Sonochemical synthesis of hydroxyapatite nanoflowers using creatine phosphate disodium salt as an organic phosphorus source and their application in protein adsorption

RSC Advances ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 9686-9692 ◽  
Author(s):  
Chao Qi ◽  
Ying-Jie Zhu ◽  
Cheng-Tie Wu ◽  
Tuan-Wei Sun ◽  
Ying-Ying Jiang ◽  
...  

Hydroxyapatite nanosheets-assembled nanoflowers are sonochemically synthesized using creatine phosphate, which have excellent cytocompatibility and relatively high protein adsorption ability.

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14906-14915 ◽  
Author(s):  
Chao Qi ◽  
Ying-Jie Zhu ◽  
Bing-Qiang Lu ◽  
Jin Wu ◽  
Feng Chen

Amorphous magnesium phosphate flower-like hierarchical nanostructures are synthesized using fructose 1,6-bisphosphate trisodium salt by the microwave hydrothermal method.


2019 ◽  
Vol 96 ◽  
pp. 426-435 ◽  
Author(s):  
Lian-Hua Fu ◽  
Chao Qi ◽  
Yan-Ru Hu ◽  
Chang-Gen Mei ◽  
Ming-Guo Ma

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Ryoji Sawada ◽  
Yuya Katou ◽  
Hirofumi Shibata ◽  
Max Katayama ◽  
Toru Nonami

Titanium-based materials are widely used for implant treatments such as artificial dental roots. Surface treatment has the potential to improve not only the biocompatibility but also the chemical and mechanical durability of the surface without changing the mechanical properties of the metal. A relatively thick titanium oxide film can be formed by the anodic oxidation method. Phosphoric acid or sulfuric acid electrolytic solution has previously been used for anodic oxidation. Such anodized films have excellent film hardness, abrasion resistance, and adhesion. In this study, titanium plate was anodized using an aqueous solution of sulfuric acid in which titanium oxide powder was suspended. A 2800-nm-thick titanium oxide film was formed, which was thicker than that obtained using phosphoric acid electrolyte. The titanium plate was immersed in simulated body fluid for 1 day to evaluate the photocatalytic activity and protein adsorption ability, and a homogeneous crack-free hydroxyapatite layer was formed. This titanium plate showed high methylene blue bleaching capacity. The adsorption ability of the acidic protein of the anodized titanium plate subjected to the above treatment was high. This suggests that this titanium plate has antimicrobial properties and protein adsorption ability. Thus, we report that a titanium plate, anodized with a sulfuric acid aqueous electrolyte solution containing suspended TiO2 powder and immersed in simulated body fluid, might behave as an antibacterial and highly biocompatible implant material.


RSC Advances ◽  
2015 ◽  
Vol 5 (30) ◽  
pp. 23958-23964 ◽  
Author(s):  
Genxing Zhu ◽  
Yadong Hu ◽  
Yuling Yang ◽  
Ruibo Zhao ◽  
Ruikang Tang

Uniform β-tricalcium phosphate porous nanospheres with substructures are prepared by a solvothermal method using (CH3O)3PO as the organic phosphorus source and they demonstrate excellent biocompatibility.


2011 ◽  
Vol 9 (70) ◽  
pp. 918-927 ◽  
Author(s):  
Wing-Hin Lee ◽  
Ching-Yee Loo ◽  
Kim Linh Van ◽  
Alexander V. Zavgorodniy ◽  
Ramin Rohanizadeh

Hydroxyapatite (HA) is a material of choice for bone grafts owing to its chemical and structural similarities to the mineral phase of hard tissues. The combination of osteogenic proteins with HA materials that carry and deliver the proteins to the bone-defective areas will accelerate bone regeneration. The study investigated the treatment of HA particles with different amino acids such as serine (Ser), asparagine (Asn), aspartic acid (Asp) and arginine (Arg) to enhance the adsorption ability of HA carrier for delivering therapeutic proteins to the body. The crystallinity of HA reduced when amino acids were added during HA preparation. Depending on the types of amino acid, the specific surface area of the amino acid-functionalized HA particles varied from 105 to 149 m 2 g –1 . Bovine serum albumin (BSA) and lysozyme were used as model proteins for adsorption study. The protein adsorption onto the surface of amino acid-functionalized HA depended on the polarities of HA particles, whereby, compared with lysozyme, BSA demonstrated higher affinity towards positively charged Arg-HA. Alternatively, the binding affinity of lysozyme onto the negatively charged Asp-HA was higher when compared with BSA. The BSA and lysozyme adsorptions onto the amino acid-functionalized HA fitted better into the Freundlich than Langmuir model. The amino acid-functionalized HA particles that had higher protein adsorption demonstrated a lower protein-release rate.


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