scholarly journals Quantitative, reagentless, single-step electrochemical detection of anti-DNA antibodies directly in blood serum

2010 ◽  
Vol 46 (10) ◽  
pp. 1742 ◽  
Author(s):  
Francesco Ricci ◽  
Gianluca Adornetto ◽  
Danila Moscone ◽  
Kevin W. Plaxco ◽  
Giuseppe Palleschi
Keyword(s):  
Blood Serum ◽  
Electrochemical Detection ◽  
Single Step ◽  
Dna Antibodies

A Single-Step Gold Nanoparticle–Blood Serum Interaction Assay Reveals Humoral Immunity Development and Immune Status of Animals from Neonates to Adults

2018 ◽  
Vol 5 (2) ◽  
pp. 228-238 ◽  
Author(s):  
Tianyu Zheng ◽  
John Crews ◽  
Jodi L. McGill ◽  
Kunal Dhume ◽  
Caroline Finn ◽  
...  
Keyword(s):  
Blood Serum ◽  
Gold Nanoparticle ◽  
Humoral Immunity ◽  
Immune Status ◽  
Single Step

A flower-structured MoS2-decorated f-MWCNTs/ZnO hybrid nanocomposite-modified sensor for the selective electrochemical detection of vitamin C

2019 ◽  
Vol 43 (38) ◽  
pp. 15105-15114 ◽  
Author(s):  
N. Murugan ◽  
T. H. Vignesh Kumar ◽  
N. Ramila Devi ◽  
Ashok K. Sundramoorthy
Keyword(s):  
Vitamin C ◽  
Blood Serum ◽  
Electrochemical Sensor ◽  
Electrochemical Detection ◽  
Selective Detection ◽  
Hybrid Nanocomposite ◽  
Serum Samples ◽  
Modified Sensor

We synthesized an MoS2/f-MWCNTs/ZnO composite and successfully used it to prepare an electrochemical sensor for the selective detection of AA in blood serum samples.

scholarly journals Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6700
Author(s):  
Ramaraj Sukanya ◽  
Karuppaiah Balamurugan ◽  
Shen-Ming Chen ◽  
Ramachandran Rajakumaran ◽  
K. Muthupandi ◽  
...  
Keyword(s):  
Blood Serum ◽  
Electrochemical Detection ◽  
Differential Pulse ◽  
Electrochemical Analysis ◽  
Antibacterial Drug ◽  
Linear Calibration ◽  
Serum Samples ◽  
Pulse Voltammetry ◽  
Related Compounds ◽  
Selective Sensor

In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 μM, was observed, coupled with a detection limit of 0.0054 μM and a sensitivity of 0.055 μA/μM. In addition, the ZTO/TO MPs/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO/TO MPs/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO/TO MPs/GCE for the electrochemical analysis of SCZ in complex biological samples.

scholarly journals Electrochemical detection of ascorbic acid in artificial sweat using a flexible alginate/CuO-modified electrode

2020 ◽  
Vol 187 (9) ◽  
Author(s):  
Bergoi Ibarlucea ◽  
Arnau Pérez Roig ◽  
Dmitry Belyaev ◽  
Larysa Baraban ◽  
Gianaurelio Cuniberti
Keyword(s):  
Ascorbic Acid ◽  
Cyclic Voltammetry ◽  
Electrochemical Detection ◽  
Limit Of Detection ◽  
Low Cost ◽  
Reference Electrode ◽  
Single Step ◽  
Repeated Measurements ◽  
Relative Standard ◽  
Artificial Sweat

Abstract A flexible sensor is presented for electrochemical detection of ascorbic acid in sweat based on single-step modified gold microelectrodes. The modification consists of electrodeposition of alginate membrane with trapped CuO nanoparticles. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can withstand mechanical stress beyond requirements for skin monitoring. After characterization of the membrane via optical and scanning electron microscopy and cyclic voltammetry, the oxidative properties of CuO are exploited toward ascorbic acid for amperometric measurement at micromolar levels in neutral buffer and acidic artificial sweat, at ultralow applied potential (− 5 mV vs. Au pseudo-reference electrode). Alternatively, measurement of the horizontal shift of redox peaks by cyclic voltammetry is also possible. Obtaining a limit of detection of 1.97 μM, sensitivity of 0.103 V log (μM)−1 of peak shift, and linear range of 10–150 μM, the effect of possible interfering species present in sweat is minimized, with no observable cross-reaction, thus maintaining a high degree of selectivity despite the absence of enzymes in the fabrication scheme. With a lateral flow approach for sample delivery, repeated measurements show recovery in few seconds, with relative standard deviation of about 20%, which can serve to detect increased loss or absence of vitamin, and yet be improved in future by optimized device designs. This sensor is envisioned as a promising component of wearable devices for e.g. non-invasive monitoring of micronutrient loss through sweat, comprising features of light weight, low cost, and easy fabrication needed for such application.

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