scholarly journals Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer

2004 ◽  
Vol 11 (8) ◽  
pp. 555-569 ◽  
Author(s):  
Patricia C Ryan ◽  
John L Jakubczak ◽  
David A Stewart ◽  
Lynda K Hawkins ◽  
Cheng Cheng ◽  
...  
Keyword(s):  
Intravenous Injection ◽  
Human Cancer ◽  
Oncolytic Adenovirus ◽  
Antitumor Efficacy ◽  
Single Intravenous Injection ◽  
Tumor Selective

scholarly journals Enhanced antitumor efficacy of telomerase-specific oncolytic adenovirus with valproic acid against human cancer cells

2012 ◽  
Vol 19 (11) ◽  
pp. 767-772 ◽  
Author(s):  
Y Watanabe ◽  
Y Hashimoto ◽  
S Kagawa ◽  
H Kawamura ◽  
K Nagai ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Cancer Cells ◽  
Human Cancer ◽  
Oncolytic Adenovirus ◽  
Antitumor Efficacy ◽  
Human Cancer Cells

The oncolytic adenovirus Ad-iREP-2 utilizes p53-dependent rna interference for tumor-selective replication

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
E Gürlevik ◽  
P Schache ◽  
L Zender ◽  
MP Manns ◽  
S Kubicka ◽  
...  
Keyword(s):  
Rna Interference ◽  
Oncolytic Adenovirus ◽  
Tumor Selective

RATE OF DISAPPEARANCE OF GROWTH HORMONE FROM THE PLASMA OF RATS AFTER A SINGLE INTRAVENOUS INJECTION

1955 ◽  
Vol 19 (2) ◽  
pp. 181-184 ◽  
Author(s):  
Carl A. Gemzell ◽  
Frank Heijkenskjöld ◽  
Lars Ström
Keyword(s):  
Growth Hormone ◽  
Intravenous Injection ◽  
Single Intravenous Injection

The Distribution of [14C]Cholesterol in Muscle and Skin of Rhesus Monkeys after Intravenous Injection

1976 ◽  
Vol 50 (4) ◽  
pp. 307-310
Author(s):  
C. D. Moutafis ◽  
N. B. Myant
Keyword(s):  
Intravenous Injection ◽  
Rhesus Monkeys ◽  
Plasma Cholesterol ◽  
Specific Radioactivity ◽  
Compartment System ◽  
Local Synthesis ◽  
Single Intravenous Injection ◽  
Small Pool ◽  
Slow Turnover

1. The specific radioactivity of [14C]cholesterol in plasma and in serial biopsies of muscle and skin was measured in Rhesus monkeys for 156 days after a single intravenous injection of [14C]cholesterol. 2. Analysis of the specific radioactivity—time curves in terms of a two-compartment system indicated that all the cholesterol of muscle is exchangeable with the plasma cholesterol and that local synthesis does not contribute significantly to the cholesterol in muscle. 3. Analysis of the curve for specific radioactivity of skin cholesterol suggested the presence of a small pool of cholesterol with slow turnover. A contribution to skin cholesterol from local synthesis could not be excluded.

Pharmacokinetics and Tissue Residues of Sulfathiazole and Sulfamethazine in Pigs

1994 ◽  
Vol 57 (9) ◽  
pp. 796-801 ◽  
Author(s):  
LIEVE S. G. VAN POUCKE ◽  
CARLOS H. VAN PETEGHEM
Keyword(s):  
Intravenous Injection ◽  
Half Life ◽  
Intramuscular Injection ◽  
Compartment Model ◽  
Absolute Bioavailability ◽  
Pharmacokinetic Parameters ◽  
Tissue Concentrations ◽  
Single Intravenous Injection ◽  
The Individual ◽  
Residue Study

The plasma pharmacokinetics and tissue penetration of sulfathiazole (ST) and sulfamethazine (SM) after intravenous and intramuscular injection in pigs were studied. Following a single intravenous dose of 40 mg ST/kg of bodyweight or 80 mg SM/kg of bodyweight, the plasma ST and SM concentrations were best fitted to a two-compartment model. The areas under the curve were 447 ± 39 and 1485 ± 41 mg/h/L, clearances were 0.090 ± 0.007 and 0.054 ± 0.001 L/kg/h, volumes of distribution were 1.16 ± 0.16 and 0.77 ± 0.06 L/kg, half-lifes in distribution phase were l.18 ± 0.57 and 0.23 ± 0.16 h and half-lifes in eliminations phase were 9.0 ± l.6 and 9.8 ± 0.6 h. When the two compounds were administered simultaneously as a single intravenous injection, the pharmacokinetic parameters for ST were not significantly different. The values for SM show statistical differences for some important parameters: α, β and the AUC0–>∞ were significantly decreased and t1/2α, Vd and CIB were significantly increased. It can be concluded that after a single intravenous injection of 40 mg/kg, sulfathiazole has a high tl/2β resulting in higher tissue concentrations. This half-life, which is higher than what is reported in the literature, is not influenced by the simultaneous presence of sulfamethazine. The tl/2β for sulfamethazine after a single intravenous injection of 80 mg/kg is comparable to the data from the literature and is not influenced by the presence of sulfathiazole. Sulfathiazole and SM were also administered simultaneously as an intramuscular injection to healthy pigs at a dosage of 40 and 80 mg/kg bodyweight. Pharmacokinetic experiments were conducted on three pigs. From this pharmacokinetic study it can be concluded that upon a single intramuscular administration of 40 mg/kg of ST and 80 mg/kg of SM the absolute bioavailability in pigs is 0.92 ± 0.04 for ST and l.01 ± 0.07 for SM. Six pigs received five intramuscular im) injections as a single dose of ST and SM every 24 h for five consecutive days for the residue study. The pigs were slaughtered at different times after the last dose was given and samples were taken from various tissues and organs. Concentrations were determined by a microbiological method and a HPTLC method. No edible tissue contained more than 100 μg/kg of the individual sulfonamides after 10 days of withdrawal. It means that adult animals which have a shorter half-life and thus lower tissue concentrations will certainly meet the economic community EC) maximum residue limits after a 10 days withdrawal period.

scholarly journals Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of theMDR1promoter activity

Oncotarget ◽  
2015 ◽  
Vol 6 (35) ◽  
pp. 38308-38326 ◽  
Author(s):  
Bing-Hua Su ◽  
Gia-Shing Shieh ◽  
Yau-Lin Tseng ◽  
Ai-Li Shiau ◽  
Chao-Liang Wu
Keyword(s):  
Oncolytic Adenovirus ◽  
Antitumor Efficacy

scholarly journals Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection

Cell Cycle ◽  
2011 ◽  
Vol 10 (16) ◽  
pp. 2737-2741 ◽  
Author(s):  
Hiroyuki Kishimoto ◽  
Ryoichi Aki ◽  
Yasuo Urata ◽  
Michael Bouvet ◽  
Masashi Momiyama ◽  
...  
Keyword(s):  
Human Cancer ◽  
Genetic Labeling ◽  
Tumor Selective ◽  
Live Mouse

scholarly journals The antitumor efficacy of IL-24 mediated by E1A and E1B triple regulated oncolytic adenovirus

2010 ◽  
Vol 10 (3) ◽  
pp. 242-250 ◽  
Author(s):  
Lian Li Xiao ◽  
Yu Mei Wu ◽  
Jing Qian ◽  
Yuan Tan ◽  
Guo Liang Xie ◽  
...  
Keyword(s):  
Oncolytic Adenovirus ◽  
Antitumor Efficacy
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