Glycosylated zinc(ii) phthalocyanines as efficient photosensitisers for photodynamic therapy. Synthesis, photophysical properties and in vitro photodynamic activity

2008 ◽  
Vol 6 (12) ◽  
pp. 2173 ◽  
Author(s):  
Chi-Fung Choi ◽  
Jian-Dong Huang ◽  
Pui-Chi Lo ◽  
Wing-Ping Fong ◽  
Dennis K. P. Ng
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties ◽  
Photodynamic Activity

Mitochondria-targeted porphyrin-based photosensitizers containing triphenylphosphonium cations showing efficient in vitro photodynamic therapy effects

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1505-1514 ◽  
Author(s):  
Xing Guo ◽  
Hao Wu ◽  
Wei Miao ◽  
Yangchun Wu ◽  
Erhong Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Fluorescence Spectroscopy ◽  
Hela Cells ◽  
Photophysical Properties ◽  
Quantum Yields ◽  
Subcellular Organelle

Subcellular organelle-targeted photosensitizers have recently reported to be effective photodynamic therapy (PDT) agents. In this work, three porphyrin-derived photosensitizers, containing one, two or four triphenylphosphonium targeting groups, were synthesized and characterized by NMR, HRMS, UV-vis and fluorescence spectroscopy. These photosensitizers showed similar photophysical properties to classical porphyrins and exhibited excellent [Formula: see text]O[Formula: see text] quantum yields in acetonitrile. Subcellular colocalization indicated that all three photosensitizers specifically stain the mitochondria of HeLa cells. Photosensitizer mito-dp, containing two triphenylphosphonium cations was found to be the most uptaken by cells and exhibited the best PDT effect with an effective phototoxicity (IC[Formula: see text] (light) [Formula: see text] 12.4 nM), suggestive of a higher practicable potential of mitochondria-targeted PDT agents in cancer therapy.

Synthesis, photophysical properties and in vitro evaluation of a chlorambucil conjugated ruthenium(ii) complex for combined chemo-photodynamic therapy against HeLa cells

2017 ◽  
Vol 5 (24) ◽  
pp. 4623-4632 ◽  
Author(s):  
Jing-Xiang Zhang ◽  
Mei Pan ◽  
Cheng-Yong Su
Keyword(s):  
Photodynamic Therapy ◽  
Hela Cells ◽  
Photophysical Properties ◽  
Inhibitory Effect ◽  
Antiproliferative Effect ◽  
In Vitro Evaluation

We designed a new heteroleptic Ru(ii) complex CHL-RuL as an imaging-guided chemotherapy/PDT agent, which shows a moderate antiproliferative effect in dark and strong photodynamic inhibitory effect against HeLa cells.

Cyanines as efficient photosensitizers in photodynamic reaction: Photophysical properties and in vitro photodynamic activity

2011 ◽  
Vol 76 (4) ◽  
pp. 473-479 ◽  
Author(s):  
J. Kulbacka ◽  
A. Pola ◽  
D. Mosiadz ◽  
A. Choromanska ◽  
P. Nowak ◽  
...  
Keyword(s):  
Photophysical Properties ◽  
Photodynamic Activity ◽  
Photodynamic Reaction

Photodynamic activity of 2,6-dibrominated dimethylaminophenylbuta-1,3-dienylBODIPY dyes

2020 ◽  
Vol 25 (01) ◽  
pp. 47-55
Author(s):  
Gugu Kubheka ◽  
Balaji Babu ◽  
Earl Prinsloo ◽  
Nagao Kobayashi ◽  
John Mack ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Photodynamic Activity ◽  
Depth Study ◽  
Mcf 7

Mono- and disubstituted 2,6-dibromo-dimethylaminophenylbuta-1,3-dienylBODIPY dyes were successfully prepared, and their in vitro photodynamic activities against MCF-7 breast cancer cells were evaluated with a Thorlabs M660L4 660 nm LED (336 J · cm[Formula: see text]. The IC[Formula: see text] value of the monophenylbuta-1,3-dienylBODIPY was ca. 2.1 [Formula: see text]M, while that of the diphenylbuta-1,3-dienylBODIPY was > 50 [Formula: see text]M. Both dyes exhibited minimal dark toxicity. The results demonstrate that monosubstituted 2,6-dibromo-dimethylaminophenylbuta-1,3-dienylBODIPY dyes merit further in-depth study for use as photosensitizer dyes in photodynamic therapy.

