scholarly journals Pseudosparse neural coding in the visual system of primates

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Sidney R. Lehky ◽  
Keiji Tanaka ◽  
Anne B. Sereno
Keyword(s):  
Neural Coding ◽  
Macaque Monkey ◽  
Implicit Assumption ◽  
Data Set ◽  
Efficient Coding ◽  
Population Responses ◽  
Lateral Intraparietal Cortex ◽  
Neural Populations ◽  
Neurophysiological Data ◽  
The Mean

AbstractWhen measuring sparseness in neural populations as an indicator of efficient coding, an implicit assumption is that each stimulus activates a different random set of neurons. In other words, population responses to different stimuli are, on average, uncorrelated. Here we examine neurophysiological data from four lobes of macaque monkey cortex, including V1, V2, MT, anterior inferotemporal cortex, lateral intraparietal cortex, the frontal eye fields, and perirhinal cortex, to determine how correlated population responses are. We call the mean correlation the pseudosparseness index, because high pseudosparseness can mimic statistical properties of sparseness without being authentically sparse. In every data set we find high levels of pseudosparseness ranging from 0.59–0.98, substantially greater than the value of 0.00 for authentic sparseness. This was true for synthetic and natural stimuli, as well as for single-electrode and multielectrode data. A model indicates that a key variable producing high pseudosparseness is the standard deviation of spontaneous activity across the population. Consistently high values of pseudosparseness in the data demand reconsideration of the sparse coding literature as well as consideration of the degree to which authentic sparseness provides a useful framework for understanding neural coding in the cortex.

scholarly journals Dimensionality of Object Representations in Monkey Inferotemporal Cortex

2014 ◽  
Vol 26 (10) ◽  
pp. 2135-2162 ◽  
Author(s):  
Sidney R. Lehky ◽  
Roozbeh Kiani ◽  
Hossein Esteky ◽  
Keiji Tanaka
Keyword(s):  
Receptive Fields ◽  
Basis Set ◽  
Visual Object ◽  
Object Representations ◽  
Inferotemporal Cortex ◽  
Data Set ◽  
Set Size ◽  
Neural Populations ◽  
Neurophysiological Data ◽  
Independent Features

We have calculated the intrinsic dimensionality of visual object representations in anterior inferotemporal (AIT) cortex, based on responses of a large sample of cells stimulated with photographs of diverse objects. Because dimensionality was dependent on data set size, we determined asymptotic dimensionality as both the number of neurons and number of stimulus image approached infinity. Our final dimensionality estimate was 93 (SD: [Formula: see text] 11), indicating that there is basis set of approximately 100 independent features that characterize the dimensions of neural object space. We believe this is the first estimate of the dimensionality of neural visual representations based on single-cell neurophysiological data. The dimensionality of AIT object representations was much lower than the dimensionality of the stimuli. We suggest that there may be a gradual reduction in the dimensionality of object representations in neural populations going from retina to inferotemporal cortex as receptive fields become increasingly complex.

Mutual Information, Fisher Information, and Efficient Coding

2016 ◽  
Vol 28 (2) ◽  
pp. 305-326 ◽  
Author(s):  
Xue-Xin Wei ◽  
Alan A. Stocker
Keyword(s):  
Mutual Information ◽  
Fisher Information ◽  
Neural Coding ◽  
Population Coding ◽  
Neural Population ◽  
Small Noise ◽  
Efficient Coding ◽  
Coding Efficiency ◽  
Stimulus Variable ◽  
Neural Populations

Fisher information is generally believed to represent a lower bound on mutual information (Brunel & Nadal, 1998 ), a result that is frequently used in the assessment of neural coding efficiency. However, we demonstrate that the relation between these two quantities is more nuanced than previously thought. For example, we find that in the small noise regime, Fisher information actually provides an upper bound on mutual information. Generally our results show that it is more appropriate to consider Fisher information as an approximation rather than a bound on mutual information. We analytically derive the correspondence between the two quantities and the conditions under which the approximation is good. Our results have implications for neural coding theories and the link between neural population coding and psychophysically measurable behavior. Specifically, they allow us to formulate the efficient coding problem of maximizing mutual information between a stimulus variable and the response of a neural population in terms of Fisher information. We derive a signature of efficient coding expressed as the correspondence between the population Fisher information and the distribution of the stimulus variable. The signature is more general than previously proposed solutions that rely on specific assumptions about the neural tuning characteristics. We demonstrate that it can explain measured tuning characteristics of cortical neural populations that do not agree with previous models of efficient coding.

