scholarly journals Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole

Materials ◽  
2021 ◽  
Vol 14 (21) ◽  
pp. 6700
Author(s):  
Ramaraj Sukanya ◽  
Karuppaiah Balamurugan ◽  
Shen-Ming Chen ◽  
Ramachandran Rajakumaran ◽  
K. Muthupandi ◽  
...  
Keyword(s):  
Blood Serum ◽  
Electrochemical Detection ◽  
Differential Pulse ◽  
Electrochemical Analysis ◽  
Antibacterial Drug ◽  
Linear Calibration ◽  
Serum Samples ◽  
Pulse Voltammetry ◽  
Related Compounds ◽  
Selective Sensor

In this study, we synthesized heterostructured zinc stannate/tin oxide microparticles (ZTO/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 μM, was observed, coupled with a detection limit of 0.0054 μM and a sensitivity of 0.055 μA/μM. In addition, the ZTO/TO MPs/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO/TO MPs/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO/TO MPs/GCE for the electrochemical analysis of SCZ in complex biological samples.

scholarly journals Electrochemical Nanocomposite Single-Use Sensor for Dopamine Detection

Sensors ◽  
2019 ◽  
Vol 19 (14) ◽  
pp. 3097 ◽  
Author(s):  
Giulia Selvolini ◽  
Cinzia Lazzarini ◽  
Giovanna Marrazza
Keyword(s):  
Limit Of Detection ◽  
Differential Pulse ◽  
Sensor Response ◽  
Sensor Surface ◽  
Serum Samples ◽  
Dopamine Detection ◽  
Sensitive Sensor ◽  
Single Use ◽  
Pulse Voltammetry ◽  
Nanocomposite Sensor

In this work, we report the development of a simple and sensitive sensor based on graphite screen-printed electrodes (GSPEs) modified by a nanocomposite film for dopamine (DA) detection. The sensor was realized by electrodepositing polyaniline (PANI) and gold nanoparticles (AuNPs) onto the graphite working electrode. The sensor surface was fully characterized by means of the cyclic voltammetry (CV) technique using [Fe(CN)6]4−/3− and [Ru(NH3)6]2+/3+ as redox probes. The electrochemical behavior of the nanocomposite sensor towards DA oxidation was assessed by differential pulse voltammetry (DPV) in phosphate buffer saline at physiological pH. The sensor response was found to be linearly related to DA concentration in the range 1–100 μM DA, with a limit of detection of 0.86 μM. The performance of the sensor in terms of reproducibility and selectivity was also studied. Finally, the sensor was successfully applied for a preliminary DA determination in human serum samples.

A flower-structured MoS2-decorated f-MWCNTs/ZnO hybrid nanocomposite-modified sensor for the selective electrochemical detection of vitamin C

2019 ◽  
Vol 43 (38) ◽  
pp. 15105-15114 ◽  
Author(s):  
N. Murugan ◽  
T. H. Vignesh Kumar ◽  
N. Ramila Devi ◽  
Ashok K. Sundramoorthy
Keyword(s):  
Vitamin C ◽  
Blood Serum ◽  
Electrochemical Sensor ◽  
Electrochemical Detection ◽  
Selective Detection ◽  
Hybrid Nanocomposite ◽  
Serum Samples ◽  
Modified Sensor

We synthesized an MoS2/f-MWCNTs/ZnO composite and successfully used it to prepare an electrochemical sensor for the selective detection of AA in blood serum samples.

scholarly journals Development of a Label-Free Electrochemical Aptasensor for the Detection of Tau381 and its Preliminary Application in AD and Non-AD Patients’ Sera

Biosensors ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 84 ◽  
Author(s):  
Dan Tao ◽  
Bingqing Shui ◽  
Yingying Gu ◽  
Jing Cheng ◽  
Weiying Zhang ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Early Stage ◽  
Differential Pulse ◽  
Electrical Signal ◽  
Label Free ◽  
Modified Glassy Carbon Electrode ◽  
Serum Samples ◽  
Pulse Voltammetry ◽  
Aptamer Sensor ◽  
Preliminary Application

The electrochemical aptamer sensor has been designed for detecting tau381, a critical biomarker of Alzheimer′s disease in human serum. The aptasensor is obtained by immobilizing the aptamer on a carboxyl graphene/thionin/gold nanoparticle modified glassy-carbon electrode. As a probe and bridge molecule, thionin connected carboxyl graphene and gold nanoparticles, and gave the electrical signal. Under optimal conditions, the increment of differential pulse voltammetry signal increased linearly with the logarithm of tau381 concentration in the range from 1.0 pM to 100 pM, and limit of detection was 0.70 pM. The aptasensor reliability was evaluated by determining its selectivity, reproducibility, stability, detection limit, and recovery. Performance analysis of the tau381 aptasensor in 10 patients’ serum samples showed that the aptasensor could screen patients with and without Alzheimer′s disease. The proposed aptasensor has potential for use in clinically diagnosing Alzheimer′s disease in the early stage.

hYKL-40 cancer biomarker electroanalysis in serum samples and model cell lysates: capacitive immunosensing compared with enzyme label immunosorbent assays (ELISA)

The Analyst ◽  
2017 ◽  
Vol 142 (3) ◽  
pp. 503-510 ◽  
Author(s):  
W. Chaocharoen ◽  
A. Schulte ◽  
W. Suginta
Keyword(s):  
Brain Tumor ◽  
Blood Serum ◽  
Electrochemical Analysis ◽  
Cancer Biomarker ◽  
Serum Samples ◽  
Tumor Patients ◽  
Cell Lysates ◽  
Model Cell ◽  
Enzyme Label ◽  
Immunosorbent Assays

The first electrochemical analysis of molecular cancer biomarker hYKL-40in blood serum samples of breast and brain tumor patientsviacapacitive immunosensing.

