scholarly journals Primary stability and PES/WES evaluation for immediate implants in the aesthetic zone: a pilot clinical double-blind randomized study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Arturo Sanchez-Perez ◽  
Ana I. Nicolas-Silvente ◽  
Carmen Sanchez-Matas ◽  
Silvia Molina-García ◽  
Carlos Navarro-Cuellar ◽  
...  
Keyword(s):  
Randomized Study ◽  
Primary Stability ◽  
Implant Design ◽  
Control Group ◽  
Double Blind ◽  
Anterior Maxilla ◽  
Immediate Implants ◽  
Bone Level ◽  
The Aesthetic ◽  
Secondary Stability

AbstractThe use of immediate implants in the aesthetic area is a technique widely used in modern implantology. The characteristics of the patient, the implant, and the surgical procedure used may influence the final results. The aim was to assess whether the implant design affects primary (P.S.) and secondary stability (S.S.), bone level (B.L.), and PES/WES evaluation. Twenty implants with two different designs (n = 10) were immediately placed and randomly located in the upper anterior maxilla with no grafting material. Implant-Stability-Quotient (ISQ), B.L., and Pink-Esthetic-Score/White-Esthetic-Score (PES/WES) were evaluated. Shapiro–Wilk normality test was performed to determine the sample normality, as the data did not follow a normal distribution, the Wilcoxon-Mann–Whitney test was applied (p < 0.05). ISQ was determined at placement (PS): control 59.1 (C.I.54.8–63.3); experimental 62.2(C.I.60.1–64.2) and three months after placement (SS): control 62.2.1 (C.I.53.3–71.0); experimental 67.2(C.I.65.8–68.5). The BL was measured at three months after placement: control 0.38 mm (C.I.− 0.06 to  + 0.83); experimental 0.76 mm (C.I.0.33–1.19) and at 12 months post-loading: control 0.07 mm (C.I.− 0.50–0.65); experimental 0.90 mm (C.I.0.38–1.42). PES/WES values were evaluated for the control group: 15 (C.I.12.68–17.32), and for the experimental group 15.20 (C.I.11.99–18.41). No significant differences were shown between both implant designs. A good grade of osseointegration and primary/secondary stability was achieved, as well as proper maintenance of crestal bone and adequate PES/WES scores. The criteria for selection for the ideal patient for immediate implant placement is essential.ClinicalTrials Protocol ID: NCT04343833.

scholarly journals One-Abutment One-Time Effect on Peri-Implant Marginal Bone: A Prospective, Controlled, Randomized, Double-Blind Study

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4179
Author(s):  
Filipe Moreira ◽  
Salomão Rocha ◽  
Francisco Caramelo ◽  
João P. Tondela
Keyword(s):  
Bone Loss ◽  
Statistical Significance ◽  
Test Group ◽  
Primary Stability ◽  
Control Group ◽  
Double Blind Study ◽  
Double Blind ◽  
Implant Placement ◽  
Bone Level ◽  
The Mean

Objective: To evaluate the peri-implant hard tissue change at 6 and 12 months after implant placement between definitive abutment placed at the same time of implant surgery, never removing it, and healing abutment disconnected and reconnected three times until the placement of the final rehabilitation. Material and methods: Each partial edentulous patient could receive between 1 and 4 platform-switched implants in the posterior regions. If the implants had primary stability—implant stability quotient (ISQ) equal to or greater than 50, they were randomized to the test group with the abutment inserted at the same time of implant placement (DA) or to the control group, receiving a healing abutment (PA). At 6 and 12 months after surgery, data related with vertical bone level changes (primary outcome) and other clinical parameters (implant mobility, bleeding on probing, probing depth, plaque index) were assessed. Results: 53 implants were included in the trial and completed 12 months follow-up (overall survival rate: 100%). All implants achieved primary stability, with an average ISQ value of 80.9 on the day of surgery. From surgery to 6 months, the mean bone loss was 0.14 ± 0.18 mm for the DA group and 0.23 ± 0.29 mm for the PA group, without statistical significance difference. Between 6 and 12 months, the mean bone loss was 0.14 ± 0.21 mm for the DA group and 0.21 ± 0.27 mm for the PA group, also without statistical significance between the two groups. There were no statistically significant differences (p = 0.330) in total bone loss after 12 months between the control and the study groups. Conclusions: The one abutment one time protocol has at least an equivalent effect on the peri-implant bone level changes when compared with the use of healing abutments that are disconnected and reconnected at least three times.

