Simultaneous colorimetric detection of four drugs in their pharmaceutical formulations using unmodified gold nanoparticles as a probe

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 19924-19932 ◽  
Author(s):  
Karuna A. Rawat ◽  
Hirakendu Basu ◽  
Rakesh Kumar Singhal ◽  
Suresh Kumar Kailasa

Schematic representation for the aggregation of unmodified Au NPs induced by four drugs (venlafaxine, imipramine, amlodipine, and alfuzosin).

2020 ◽  
Vol 44 (6) ◽  
pp. 2241-2246
Author(s):  
Jiaoyan Qiu ◽  
Ling Fu ◽  
Hongsen Wang ◽  
Ruifen Zou ◽  
Yujie Zhang ◽  
...  

A colorimetric method for the detection of Cs+ using Au NPs and Prussian blue based on a nonmorphological transition mechanism.


2014 ◽  
Vol 6 (7) ◽  
pp. 2031-2033 ◽  
Author(s):  
Li-Qing Zheng ◽  
Xiao-Dong Yu ◽  
Jing-Juan Xu ◽  
Hong-Yuan Chen

Based on the hydrophobic effect inducing the aggregation of Au NPs, a rapid and low-cost colorimetric method for detection of quaternary ammonium surfactants using citrate-stabilized AuNPs was developed.


RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 39182-39191 ◽  
Author(s):  
Betha Saineelima B. Kasibabu ◽  
Jigna R. Bhamore ◽  
Stephanie L. D'souza ◽  
Suresh Kumar Kailasa

A schematic representation of the mechanism for the colorimetric sensing of Cys and Lys using DIC–Au NPs as a probe.


RSC Advances ◽  
2015 ◽  
Vol 5 (6) ◽  
pp. 4245-4255 ◽  
Author(s):  
Vaibhavkumar N. Mehta ◽  
Suresh Kumar Kailasa

In this study, a colorimetric probe was developed based on malonamide dithiocarbamate functionalized gold nanoparticles (MA–DTC–Au NPs) for the simultaneous colorimetric detection of Cu2+ and Hg2+ ions.


RSC Advances ◽  
2015 ◽  
Vol 5 (42) ◽  
pp. 33468-33477 ◽  
Author(s):  
Vaibhavkumar N. Mehta ◽  
Rakesh Kumar Singhal ◽  
Suresh Kumar Kailasa

Schematic representation for the colorimetric sensing of Al3+ion using PCA-DTC-Au NPs as a probe.


2021 ◽  
Vol 8 (5) ◽  
pp. 210185
Author(s):  
Daim Asif Raja ◽  
Fazeelah Munir ◽  
Muhammad Raza Shah ◽  
Muhammad Iqbal Bhanger ◽  
Muhammad Imran Malik

The development of metal nanoparticle-based facile colorimetric assays for drugs and insecticides is an emerging area of current scientific research. In the present work, polypropylene glycol was used for stabilization of gold nanoparticles (AuNPs) in a simple one-pot two-phase process and subsequently employed it for the specific detection of cephradine (CPH). The characterization of the prepared PPG-AuNPs was conducted through various analytical techniques such as UV-visible spectrophotometry, Fourier transform infrared spectroscopy, atomic force microscopy (AFM), zeta potential and zetasizer techniques. As the major target of the study, the stabilized PPG-AuNPs were employed for colorimetric detection of CPH and other drugs. Typical wine-red colour of PPG-AuNPs disappeared immediately and surface plasmon resonance band quenched by addition of CPH in the presence of several other interferents (drugs and salts) and in real samples. PPG-AuNPs permitted efficient, selective, reliable and rapid determination in a concentration range of 0.01–120 mM with a detection limit (LoD) of 11.0 mM. The developed sensor has the potential to be used for fast scanning of pharmaceutical formulations for quantification of CPH at production facilities.


2014 ◽  
Vol 6 (22) ◽  
pp. 9007-9014 ◽  
Author(s):  
Stephanie L. D'souza ◽  
Ranjan Kumar Pati ◽  
Suresh Kumar Kailasa

Schematic representation of the analytical process for detecting dichlorvos using AA–Au NPs as a colorimetric probe.


2018 ◽  
Vol 8 (12) ◽  
pp. 2589 ◽  
Author(s):  
Hasan Aldewachi ◽  
Nicola Woodroofe ◽  
Philip Gardiner

In this report, we investigated three stabilization strategies of gold nanoparticles and their practical application for the visual detection of dipeptidyl peptidase IV (DPP-IV). Citrate-capped gold nanoparticles (Au NPs) are generally unstable in high-ionic-strength samples. Au NPs are easily tagged with various proteins and biomolecules rich in amino acids, leading to important biomedical applications including targeted drug delivery, cellular imaging, and biosensing. The investigated assays were based on different modes of stabilization, such as the incorporation of polyethylene glycol (PEG) groups, stabilizer peptide, and bifunctionalization. Although all approaches provided highly stable Au NP platforms demonstrated by zeta potential measurements and resistance to aggregation in a high-ionic-strength saline solution, we found that the Au NPs modified with a separate stabilizer ligand provided the highest stability and was the only platform that demonstrated sensitivity to the addition of DPP-IV, whilst PEGylated and peptide-stabilized Au NPs showed no significant response.


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