Synthesis of Co/TiO2 Nanocomposite and its Use in Construction of a Sensitive and Selective Sensor for Determination of Ciprofloxacin

2013 ◽  
Vol 829 ◽  
pp. 563-567 ◽  
Author(s):  
Mojtaba Shamsipur ◽  
Mohammad Bagher Gholivand ◽  
Sara Dehdashtian ◽  
Mostafa Feyzi ◽  
Fataneh Jafari
Keyword(s):  
Sol Gel ◽  
Differential Pulse ◽  
Gravimetric Analysis ◽  
Carbon Paste ◽  
Ftir Spectrometry ◽  
Pulse Voltammetry ◽  
Optimized Conditions ◽  
Paste Electrode ◽  
Selective Sensor

The Co/TiO2 nanocomposite was synthesized by a modified sol-gel method. The surface structure and composition of nanoparticles were characterized by scanning electron microscopy (SEM), X-ray powder diffraction analysis (XRD), Fourier transform infrared (FTIR) spectrometry, thermal gravimetric analysis (TGA) and N2 physisorption. A carbon paste electrode (CPE) modified with Co/TiO2 nanocomposite was prepared and used for low level determination of antibiotic ciprofloxacin (CF) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimized conditions, the modified electrode exhibited a linear response over the concentration range of 0.1 to 70 μM CF, with a detection limit of 0.03 μM. The proposed sensor was applied to the CF determination in serum and urine samples.

scholarly journals Signal amplification for sumatriptan sensing based on polymeric surface decorated with Cu nanoparticles

2018 ◽  
Vol 83 (4) ◽  
pp. 449-462
Author(s):  
Ghasem Karim-Nezhad ◽  
Samane Khanaliloo ◽  
Zeynab Khorablou ◽  
Seyed Dorraji
Keyword(s):  
Signal Amplification ◽  
Biological Fluids ◽  
Differential Pulse ◽  
Cu Nanoparticles ◽  
Linear Calibration ◽  
Polymeric Surface ◽  
Sensitive Determination ◽  
Pulse Voltammetry ◽  
Uniform Deposition

A new nanocomposite, Cu NPs/poly-melamine, was deposited on a glassy carbon electrode by cyclic voltammetry. The uniform deposition of the nanocomposite was observed by the field emission scanning electron microscopy. The electron transfer characteristics of the drug sumatriptan (SUM), was greatly improved on the modified electrode. The prepared electrode was used for the sensitive determination of SUM by the differential pulse voltammetry. Linear calibration curve was obtained in the concentration ranges of 0.08?0.58 and 0.58?6.5 ?M, and the detection limit of 0.025 ?M. The proposed method was evaluated by the determination of SUM in human biological fluids such as urine and blood plasma with satisfactory results (recovery > 99 %).

A 2D/2D NiCo-MOF/Ti3C2 heterostructure for simultaneous detection of acetaminophen, dopamine and uric acid by differential pulse voltammetry

2021 ◽  
Author(s):  
Xing Lu ◽  
Feng Zhang ◽  
Yimeng Sun ◽  
Kai Yu ◽  
Guo Wei ◽  
...  
Keyword(s):  
Uric Acid ◽  
Differential Pulse Voltammetry ◽  
Electrochemical Detection ◽  
Simultaneous Detection ◽  
Differential Pulse ◽  
Enzymatic Biosensor ◽  
Pulse Voltammetry

A 2D-2D NiCo-MOF/Ti3C2 heterojunction is constructed as a non-enzymatic biosensor for the simultaneous electrochemical detection of acetaminophen (AP), dopamine (DA) and uric acid (UA) by differential pulse voltammetry. Benefiting from...

Electrochemical Detection of Bisphenol A Based on N-Doped Carbon Quantum Dots@Carbon Nanotubes Composite

2020 ◽  
Vol 20 (12) ◽  
pp. 7610-7617
Author(s):  
Zhongzhen Chen ◽  
Haiping Huang ◽  
Yanan Chen ◽  
Ying Ye ◽  
Shuzhen Wu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Carbon Nanotubes ◽  
Quantum Dots ◽  
Bisphenol A ◽  
Differential Pulse Voltammetry ◽  
Electrochemical Detection ◽  
Glassy Carbon ◽  
Differential Pulse ◽  
Carbon Quantum Dots ◽  
Pulse Voltammetry

A novel nanocomposite of N-Doped Carbon Quantum Dots@Carbon Nanotubes was synthesized in this study for electrochemical detection of bisphenol A by differential pulse voltammetry. The nanocomposite was characterized by transmission electron microscopy, scanning electron microscopy, X-ray powder diffraction and Fourier transform infrared spectroscopy. Electrochemical properties of the nanocomposite modified glassy carbon electrodes were studied via cyclic voltammetry. Differential pulse voltammetry experimental results showed that N-Doped Carbon Quantum Dots@Carbon Nanotubes/glassy carbon electrode exhibited excellent catalysis activity towards electrochemical oxidation of bisphenol A. The oxidation peak current was linearly increased with concentration of bisphenol A in the range from 0.4 μM to 40 μM, with a limit of detection of 65 nM.

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