Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas

AimsConsidering morphological heterogeneity of lung adenocarcinoma (LUAD) and no objective prognostic grading system existing currently, we aim to establish an ‘optimised architecture-based grading system’ (OAGS) to predict prognosis for resected LUAD.MethodsA multicentral study involving three independent cohorts of LUAD was conducted. Predictive ability of the OAGS for recurrence-free probability (RFP) and overall survival (OS) was assessed in training cohort (n=228) by the area under the receiver operating characteristic curve (AUC), Harrell’s concordance index (C-index) and Kaplan-Meier survival analyses, which was validated in testing (n=135) and validation (n=226) cohorts.ResultsThe OAGS consists of: grade 1 for lepidic, papillary or acinar predominant tumour with no or less than 5% of high-grade patterns (cribriform, solid and or micropapillary), grade 2 for lepidic, papillary or acinar predominant tumour with 5% or more of high-grade patterns, and grade 3 for cribriform, solid or micropapillary predominant tumour. In all stages, the OAGS outperformed the pattern-dominant grading system and IASLC grading system for predicting RFP (C-index, 0.649; AUC, 0.742) and OS (C-index, 0.685; AUC, 0.754). Multivariate analysis identified it as an independent predictor of both (RFP, p<0.001; OS, p<0.001). Furthermore, in pT1-2aN0M0 subgroup, the OAGS maintained its ability to predict recurrence (C-index, 0.699; AUC, 0.769) and stratified patients into different risk groups of RFP (p<0.001). These results were confirmed in testing and validation cohorts.ConclusionsThe OAGS is an independent prognostic factor and shows a robust ability to predict prognosis for resected LUAD.

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Invasion is not an independent prognostic factor in high-grade glioma

Journal of Cancer Research and Therapeutics ◽

10.4103/0973-1482.87039 ◽

2011 ◽

Vol 7 (3) ◽

pp. 331 ◽

Cited By ~ 3

Author(s):

Ashwatha Narayana ◽

Saroj Kunnakkat ◽

John Golfinos ◽

Praveen Medabalmi ◽

RN Pat Eagan ◽

...

Keyword(s):

Prognostic Factor ◽

High Grade Glioma ◽

Independent Prognostic Factor ◽

High Grade

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Mutations in TP53 Gene Is Independent Prognostic Factor for High Grade B-Cell Lymphoma

Blood ◽

10.1182/blood.v128.22.5402.5402 ◽

2016 ◽

Vol 128 (22) ◽

pp. 5402-5402

Author(s):

Anna Evgenevna Misyurina ◽

Vsevolod Andreevich Misyurin ◽

Andrey Vitalievich Misyurin ◽

Alla Mikhailovna Kovrigina ◽

Sergey Kirillovich Kravchenko ◽

...

Keyword(s):

Adverse Effect ◽

Prognostic Factor ◽

B Cell ◽

Tp53 Mutation ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Tp53 Gene ◽

Independent Prognostic Factor ◽

High Grade ◽

Tp53 Mutations

Abstract Background. TP53 mutations were described to have a negative impact on prognosis of patients with B-chronic lymphoid leukemia and diffuse large cell lymphoma. However, a role of TP53 mutations in high-grade B-cell lymphomas (HGL) is not well defined in context of other genetic aberrations. Materials and methods. 23 patients (7 males and 16 females) had diagnosis of HGL were treated in National Research Center for hematology, Moscow, Russia. Median age was 49 years old (30-76). 5 patients had HGL with c-MYC (MYC-R) and BCL2 genes rearrangements and 2 - HGB with MYC-R and BCL6 rearrangements. 17 (74%) patients had MYC-R, 11/23 (48%) had double expresser lymphoma (MYC≥40%, BCL2≥50%) (DE). Median of observation time was 29,1 months (6,3-99,8). 19 (82%) of patients had IPI score 3-5 points. 16 patients underwent LM-B-04 with rituximab (Table 1), 5 - R-(DA)-EPOCH, 2 - R-CHOP-21. In 5 cases autologous stem cell transplantation was performed. Sanger sequencing was performed to identify mutations in exons 5-8 of TP53 gene using DNA extracted from formalin fixed paraffin embedded tissue («Extra-DNA» kit, «Genetechnology» LLC). Primers to TP53 gene were synthesized based on nucleotide sequences data available online on website ncbi.com by «Evrogene». To evaluate an influence of such factors as TP53 mutation (TP53mut), MYC-R, DHL, DE, gender, therapy on overall survival (OS) and time to progression (TTP) were performed multivariate dispersion analysis and Cox regression analysis (STATISTICA 10). Results: 8 (35%) cases with TP53mut were identified: c.535C>T 45,6% p.H179Y, c.524G>C 15,6% p.R175P, c.743G>A 75,6% p.R247Q, c.487T>A 25,2% p.Y163N, c.824G>A 75% p.C275Y, c.713G>A 87,7% p.C238Y, c.745A>G 31,9% p.R249G, c.639A>G 41,8% p.R213R. 7/8 of them harbored MYC-R, 2/8 had DHL. In univariate (Picture 1, 2) and multivariate analysis pts harboring TP53mut had worse OS (median OS was 6,2 (0,7-9,5) vs 25,5 (0,7-99,8) months, p=0,004) and shorter TTP (median TTP 3,5 (0,7-9,5) vs 23,1 (0,7-99,8) months, p=0,027) than patients without TP53mut. DHL status had also an adverse effect on OS with lower significance than in pts with TP53mut (p=0,022). Adverse effect of TP53mut trends to play a role in combination with c-MYC gene rearrangement, thus5 pts TP53mut/MYC-R had shorter TTP than 5 DHL pts (3,4 (1,1-9,5) vs 7,3 (0,6-67,1) months, p=0,07). Conclusion: High-grade lymphoma has a more powerful and independent prognostic factor than double-hit status - TP53 mutation that contribute inferior prognosis. This factor shouldn't be underestimated in routine diagnostics because of its frequency and requirement of a different therapeutic approach. Disclosures No relevant conflicts of interest to declare.