Influence of implant design, length, diameter, and anatomic region on implant stability: a randomized clinical trial

2021 ◽  
Vol 61 (1) ◽  
Author(s):  
André Moreira ◽  
◽  
José Rosa ◽  
Filipe Freitas ◽  
Helena Francisco ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Primary Stability ◽  
Implant Design ◽  
Implant Stability ◽  
Anterior Maxilla ◽  
Implant Stability Quotient ◽  
Relevant Effect ◽  
Posterior Maxilla ◽  
Significant Difference ◽  
Secondary Stability

Objectives: To evaluate the influence of implant geometry and anatomical region on implant stability. Methods: A randomized controlled clinical trial was conducted on 45 patients, in whom a total of 79 implants were placed: 40 MIS C1 Implants and 39 MIS Seven Implants. The implant stability quotient was measured using resonance frequency analysis immediately after implant placement and 8 weeks later with an Osstell Mentor device. Results: 76 implants were analyzed. The implant stability quotient was statistically significantly higher for secondary stability than primary stability (68.7±8,6 vs. 65.2±10.3, respectively, p=0.023). Considering primary stability, no statistical differences were found between the implant lengths 8.0 mm, 10.0 mm, 11.0 mm, and 11.5 mm (67.9±7.6, 63.9±10, 57.2±11.1, and 66.4±11.3, respectively, p=0.312). The same was observed for secondary stability (68.4±9.4, 67.9±9.3, 74.7±1.5, and 69.2±7.9, respectively, p=0.504). Also, there were no statistically significant differences between the implant diameters 3.75 mm and 4.20 mm concerning primary stability (64.3±8.7 and 66.1±11.7 respectively, p=0.445) or secondary stability (68.8±8.2 and 68.7±9.1 respectively, p=0.930). Regarding implant design, a statistically significant difference was found only for secondary stability, favoring MIS Seven implants (p=0.048). The intraoral location was statistically significant for both primary and secondary stability, as these were higher on the anterior maxilla than the posterior maxilla and mandible (p<0.05). Conclusions: The diameter and length of the implants studied did not influence their stability. Implant design may influence secondary stability, whereas intraoral location has a relevant effect on primary and secondary stability.

scholarly journals Influence of implant design, length, diameter, and anatomic region on implant stability: a randomized clinical trial

2021 ◽  
Vol 62 (1) ◽  
Author(s):  
André Moreira ◽  
◽  
José Rosa ◽  
Filipe Freitas ◽  
Helena Francisco ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Primary Stability ◽  
Implant Design ◽  
Implant Stability ◽  
Anterior Maxilla ◽  
Implant Stability Quotient ◽  
Relevant Effect ◽  
Posterior Maxilla ◽  
Significant Difference ◽  
Secondary Stability

Objectives: To evaluate the influence of implant geometry and anatomical region on implant stability. Methods: A randomized controlled clinical trial was conducted on 45 patients, in whom a total of 79 implants were placed: 40 MIS C1 Implants and 39 MIS Seven Implants. The implant stability quotient was measured using resonance frequency analysis immediately after implant placement and 8 weeks later with an Osstell Mentor device. Results: 76 implants were analyzed. The implant stability quotient was statistically significantly higher for secondary stability than primary stability (68.7±8,6 vs. 65.2±10.3, respectively, p=0.023). Considering primary stability, no statistical differences were found between the implant lengths 8.0 mm, 10.0 mm, 11.0 mm, and 11.5 mm (67.9±7.6, 63.9±10, 57.2±11.1, and 66.4±11.3, respectively, p=0.312). The same was observed for secondary stability (68.4±9.4, 67.9±9.3, 74.7±1.5, and 69.2±7.9, respectively, p=0.504). Also, there were no statistically significant differences between the implant diameters 3.75 mm and 4.20 mm concerning primary stability (64.3±8.7 and 66.1±11.7 respectively, p=0.445) or secondary stability (68.8±8.2 and 68.7±9.1 respectively, p=0.930). Regarding implant design, a statistically significant difference was found only for secondary stability, favoring MIS Seven implants (p=0.048). The intraoral location was statistically significant for both primary and secondary stability, as these were higher on the anterior maxilla than the posterior maxilla and mandible (p<0.05). Conclusions: The diameter and length of the implants studied did not influence their stability. Implant design may influence secondary stability, whereas intraoral location has a relevant effect on primary and secondary stability.

