Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

Compendium of Conventional and Targeted Drug Delivery Formulation Used for the Treatment and Management of the Wound Healing

2021 ◽  
Vol 18 ◽  
Author(s):  
Ajay Singh ◽  
Zeba Maqsood ◽  
Mohammad Kashif Iqubal ◽  
Javed Ali ◽  
Sanjula Baboota
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Healing Process ◽  
Wound Healing Process ◽  
Combination Drug ◽  
Delayed Wound Healing ◽  
Accelerate Wound Healing ◽  
Synthetic Drugs ◽  
Normal Wound Healing

: Wound healing is a complex and dynamic phenomenon that involves the restoration of normal physiology and functioning of injured tissue. The process of wound healing is primarily regulated by various cytokines, inflammatory mediators, and growth factors at the molecular level. Any intervention in the normal wound healing process leads to further tissue damage, which in turn leads to delayed wound healing. Several natural, synthetic drugs and their combinations were used to restored and accelerate the wound healing process. However, the conventional delivery carriers were not much effective, and thus, nowadays, nanocarriers are gaining much popularity since they are playing a pivotal role in drug delivery. Since nanocarriers have their own applicability and benefits (enhance the bioavailability, site-specific targeting) so, they can accelerate wound healing more efficiently. This review briefly discussed about the various events that take place during the wound healing process with emphasis on various natural, synthetic, and combination drug therapy used for accelerating wound healing and the role of nanotechnology-based approaches in chronic wound healing.

scholarly journals Multi-Functional Core-Shell Nanofibers for Wound Healing

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1546
Author(s):  
Zhen Li ◽  
Shunqi Mei ◽  
Yajie Dong ◽  
Fenghua She ◽  
Puwang Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Drug Release ◽  
Release Rate ◽  
Healing Process ◽  
Wound Healing Process ◽  
Core Shell ◽  
High Production Rate ◽  
Centrifugal Spinning ◽  
Multiple Drugs

Core-shell nanofibers have great potential for bio-medical applications such as wound healing dressings where multiple drugs and growth factors are expected to be delivered at different healing phases. Compared to monoaxial nanofibers, core-shell nanofibers can control the drug release profile easier, providing sustainable and effective drugs and growth factors for wound healing. However, it is challenging to produce core-shell structured nanofibers with a high production rate at low energy consumption. Co-axial centrifugal spinning is an alternative method to address the above limitations to produce core-shell nanofibers effectively. In this study, a co-axial centrifugal spinning device was designed and assembled to produce core-shell nanofibers for controlling the release rate of ibuprofen and hEGF in inflammation and proliferation phases during the wound healing process. Core-shell structured nanofibers were confirmed by TEM. This work demonstrated that the co-axial centrifugal spinning is a high productivity process that can produce materials with a 3D environment mimicking natural tissue scaffold, and the specific drug can be loaded into different layers to control the drug release rate to improve the drug efficiency and promote wound healing.

Alginate hydrogel enriched with Ambystoma mexicanum epidermal lipoxygenase-loaded pectin nanoparticles for enhanced wound healing

2019 ◽  
Vol 34 (8) ◽  
pp. 1171-1187
Author(s):  
Farnoush Oveissi ◽  
Naser Tavakoli ◽  
Mohsen Minaiyan ◽  
Mohammad Reza Mofid ◽  
Azade Taheri
Keyword(s):  
Wound Healing ◽  
Wound Closure ◽  
Healing Process ◽  
Ambystoma Mexicanum ◽  
Wound Healing Process ◽  
Clinical Use ◽  
Sustained Delivery ◽  
Alginate Hydrogel ◽  
Wound Site ◽  
Minimal Scarring

Epidermal lipoxygenase enzyme extracted from Ambystoma mexicanum (AmbLOXe) is known to accelerate the wound-healing process. AmbLOXe as a protein suffers from inactivation and losing its activity during formulation. Therefore, a delivery system that protects AmbLOXe from inactivation and preserves its activity is needed. We prepared AmbLOXe-loaded pectin nanoparticles (AmbLOXe Pec-NPs) and placed them into an alginate hydrogel. AmbLOXe Pec-NPs incorporation into the alginate hydrogel provides a means for controlled and sustained delivery of AmbLOXe to the wound site. Furthermore, the suitable swelling behavior and mechanical properties of AmbLOXe Pec-NPs alginate hydrogel make it feasible for clinical use. AmbLOXe Pec-NPs alginate hydrogel significantly enhanced the wound-healing process on the rat full-thickness excisional wounds, increased the rate of wound closure, enhanced the re-epithelialization and decreased the incidence of abnormal scarring. AmbLOXe Pec-NPs alginate hydrogel can be proposed as an effective wound hydrogel for improving wound healing with minimal scarring.

