Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer

Numerous cells with very large and irregular nuclei (“monster” cells) have not hitherto been reported in desmoplastic melanoma (DM). Their prognostic significance in melanomas is a matter of debate, although some authors have associated them with more aggressive tumor behavior. We report a mixed DM on the scalp of an 88-year-old woman imitating an atypical fibroxanthoma. Tumor cells stained positive for SOX10, S100, and cyclin D1; BRAF mutation status was negative, and fluorescence in situ hybridization analysis showed copy number gains in 11q13 (cyclin D1) and 6p25 (RREB1), and loss in 6q23 (MYB). Cyclin D1 amplification is associated with poor prognosis in melanoma.

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Malignant peritoneal mesothelioma

KYAMC Journal ◽

10.3329/kyamcj.v8i2.35704 ◽

2018 ◽

Vol 8 (2) ◽

pp. 40-42

Author(s):

Sayeed Bin Sharif

Keyword(s):

Early Diagnosis ◽

Rare Disease ◽

Incidence Rate ◽

Malignant Mesothelioma ◽

Poor Prognosis ◽

Standard Treatment ◽

Peritoneal Mesothelioma ◽

Malignant Peritoneal Mesothelioma ◽

Aggressive Tumor ◽

Reported Data

Malignant mesothelioma is one of the rare disease. It is an aggressive tumor arising from the mesothelial lining of the pleura or peritoneum. In our country there is no reported data or known incidence rate. It has an association with exposure to asbestos and usually has a poor prognosis. Early diagnosis and establishment of a standard treatment for malignant peritoneal mesothelioma is difficult. We report on a case of malignant peritoneal mesothelioma in a 59-year-old man with huge abdominal swelling, ascites and respiratory distress.KYAMC Journal Vol. 8, No.-2, Jan 2018, Page 40-42

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Merkel Cell Carcinoma of the Genitourinary Tract

Archives of Pathology & Laboratory Medicine ◽

10.5858/2010-0072-rsr2 ◽

2011 ◽

Vol 135 (8) ◽

pp. 1067-1071 ◽

Cited By ~ 4

Author(s):

Manju Aron ◽

Ming Zhou

Keyword(s):

Cell Carcinoma ◽

Merkel Cell Carcinoma ◽

Causative Agent ◽

Targeted Therapies ◽

Poor Prognosis ◽

Accurate Diagnosis ◽

Genitourinary Tract ◽

Merkel Cell ◽

Urothelial Carcinomas ◽

Aggressive Tumor

Merkel cell carcinomas are rare cutaneous neoplasms that are known to metastasize to various mucosal sites, including the genitourinary tract. Primary Merkel cell carcinomas of the genitourinary tract are extremely rare and may be mistaken for other more common carcinomas of the genitourinary tract, including urothelial carcinomas and prostatic carcinomas. However, primary Merkel cell carcinoma of the genitourinary tract is a very aggressive tumor with poor prognosis. Accurate diagnosis is crucial for appropriate clinical treatment. The discovery of the Merkel cell polyomavirus as a possible causative agent adds a new dimension in the understanding of the pathogenesis and diagnosis, and possible targeted therapies for this tumor.

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A case of Stage I exophytic tongue cancer with early poor prognosis

Journal of Japanese Society of Oral Oncology ◽

10.5843/jsot.25.199 ◽

2013 ◽

Vol 25 (4) ◽

pp. 199-205

Author(s):

Toru Inomata ◽

Kayo Nakau ◽

Syuhei Okamoto ◽

Hisashi Okamura ◽

Hirohumi Shoji ◽

...

Keyword(s):

Poor Prognosis ◽

Tongue Cancer ◽

Stage I

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Sinonasal Teratocarcinosarcoma with Intracranial Extension: A Case Report with Discussion of Imaging and Histopathologic Correlates

Neurographics ◽

10.3174/ng.1900008 ◽

2019 ◽

Vol 9 (6) ◽

pp. 405-408

Author(s):

A. Rizvi ◽

H. Mehta ◽

S. Bobra ◽

G. M. Kleinman ◽

D. N. Jourdy ◽

...

Keyword(s):

Poor Prognosis ◽

Case Reports ◽

Malignant Neoplasm ◽

Undifferentiated Carcinoma ◽

Chemoradiation Therapy ◽

Intracranial Extension ◽

Imaging Features ◽

Lymphoma Treatment ◽

Sinonasal Teratocarcinosarcoma ◽

Aggressive Tumor

Sinonasal teratocarcinosarcoma is a rare, malignant neoplasm of the head and neck, and a locally aggressive tumor with a poor prognosis. Few case reports have been published. We present a case of recurrent sinonasal teratocarcinosarcoma in a 39-year-old man with extension into the intracranial compartment. Here we discuss the histopathologic characteristics and nonspecific imaging features, with key differential considerations, including squamous cell carcinoma, adenocarcinoma, sinonasal undifferentiated carcinoma, esthesioneuroblastoma, and lymphoma. Treatment is ultimately composed of surgical resection and chemoradiation therapy.

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Silencing of TRPM8 inhibits aggressive tumor phenotypes and enhances gemcitabine sensitivity in pancreatic cancer

Pancreatology ◽

10.1016/j.pan.2018.08.011 ◽

2018 ◽

Vol 18 (8) ◽

pp. 935-944 ◽

Cited By ~ 7

Author(s):

JieFeng Liu ◽

GuoHuang Hu ◽

YuJing Gong ◽

QianLe Yu ◽

Bin He ◽

...

Keyword(s):

Pancreatic Cancer ◽

Aggressive Tumor ◽

Tumor Phenotypes

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CCR4 Expression Is Associated With Poor Prognosis in Patients With Early Stage (pN0) Oral Tongue Cancer

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2018.09.035 ◽

2019 ◽

Vol 77 (2) ◽

pp. 426-432

Author(s):

Lei Wang ◽

Mei Zhang ◽

Yuntao Zhu ◽

Xin Zhang ◽

Yongmei Yang ◽

...

Keyword(s):

Poor Prognosis ◽

Tongue Cancer ◽

Early Stage ◽

Oral Tongue ◽

Oral Tongue Cancer

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The Role of Cysteine Cathepsins in Cancer Progression and Drug Resistance

International Journal of Molecular Sciences ◽

10.3390/ijms20143602 ◽

2019 ◽

Vol 20 (14) ◽

pp. 3602 ◽

Cited By ~ 15

Author(s):

Magdalena Rudzińska ◽

Alessandro Parodi ◽

Surinder M. Soond ◽

Andrey Z. Vinarov ◽

Dmitry O. Korolev ◽

...

Keyword(s):

Drug Resistance ◽

Cancer Progression ◽

Cancer Biology ◽

Lysosomal Enzymes ◽

Tumor Biology ◽

Therapeutic Strategies ◽

Cysteine Cathepsins ◽

Aggressive Tumor ◽

Tumor Phenotypes

Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.

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