On-demand generation of singlet oxygen from a smart graphene complex for the photodynamic treatment of cancer cells

2014 ◽  
Vol 2 (10) ◽  
pp. 1412-1418 ◽  
Author(s):  
Liang Yan ◽  
Ya-Nan Chang ◽  
Wenyan Yin ◽  
Gan Tian ◽  
Liangjun Zhou ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Photodynamic Treatment ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
On Demand

We engineered a novel nanocomplex of a photosensitizer, an aptamer and graphene oxide, which could function as a “cage” for controlling singlet oxygen generation, and efficiently deliver the photosensitizers to cancer cells.

scholarly journals Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two trans coordination sites

2016 ◽  
Vol 7 (8) ◽  
pp. 4922-4929 ◽  
Author(s):  
V. H. S. van Rixel ◽  
B. Siewert ◽  
S. L. Hopkins ◽  
S. H. C. Askes ◽  
A. Busemann ◽  
...  
Keyword(s):  
Cell Death ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Green Light ◽  
Oxygen Generation ◽  
Light Cell ◽  
Singlet Oxygen Generation ◽  
Coordination Sites ◽  
Induced Apoptosis ◽  
Apoptosis In Cancer Cells

In this work, two new photopharmacological ruthenium prodrugs are described that can be activated by green light. Cell death occurs via apoptosis; it is not a consequence of singlet oxygen generation, but of light-induced photosubstitution reactions.

Absorption-dependent generation of singlet oxygen from gold bipyramids excited under low power density

RSC Advances ◽  
2015 ◽  
Vol 5 (100) ◽  
pp. 81897-81904 ◽  
Author(s):  
Junliang Lv ◽  
Xin Zhang ◽  
Nana Li ◽  
Baoju Wang ◽  
Sailing He
Keyword(s):  
Photodynamic Therapy ◽  
Low Power ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Power Density ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Photodynamic Therapy Of Cancer

Gold bipyramid-mediated singlet oxygen generation for photodynamic therapy of cancer cells in the optical biological window.

scholarly journals A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

2016 ◽  
Vol 7 (3) ◽  
pp. 1862-1866 ◽  
Author(s):  
Youyong Yuan ◽  
Chong-Jing Zhang ◽  
Shidang Xu ◽  
Bin Liu
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Oxygen Sensor ◽  
Aggregation Induced Emission ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.

scholarly journals A multifunctional nanoprobe for targeting tumors and mitochondria with singlet oxygen generation and monitoring mitochondrion pH changes in cancer cells by ratiometric fluorescence imaging

2020 ◽  
Vol 11 (14) ◽  
pp. 3636-3643 ◽  
Author(s):  
Jingjin Zhao ◽  
Mengbing Zou ◽  
Mengjiao Huang ◽  
Liangliang Zhang ◽  
Keqin Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Ratiometric Fluorescence ◽  
Oxygen Generation ◽  
Ph Changes ◽  
Singlet Oxygen Generation ◽  
Multifunctional Nanoprobe

A multifunctional nanoprobe with singlet oxygen generation that can target tumors and mitochondria was developed for photodynamic therapy of tumors and monitoring mitochondrion pH changes in cancer cells by ratiometric fluorescence imaging.

WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells

Nanoscale ◽  
2014 ◽  
Vol 6 (17) ◽  
pp. 10394-10403 ◽  
Author(s):  
Yuan Yong ◽  
Liangjun Zhou ◽  
Zhanjun Gu ◽  
Liang Yan ◽  
Gan Tian ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Large Scale ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

We have developed a facile strategy to fabricate WS2 nanosheets in a large scale that could not only efficiently load photosensitizers but also regulate their singlet-oxygen generation by NIR irradiation.

Graphene oxide functionalized with methylene blue and its performance in singlet oxygen generation

2013 ◽  
Vol 48 (7) ◽  
pp. 2636-2639 ◽  
Author(s):  
M. Wojtoniszak ◽  
D. Rogińska ◽  
B. Machaliński ◽  
M. Drozdzik ◽  
E. Mijowska
Keyword(s):  
Methylene Blue ◽  
Graphene Oxide ◽  
Singlet Oxygen ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Enhanced singlet oxygen generation of a soft salt through efficient energy transfer between two ionic metal complexes

2018 ◽  
Vol 47 (16) ◽  
pp. 5582-5588 ◽  
Author(s):  
Yun Ma ◽  
Shujun Zhang ◽  
Huanjie Wei ◽  
Yafang Dong ◽  
Liang Shen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Energy Transfer ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Efficient Energy Transfer ◽  
Oxygen Generation ◽  
Efficient Energy ◽  
Singlet Oxygen Generation ◽  
Photodynamic Therapy Of Cancer ◽  
First Time

A novel soft salt based photosensitizer was successfully developed for application in photodynamic therapy of cancer cells for the first time.

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