.1% of the patients had a large history of IRD (> 10 years). 10.4% of patients had previously pulmonary involvement. The study includes 143 patients taking Methotrexate, 89 patients taking anti-TNFα therapy and 27 Rituximab. In the univariant analysis, no differences were seen in the severity of COVID-19 infection in patients taking methotrexate. 63% of the all patients taking Rituximab included in the registry need hospitalization and 22% of them died. Hypertension, COPD or cardiovascular disease was associated with hospitalization.Independent factors associated with COVID-19 hospitalization in the multivariate analysis was: age (>62 years), male sex, IMC >30, previous cardiovascular comorbidities and the IRD disease duration (> 10 years). Independent factors associated with COVID-19 related death was: age (> 62 years), having a CTD diagnose, pulmonary involvement before infection and chronical GC treatment.Conclusion:Patients with IRD represent a population of particular interest in the pandemic context because the baseline immunological alteration and the treated with immunosuppressants agents they receive, comorbidities and the well-known risk of severe infection. Older age, male sex, cardiovascular comorbidities were factors associated with high risk of hospitalization in IRD patients. CTD diseases, previously pulmonary involvement and chronical GC treatment with more than 10mg/day were associated with high risk of death. Neither anti TNF-α treatment nor Methotrexate were risk factor for hospitalization or death COVID-19 related in IRD patients.Disclosure of Interests:None declared

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