scholarly journals Efficacy of dexamethasone in reducing the incidence of postoperative sore throat: a double blind randomized study

2018 ◽  
Vol 5 (1) ◽  
pp. 10-15 ◽  
Author(s):  
Sujita Manandhar ◽  
Kishor Manandhar ◽  
Sharad Khakrel
Keyword(s):  
Endotracheal Tube ◽  
Sore Throat ◽  
Randomized Study ◽  
Saline Group ◽  
Controlled Study ◽  
Control Group ◽  
Lower Grade ◽  
Postoperative Sore Throat ◽  
Double Blind ◽  
Dexamethasone Group

Introductions: Postoperative sore throat (POST) is a commonly seen adverse event after general anesthesia with endotracheal intubation. Dexamethasone, a potent corticosteroid with anti-inflammatory action is the most popular steroid studied in this regard with positive results. Methods: This randomized, prospective, double-blinded, placebo-controlled study was conducted on one hundred and ten adult patients of either sex, American Society of Anesthesiologists physical status I & II, undergoing elective surgeries requiring endotracheal tube intubation. After obtaining written informed consent, they were randomly divided into Control (A, n=55) and Dexamethasone (B, n=55) groups and received either an injection of Dexamethasone (Group B) 8 mg intravenously or an equivalent volume of Normal Saline (Group A) just before entering the operating theatre. All the patients received a similar anesthesia with endotracheal tube intubation and at the end of surgery, extubated and transferred to the post-anesthesia care unit. The incidence and severity of sore throat were assessed at 1, 6 and 24 hours post-extubation. Severity of sore throat were graded on a 4 point scale, p <0.05 was considered significant. Results: Incidence of POST in Dexamethasone group was found significantly low compared to the control group up to six hours (p<0.05) but was comparable at 24 hours post extubation. Severity of POST in the study group was of lower grade in compare to control group. Conclusions: Prophylactic intravenous Dexamethasone 8 mg administered to patients undergoing elective surgeries requiring endotracheal tube intubation significantly reduces the incidence and severity of POST up to six hours post-extubation.

scholarly journals One Abutment One Time: A Multicenter, Prospective, Controlled, Randomized Study

2020 ◽  
Vol 17 (24) ◽  
pp. 9453
Author(s):  
José Vicente Ríos-Santos ◽  
Gregorio Tello-González ◽  
Pedro Lázaro-Calvo ◽  
Francisco Javier Gil Mur ◽  
Blanca Ríos-Carrasco ◽  
...  
Keyword(s):  
Bone Loss ◽  
Statistical Significance ◽  
Randomized Study ◽  
Study Groups ◽  
Control Group ◽  
Implant Stability ◽  
Chi Square ◽  
Implant Placement ◽  
Qualitative Variables ◽  
Bone Level