Gustatory neural coding in the amygdala of the alert macaque monkey

1993 ◽  
Vol 69 (6) ◽  
pp. 1810-1820 ◽  
Author(s):  
T. R. Scott ◽  
Z. Karadi ◽  
Y. Oomura ◽  
H. Nishino ◽  
C. R. Plata-Salaman ◽  
...  
Keyword(s):  
Neural Coding ◽  
Rhesus Macaques ◽  
Activity Patterns ◽  
Monosodium Glutamate ◽  
Macaque Monkey ◽  
Stimulus Concentration ◽  
Taste Cells ◽  
The Mean ◽  
Evoked Activity ◽  
Basic Stimulus

1. Neurons in the amygdala are implicated in mediating hedonic appreciation, emotional expression, and conditioning, particularly as these relate to feeding. The amygdala receives projections from the primary taste cortex in monkeys, offering a route by which it could gain access to the gustatory information required to guide feeding behavior. We recorded the activity of 35 neurons in the amygdala of alert rhesus macaques in response to a range of gustatory intensities and qualities to characterize taste-evoked activity in this area. 2. The stimulus array comprised 26 chemicals, including four concentrations of each of the four basic taste stimuli, a series of other sugars, salts, and acids, monosodium glutamate, and orange juice. 3. Neurons responsive to taste stimulation could be found in a 76-mm3 region of the amygdala, centered 9.1 mm lateral to the midline, 14.9 mm anterior to the interaural line, and 25.7 mm below the surface of the dura. They composed 7.2% (35/484) of the cells tested for gustatory sensitivity in the amygdala. 4. The mean spontaneous activity of taste cells was 8.2 +/- 2.3 (SE) spikes per second. This rather high level provided an opportunity for reductions from spontaneous rate that was used regularly in the amygdala. When these negative response rates were included, the mean breadth-of-tuning coefficient of this sample of taste cells was 0.82. There was no strong evidence for gustatory neuron types, nor were functionally similar cells located together in a chemotopic arrangement. 5. Responses across 1.5 log units of stimulus concentration were nearly flat, with increasing excitation in some neurons largely offset by increasing inhibition in others. Taking the absolute value of the evoked activity, concentration-response functions rose monotonically to all basic stimuli except HCl, but were not sufficiently steep to account for human psychophysical data. The neural response to HCl did not rise with stimulus concentration within the range used. 6. Neural patterns representing the taste qualities of the basic stimuli were less sharply separated in the amygdala than at lower-order gustatory relays. Glucose elicited activity patterns that were most distinct from those of the nonsweet chemicals; those associated with NaCl were next most distinct. There was no clear separation between the patterns generated by chemicals that humans describe as sour and bitter. Monosodium glutamate evoked responses that did not correlate well with those of any basic stimulus, implying that its quality cannot be subsumed under the four basic tastes.(ABSTRACT TRUNCATED AT 400 WORDS)

Reproducibility and efficiency in handling complex neurophysiological data

Neuroforum ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Michael Denker ◽  
Sonja Grün ◽  
Thomas Wachtler ◽  
Hansjörg Scherberger
Keyword(s):  
Best Practices ◽  
Data Management ◽  
Data Integrity ◽  
Behavioral Neuroscience ◽  
Data Set ◽  
Data Publication ◽  
Electrophysiological Data ◽  
Data Formats ◽  
Neurophysiological Data ◽  
Community Effort

Abstract Preparing a neurophysiological data set with the aim of sharing and publishing is hard. Many of the available tools and services to provide a smooth workflow for data publication are still in their maturing stages and not well integrated. Also, best practices and concrete examples of how to create a rigorous and complete package of an electrophysiology experiment are still lacking. Given the heterogeneity of the field, such unifying guidelines and processes can only be formulated together as a community effort. One of the goals of the NFDI-Neuro consortium initiative is to build such a community for systems and behavioral neuroscience. NFDI-Neuro aims to address the needs of the community to make data management easier and to tackle these challenges in collaboration with various international initiatives (e.g., INCF, EBRAINS). This will give scientists the opportunity to spend more time analyzing the wealth of electrophysiological data they leverage, rather than dealing with data formats and data integrity.

