A core/shell/satellite anticancer platform for 808 NIR light-driven multimodal imaging and combined chemo-/photothermal therapy

Nanoscale ◽  
2015 ◽  
Vol 7 (32) ◽  
pp. 13747-13758 ◽  
Author(s):  
Guixin Yang ◽  
Ruichan Lv ◽  
Fei He ◽  
Fengyu Qu ◽  
Shili Gai ◽  
...  
Keyword(s):  
Light Source ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Near Infrared ◽  
Core Shell ◽  
Nir Light ◽  
Anti Cancer

A novel core/shell/satellite anti-cancer nanoplatform exhibits simultaneous multimodal imaging and synergistic chemo- and photothermal therapy when irradiated by a single 808 nm near infrared (NIR) light source.

scholarly journals Photothermal Therapy Using Gold Nanorods and Near-Infrared Light in a Murine Melanoma Model Increases Survival and Decreases Tumor Volume

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Mary K. Popp ◽  
Imane Oubou ◽  
Colin Shepherd ◽  
Zachary Nager ◽  
Courtney Anderson ◽  
...  
Keyword(s):  
Light Source ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Tumor Volume ◽  
Infrared Light ◽  
Led Light ◽  
Murine Melanoma ◽  
Nir Light ◽  
Melanoma Model

Photothermal therapy (PTT) treatments have shown strong potential in treating tumors through their ability to target destructive heat preferentially to tumor regions. In this paper we demonstrate that PTT in a murine melanoma model using gold nanorods (GNRs) and near-infrared (NIR) light decreases tumor volume and increases animal survival to an extent that is comparable to the current generation of melanoma drugs. GNRs, in particular, have shown a strong ability to reach ablative temperatures quickly in tumors when exposed to NIR light. The current research tests the efficacy of GNRs PTT in a difficult and fast growing murine melanoma model using a NIR light-emitting diode (LED) light source. LED light sources in the NIR spectrum could provide a safer and more practical approach to photothermal therapy than lasers. We also show that the LED light source can effectively and quickly heatin vitroandin vivomodels to ablative temperatures when combined with GNRs. We anticipate that this approach could have significant implications for human cancer therapy.

Cu2−xSe@mSiO2–PEG core–shell nanoparticles: a low-toxic and efficient difunctional nanoplatform for chemo-photothermal therapy under near infrared light radiation with a safe power density

Nanoscale ◽  
2014 ◽  
Vol 6 (8) ◽  
pp. 4361-4370 ◽  
Author(s):  
Xijian Liu ◽  
Qian Wang ◽  
Chun Li ◽  
Rujia Zou ◽  
Bo Li ◽  
...  
Keyword(s):  
Power Density ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Core Shell ◽  
Light Radiation ◽  
Shell Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Core Shell Nanoparticles

A difunctional nanoplatform based on the Cu2−xSe@mSiO2–PEG core–shell nanoparticles demonstrates an excellent biocompatibility and can be used for combining photothermal- and chemotherapies driven by NIR light.

Multimodal imaging and photothermal therapy were simultaneously achieved in the core–shell UCNR structure by using single near-infrared light

2017 ◽  
Vol 46 (36) ◽  
pp. 12147-12157 ◽  
Author(s):  
Chen Wang ◽  
Liangge Xu ◽  
Jiating Xu ◽  
Dan Yang ◽  
Bin Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Near Infrared ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Core Shell ◽  
Imaging Diagnosis ◽  
The Core ◽  
Shell Nanostructures ◽  
Bio Imaging

Core–shell nanostructures consisting of plasmonic materials and lanthanide-doped upconversion nanoparticles (UCNPs) show promising applications in theranostics including bio-imaging, diagnosis and therapy.

Bi19S27I3 nanorods: a new candidate for photothermal therapy in the first and second biological near-infrared windows

Nanoscale ◽  
2021 ◽  
Author(s):  
Jinsong Xiong ◽  
Qinghuan Bian ◽  
Shuijin Lei ◽  
Yatian Deng ◽  
Kehan Zhao ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Research Interest ◽  
The Past ◽  
Nir Light ◽  
Considerable Research ◽  
Key Factor

Near-infrared (NIR) light induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in the photothermal therapy...

scholarly journals Near-Infrared-Triggered Upconverting Nanoparticles for Biomedicine Applications

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 756
Author(s):  
Manoj Kumar Mahata ◽  
Ranjit De ◽  
Kang Taek Lee
Keyword(s):  
Drug Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cutting Edge ◽  
Clinical Translation ◽  
Basic Knowledge ◽  
Nanotechnology Research ◽  
Nir Light