Aim: (PRIMARY) Assess the changes in bone level (6 and 12 months after implant placement) between the test (definitive abutment (DEF)) and control (healing abutment (HEA)) groups. (SECONDARY) Assess the changes in bone level (6 and 12 months after implant placement) between the 1 mm high abutment group and 2 mm abutment group. Evaluate changes in implant stability recorded with analysis of the resonance frequency (RFA) Osstell system, at 6 and 12 months after implant placement, between the control group (HEA) and test (DEF). For the DEF group, the abutment was placed at the time of the surgery and was never removed. For the HEA group, the abutment was removed three times during the manufacture of the crowns. The abutments used were 1 mm high (Subgroup A) and 2 mm high (Subgroup B). Materials and methods: A total of 147 patients were selected between 54.82 ± 11.92 years old. After implant placement, patients were randomly distributed in the DEF and HEA group. After the implant placement, a periapical radiograph was taken to assess the peri-implant bone level; the same procedure was carried out 6 and 12 months post-placement. To compare the qualitative variables between the groups (HEA/DEF), the Chi-square test was used; for quantitative (MANOVA). Results: After a year, the accumulated bone loss was 0.48 ± 0.71 mm for the HEA group and 0.36 ± 0.79 mm for the DEF group, without statistical significance. Differences were only found due to timing (time) between 0 and 6 months (=0.001) and 0 and 12 months (0.001), with no differences attributable to the study groups (DEF and HEA). The accumulated bone loss (1 year) was 0.45 ± 0.78 mm for the 1 mm abutment group and 0.41 ± 0.70 mm for the 2 mm abutment group (p = 0.02). No differences were observed in implant stability between groups. Conclusions: The “One Abutment—One Time” concept does not reduce peri-implant bone loss compared to the connection–disconnection technique. The height of the abutment does influence bone loss: the higher the abutment, the lower the bone loss.

Comparative assessment of the primary stability of Straumann® BLX implant design using an in-vitro sinus lift-simultaneous implant insertion model

2021 ◽  
Author(s):  
Marie Emmert ◽  
Johannes Spille ◽  
Eleonore Behrens ◽  
Mustafa Ayna ◽  
Fatih Karayurek ◽  
...  
Keyword(s):  
Primary Stability ◽  
Implant Design ◽  
Control Group ◽  
Study Group ◽  
Sinus Lift ◽  
Wide Diameter ◽  
Resonance Frequence ◽  
The Stability ◽  
Standard Implant

Straumann ®  BLX is a novel implant system, which has been proclaimed to provide an ideal primary stability in all types of bone. In the current study, the primary stability of Straumann ®  BLX implant systems with Straumann ®  tapered effect (TE) implants have been comparatively assessed in bovine ribs by using a simultaneous sinus elevation and implant insertion model.  In the study group, BLX (4.0 x 12 mm), TE (4.1 x 12 mm), BLX (4,5 x 12 mm) and TE (4.8 x 12 mm) were placed in each bony window, which resembles sinus maxillaris. As a control, BLX and TE implants with same sizes were inserted into the proximal diaphysis of the bovine ribs. A total of 40 implant insertions were performed. The stability was measured with resonance frequence analysis. In the study group, TE implants of 4.8 mm showed significantly higher values compared to 4.5 mm BLX implants (p=0.116). However, BLX implants of 4.0 mm in the control group showed higher stability compared to TE with 4.0 mm diameter. (p=0.014).  The primary stability of BLX implants in the control group was significantly higher compared to the experimental group in both widths (p=0.018 for BLX 4.0 and p=0.002 for BLX 4.5 respectively). The use of TE design with wide diameter in simultaneous implant placement with sinus lift could present higher ISQ values and might be more appropriate option for implant recipient sites with poor bone volume and quality. However, the advantage of BLX design in standard implant insertion protocols could be precious.

scholarly journals Preoperative Fasting Abbreviation and its Effects on Postoperative Nausea and Vomiting Incidence in Gynecological Surgery Patients

2020 ◽  
Vol 42 (08) ◽  
pp. 468-475
Author(s):  
Gisele Vissoci Marquini ◽  
Francisco Edes da Silva Pinheiro ◽  
Alfredo Urbano da Costa Vieira ◽  
Rogério Melo da Costa Pinto ◽  
Maria Gabriela Baumgarten Kuster Uyeda ◽  
...  
Keyword(s):  
At Risk ◽  
Postoperative Nausea ◽  
Randomized Study ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
Control Group ◽  
Gynecological Surgery ◽  
Preoperative Fasting ◽  
Double Blind ◽  
Significant Difference

