scholarly journals Curcumin derivatives as photosensitizers in photodynamic therapy: photophysical properties and in vitro studies with prostate cancer cells

2020 ◽  
Vol 19 (2) ◽  
pp. 193-206 ◽  
Author(s):  
K. T. Kazantzis ◽  
K. Koutsonikoli ◽  
B. Mavroidi ◽  
M. Zachariadis ◽  
P. Alexiou ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Absorption Maximum ◽  
Photophysical Properties ◽  
In Vitro Studies ◽  
Prostate Cancer Cells ◽  
Curcumin Derivatives ◽  
Curcumin I

Increased absorption maximum for the dimethylaminocurcumin with strong PD effect on prostate cancer cells; Intense PD effect of curcumin III on prostate cancer cells; Exciting biphasic PD response by curcumin I and cinnamaldehyde-derived curcumin.

In vivo and in vitro studies of anticancer actions of α-TEA for human prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (8) ◽  
pp. 849-860 ◽  
Author(s):  
Li Jia ◽  
Weiping Yu ◽  
Pei Wang ◽  
Bob G. Sanders ◽  
Kimberly Kline
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
In Vitro Studies ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

scholarly journals In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol

2008 ◽  
Vol 3 (1) ◽  
Author(s):  
Robert Michael Hermann ◽  
Hendrik Andreas Wolff ◽  
Hubertus Jarry ◽  
Paul Thelen ◽  
Carsten Gruendker ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Low Dose ◽  
In Vitro Studies ◽  
Prostate Cancer Cells

scholarly journals [Mn(PaPy2Q)(NO)]ClO4, a Near-Infrared Light activated release of Nitric Oxide drug as a nitric oxide donor for therapy of human prostate cancer cells in vitro and in vivo

2021 ◽  
Vol 137 ◽  
pp. 111388
Author(s):  
Yuwan Zhao ◽  
Zhuo Li ◽  
Huancheng Tang ◽  
Shanhong Lin ◽  
Wenfeng Zeng ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Nitric Oxide ◽  
Cancer Cells ◽  
Near Infrared ◽  
Nitric Oxide Donor ◽  
Infrared Light ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells

Targeting the HGF/SF receptor c-met using a hammerhead ribozyme transgene reduces in vitro invasion and migration in prostate cancer cells

The Prostate ◽  
2004 ◽  
Vol 60 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Gaynor Davies ◽  
Gareth Watkins ◽  
Malcolm D. Mason ◽  
Wen G. Jiang
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Hammerhead Ribozyme ◽  
Prostate Cancer Cells ◽  
Invasion And Migration ◽  
In Vitro Invasion ◽  
And Migration

scholarly journals Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Denisa Baci ◽  
Antonino Bruno ◽  
Caterina Cascini ◽  
Matteo Gallazzi ◽  
Lorenzo Mortara ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cells ◽  
Dietary Supplements ◽  
Cell Lines ◽  
Angiogenic Factors ◽  
Migration And Invasion ◽  
Prostate Cancer Cells

Abstract Background Prostate cancer (PCa) is a leading cause of cancer-related death in males worldwide. Exacerbated inflammation and angiogenesis have been largely demonstrated to contribute to PCa progression. Diverse naturally occurring compounds and dietary supplements are endowed with anti-oxidant, anti-inflammatory and anti-angiogenic activities, representing valid compounds to target the aberrant cytokine/chemokine production governing PCa progression and angiogenesis, in a chemopreventive setting. Using mass spectrometry analysis on serum samples of prostate cancer patients, we have previously found higher levels of carnitines in non-cancer individuals, suggesting a protective role. Here we investigated the ability of Acetyl-L-carnitine (ALCAR) to interfere with key functional properties of prostate cancer progression and angiogenesis in vitro and in vivo and identified target molecules modulated by ALCAR. Methods The chemopreventive/angiopreventive activities ALCAR were investigated in vitro on four different prostate cancer (PCa) cell lines (PC-3, DU-145, LNCaP, 22Rv1) and a benign prostatic hyperplasia (BPH) cell line. The effects of ALCAR on the induction of apoptosis and cell cycle arrest were investigated by flow cytometry (FC). Functional analysis of cell adhesion, migration and invasion (Boyden chambers) were performed. ALCAR modulation of surface antigen receptor (chemokines) and intracellular cytokine production was assessed by FC. The release of pro-angiogenic factors was detected by a multiplex immunoassay. The effects of ALCAR on PCa cell growth in vivo was investigated using tumour xenografts. Results We found that ALCAR reduces cell proliferation, induces apoptosis, hinders the production of pro inflammatory cytokines (TNF-α and IFN-γ) and of chemokines CCL2, CXCL12 and receptor CXCR4 involved in the chemotactic axis and impairs the adhesion, migration and invasion capabilities of PCa and BPH cells in vitro. ALCAR exerts angiopreventive activities on PCa by reducing production/release of pro angiogenic factors (VEGF, CXCL8, CCL2, angiogenin) and metalloprotease MMP-9. Exposure of endothelial cells to conditioned media from PCa cells, pre-treated with ALCAR, inhibited the expression of CXCR4, CXCR1, CXCR2 and CCR2 compared to those from untreated cells. Oral administration (drinking water) of ALCAR to mice xenografted with two different PCa cell lines, resulted in reduced tumour cell growth in vivo. Conclusions Our results highlight the capability of ALCAR to down-modulate growth, adhesion, migration and invasion of prostate cancer cells, by reducing the production of several crucial chemokines, cytokines and MMP9. ALCAR is a widely diffused dietary supplements and our findings provide a rational for studying ALCAR as a possible molecule for chemoprevention approaches in subjects at high risk to develop prostate cancer. We propose ALCAR as a new possible “repurposed agent’ for cancer prevention and interception, similar to aspirin, metformin or beta-blockers.

Differential effects of transforming growth factor β on human prostate cancer cells in vitro

1989 ◽  
Vol 62 (1) ◽  
pp. 79-87 ◽  
Author(s):  
George Wilding ◽  
Gerhard Zugmeier ◽  
Cornelius Knabbe ◽  
Katherine Flanders ◽  
Edward Gelmann
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Differential Effects

Schiff base-Poloxamer P85 combination demonstrates chemotherapeutic effect on prostate cancer cells in vitro

2017 ◽  
Vol 86 ◽  
pp. 492-501 ◽  
Author(s):  
Selami Demirci ◽  
Ayşegül Doğan ◽  
Neşe Başak Türkmen ◽  
Dilek Telci ◽  
Albert A. Rizvanov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Schiff Base ◽  
Cancer Cells ◽  
Prostate Cancer Cells ◽  
Chemotherapeutic Effect
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