scholarly journals Relationship between large-scale ionospheric field-aligned currents and electron/ion precipitations: DMSP observations

2020 ◽  
Vol 72 (1) ◽  
Author(s):  
Chao Xiong ◽  
Claudia Stolle ◽  
Patrick Alken ◽  
Jan Rauberg
Keyword(s):  
Time Distribution ◽  
Large Scale ◽  
Particle Flux ◽  
Particle Energy ◽  
Lower Latitude ◽  
Particle Precipitation ◽  
Data Set ◽  
The Mean ◽  
Two Parameters ◽  
Meteorological Satellite

Abstract In this study, we have derived field-aligned currents (FACs) from magnetometers onboard the Defense Meteorological Satellite Project (DMSP) satellites. The magnetic latitude versus local time distribution of FACs from DMSP shows comparable dependences with previous findings on the intensity and orientation of interplanetary magnetic field (IMF) By and Bz components, which confirms the reliability of DMSP FAC data set. With simultaneous measurements of precipitating particles from DMSP, we further investigate the relation between large-scale FACs and precipitating particles. Our result shows that precipitation electron and ion fluxes both increase in magnitude and extend to lower latitude for enhanced southward IMF Bz, which is similar to the behavior of FACs. Under weak northward and southward Bz conditions, the locations of the R2 current maxima, at both dusk and dawn sides and in both hemispheres, are found to be close to the maxima of the particle energy fluxes; while for the same IMF conditions, R1 currents are displaced further to the respective particle flux peaks. Largest displacement (about 3.5°) is found between the downward R1 current and ion flux peak at the dawn side. Our results suggest that there exists systematic differences in locations of electron/ion precipitation and large-scale upward/downward FACs. As outlined by the statistical mean of these two parameters, the FAC peaks enclose the particle energy flux peaks in an auroral band at both dusk and dawn sides. Our comparisons also found that particle precipitation at dawn and dusk and in both hemispheres maximizes near the mean R2 current peaks. The particle precipitation flux maxima closer to the R1 current peaks are lower in magnitude. This is opposite to the known feature that R1 currents are on average stronger than R2 currents.

scholarly journals Numerical simulations of spreading of the Persian Gulf outflow into the Oman Sea

Ocean Science ◽  
2010 ◽  
Vol 6 (4) ◽  
pp. 887-900 ◽  
Author(s):  
M. Ezam ◽  
A. A. Bidokhti ◽  
A. H. Javid
Keyword(s):  
Persian Gulf ◽  
Bottom Topography ◽  
World Ocean ◽  
Monthly Precipitation ◽  
Boundary Current ◽  
Surface Salinity ◽  
Data Set ◽  
Open Boundaries ◽  
The Mean ◽  
The Persian Gulf

Abstract. A three dimensional numerical model namely POM (Princeton Ocean Model) and observational data are used to study the Persian Gulf outflow structure and its spreading pathways during 1992. In the model, the monthly wind speed data were taken from ICOADS (International Comprehensive Ocean-Atmosphere Data Set) and the monthly SST (sea surface temperatures) were taken from AVHRR (Advanced Very High Resolution Radiometer) with the addition of monthly net shortwave radiations from NCEP (National Center for Environmental Prediction). The mean monthly precipitation rates from NCEP data and the calculated evaporation rates are used to impose the surface salinity fluxes. At the open boundaries the temperature and salinity were prescribed from the mean monthly climatological values from WOA05 (World Ocean Atlas 2005). Also the four major components of the tide were prescribed at the open boundaries. The results show that the outflow mainly originates from two branches at different depths in the Persian Gulf. The permanent branch exists during the whole year deeper than 40 m along the Gulf axis and originates from the inner parts of the Persian Gulf. The other seasonal branch forms in the vicinity of the shallow southern coasts due to high evaporation rates during winter. Near the Strait of Hormuz the two branches join and form the main outflow source water. The results of simulations reveal that during the winter the outflow boundary current mainly detaches from the coast well before Ras Al Hamra Cape, however during summer the outflow seems to follow the coast even after this Cape. This is due to a higher density of the colder outflow that leads to more sinking near the coast in winter. Thus, the outflow moves to a deeper depth of about 500 m (for which some explanations are given) while the main part detaches and spreads at a depth of about 300 m. However in summer it all moves at a depth of about 200–250 m. During winter, the deeper, stronger and wider outflow is more affected by the steep topography, leading to separation from the coast. While during summer, the weaker and shallower outflow is less influenced by bottom topography and so continues along the boundary.