Abstract Objective To investigate the effects of preoperative fasting abbreviation with a carbohydrate and protein-enriched solution, on postoperative nausea and vomiting (PONV) incidence in gynecological surgery patients, a population naturally at risk for such unpleasant episodes. Methods The present prospective double-blind randomized study was performed at The Hospital Municipal e Maternidade Dr. Odelmo Leão Carneiro (HMMOLC, in the Portuguese acronym), in Uberlândia, state of Minas Gerais, Brazil, in partnership with the Gynecology Department of the Universidade Federal de São Paulo (UNIFESP), approved by the Human Research Ethics Committee of UNIFESP and the board of HMMOLC, and included in the Brazil Platform and in the Brazilian Clinical Trial Registry. After signing the consent form, 80 women, who were submitted to gynecological surgery in the period from January to June 2016, were randomized into 2 groups: control group (n = 42) and juice group (n = 38). They received, respectively, 200 mL of inert solution or liquid enriched with carbohydrate and protein 4 hours presurgery. The incidence, frequency and intensity of PONV were studied using the Visual Analogue Scale (VAS), with statistical analysis performed by the software IBM SPSS Statistics for Windows, Version 20.0 (IBM Corp, Armonk, NY, USA). Results The incidence of nausea and vomiting was lower than in the literature, to this population, with 18.9% (14/74) for the control group and 10.8% (8/74) for the juice group, respectively, with no statistically significant difference between the groups. Conclusion The incidence of nausea and vomiting was lower than in the literature, but it cannot be said that this is due to the abbreviation of fasting. It can provide greater comfort, with the possibility of PONV prevention in patients at risk for these episodes.

scholarly journals Selective neuromodulation induced by alpha-based neurofeedback learning: A double-blind randomized study

2020 ◽  
Author(s):  
Fanny Grosselin ◽  
Audrey Breton ◽  
Lydia Yahia-Cherif ◽  
Xi Wang ◽  
Giuseppe Spinelli ◽  
...  
Keyword(s):  
Brain Activity ◽  
Randomized Study ◽  
Training Group ◽  
Alpha Activity ◽  
Controlled Study ◽  
Control Group ◽  
Double Blind Study ◽  
List Type ◽  
Double Blind ◽  
Wearable Eeg

AbstractBackgroundThe neuromodulation induced by neurofeedback training (NFT) remains a matter of debate. Investigating the modulation of brain activity specifically associated with NF requires controlling for multiple factors, such as reward, performance, congruency between task and targeted brain activity. This can be achieved using sham feedback (FB) control condition, equating all aspects of the experiment but the closed-loop between brain activity and FB.ObjectiveWe aimed at investigating the modulation of individual alpha EEG activity induced by NFT in a double-blind, randomized, sham-controlled study.MethodsForty-eight healthy participants were assigned to either NF (n=25) or control (n=23) group and performed 12 NFT sessions of alpha upregulation with a wearable EEG device. Participants of the NF group received FB based on their individual alpha activity. The control group received the auditory FB of participants of the NF group.ResultsAn increase of alpha activity across training sessions was observed in the NF group only (p<0.001). This neuromodulation was selective in that it was not observed for theta (4-8Hz) and low beta (13-18Hz) activities. It was associated with an increased feeling of control (p<0.001), more marked for NF than control group. Anxiety level decreased and relaxation feeling increased with training in both groups.ConclusionsNFT across multiple sessions can induce specific brain modulation, suggesting a neuroplasticity selective of the targeted brain activity. Our results pave the way to self-learnt, NF-based neuromodulation with light-weighted, wearable EEG systems for various applications (e.g. epilepsy, sleep, attention).HighlightsRandomized double-blind study of neuromodulation induced by EEG-neurofeedback (NF)Sham feedback (FB) was used for the control groupTargeted alpha activity increased selectively over the 12 NF training sessionsThis neuromodulation was observed only in the real NF training groupThe feeling of control across sessions increased more for real than sham FB group

scholarly journals EFFECTS OF ONCE-DAILY VERSUS TWICE DAILY DOSING OF CALCIUM FRUCTOBORATE ON KNEE DISCOMFORT. A 90 DAY, DOUBLE-BLIND, PLACEBO CONTROLLED RANDOMIZED CLINICAL STUDY

