scholarly journals Escherichia coli colonizing the neurogenic bladder are similar to widespread clones causing disease in patients with normal bladder function

Spinal Cord ◽  
2008 ◽  
Vol 46 (9) ◽  
pp. 633-638 ◽  
Author(s):  
T A Schlager ◽  
J R Johnson ◽  
L M Ouellette ◽  
T S Whittam
Keyword(s):  
Escherichia Coli ◽  
Neurogenic Bladder ◽  
Bladder Function ◽  
Normal Bladder

scholarly journals Engineered Stem Cells Improve Neurogenic Bladder by Overexpressing SDF-1 in a Pelvic Nerve Injury Rat Model

2020 ◽  
Vol 29 ◽  
pp. 096368972090246 ◽  
Author(s):  
Guan Qun Zhu ◽  
Seung Hwan Jeon ◽  
Kyu Won Lee ◽  
Hyuk Jin Cho ◽  
U-Syn Ha ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Neurogenic Bladder ◽  
Rat Model ◽  
Bladder Wall ◽  
Bladder Function ◽  
Pelvic Nerve ◽  
Injured Nerve

There is still a lack of sufficient research on the mechanism behind neurogenic bladder (NB) treatment. The aim of this study was to explore the effect of overexpressed stromal cell-derived factor-1 (SDF-1) secreted by engineered immortalized mesenchymal stem cells (imMSCs) on the NB. In this study, primary bone marrow mesenchymal stem cells (BM-MSCs) were transfected into immortalized upregulated SDF-1-engineered BM-MSCs (imMSCs/eSDF-1+) or immortalized normal SDF-1-engineered BM-MSCs (imMSCs/eSDF-1−). NB rats induced by bilateral pelvic nerve (PN) transection were treated with imMSCs/eSDF-1+, imMSCs/eSDF-1−, or sham. After a 4-week treatment, the bladder function was assessed by cystometry and voiding pattern analysis. The PN and bladder tissues were evaluated via immunostaining and western blotting analysis. We found that imMSCs/eSDF-1+ expressed higher levels of SDF-1 in vitro and in vivo. The treatment of imMSCs/eSDF-1+ improved NB and evidently stimulated the recovery of bladder wall in NB rats. The recovery of injured nerve was more effective in the NB+imMSCs/eSDF-1+ group than in other groups. High SDF-1 expression improved the levels of vascular endothelial growth factor and basic fibroblast growth factor. Apoptosis was decreased after imMSCs injection, and was detected rarely in the NB+imMSCs/eSDF-1+ group. Injection of imMSCs boosted the expression of neuronal nitric oxide synthase, p-AKT, and p-ERK in the NB+imMSCs/eSDF-1+ group than in other groups. Our findings demonstrated that overexpression of SDF-1 induced additional MSC homing to the injured tissue, which improved the NB by accelerating the restoration of injured nerve in a rat model.

Bladder Problems

2013 ◽  
Author(s):  
J. Eric Ahlskog
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Neurogenic Bladder ◽  
Soft Tissues ◽  
Bladder Wall ◽  
Bladder Function ◽  
System Control ◽  
Autonomic Nervous ◽  
Age Related ◽  
The Central Nervous System

Urinary problems occur with normal aging. In women they often relate to the changes in female anatomy due to the delivering of babies. With superimposed age-related changes in soft tissues, laxity may result in incontinence (loss of urinary control), especially with coughing, laughing, or straining. In men the opposite symptom tends to occur: urinary hesitancy (inability to evacuate the bladder). This is due to constriction of the bladder outlet by an enlarging prostate; the prostate normally surrounds the urethra, through which urine passes. DLB and PDD are often associated with additional bladder problems. Recall that the autonomic nervous system regulates bladder function and that this system tends to malfunction in Lewy disorders. Hence, reduced bladder control is frequent among those with DLB, PDD, and Parkinson’s disease. This condition is termed neurogenic bladder, which implies that the autonomic nervous system control of bladder reflexes is not working properly. This may manifest as urgency with incontinence or hesitancy. Neurogenic bladder problems require different strategies than those used for treating the simple age-related problems that develop in mid-life and beyond. Moreover, there are certain caveats to treatment once a neurogenic bladder is recognized. The bladder is simply a reservoir that holds urine. It is located in the lower pelvis and is distant from the kidneys. The kidneys essentially filter the circulating blood and make the urine. The urine flows down from the kidneys into the bladder, as shown in Figure 14.1. Normally, as the bladder slowly fills with urine, a reflex is triggered when it is nearly full. This results in conscious awareness of the need to urinate, plus it primes the reflexive tendency of the bladder to contract in order to expel the urinary contents. The bladder is able to contract because of muscles in the bladder walls. Normally, nerves activate these muscles at the appropriate time, which forcefully squeeze the bladder, expelling the urine. Nerve sensors in the bladder wall are activated by bladder filling and transmit this information to the central nervous system, ramping up bladder wall muscle activity.

