Application of twin screw extrusion to the manufacture of cocrystals: scale-up of AMG 517–sorbic acid cocrystal production
Keyword(s):
Scale Up
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The application of twin screw extrusion (TSE) in the scale-up of cocrystal production was investigated by using AMG 517–sorbic acid as a model system. Extrusion parameters that influenced conversion to the cocrystal such as temperature, feed rate and screw speed were investigated. Extent of conversion to the cocrystal was found to have a strong dependence on temperature and a moderate dependence on feed rate and screw speed. Cocrystals made by the TSE process were found to have superior mechanical properties than solution grown cocrystals. Additionally, moving to a TSE process eliminated the need for solvent.
1997 ◽
Vol 32
(3)
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pp. 251-267
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1986 ◽
Vol 6
(2)
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pp. 225-231
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Keyword(s):
1994 ◽
Vol 54
(12)
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pp. 1855-1861
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Keyword(s):