2018 ◽  
pp. 1-6
Author(s):  
Z. Pietrzkowski ◽  
A. Roldán Mercado-Sesma ◽  
R. Argumedo ◽  
M. Cervantes ◽  
B. Nemzer ◽  
...  
Keyword(s):  
Randomized Study ◽  
Control Group ◽  
Mcgill Pain Questionnaire ◽  
Double Blind ◽  
Test Analysis ◽  
Once Daily ◽  
Double Blind Placebo ◽  
Randomized Clinical Study ◽  
Supplementation Period ◽  
Calcium Fructoborate

Importance: Previous research showed that a twice-daily 108 mg dose of calcium fructoborate (CFB) improved knee discomfort during a 2-week supplementation period. This current double-blind, placebo-controlled randomized study investigates the effects of CFB supplementation on knee discomfort during 90 days of supplementation. Purpose: To evaluate the comparative effects of once-daily and twice-daily dosing of calcium fructoborate on knee joint discomfort for ninety days. Design: 120 participants with self-reported knee discomfort were recruited and randomized into three groups (each N=40). Participants received: 108 mg CFB twice per day (CFB-G1); or, 216 mg CFB in a single dose (CFB-G2); or, placebo. Setting: Subjects were recruited through advertisement in local papers. The researchers assessed intake and within-study levels of knee discomfort by using the McGill Pain Questionnaire (MPQ) and the Western Ontario and McMaster University Arthritis Index (WOMAC). Results: 62 female and 59 male subjects completed the study. Subjects’ average age was (52.84 ± 8.19 years) and average BMI was (26.76 ± 2.50 kg/m2). Statistical differences between groups were calculated using a two-sided, two-sample t-test. Analysis of variance (ANOVA) was used to estimate within-group changes in mean WOMAC and MPQ scores as well as against the control group. When compared to placebo, CFB-G1 showed a significant decrease in reported discomfort on day 14 (P=0.02,) day 30 (P=0.003), day 60 (P<0.0001) and day 90 (P<0.0001) according to WOMAC Scores. A similar decrease was observed for CFB-G2 WOMAC Scores on day 14 (P=0.02), day 30 (P=0.0003), day 60 (P<0.0001) and day 90 (P<0.0001). When compared to placebo, the MPQ score for CFB-G1 group decreased on day 7 (P=0.002), day 14 (P=0.001), day 30 (P<0.0001), day 60 (P<0.0001) and day 90 (P<0.0001). MPQ score decreases were also observed for CFB-G2 group on day 7 (P=0.02), day 14 (P=0.01), day 30 (P<0.0001), day 60 (P<0.0001) and day 90 (P<0.0001). When comparing CFB-G1 and CFB-G2, no significant differences were observed. Importantly, no changes were observed in the WOMAC and MPQ scores within the placebo group. Conclusion: Both CFB groups showed early and significantly improved levels of knee comfort. Knee comfort continued to significantly improve throughout the duration of this 90-day study. No significant differences were observed between the once-daily and the twice–daily doses of CFB.

scholarly journals Effects of intravenous arginine on the healing of human skin graft donor sites: A randomized controlled trial

2015 ◽  
Vol 10 (4) ◽  
pp. 739
Author(s):  
Ke Li ◽  
Wei Lin ◽  
Li-Jun Wu ◽  
Qiang Qi ◽  
Guo Liang Shen ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Graft ◽  
Controlled Trial ◽  
Randomized Study ◽  
Control Group ◽  
Double Blind ◽  
Neutrophil Influx ◽  
Total Plasma Protein ◽  
Graft Donor ◽  
Plasma Arginine

<p class="Abstract">We expounded the effect of intravenous arginine on the healing of human skin graft donor sites. This randomized study was double blind and controlled by placebos from October 2012 to May 2015. Nine patients were selected into the arginine group and 10 were selected into the control group. There was no significance in age, weight, BMI, CRP, albumin and total plasma protein in arginine and control groups. Angiogenesis, re-epithelialization and neutrophil influx of wound healing were measured. The concentrations of plasma amino acid were measured to evaluate our intervention. In our study, plasma arginine and ornithine concentrations in arginine group were the highest after arginine-treated at 2 days. Supplementation of intravenous arginine could not affect on healing of human skin graft donor sites, improve angiogenesis, reepithelialization or neutrophil influx in rats.</p><p> </p>

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