A novel graphene oxide based fluorescent nanosensing strategy with hybridization chain reaction signal amplification for highly sensitive biothiol detection

2014 ◽  
Vol 50 (80) ◽  
pp. 11879-11882 ◽  
Author(s):  
Jia Ge ◽  
Zhi-Mei Huang ◽  
Qiang Xi ◽  
Ru-Qin Yu ◽  
Jian-Hui Jiang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Fluorescence Quenching ◽  
Signal Amplification ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Highly Sensitive

A novel fluorescent nanosensor was developed for detecting biothiols via coupling graphene based fluorescence quenching with T–Hg(ii)–T controlled hybridization chain reaction.

A highly sensitive strategy for base excision repair enzyme activity detection based on graphene oxide mediated fluorescence quenching and hybridization chain reaction

The Analyst ◽  
2016 ◽  
Vol 141 (1) ◽  
pp. 96-99 ◽  
Author(s):  
Qiang Xi ◽  
Jun-Jie Li ◽  
Wen-Fang Du ◽  
Ru-Qin Yu ◽  
Jian-Hui Jiang
Keyword(s):  
Enzyme Activity ◽  
Fluorescence Quenching ◽  
Base Excision Repair ◽  
Excision Repair ◽  
Hybridization Chain Reaction ◽  
Activity Detection ◽  
Chain Reaction ◽  
Repair Enzyme ◽  
Highly Sensitive ◽  
Base Excision

We report a highly sensitive strategy for UDG activity detection by combining HCR amplification and a GO-based fluorescence quenching platform.

Dual signal-amplification electrochemical detection of DNA sequence based on molybdenum selenide nanorod and hybridization chain reaction

2016 ◽  
Vol 8 (26) ◽  
pp. 5234-5241 ◽  
Author(s):  
Liu Yang ◽  
Yanfu Li
Keyword(s):  
Dna Sequences ◽  
Signal Amplification ◽  
Hybridization Chain Reaction ◽  
Chain Reaction ◽  
Molybdenum Selenide ◽  
Highly Sensitive ◽  
Immunodeficiency Virus ◽  
Highly Sensitive Detection ◽  
Dual Signal Amplification

A new electrochemical biosensor based on the hybridization chain reaction and layered molybdenum selenide (MoSe2) stacked nanorod for dual-signal amplification is developed for the highly sensitive detection of the DNA sequences of Human Immunodeficiency Virus type 1 (HIV-1).

Ribonuclease H Enzyme Activity Detection Based on Hybridization Chain Reaction Amplification and Graphene Oxide Nanosheets Fluorescence Quenching

2020 ◽  
Vol 20 (3) ◽  
pp. 1409-1416
Author(s):  
Cun Liu ◽  
Ying Tang ◽  
Yao Chen ◽  
Jing Deng ◽  
Wen Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Fluorescence Quenching ◽  
Rnase H ◽  
Ribonuclease H ◽  
Hybridization Chain Reaction ◽  
Activity Detection ◽  
Chain Reaction ◽  
Replication Process ◽  
Hiv Virus ◽  
Aids Drugs

Ribonuclease H (RNase H) plays key roles in HIV virus replication process and can be used as an important target for anti-AIDS drugs screening. Therefore, we constructed a fluorescent nanosensor based on signal amplification of hybridization chain reaction (HCR) and fluorescence quenching of graphene oxide (GO) nanosheets. The nanosensor provided highly sensitive and selective platform for RNase H activity detection. This method also exhibited a good linear relationship in the range of 0.001–5 U/mL, and the detection limit was 0.0007 U/mL. Our results suggested that the developed system is a promising platform for monitoring the RNase H activity, showing great potential in the biomedical studies and drugs screening.

Netlike hybridization chain reaction assembly of DNA nanostructures enables exceptional signal amplification for sensing trace cytokines

Nanoscale ◽  
2019 ◽  
Vol 11 (35) ◽  
pp. 16362-16367 ◽  
Author(s):  
Yao Qin ◽  
Daxiu Li ◽  
Ruo Yuan ◽  
Yun Xiang
Keyword(s):  
Signal Amplification ◽  
Sensitive Detection ◽  
Hybridization Chain Reaction ◽  
Dna Nanostructures ◽  
Chain Reaction ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Target-induced assembly formation of netlike DNA nanostructures leads to highly sensitive detection of cytokines.

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