Due to the unique properties of lanthanide-doped upconverting nanoparticles (UCNP) under near-infrared (NIR) light, the last decade has shown a sharp progress in their biomedicine applications. Advances in the techniques for polymer, dye, and bio-molecule conjugation on the surface of the nanoparticles has further expanded their dynamic opportunities for optogenetics, oncotherapy and bioimaging. In this account, considering the primary benefits such as the absence of photobleaching, photoblinking, and autofluorescence of UCNPs not only facilitate the construction of accurate, sensitive and multifunctional nanoprobes, but also improve therapeutic and diagnostic results. We introduce, with the basic knowledge of upconversion, unique properties of UCNPs and the mechanisms involved in photon upconversion and discuss how UCNPs can be implemented in biological practices. In this focused review, we categorize the applications of UCNP-based various strategies into the following domains: neuromodulation, immunotherapy, drug delivery, photodynamic and photothermal therapy, bioimaging and biosensing. Herein, we also discuss the current emerging bioapplications with cutting edge nano-/biointerfacing of UCNPs. Finally, this review provides concluding remarks on future opportunities and challenges on clinical translation of UCNPs-based nanotechnology research.

Design of Gold Hollow Nanorods with Controllable Aspect Ratio for Multimodal Imaging and Combined Chemo-Photothermal Therapy in the Second Near-Infrared Window

2018 ◽  
Vol 10 (43) ◽  
pp. 36703-36710 ◽  
Author(s):  
Kai Cai ◽  
Weiyun Zhang ◽  
Jin Zhang ◽  
Huiqiao Li ◽  
Heyou Han ◽  
...  
Keyword(s):  
Aspect Ratio ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Near Infrared ◽  
Infrared Window

Theranostic Nanomedicine Carrying L‐Menthol and Near‐Infrared Dye for Multimodal Imaging‐Guided Photothermal Therapy of Cancer

2019 ◽  
Vol 8 (16) ◽  
pp. 1900409 ◽  
Author(s):  
Chunyang Zhang ◽  
Jie Liu ◽  
Huanling Guo ◽  
Wei Wang ◽  
Ming Xu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
Near Infrared ◽  
Near Infrared Dye

A Near-Infrared Small Molecule Coupled with Rigidness and Flexibility for High-Performance Multimodal Imaging-Guided Photodynamic and Photothermal Synergistic Therapy

2021 ◽  
Author(s):  
Xiaozhen Li ◽  
Fang Fang ◽  
Bo Sun ◽  
Chao YIN ◽  
Jihua Tan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Application ◽  
Small Molecule ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
High Performance ◽  
Near Infrared ◽  
The Other ◽  
Lesion Site ◽  
Comprehensive Information

Photodynamic therapy (PDT) synergized photothermal therapy (PTT) shows superior clinical application prospect than single PDT or PTT. On the other hand, multimodal imaging can delineate comprehensive information of lesion site...

CuS@mSiO2-PEG core–shell nanoparticles as a NIR light responsive drug delivery nanoplatform for efficient chemo-photothermal therapy

2015 ◽  
Vol 44 (22) ◽  
pp. 10343-10351 ◽  
Author(s):  
Xijian Liu ◽  
Qilong Ren ◽  
Fanfan Fu ◽  
Rujia Zou ◽  
Qian Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photothermal Therapy ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Nir Light ◽  
Core Shell Nanoparticles

A difunctional nanoplatform (CuS@mSiO2-PEG) acted as a NIR light induced photothermal-triggered drug delivery system for efficient chemo-photothermal therapy.

scholarly journals Core-Shell Structures of Upconversion Nanocrystals Coated with Silica for Near Infrared Light Enabled Optical Imaging of Cancer Cells

Micromachines ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 400 ◽  
Author(s):  
Kumbam Lingeshwar Reddy ◽  
Neeraj Prabhakar ◽  
Jessica Rosenholm ◽  
Venkata Krishnan
Keyword(s):  
Optical Imaging ◽  
Cancer Cells ◽  
Near Infrared ◽  
Shell Structures ◽  
Therapeutic Window ◽  
Luminescence Spectroscopy ◽  
Core Shell ◽  
Shell Nanostructures ◽  
Nir Light ◽  
Upconversion Nanocrystals

Optical imaging of cancer cells using near infrared (NIR) light is currently an active area of research, as this spectral region directly corresponds to the therapeutic window of biological tissues. Upconversion nanocrystals are photostable alternatives to conventional fluorophores. In our work, we have prepared upconversion nanocrystals of NaYF4:Yb/Er and encapsulated them in silica to form core-shell structures. The as-prepared core-shell nanostructures have been characterized for their structure, morphology, and optical properties using X-ray diffraction, transmission electron microscopy coupled with elemental mapping, and upconversion luminescence spectroscopy, respectively. The cytotoxicity examined using cell viability assay indicated a low level of toxicity of these core-shell nanostructures. Finally, these core-shell nanostructures have been utilized as photostable probes for NIR light enabled optical imaging of human breast cancer cells. This work paves the way for the development of advanced photostable, biocompatible, low-toxic core-shell nanostructures for potential optical imaging of biological cells and tissues.

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