Non-sampling error in ozone biomonitoring: the role of operator training

2009 ◽  
Vol 11 (4) ◽  
pp. 736 ◽  
Author(s):  
Alessandra Francini ◽  
Elisa Pellegrini ◽  
Giacomo Lorenzini ◽  
Cristina Nali
F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 715 ◽  
Author(s):  
William Waddingham ◽  
David Graham ◽  
Matthew Banks ◽  
Marnix Jansen

Gastric adenocarcinoma is a disease that is often detected late, at a stage when curative treatment is unachievable. This must be addressed through changes in our approach to the identification of patients at increased risk by improving the detection and risk assessment of premalignant changes in the stomach, including chronic atrophic gastritis and intestinal metaplasia. Current guidelines recommend utilising random biopsies in a pathology-led approach in order to stage the extent and severity of gastritis and intestinal metaplasia. This random method is poorly reproducible and prone to sampling error and fails to acknowledge recent advances in our understanding of the progression to gastric cancer as a non-linear, branching evolutionary model. Data suggest that recent advances in endoscopic imaging modalities, such as narrow band imaging, can achieve a high degree of accuracy in the stomach for the diagnosis of these premalignant changes. In this review, we outline recent data to support a paradigm shift towards an endoscopy-led approach to diagnosis and staging of premalignant changes in the stomach. High-quality endoscopic interrogation of the chronically inflamed stomach mucosa, supported by targeted biopsies, will lead to more accurate risk assessment, with reduced rates of under or missed diagnoses.


2011 ◽  
Vol 50 (1) ◽  
pp. 255-266 ◽  
Author(s):  
Nicholas Cook

Abstract This comment addresses the role of sampling error in extreme value analysis. A note published in this journal claimed that Weibull’s 1939 estimator for sample probability has a unique status that invalidates all other estimators and renders invalid all of the developments of unbiased distribution-dependent estimators made since 1939. The note concluded that the use of distribution-dependent estimators should be abandoned and that many estimates of the weather-related risks should be reevaluated and the related building codes and other related regulations updated. This comment uses rigorous statistical proofs to make the diametrically opposite case: namely, that development of distribution-dependent estimators has resulted in an improvement in accuracy over the past half century and that no changes are required to the basis of weather-related building codes and regulations. These rigorous proofs are supplemented by sampling experiments that demonstrate their validity. This comment provides an introduction to the basic statistical concepts of the statistical modeling of extremes, including unbiased estimators for the model parameters.


2020 ◽  
Vol 26 (2-3) ◽  
pp. 89-93
Author(s):  
B.P. Hromovyk ◽  
◽  
Yu.I. Kremin ◽  

Aim. Study of the opinion of pharmaceutical specialists working at pharmacies on the role of material and moral incentives and obstacles in their implementation in the process of motivating professionals to work. Material and Methods. The study was conducted in the period from June 26 to August 26, 2020 via an anonymous online survey of 348 pharmaceutical specialists working at pharmacies in Ukraine on a questionnaire developed in Google form and posted in nine pharmaceutical groups on Facebook social network. The respondents represented all regions of Ukraine, except for the annexed Autonomous Republic of Crimea and the occupied territories of Donetsk and Luhansk regions. The marginal sampling error was 5.1%. Results and Discussion. It was found that the vast majority of respondents believe they should be paid higher salaries for that the amount of work they do. The ratio of the average salary of Ukrainian pharmaceutical specialists to the minimum wage in the country is at least twofold less than that of their European counterparts. It was found that among the incentives, employers primarily use the accrual of interest on sales and the bonus system. It is determined that respect on the part of colleagues and visitors of pharmacies, a proper moral climate in the team and good working conditions are important for the respondents. At the same time, the concern of pharmaceutical specialists with a high degree of carried responsibility, very hard work, inexpediency of management requirements, and penalties at the pharmacy was revealed. Conclusion. It is established that pharmaceutical professionals do not receive the desired material and moral satisfaction from working at pharmacies, and employers underuse the existing forms of incentives for work achievements, which leads to disappointment of pharmaceutical professionals in the chosen profession and to the high staff turnover at pharmacies. Key words: pharmaceutical specialist, salary, material and moral incentives


2019 ◽  
Vol 40 (1/2) ◽  
pp. 74-87
Author(s):  
Umut Al ◽  
Güleda Dogan ◽  
Irem Soydal ◽  
Zehra Taskin

Purpose In this paper, the Libraries for Everyone Project and the studies carried out within the scope of the project are presented; the role of libraries as learning environments is discussed; and the data obtained from the library usage research/survey are shared. The paper aims to discuss these issues. Design/methodology/approach The research includes the findings of a questionnaire study that was applied in May, 2017 to 4,566 respondents from 147 libraries participating in the project. The population is represented with a 99% confidence level and a sampling error of 0.02. The sample size was decided based on the number of registered members in the libraries. Findings Municipal libraries have potential to be used as learning environments. Originality/value The usage survey reported in the study is the most comprehensive usage study on municipal libraries so far in terms of the number of participants. The Libraries for Everyone Project is the most extensive project implemented at municipal libraries in Turkey.


