Alternating droplet generation and controlled dynamic droplet fusion in microfluidic device for CdS nanoparticle synthesis

Lab on a Chip ◽  
2006 ◽  
Vol 6 (2) ◽  
pp. 174 ◽  
Author(s):  
Lung-Hsin Hung ◽  
Kyung M. Choi ◽  
Wei-Yu Tseng ◽  
Yung-Chieh Tan ◽  
Kenneth J. Shea ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Nanoparticle Synthesis ◽  
Droplet Generation ◽  
Cds Nanoparticle

scholarly journals Negative Pressure Provides Simple and Stable Droplet Generation in a Flow-Focusing Microfluidic Device

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 662
Author(s):  
Nikita A. Filatov ◽  
Anatoly A. Evstrapov ◽  
Anton S. Bukatin
Keyword(s):  
Microfluidic Device ◽  
Negative Pressure ◽  
Low Cost ◽  
Control Valve ◽  
Droplet Microfluidics ◽  
Droplet Generation ◽  
Electric Signal ◽  
Absolute Pressure ◽  
Flow Focusing ◽  
Wide Range

Droplet microfluidics is an extremely useful and powerful tool for industrial, environmental, and biotechnological applications, due to advantages such as the small volume of reagents required, ultrahigh-throughput, precise control, and independent manipulations of each droplet. For the generation of monodisperse water-in-oil droplets, usually T-junction and flow-focusing microfluidic devices connected to syringe pumps or pressure controllers are used. Here, we investigated droplet-generation regimes in a flow-focusing microfluidic device induced by the negative pressure in the outlet reservoir, generated by a low-cost mini diaphragm vacuum pump. During the study, we compared two ways of adjusting the negative pressure using a compact electro-pneumatic regulator and a manual airflow control valve. The results showed that both types of regulators are suitable for the stable generation of monodisperse droplets for at least 4 h, with variations in diameter less than 1 µm. Droplet diameters at high levels of negative pressure were mainly determined by the hydrodynamic resistances of the inlet microchannels, although the absolute pressure value defined the generation frequency; however, the electro-pneumatic regulator is preferable and convenient for the accurate control of the pressure by an external electric signal, providing more stable pressure, and a wide range of droplet diameters and generation frequencies. The method of droplet generation suggested here is a simple, stable, reliable, and portable way of high-throughput production of relatively large volumes of monodisperse emulsions for biomedical applications.

Encapsulation of single cells on a microfluidic device integrating droplet generation with fluorescence-activated droplet sorting

2013 ◽  
Vol 15 (3) ◽  
pp. 553-560 ◽  
Author(s):  
Liang Wu ◽  
Pu Chen ◽  
Yingsong Dong ◽  
Xiaojun Feng ◽  
Bi-Feng Liu
Keyword(s):  
Microfluidic Device ◽  
Single Cells ◽  
Droplet Generation ◽  
Droplet Sorting

scholarly journals Droplet Generation in a Flow-Focusing Microfluidic Device with External Mechanical Vibration

Micromachines ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 743
Author(s):  
Zhaoqin Yin ◽  
Zemin Huang ◽  
Xiaohui Lin ◽  
Xiaoyan Gao ◽  
Fubing Bao
Keyword(s):  
Microfluidic Device ◽  
Vibration Frequency ◽  
Linear Correlation ◽  
Vibration Amplitude ◽  
Mechanical Vibration ◽  
Droplet Generation ◽  
Flow Focusing ◽  
Generation Frequency ◽  
External Vibration ◽  
Shrinkage Process

The demand for highly controllable droplet generation methods is very urgent in the medical, materials, and food industries. The droplet generation in a flow-focusing microfluidic device with external mechanical vibration, as a controllable droplet generation method, is experimentally studied. The effects of vibration frequency and acceleration amplitude on the droplet generation are characterized. The linear correlation between the droplet generation frequency and the external vibration frequency and the critical vibration amplitude corresponding to the imposing vibration frequency are observed. The droplet generation frequency with external mechanical vibration is affected by the natural generation frequency, vibration frequency, and vibration amplitude. The droplet generation frequency in a certain microfluidic device with external vibration is able to vary from the natural generation frequency to the imposed vibration frequency at different vibration conditions. The evolution of dispersed phase thread with vibration is remarkably different with the process without vibration. Distinct stages of expansion, shrinkage, and collapse are observed in the droplet formation with vibration, and the occurrence number of expansion–shrinkage process is relevant with the linear correlation coefficient.

scholarly journals Microfluidic on-demand droplet generation, storage, retrieval, and merging for single-cell pairing

Lab on a Chip ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 493-502 ◽  
Author(s):  
Hesam Babahosseini ◽  
Tom Misteli ◽  
Don L. DeVoe
Keyword(s):  
Single Cell ◽  
Aqueous Phase ◽  
Microfluidic Device ◽  
Droplet Generation ◽  
Microfluidic Platform ◽  
On Demand

A multifunctional microfluidic platform combining on-demand aqueous-phase droplet generation, multi-droplet storage, and controlled merging of droplets selected from a storage library in a single integrated microfluidic device is described.

scholarly journals On demand nanoliter-scale microfluidic droplet generation, injection, and mixing using a passive microfluidic device

2015 ◽  
Vol 9 (1) ◽  
pp. 014119 ◽  
Author(s):  
Uwe Tangen ◽  
Abhishek Sharma ◽  
Patrick Wagler ◽  
John S. McCaskill
Keyword(s):  
Microfluidic Device ◽  
Droplet Generation ◽  
On Demand

scholarly journals Selective cell encapsulation, lysis, pico-injection and size-controlled droplet generation using traveling surface acoustic waves in a microfluidic device

Lab on a Chip ◽  
2020 ◽  
Vol 20 (21) ◽  
pp. 3914-3921
Author(s):  
Kirk Mutafopulos ◽  
Peter J. Lu ◽  
Ryan Garry ◽  
Pascal Spink ◽  
David A. Weitz
Keyword(s):  
Microfluidic Device ◽  
Acoustic Waves ◽  
Single Cells ◽  
Surface Acoustic Waves ◽  
Cell Encapsulation ◽  
Droplet Generation ◽  
New Materials ◽  
On Demand ◽  
Interdigital Transducer ◽  
Size Controlled

We generate traveling surface acoustic waves with an interdigital transducer to create droplets on-demand; encapsulate single cells; lyse cells and immediately encapsulate their contents; and pico-inject new materials into existing droplets.

A microfluidic device fully integrated with three pH sensing electrodes and passive mixer for nanoparticle synthesis

2015 ◽  
Author(s):  
Ryohei Komiyama ◽  
Hidetoshi Miyashita ◽  
Tomoaki Kageyama ◽  
Koutoku Ohmi ◽  
Sang-Seok Lee ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Nanoparticle Synthesis ◽  
Ph Sensing ◽  
Passive Mixer ◽  
Fully Integrated

scholarly journals A hand-held, power-free microfluidic device for monodisperse droplet generation

MethodsX ◽  
2018 ◽  
Vol 5 ◽  
pp. 984-990 ◽  
Author(s):  
I-Jane Chen ◽  
Tao Wu ◽  
Shuhuan Hu
Keyword(s):  
Microfluidic Device ◽  
Droplet Generation ◽  
Monodisperse Droplet
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