Applications of Nanoemulsion for the Wound-Healing Process

2022 ◽  
pp. 466-493
Author(s):  
S. M. Shaheedha
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Tumor Microenvironment ◽  
Healing Process ◽  
Wound Healing Process ◽  
Liquid Matrix ◽  
Physical Methods ◽  
Micro Emulsion ◽  
Chronic Injuries ◽  
Nano Emulsion

Attention to nanoemulsions has significantly grown in recent years as a result of their unique features like better stability, special appearance, higher performance, and sensorial merits. Chronic injuries are the consequence of a disturbance in the extremely coordinated cataract of wound healing actions. Nevertheless, correlated with variations in the timescales of various physical methods embroiled in tissue renewal, the aggression of the tumor microenvironment, rich in decaying enzymes, as well as its increased pH, demands the use of efficient drug delivery applications. This chapter summarizes that the various stages of wound healing include four phases: hemostatic stage, inflammation, proliferation, and remodeling process, respectively. Moreover, the major reported classes of lipid-based elements were either vesicular (liposome, permeation increased vesicle, etc.), emulsion-based behavior (nano-emulsion and micro-emulsion), or comprise a solid-based liquid matrix in the wound-healing process.

The Influence of Photodynamic Therapy on the Wound Healing Process in Rats

2001 ◽  
Vol 15 (3) ◽  
pp. 176-186 ◽  
Author(s):  
R. S. Jayasree ◽  
A. K. Gupta ◽  
K. Rathinam ◽  
P. V. Mohanan ◽  
M. Mohanty
Keyword(s):  
Wound Healing ◽  
Photodynamic Therapy ◽  
Healing Process ◽  
Wound Healing Process

scholarly journals The emerging roles of neutrophil extracellular traps in wound healing

2021 ◽  
Vol 12 (11) ◽  
Author(s):  
Shuainan Zhu ◽  
Ying Yu ◽  
Yun Ren ◽  
Liying Xu ◽  
Huilin Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Neutrophil Extracellular Traps ◽  
Neutrophil Extracellular Trap ◽  
Wound Healing Process ◽  
Loss Of Function ◽  
Delayed Wound Healing ◽  
Wound Site ◽  
Extracellular Traps ◽  
Extracellular Trap

AbstractDelayed wound healing causes problems for many patients both physically and psychologically, contributing to pain, economic burden, loss of function, and even amputation. Although many factors affect the wound healing process, abnormally prolonged or augmented inflammation in the wound site is a common cause of poor wound healing. Excessive neutrophil extracellular trap (NET) formation during this phase may amplify inflammation and hinder wound healing. However, the roles of NETs in wound healing are still unclear. Herein, we briefly introduce NET formation and discuss the possible NET-related mechanisms in wound healing. We conclude with a discussion of current studies, focusing on the roles of NETs in diabetic and normoglycemic wounds and the effectiveness of NET-targeting treatments in wound healing.

scholarly journals Development and use of biomaterials as wound healing therapies

2019 ◽  
Vol 7 ◽  
Author(s):  
Rachael Zoe Murray ◽  
Zoe Elizabeth West ◽  
Allison June Cowin ◽  
Brooke Louise Farrugia
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Skin Substitutes ◽  
Vast Number ◽  
Recent Advances ◽  
Future Direction

Abstract There is a vast number of treatments on the market for the management of wounds and burns, representing a multi-billion dollar industry worldwide. These include conventional wound dressings, dressings that incorporate growth factors to stimulate and facilitate the wound healing process, and skin substitutes that incorporate patient-derived cells. This article will review the more established, and the recent advances in the use of biomaterials for wound healing therapies, and their future direction.