2020 ◽  
Author(s):  
Sina Khatami ◽  
Murray Peel ◽  
Tim Peterson ◽  
Andrew Western

<p>Hydrological models are conventionally evaluated in terms of their response surface or likelihood surface constructed with the model parameter space. To evaluate models as hypotheses, we developed the method of <em>Flux Mapping</em> to construct a hypothesis space based on model process representation. Here we defined the hypothesis space based on dominant runoff generating mechanisms, and acceptable model runs are defined as total simulated flow with similar (and minimal) model error simulated by distinct combinations of runoff components. We demonstrate that the hypothesis space in each modeling case is the result of interplay between the factors of model structure, parameter sampling, choice of error metric, and data information content. The aim of this study is to disentangle the role of each factor in this interplay. We used two model structures (SACRAMENTO and SIMHYD), two parameter sampling approaches (small samples based on guided-search and large samples based on Latin Hypercube Sampling), three widely used error metrics (NSE, KGE, and WIA — Willmott’s Index of Agreement), and hydrological data from a range of Australian catchments. First, we characterized how the three error metrics behave under different error regimes independent of any modeling. We then conducted a series of controlled experiments, i.e. a type of one-factor-at-a-time sensitivity analysis, to unpack the role of each factor in runoff simulation. We show that KGE is a more reliable error metric compared to NSE and WIA for model evaluation. We also argue that robust error metrics and sufficient parameter sampling are necessary conditions for evaluating models as hypotheses under uncertainty. We particularly argue that sampling sufficiency, regardless of the sampling strategy, should be further evaluated based on its interaction with other modeling factors determining the model response. We conclude that the interplay of these modeling factors is complex and unique to each modeling case, and hence generalizing model-based inferences should be done with caution particularly in characterizing hydrological processes in large-sample hydrology.</p>


2012 ◽  
Vol 136 (12) ◽  
pp. 1492-1501 ◽  
Author(s):  
Lida P. Hariri ◽  
Mari Mino-Kenudson ◽  
Eugene J. Mark ◽  
Melissa J. Suter

Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology.


2017 ◽  
Vol 41 (5) ◽  
Author(s):  
Nicola Barabas ◽  
Andreas Bietenbeck

AbstractInsufficient operator training has been identified as an underlying root cause for many errors of point-of-care testing. However, while the need for operator training is beyond doubt, the practical solutions on how to train operators remain challenging. Therefore a multidisciplinary team of experts created the application guide VDE-AR-E 2411-2-101 “Schulung professioneller Anwender von patientennahen Tests” (Training of professional users of devices for near-patient testing). This work is based on the talk of Nicola Barabas during the POCT-Symposium in Munich 2017 and presents selected aspects of the application guide such as the role of the manufacturer, the learning path, the selection of training topics, the train-the-trainer concept and e-learning.


2014 ◽  
Vol 7 (3) ◽  
pp. 2339-2379 ◽  
Author(s):  
R. Checa-Garcia ◽  
A. Tokay ◽  
F. J. Tapiador

Abstract. This paper investigates the binning effects on drop size distribution (DSD) measurements obtained by Joss-Waldvogel disdrometer (JWD), Precipitation Occurrence Sensor System (POSS), Thies disdrometer (Thies), Parsivel OTT disdrometer, two-dimensional video disdrometer (2DVD) and optical spectro-pluviometer (OSP) instruments, therefore the evaluation comprises non-regular bin sizes and the effect of minimum and maximum measured sizes of drops. To achieve this goal, 2DVD measurements and simulated gamma size distributions were considered. The analysis of simulated gamma DSD binned according each instrument was performed to understand the role of discretisation and truncation effects together on the integral rainfall parameters and estimators of the DSD parameters. In addition, the drop-by-drop output of the 2DVD is binned to simulate the raw output of the other disdrometers which allowed us estimate sampling and binning effects on selected events from available dataset. From simulated DSD it has been found that binning effects exist in integral rainfall parameters and in the evaluation of DSD parameters of a gamma distribution. This study indicates that POSS and JWD exhibit underestimation of concentration and mean diameter due to binning. Thies and Parsivel report a positive bias for rainfall and reflectivity (reaching 5% for heavy rainfall intensity events). Regarding to DSD parameters, distributions of estimators for the shape and scale parameters were analyzed by moment, truncated moment and maximum likelihood methods. They reported noticeable differences between instruments for all methodologies of estimation applied. The measurements of 2DVD allow sampling error estimation of instruments with smaller capture areas than 2DVD. The results show that the instrument differences due to sampling were a~relevant uncertainty but that concentration, reflectivity and mass-weighted diameter were sensitive to binning.


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