scholarly journals EPID-22. CHARACTERIZATION OF RADIATION-INDUCED MENINGIOMAS IN A BRAIN TUMOR DATABASE

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii83-ii83
Author(s):  
Nilan Vaghjiani ◽  
Andrew Schwieder ◽  
Sravya Uppalapati ◽  
Zachary Kons ◽  
Elizabeth Kazarian ◽  
...  
Keyword(s):  
African American ◽  
Brain Tumor ◽  
Radiation Treatment ◽  
Latency Period ◽  
Data Set ◽  
Who Grade ◽  
Significant Difference ◽  
Radiation Induced ◽  
Grade Ii ◽  
The Mean

Abstract PURPOSE Radiation-induced meningiomas (RIMs) are associated with previous exposure to therapeutic irradiation. RIMs are rare and have not been well characterized relative to spontaneous meningiomas (SMs). METHODS 1003 patients with proven or presumed meningiomas were identified from the VCU brain tumor database. Chart review classified RIM patients and their characteristics. RESULTS Of the 1003 total patients, 76.47% were female with a mean ± SD age of 67.55 ± 15.50 years. 15 RIM patients were identified (66.67% female), with a mean ± SD age of 52.67 ± 15.46 years, 5 were African American and 10 were Caucasian. The incidence of RIMs was 1.49% in our data set. The mean age at diagnosis was 43.27 ± 15.06 years. The mean latency was 356.27 ± 116.96 months. The mean initiating dose was 44.28 ± 14.68 Gy. There was a significant difference between mean latency period and ethnicity, 258.3 months for African American population, and 405.2 months for Caucasian population (p = 0.003). There was a significant difference between the mean number of lesions in females (2.8) versus males (1.2; p = 0.046). Of the RIMs with characterized histology, 6 (55%) were WHO grade II and 5 (45%) were WHO grade I, demonstrating a prevalence of grade II tumors approximately double that found with SMs. RIMs were treated with combinations of observation, surgery, radiation, and medical therapy. Of the 8 patients treated with radiation, 4 demonstrated response. 8 of the 15 patients (53%) demonstrated recurrence/progression despite treatment. CONCLUSION RIMs are important because of the associated higher grade histology, gender, and ethnic incidences, and increased recurrence/progression compared to SMs. Despite the presumed contributory role of prior radiation, RIMs demonstrate a significant rate of responsiveness to radiation treatment.

A MODIFIED RATIO TYPE ESTIMATOR OF FINITE POPULATION MEAN UNDER STRATIFIED RANDOM SAMPLING SCHEME

2021 ◽  
pp. 58-60
Author(s):  
Naziru Fadisanku Haruna ◽  
Ran Vijay Kumar Singh ◽  
Samsudeen Dahiru
Keyword(s):  
Mean Square Error ◽  
Random Sampling ◽  
Minimum Mean Square Error ◽  
Real Life ◽  
Population Data ◽  
Auxiliary Variable ◽  
Mean Square ◽  
Data Set ◽  
Population Mean ◽  
The Mean

In This paper a modied ratio-type estimator for nite population mean under stratied random sampling using single auxiliary variable has been proposed. The expression for mean square error and bias of the proposed estimator are derived up to the rst order of approximation. The expression for minimum mean square error of proposed estimator is also obtained. The mean square error the proposed estimator is compared with other existing estimators theoretically and condition are obtained under which proposed estimator performed better. A real life population data set has been considered to compare the efciency of the proposed estimator numerically.