scholarly journals TERAPI LARVA PADA LUKA KRONIS TERBUKA

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Sunny Wangko
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Chronic Wound ◽  
Healing Process ◽  
Bioactive Molecules ◽  
Wound Management ◽  
Wound Healing Process ◽  
Beneficial Effects ◽  
Infected Wounds ◽  
Larval Therapy

Abstract: The usage of larvae in wound treatment has been known across the centuries in different countries. However, larval therapy is offered when the conventional therapy has failed in the management of chronic, infected wounds. Concerning the larval therapy, it was presumed that the wound healing was due to the mechanical debridement effect of the larval movement and of their hooks. To date, a variety of study reports reveals that there are several beneficial effects of the larval therapy, inter alia: secretion/excretion of larvae contains enzymes, growth factors, and cytokines that collaborate in the wound healing process. The bioactive molecules in the secretion/excretion of the larvae has to be further studied and to be developed, therefore, they can be applied in the wound management efficiently and economically. Keywords: larval therapy, chronic wound, healing process.     Abstrak: Walaupun pemanfaatan larva pada luka kronis telah sangat lama dikenal di berbagai negara, terapi larva umumnya digunakan bila terapi konvensional telah gagal. Awalnya diduga bahwa efek debridemen mekanis oleh gerakan larva dan kaitnya yang paling berperan. Dewasa ini, laporan berbagi studi telah mengungkapkan bahwa larva menyekresi dan menyintesis berbagai bahan baik berupa enzim, sitokin, dan growth factors yang turut berperan dalam proses penyembuhan luka. Adanya molekul bioaktif dalam ekskresi dan sekresi larva perlu diteliti dan dikembangkan agar dapat diaplikasikan dengan lebih efisien dan ekonomis. Kata kunci: terapi larva, luka kronis, penyembuhan luka.

scholarly journals Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

2021 ◽  
Vol 22 (17) ◽  
pp. 9512
Author(s):  
Daniela Miricescu ◽  
Silviu Constantin Badoiu ◽  
Iulia-Ioana Stanescu-Spinu ◽  
Alexandra Ripszky Totan ◽  
Constantin Stefani ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Healing ◽  
Growth Factors ◽  
Healing Process ◽  
Reactive Oxygen ◽  
Burn Injuries ◽  
Wound Healing Process ◽  
Oxygen Species ◽  
Clotting Factors ◽  
Major Health Problem

Burns can be caused by various factors and have an increased risk of infection that can seriously delay the wound healing process. Chronic wounds caused by burns represent a major health problem. Wound healing is a complex process, orchestrated by cytokines, growth factors, prostaglandins, free radicals, clotting factors, and nitric oxide. Growth factors released during this process are involved in cell growth, proliferation, migration, and differentiation. Reactive oxygen species are released in acute and chronic burn injuries and play key roles in healing and regeneration. The main aim of this review is to present the roles of growth factors, reactive oxygen species, and metformin in the healing process of burn injuries.

scholarly journals PHOTODYNAMIC THERAPY EFFECTS ON MICROFLORA IN THE TREATMENT OF PURULATORY-NECROTIC PROCESSES OF SOFT TISSUES (CLINICAL AND EXPERIMENTAL WORK)

2020 ◽  
pp. 26-29
Author(s):  
Y. D. Khvorostov ◽  
S. O. Morozov ◽  
H. M. Herasymov ◽  
V. V. Derikolenko ◽  
S. S. Solodovidchenko
Keyword(s):  
Wound Healing ◽  
Photodynamic Therapy ◽  
Experimental Work ◽  
Soft Tissues ◽  
Healing Process ◽  
Wound Healing Process ◽  
Complex Treatment ◽  
Bacterial Composition ◽  
Purulent Wounds ◽  
Treatment Of Wounds

Summary. The effect of PDT on the wound healing process and the Bacterial composition of wounds has not been fully studied. Material and methods. The effects of PDT of various wavelengths on the most common microflora of purulent wounds and the course of the wound process are investigated. Results and discussion. The application of PDT increased the sensitivity of microflora to ABD, and also stimulated reparative processes — the growth of granulation tissue and marginal epithelization. Conclusions. The application of PDT in the complex treatment of wounds favorably affects wound healing, expanding the possibilities of AB therapy

Sign in / Sign up

Export Citation Format

Share Document