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Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma

International Orthopaedics ◽

10.1007/s00264-011-1208-8 ◽

2011 ◽

Vol 35 (10) ◽

pp. 1529-1536 ◽

Cited By ~ 27

Author(s):

Philipp T. Funovics ◽

Gundula Edelhauser ◽

Martin A. Funovics ◽

Christoph Laux ◽

Dominik Berzaczy ◽

...

Keyword(s):

Prognostic Factor ◽

Independent Prognostic Factor ◽

High Grade ◽

C Reactive Protein ◽

Reactive Protein ◽

High Grade Osteosarcoma

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IMP3 expression in lesions of the biliary tract: a marker for high-grade dysplasia and an independent prognostic factor in bile duct carcinomas

Human Pathology ◽

10.1016/j.humpath.2009.01.024 ◽

2009 ◽

Vol 40 (10) ◽

pp. 1377-1383 ◽

Cited By ~ 44

Author(s):

Marc-Oliver Riener ◽

Florian R. Fritzsche ◽

Pierre-Alain Clavien ◽

Bernhard C. Pestalozzi ◽

Nicole Probst-Hensch ◽

...

Keyword(s):

Bile Duct ◽

Prognostic Factor ◽

Biliary Tract ◽

Independent Prognostic Factor ◽

High Grade Dysplasia ◽

High Grade

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The Prognostic Value of the Prognostic Nutritional Index in Operable High-Grade Glioma Patients and the Establishment of a Nomogram

Frontiers in Oncology ◽

10.3389/fonc.2021.724769 ◽

2022 ◽

Vol 11 ◽

Author(s):

Qian He ◽

Wei Zhao ◽

Qinglan Ren

Keyword(s):

Regression Analysis ◽

Prognostic Factor ◽

Prognostic Value ◽

Cox Regression ◽

High Grade Glioma ◽

Independent Prognostic Factor ◽

High Grade ◽

Cox Regression Analysis ◽

Kaplan Meier ◽

Grade Iii

BackgroundStudies confirmed the predictive value of the prognostic nutrition index (PNI) in many malignant tumors. However, it did not reach a consensus in glioma. Therefore, this study investigated the prognostic value of preoperative PNI in operable high-grade glioma and established a nomogram.MethodsClinical data of high-grade glioma patients were retrospectively analyzed. The primary endpoint was overall survival (OS). Survival analysis was conducted by the Kaplan–Meier method, log-rank test, and Cox regression analysis. A nomogram was established. The prediction effect of the nomogram covering PNI was verified by area under the curve (AUC).ResultsA total of 91 operable high-grade glioma patients were included. Kaplan–Meier analysis showed that among grade IV gliomas (n = 55), patients with higher PNI (>44) showed a trend of OS benefit (p = 0.138). In grade III glioma (n = 36), patients with higher PNI (>47) had longer OS (p = 0.023). However, the intersecting Kaplan–Meier curve suggested that there may be some confounding factors. Cox regression analysis showed that higher PNI was an independent prognostic factor for grade IV glioma (HR = 0.388, p = 0.040). In grade III glioma, there was no statistically relationship between PNI levels and prognosis. When evaluating the prognostic ability of PNI alone by ROC, the AUC in grade III and IV gliomas was low, indicating that PNI alone had poor predictive power for OS. Interestingly, we found that the nomogram including preoperative PNI, age, extent of resection, number of gliomas, and MGMT methylation status could predict the prognosis of patients with grade IV glioma well.ConclusionThe PNI level before surgery was an independent prognostic factor for patients with grade IV glioma. The nomogram covering PNI in patients with grade IV glioma also proved the value of PNI. However, the value of PNI in grade III glioma needs to be further evaluated. More prospective studies are needed to verify this conclusion.

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