Stabilization of hypoxia-inducible factor 1α in neural stem cells with prolyl hydroxylase inhibition induces delayed tolerance against focal cerebral ischemia

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S498-S498
Author(s):  
Kon Chu ◽  
Soon-Tae Lee ◽  
Keun-Hwa Jung ◽  
Seung U Kim ◽  
Manho Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cerebral Ischemia ◽  
Neural Stem Cells ◽  
Focal Cerebral Ischemia ◽  
Hypoxia Inducible Factor ◽  
Prolyl Hydroxylase ◽  
Hypoxia Inducible Factor 1Α

scholarly journals Long-Term Effects of Magnetically Targeted Ferumoxide-Labeled Human Neural Stem Cells in Focal Cerebral Ischemia

2015 ◽  
Vol 24 (2) ◽  
pp. 183-190 ◽  
Author(s):  
Miyeoun Song ◽  
Young-Ju Kim ◽  
Yoon-Ha Kim ◽  
Jina Roh ◽  
Eun-Cheol Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cerebral Ischemia ◽  
Neural Stem Cells ◽  
Focal Cerebral Ischemia ◽  
Long Term Effects ◽  
Human Neural Stem Cells

Using a Neodymium Magnet to Target Delivery of Ferumoxide-Labeled Human Neural Stem Cells in a Rat Model of Focal Cerebral Ischemia

2010 ◽  
Vol 21 (5) ◽  
pp. 603-610 ◽  
Author(s):  
Miyeoun Song ◽  
Young-Ju Kim ◽  
Yoon-ha Kim ◽  
Jina Roh ◽  
Seung U. Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cerebral Ischemia ◽  
Neural Stem Cells ◽  
Rat Model ◽  
Focal Cerebral Ischemia ◽  
Target Delivery ◽  
Human Neural Stem Cells ◽  
Neodymium Magnet

Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1α and erythropoietin in rats

2008 ◽  
Vol 104 (4) ◽  
pp. 1185-1191 ◽  
Author(s):  
Guo-Jun Gu ◽  
Yun-Ping Li ◽  
Zao-Yun Peng ◽  
Jia-Jun Xu ◽  
Zhi-Min Kang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Hyperbaric Oxygen ◽  
Target Gene ◽  
Molecular Mechanisms ◽  
Focal Cerebral Ischemia ◽  
Hypoxia Inducible Factor ◽  
Sprague Dawley ◽  
Triphenyltetrazolium Chloride ◽  
Time Points ◽  
Hypoxia Inducible Factor 1Α

We studied the effect of hyperbaric oxygen (HBO) preconditioning on the molecular mechanisms of neuroprotection in a rat focal cerebral ischemic model. Seventy-two male Sprague-Dawley rats were pretreated with HBO (100% O2, 2 atmospheres absolute, 1 h once every other day for 5 sessions) or with room air. In experiment 1, HBO-preconditioned rats and matched room air controls were subjected to focal cerebral ischemia or sham surgery. Postinjury motor parameters and infarction volumes of HBO-preconditioned rats were compared with those of controls. In experiment 2, HBO-preconditioned rats and matched room air controls were killed at different time points. Brain levels of hypoxia-inducible factor-1α (HIF-1α) and its downstream target gene erythropoietin (EPO) analyzed by Western blotting and RT-PCR as well as HIF-1α DNA-binding and transcriptional activities were determined in the ipsilateral hemisphere. HBO induced a marked increase in the protein expressions of HIF-1α and EPO and the activity of HIF-1α, as well as the expression of EPO mRNA. HBO preconditioning dramatically improved the neurobehavioral outcome at all time points (3.0 ± 2.1 vs. 5.6 ± 1.5 at 4 h, 5.0 ± 1.8 vs. 8.8 ± 1.4 at 8 h, 6.4 ± 1.8 vs. 9.7 ± 1.3 at 24 h; P < 0.01, respectively) and reduced infarction volumes (20.7 ± 4.5 vs. 12.5 ± 3.6%, 2,3,5-Triphenyltetrazolium chloride staining) after cerebral ischemia. This observation indicates that the neuroprotection induced by HBO preconditioning may be mediated by an upregulation of HIF-1α and its target gene EPO.

Folic acid stimulates proliferation of transplanted neural stem cells after focal cerebral ischemia in rats

2013 ◽  
Vol 24 (11) ◽  
pp. 1817-1822 ◽  
Author(s):  
Huan Liu ◽  
Jiasong Cao ◽  
Haihong Zhang ◽  
Shanchun Qin ◽  
Min Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Folic Acid ◽  
Cerebral Ischemia ◽  
Neural Stem Cells ◽  
Focal Cerebral Ischemia
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