Neurogenic bladder and intermittent catheterization

2010 ◽  
Vol 4 (2) ◽  
pp. 889
Author(s):  
Naiara Barros Polita ◽  
Mitiko Morooka ◽  
Júlia Trevisan Martins ◽  
Maria Clara Giorio Kreling
Keyword(s):  
Leisure Activities ◽  
Bladder Function ◽  
Intermittent Catheterization ◽  
World War ◽  
Urinary Catheters ◽  
Normal Bladder ◽  
Palabras Clave ◽  
The First World War ◽  
Second World ◽  
First World

ABSTRACTObjective: to report the benefits of intermittent catheterization and clean technique. Method: it was performed a literature review on internet in Lilacs, Medline, Pubmed, Science Direct and CAPES theses database. The key-words used were: urinary catheters and urinary catheters/history, and the selected period from 1945 to 2009. Results: the intermittent catheterization is indicated for the conditions that lead to difficulties in voiding, especially for patients with bladder-sphincter dysfunction. It has been used since the First World War, but most used after the Second World War. Intermittent bladder catheterization is similar to normal bladder function, as it allows the cyclic emptying of the bladder, avoiding excessive distension and loss of reservoir characteristics, In addition to lower tract infection rates and prevent upper and lower urinary tract deterioration. The clean technique allows to the patient perform it, offering the return to its professional, cultural and leisure activities. Conclusion: it fits for health professionals, especially the nurse, the guidance and training of patients. Descriptors: urinary catheterization; self care; nurse; nursing; nursing care; deseases; tract urinary.RESUMOObjetivo: relatar os benefícios do cateterismo vesical intermitente e da técnica limpa.  Método: foi realizado um levantamento bibliográfico via internet nas bases de dados Lilacs, Medline, Pubmed, Science Direct e banco de teses da CAPES. As palavras-chave utilizadas foram: cateterismo urinário e cateterismo urinário/história, sendo o período selecionado de 1945 a 2009. Resultados: o cateterismo vesical intermitente é indicado para as patologias que levam a dificuldades no esvaziamento vesical, principalmente para pacientes portadores de disfunção vesico-esfincteriana. Tem sido utilizado desde a primeira Guerra Mundial, porém mais empregado após a segunda Guerra Mundial.  O cateterismo vesical intermitente se assemelha a função vesical normal, já que permite o esvaziamento cíclico da bexiga, evitando a superdistensão e a perda de suas características de reservatório, além de diminuir as taxas de infecção urinária e prevenir a deteriorização do trato urinário superior e inferior. Além disso, a técnica limpa permite que o próprio paciente a execute, proporcionando o retorno às suas atividades profissionais, culturais e de lazer. Conclusão: cabe aos profissionais de saúde, em especial ao enfermeiro, as orientações e o treinamento dos pacientes. Descritores: cateterismo urinário; autocuidado; enfermeiro; enfermagem; assistência de enfermagem; doenças; sistema urinário.RESUMENObjetivo: comunicar los beneficios de la cateterización intermitente y la técnica de limpieza. Método: se realizó una literatura a través de la Internet en la Lilacs, Medline, PubMed, Science Direct y tesis de base de datos de la CAPES. Las palabras clave utilizadas fueron: el uso de sondas y catéteres urinarios / historia, y el período seleccionado desde 1945 hasta 2009. Resultados: la cateterización intermitente es indicado para las condiciones que llevan a dificultades en la micción, especialmente para los pacientes con disfunción del esfínter de la vejiga. Se ha utilizado desde la Primera Guerra Mundial, pero la mayoría de utilizarse después de la Segunda Guerra Mundial. Sondaje vesical intermitente es similar a la función normal de la vejiga, ya que permite la superdistensão cíclica vaciado de la vejiga, y evitar la pérdida de las características del yacimiento, y puede reducir las tasas de infección urinaria y evitar el deterioro del tracto urinario superior e inferior. Por otra parte, la técnica de limpieza permite que el paciente siga, proporcionando un retorno a sus actividades profesionales, culturales y de ocio. Conclusión: es para los profesionales de la salud, especialmente la enfermera, la orientación y la formación de los pacientes. Descriptores: cateterismo urinário; autocuidado; enfermero; enfermería; atención de enfermería;  enfermedades; sistema urinário.  

