Dual-vectors of anti-cancer drugs and genes based on pH-sensitive micelles self-assembled from hybrid polypeptide copolymers

2011 ◽  
Vol 21 (9) ◽  
pp. 3100 ◽  
Author(s):  
Yong-Yong Li ◽  
Shou-Hu Hua ◽  
Wang Xiao ◽  
Hui-Yuan Wang ◽  
Xiao-Hua Luo ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Self Assembled

scholarly journals pH-Sensitive Ratiometric Fluorescent Probe for Evaluation of Tumor Treatments

Materials ◽  
2019 ◽  
Vol 12 (10) ◽  
pp. 1632
Author(s):  
Peisen Zhang ◽  
Junli Meng ◽  
Yingying Li ◽  
Zihua Wang ◽  
Yi Hou
Keyword(s):  
Ph Sensitive ◽  
Fluorescent Imaging ◽  
Tat Peptide ◽  
Cancer Drugs ◽  
Ph Response ◽  
In Vivo Experiments ◽  
Anti Cancer ◽  
Amidation Reaction

Determining therapeutic efficacy is critical for tumor precision theranostics. In order to monitor the efficacy of anti-cancer drugs (e.g., Paclitaxel), a pH-sensitive ratiometric fluorescent imaging probe was constructed. The pH-sensitive ratiometric fluorescent dye ANNA was covalently coupled to the N-terminal of the cell-penetrating TAT peptide through an amidation reaction (TAT-ANNA). The in vitro cellular experiments determined that the TAT-ANNA probe could penetrate the cell membrane and image the intracellular pH in real time. The in vivo experiments were then carried out, and the ratiometric pH response to the state of the tumor was recorded immediately after medication. The TAT-ANNA probe was successfully used to monitor the pharmacodynamics of anti-cancer drugs in vivo.

Delivering anti-cancer drugs with endosomal pH-sensitive anti-cancer liposomes

2016 ◽  
Vol 4 (4) ◽  
pp. 627-638 ◽  
Author(s):  
Gopikrishna Moku ◽  
Suresh Kumar Gulla ◽  
Narendra Varma Nimmu ◽  
Sara Khalid ◽  
Arabinda Chaudhuri
Keyword(s):  
Drug Carriers ◽  
Ph Sensitive ◽  
Acidic Ph ◽  
Cancer Drugs ◽  
Tumor Tissues ◽  
Anti Cancer ◽  
Endosomal Ph

Numerous prior studies have been reported on the use of pH-sensitive drug carriers such as micelles, liposomes, peptides, polymers, nanoparticles,etc. that are sensitive to the acidic (pH = ∼6.5) microenvironments of tumor tissues.

Facile synthesis of self-assembled spherical and mesoporous dandelion capsules of ZnO: efficient carrier for DNA and anti-cancer drugs

2014 ◽  
Vol 2 (25) ◽  
pp. 3956-3964 ◽  
Author(s):  
Vijay Bhooshan Kumar ◽  
Koushi Kumar ◽  
Aharon Gedanken ◽  
Pradip Paik
Keyword(s):  
Anticancer Drugs ◽  
Cancer Drugs ◽  
Facile Synthesis ◽  
Zno Nps ◽  
Anti Cancer ◽  
Self Assembled

Idiosyncratic self-assembled dandelion mesoporous capsules have been synthesized with ZnO NPs and NRs. The {(ZnO)nδ+–(DOX)m} and {(ZnO)nδ+–(DNA)m} complexes are very useful for delivery of anticancer drugs and genes, respectively.

pH-sensitive amphiphilic copolymer brush Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA: synthesis and self-assembled micelles for controlled anti-cancer drug release

RSC Advances ◽  
2014 ◽  
Vol 4 (76) ◽  
pp. 40232-40240 ◽  
Author(s):  
Can Yang Zhang ◽  
Wen Sheng Wu ◽  
Na Yao ◽  
Bin Zhao ◽  
Li Juan Zhang
Keyword(s):  
Drug Release ◽  
Drug Carrier ◽  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Self Assembled ◽  
Copolymer Brush

A novel pH-sensitive amphiphilic copolymer Chol-g-P(HEMA-co-DEAEMA)-b-PPEGMA and its micelles were developed as a promising anti-cancer drug carrier.

A Case of Malignant Melanoma Treated with a Combination of Anti-Cancer Drugs and Biological Response Modifiers.

1993 ◽  
Vol 55 (1) ◽  
pp. 43-46
Author(s):  
Jun YOSHIDA ◽  
Juichiro NAKAYAMA ◽  
Nobuyuki SHIMIZU ◽  
Shonosuke NAGAE ◽  
Yoshiaki HORI
Keyword(s):  
Malignant Melanoma ◽  
Biological Response ◽  
Biological Response Modifiers ◽  
Cancer Drugs ◽  
Anti Cancer

Self-Assembled Nanocarriers Based on Amphiphilic Natural Polymers for Anti- Cancer Drug Delivery Applications

2018 ◽  
Vol 23 (35) ◽  
Author(s):  
Sally Sabra ◽  
Mona Abdelmoneem ◽  
Mahmoud Abdelwakil ◽  
Moustafa Taha Mabrouk ◽  
Doaa Anwar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Anti Cancer ◽  
Drug Delivery Applications ◽  
Self Assembled ◽  
Cancer Drug Delivery

Current Scenario in Structure and Ligand-Based Drug Design on Anti-colon Cancer Drugs

2019 ◽  
Vol 24 (32) ◽  
pp. 3829-3841 ◽  
Author(s):  
Lakshmanan Loganathan ◽  
Karthikeyan Muthusamy
Keyword(s):  
Drug Discovery ◽  
Drug Design ◽  
Anticancer Agent ◽  
Computational Power ◽  
Cancer Drugs ◽  
Recent Advances ◽  
Anti Cancer ◽  
Drug Designing ◽  
Current Scenario ◽  
Molecular Modeling Studies

Worldwide, colorectal cancer takes up the third position in commonly detected cancer and fourth in cancer mortality. Recent progress in molecular modeling studies has led to significant success in drug discovery using structure and ligand-based methods. This study highlights aspects of the anticancer drug design. The structure and ligand-based drug design are discussed to investigate the molecular and quantum mechanics in anti-cancer drugs. Recent advances in anticancer agent identification driven by structural and molecular insights are presented. As a result, the recent advances in the field and the current scenario in drug designing of cancer drugs are discussed. This review provides information on how cancer drugs were formulated and identified using computational power by the drug discovery society.

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