Effect of Wave Instabilities in Thermal and Solutal Mixing of Double-Diffusive Opposed Jets Impinging in a Passive-Mixer

2-D numerical experiments are performed to investigate the flow instabilities and mixing of different non-isothermal counterflowing jets in a Passive-Mixer. The fluid is modelled as a binary mixture with thermal and solutal buoyancy effects considered through the Boussinesq approximation. The streams are arranged in a thermal and solutal buoyancy aiding configuration. Computations are carried out for three different ratios of the upper jet bulk velocity to the lower jet bulk velocity (VR), namely, VR = 0.5, 1.0 and 2. Within the parametric domain of RiT and RiC defined by region (RiT + RiC) = 3, the instability causing transition from steady to unsteady flow regime is observed for VR = 1 and 2 while no transition is found to occur at VR = 0.5. Using Landau theory, it is established that the transition from steady to unsteady flow regime is a supercritical Hopf bifurcation. A complete regime map identifying the steady and unsteady flow regimes, within the parametric space of the present study, is obtained by plotting the neutral curves of RiC and RiT (obtained using Landau theory) for different values of VR. POD analysis of the unsteady flows at VR = 1, establishes the presence of standing waves. However, for VR = 2, the presence of degenerate pairs in the POD eigenspectrum ascertains the presence of travelling waves in the unsteady flows. The standing wave unsteady flow mode is found to yield the highest rate of mixing.

Microfluidics for Multiphase Mixing and Liposomal Encapsulation of Nanobioconjugates: Passive vs. Acoustic Systems

One of the main routes to ensure that biomolecules or bioactive agents remain active as they are incorporated into products with applications in different industries is by their encapsulation. Liposomes are attractive platforms for encapsulation due to their ease of synthesis and manipulation and the potential to fuse with cell membranes when they are intended for drug delivery applications. We propose encapsulating our recently developed cell-penetrating nanobioconjugates based on magnetite interfaced with translocating proteins and peptides with the purpose of potentiating their cell internalization capabilities even further. To prepare the encapsulates (also known as magnetoliposomes (MLPs)), we introduced a low-cost microfluidic device equipped with a serpentine microchannel to favor the interaction between the liposomes and the nanobioconjugates. The encapsulation performance of the device, operated either passively or in the presence of ultrasound, was evaluated both in silico and experimentally. The in silico analysis was implemented through multiphysics simulations with the software COMSOL Multiphysics 5.5® (COMSOL Inc., Stockholm, Sweden) via both a Eulerian model and a transport of diluted species model. The encapsulation efficiency was determined experimentally, aided by spectrofluorimetry. Encapsulation efficiencies obtained experimentally and in silico approached 80% for the highest flow rate ratios (FRRs). Compared with the passive mixer, the in silico results of the device under acoustic waves led to higher discrepancies with respect to those obtained experimentally. This was attributed to the complexity of the process in such a situation. The obtained MLPs demonstrated successful encapsulation of the nanobioconjugates by both methods with a 36% reduction in size for the ones obtained in the presence of ultrasound. These findings suggest that the proposed serpentine micromixers are well suited to produce MLPs very efficiently and with homogeneous key physichochemical properties.

A CMOS RF Receiver with Improved Resilience to OFDM-Induced Second-Order Intermodulation Distortion for MedRadio Biomedical Devices and Sensors

A MedRadio RF receiver integrated circuit for implanted and wearable biomedical devices must be resilient to the out-of-band (OOB) orthogonal frequency division modulation (OFDM) blocker. As the OFDM is widely adopted for various broadcasting and communication systems in the ultra-high frequency (UHF) band, the selectivity performance of the MedRadio RF receiver can severely deteriorate by the second-order intermodulation (IM2) distortion induced by the OOB OFDM blocker. An analytical investigation shows how the OFDM-induced IM2 distortion power can be translated to an equivalent two-tone-induced IM2 distortion power. It makes the OFDM-induced IM2 analysis and characterization process for a MedRadio RF receiver much simpler and more straightforward. A MedRadio RF receiver integrated circuit with a significantly improved resilience to the OOB IM2 distortion is designed in 65 nm complementary metal-oxide-semiconductor (CMOS). The designed RF receiver is based on low-IF architecture, comprising a low-noise amplifier, single-to-differential transconductance stage, quadrature passive mixer, trans-impedance amplifier (TIA), image-rejecting complex bandpass filter, and fractional phase-locked loop synthesizer. We describe design techniques for the IM2 calibration through the gate bias tuning at the mixer, and the dc offset calibration that overcomes the conflict with the preceding IM2 calibration through the body bias tuning at the TIA. Measured results show that the OOB carrier-to-interference ratio (CIR) performance is significantly improved by 4–11 dB through the proposed IM2 calibration. The measured maximum tolerable CIR is found to be between −40.2 and −71.2 dBc for the two-tone blocker condition and between −70 and −77 dBc for the single-tone blocker condition. The analytical and experimental results of this work will be essential to improve the selectivity performance of a MedRadio RF receiver against the OOB OFDM-blocker-induced IM2 distortion and, thus, improve the robustness of the biomedical devices in harsh wireless environments in the MedRadio and UHF bands.

Origins and minimization of intermodulation distortion in a pseudo-differential CMOS beamforming receiver

This paper studies how nonlinear distortion is generated in the combination of an inverter-based low-noise amplifier and a passive mixer. The dominant nonlinearity appears to be the quadratic $$V_{gs}V_{ds}$$ V gs V ds mixing term in the passive mixer that first causes low-frequency IM2 and then upconverts it to IM3. Adding a common-mode feedback (CMFB) cancels the IM2 in a pseudo-differential structure, and hence also reduces the IM3 caused by the cascaded second order nonlinearities significantly. The effect of CMFB gain, bandwidth and linearity were analyzed, and it is concluded that from the linearity point of view, the feedback circuit does not have to be very wideband since the dominant distortion products originate from baseband. Finally, the paper takes a look at the spurious tones rising in the mixing, and how to extend the analysis to include the actual frequency translation effect.

Kinematic Measurements of Novel Chaotic Micromixers to Enhance Mixing Performances at Low Reynolds Numbers: Comparative Study

In this work, a comparative investigation of chaotic flow behavior inside multi-layer crossing channels was numerically carried out to select suitable micromixers. New micromixers were proposed and compared with an efficient passive mixer called a Two-Layer Crossing Channel Micromixer (TLCCM), which was investigated recently. The computational evaluation was a concern to the mixing enhancement and kinematic measurements, such as vorticity, deformation, stretching, and folding rates for various low Reynolds number regimes. The 3D continuity, momentum, and species transport equations were solved by a Fluent ANSYS CFD code. For various cases of fluid regimes (0.1 to 25 values of Reynolds number), the new configuration displayed a mixing enhancement of 40%–60% relative to that obtained in the older TLCCM in terms of kinematic measurement, which was studied recently. The results revealed that all proposed micromixers have a strong secondary flow, which significantly enhances the fluid kinematic performances at low Reynolds numbers. The visualization of mass fraction and path-lines presents that the TLCCM configuration is inefficient at low Reynolds numbers, while the new designs exhibit rapid mixing with lower pressure losses. Thus, it can be used to enhance the homogenization in several microfluidic systems.