Parsing of Urban Facades from 3D Point Clouds Based on a Novel Multi-View Domain

2021 ◽  
Vol 87 (4) ◽  
pp. 283-293
Author(s):  
Wei Wang ◽  
Yuan Xu ◽  
Yingchao Ren ◽  
Gang Wang
Keyword(s):  
Deep Learning ◽  
Prior Knowledge ◽  
Performance Improvement ◽  
Data Distribution ◽  
Point Clouds ◽  
Learning Models ◽  
Data Set ◽  
3D Point Clouds ◽  
Segmentation Accuracy ◽  
The Mean

Recently, performance improvement in facade parsing from 3D point clouds has been brought about by designing more complex network structures, which cost huge computing resources and do not take full advantage of prior knowledge of facade structure. Instead, from the perspective of data distribution, we construct a new hierarchical mesh multi-view data domain based on the characteristics of facade objects to achieve fusion of deep-learning models and prior knowledge, thereby significantly improving segmentation accuracy. We comprehensively evaluate the current mainstream method on the RueMonge 2014 data set and demonstrate the superiority of our method. The mean intersection-over-union index on the facade-parsing task reached 76.41%, which is 2.75% higher than the current best result. In addition, through comparative experiments, the reasons for the performance improvement of the proposed method are further analyzed.

scholarly journals Procedural Revision to the AOAC Germicidal Spray Products as Disinfectants Test Method: Establishment of Minimum and Maximum Log Density Values for Test Microbes on Inoculated Carriers

2013 ◽  
Vol 96 (3) ◽  
pp. 567-572 ◽  
Author(s):  
Rebecca M Pines ◽  
Stephen F Tomasino ◽  
Michele P Cottrill ◽  
Gordon C Hamilton ◽  
Albert E Parker
Keyword(s):  
Count Data ◽  
Geometric Mean ◽  
Test Method ◽  
Official Method ◽  
Data Set ◽  
Label Claim ◽  
Density Values ◽  
Good Repeatability ◽  
The Mean ◽  
Test Microbe

Abstract The AOAC Germicidal Spray Products as Disinfectants test method (AOAC Official Method 961.02) is used to measure the efficacy of spray products on hard inanimate surfaces; however, the method does not provide procedures to determine the population of the test microbe on inoculated glass slide carriers (e.g., carrier counts reported as CFU/carrier). Without a method to measure and monitor carrier counts, the associated efficacy data may not be reliable and repeatable. This report provides a standardized procedure to address this issue and, based on carrier count data collected by four laboratories from 2000 to 2010, proposes a specific range for the mean log density per carrier as a requirement. Laboratory-based carrier count data were collected concurrently with 116 Method 961.02 efficacy tests conducted on spray products bearing claims against Pseudomonas aeruginosa and Staphylococcus aureus. For many of the tests a soil load (SL) was added to the inoculum (as specified on the product label claim). Six carriers were assayed per test for a total of 696 carriers. All but two of the 116 mean log densities were at least 5.0 (a geometric mean of 1.0 × 105 CFU/carrier). Across the four combinations of microbes and SL treatments, the mean TestLD (mean log density across all enumerated carriers in a test) ranged from approximately 6.0 (a geometric mean of 0.9 × 106 CFU/carrier) to 6.3 (a geometric mean of 2.0 × 106 CFU/carrier). Across all microbes and SL treatments, the mean log density (±SEM) was 6.2 (±0.07) per carrier (a geometric mean of 1.5 × 106 CFU/carrier). The mean log density for six carriers per test showed good repeatability (0.32) and reproducibility (0.34). The proposed requirement for S. aureus tests and P. aeruginosa tests is a mean log density (across six carriers) between 5.0 and 6.5. A separate 2009 study at three laboratories was conducted to evaluate the persistence of P. aeruginosa, S. aureus, and Salmonella enterica on glass carriers. Based on the persistence data, a 2 h use period is proposed for using the inoculated carriers post drying. The persistence data set was also used to assess the carrier counts for S. enterica. The carrier counts were approximately one log lower for S. enterica compared to S. aureus and P. aeruginosa; a range of 4.0 to 5.5 logs is proposed as a requirement for S. enterica tests.

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