Lysosome Targeting Bis-terpyridine Ruthenium(II) Complexes: Photophysical Properties and In Vitro Photodynamic Therapy

2020 ◽  
Vol 3 (9) ◽  
pp. 6025-6038
Author(s):  
Bingqing Liu ◽  
Yibo Gao ◽  
Mohammed A. Jabed ◽  
Svetlana Kilina ◽  
Guoquan Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Photophysical Properties

scholarly journals Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

2020 ◽  
Vol 19 (2) ◽  
pp. 193-206 ◽  
Author(s):  
K. T. Kazantzis ◽  
K. Koutsonikoli ◽  
B. Mavroidi ◽  
M. Zachariadis ◽  
P. Alexiou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Absorption Maximum ◽  
Photophysical Properties ◽  
In Vitro Studies ◽  
Prostate Cancer Cells ◽  
Curcumin Derivatives ◽  
Curcumin I

Increased absorption maximum for the dimethylaminocurcumin with strong PD effect on prostate cancer cells; Intense PD effect of curcumin III on prostate cancer cells; Exciting biphasic PD response by curcumin I and cinnamaldehyde-derived curcumin.

Synthesis and photodynamic activity of new meso-tetranaphthylporphyrins derivatives

2010 ◽  
Vol 14 (08) ◽  
pp. 722-726 ◽  
Author(s):  
Jing-zhou Liu ◽  
Jun Li ◽  
Gao-mai Yang ◽  
Dan Sun ◽  
Xiang-fei Lü ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Potential Application ◽  
K562 Cells ◽  
Photodynamic Activity ◽  
Low Levels

The meso-tetranaphthylporphyrins (TNP) derivatives, 5-(2-hydroxy-1-naphthaldehyde-4-naphthyleneimine)-10,15,20-trinaphthylporphyrin 3, 5-(salicylidene-4-naphthyleneamine)-10,15,20- trinaphthylporphyrin 4 and 5-(thiophene-2-carboxaldehyde-4-naphthyleneimine)-10,15,20-trinaphthylporphyrin 5, were synthesized by the reaction of 5-(4-aminonaphthyl)-l0,15,20-trinaphthylporphyrin 2 with different aldehydes. Their photodynamic activity against K562 cells were evaluated in vitro. They displayed low levels or no dark toxicity and high phototoxicity to K562 cells, especially for 5, which offers potential application in photodynamic therapy.

Phthalocyanine-cRGD conjugate: synthesis, photophysical properties and in vitro biological activity for targeting photodynamic therapy

2016 ◽  
Vol 14 (10) ◽  
pp. 2985-2992 ◽  
Author(s):  
Liqiang Luan ◽  
Wenjuan Fang ◽  
Wei Liu ◽  
Minggang Tian ◽  
Yuxing Ni ◽  
...  
Keyword(s):  
Biological Activity ◽  
Photodynamic Therapy ◽  
Cross Section ◽  
Cellular Uptake ◽  
Photophysical Properties ◽  
Photon Absorption ◽  
Absorption Cross ◽  
Two Photon Absorption ◽  
Two Photon

Phthalocyanine-RGD conjugate was synthesized and examined for its two-photon absorption cross section (TPACS), cellular uptake, and photocytotoxicity.

scholarly journals Photodynamic properties of aza-analogues of phthalocyanines

2018 ◽  
Vol 17 (11) ◽  
pp. 1749-1766 ◽  
Author(s):  
Miroslav Miletin ◽  
Petr Zimcik ◽  
Veronika Novakova
Keyword(s):  
Photophysical Properties ◽  
Photodynamic Activity

Spectral and photophysical properties and in vitro photodynamic activity of aza-analogues of phthalocyanines are summarized.

scholarly journals Photophysical Properties of Pheophorbide-a Derivatives and Their Photodynamic Therapeutic Effects on a Tumor Cell LineIn Vitro

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Kang-Kyun Wang ◽  
Jing Li ◽  
Bong-Jin Kim ◽  
Jeong-Hyun Lee ◽  
Hee-Won Shin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triplet State ◽  
Singlet Oxygen ◽  
Alkyl Group ◽  
Photophysical Properties ◽  
Hydroxyl Group ◽  
Quantum Yields ◽  
Therapeutic Effects ◽  
Pheophorbide A

Pheophorbide-a derivatives have been reported to be potential photosensitizers for photodynamic therapy (PDT). In this study, photophysics of pheophorbide-a derivatives (PaDs) were investigated along with their photodynamic tumoricidal effectin vitro. PaDs were modified by changing the coil length and/or making the hydroxyl group (–OH) substitutions. Their photophysical properties were studied by steady-state and time-resolved spectroscopic methods. The photodynamic tumoricidal effect was evaluated in the mouse breast cancer cell line (EMT6). Lifetime and quantum yield of fluorescence and quantum yields of triplet state and singlet oxygen were studied to determine the dynamic energy flow. The coil length of the substituted alkyl group did not significantly affect the spectroscopic properties. However, the substitution with the hydroxyl group increased the quantum yields of the triplet state and the singlet oxygen due to the enhanced intersystem crossing. In order to check the application possibility as a photodynamic therapy agent, the PaDs with hydroxyl group were studied for the cellular affinity and the photodynamic tumoricidal effect of EMT6. The results showed that the cellular affinity and the photodynamic tumoricidal effect of PaDs with the hydroxyl group depended on the coil-length of the substituted alkyl group.

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