Effects of PGE2 EP3/EP4 receptors on bladder dysfunction in mice with experimental autoimmune encephalomyelitis

2013 ◽  
Vol 305 (12) ◽  
pp. F1656-F1662 ◽  
Author(s):  
Rui Xue ◽  
Zhankui Jia ◽  
Xiaomu Kong ◽  
Guofu Pi ◽  
Shengli Ma ◽  
...  
Keyword(s):  
Experimental Autoimmune Encephalomyelitis ◽  
Neurogenic Bladder ◽  
Bladder Dysfunction ◽  
Neurological Impairment ◽  
Receptor Expression ◽  
Bladder Function ◽  
Autoimmune Encephalomyelitis ◽  
Established Method ◽  
Ep Receptor ◽  
Experimental Autoimmune

To investigate the expression of four subtypes of PGE2 E-prostanoid (EP) receptors (EP1–EP4) and the effects of EP3/EP4 on bladder dysfunction in a new neurogenic bladder model induced by experimental autoimmune encephalomyelitis (EAE), the mouse model of EAE was induced using a previously established method, and bladder function in mice with different defined levels of neurological impairment was then examined, including micturition frequencies and voiding weight. Bladders were then harvested for analysis of EP receptor expression by Western blot. Activities of agonists/antagonists of EP3 and EP4 receptors as well as PGE2 were also evaluated at different stages of EAE. The results showed that EAE mice developed profound bladder dysfunction characterized by significantly increased micturition and significantly decreased urine output per micturition. EAE-induced upregulation of EP3 and EP4 receptors in the bladder was accompanied by bladder dysfunction. However, EAE had no significant effect on EP1 and EP2 receptors. Moreover, PGE2 and agonists/antagonists of EP3 and EP4 receptors significantly affected bladder dysfunction in EAE mice. Thus, we believe that EAE mice are useful for investigations of the neurogenic bladder. In addition, EP3 and EP4 receptors play a role in EAE-induced bladder dysfunction, providing us with a new target for the treatment of neurogenic bladders.

scholarly journals Sacral Fracture Causing Neurogenic Bladder: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Tatsuro Sasaji ◽  
Noboru Yamada ◽  
Kazuo Iwai
Keyword(s):  
Neurogenic Bladder ◽  
Traffic Accident ◽  
Bladder Dysfunction ◽  
Daily Life ◽  
Fracture Pattern ◽  
Sacral Fracture ◽  
Bladder Function ◽  
Neurogenic Bladder Dysfunction ◽  
Nerve Roots ◽  
One Year

A 76-year-old man presented with a Denis Zone III sacral fracture after a traffic accident. He also developed urinary retention and perineal numbness. The patient was diagnosed with neurogenic bladder dysfunction caused by the sacral fracture. A computed tomogram (CT) revealed that third sacral lamina was fractured and displaced into the spinal canal, but vertebral body did not displace. The fracture lines began at the center of lamina and extended bilateraly. The fracture pattern was unique. The sacrum was osteoporosis, and this fracture may be based on osteoporosis. We performed laminectomy to decompress sacral nerve roots. One month after surgery, the patient was able to urinate. Three months after surgery, his bladder function recovered normally. One year after surgery, he returned to a normal daily life and had no complaints regarding urination. One-year postoperative CT showed the decompressed third sacrum without displacement.

Microvasculature of the Urinary Bladder of the Dog: A Study Using Vascular Corrosion Casting

2007 ◽  
Vol 13 (3) ◽  
pp. 220-227 ◽  
Author(s):  
Fred E. Hossler ◽  
Race L. Kao
Keyword(s):  
Blood Flow ◽  
Urinary Bladder ◽  
Bladder Wall ◽  
Three Dimensional ◽  
Capillary Density ◽  
Normal Function ◽  
Bladder Function ◽  
Corrosion Casting ◽  
Normal Bladder ◽  
And Control

The urinary bladder is an unusual organ in that its normal function includes filling and emptying with alternating changes in internal pressure. Although fluctuations in blood flow to the bladder wall are known to accompany these changes, detailed descriptions of the bladder microvasculature are sparse. The present study uses vascular corrosion casting and scanning electron microscopy to describe the three-dimensional anatomy of the microvasculature of the urinary bladder of the dog. Specialized features of that microvasculature, including collateral circulation, vessel folding, vessel orientation, the presence of valves and sphincters, and mucosal capillary density, that may enhance and control blood flow during normal bladder function, are described and discussed.

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