Combinatorial targeting polymeric micelles for anti-tumor drug delivery

2015 ◽  
Vol 3 (19) ◽  
pp. 4043-4051 ◽  
Author(s):  
Saina Yang ◽  
Feiyan Zhu ◽  
Qian Wang ◽  
Fuxin Liang ◽  
Xiaozhong Qu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Polymeric Micelles ◽  
Tumor Ph ◽  
Tumor Drug Delivery ◽  
Targeting Ability

Polymeric micelles with combinatorial targeting ability for cancer cells was achieved by co-assembly of cRGD-PEO-b-PCL and tumor pHesensitive PEG-DOX.

scholarly journals Multifunctional exosome-mimetics for targeted anti-glioblastoma therapy by manipulating protein corona

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jun-Yong Wu ◽  
Yong-Jiang Li ◽  
Jiemin Wang ◽  
Xiong-Bin Hu ◽  
Si Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Serum Proteins ◽  
Protein Corona ◽  
Significant Inhibition ◽  
Brain Drug Delivery ◽  
New Strategy ◽  
Penetration Ability ◽  
Tumor Drug Delivery ◽  
Targeting Ability ◽  
Tumor Area

AbstractTargeted drug delivery to the glioblastoma (GBM) overcoming blood–brain barrier (BBB) has been challenging. Exosomes are promising vehicles for brain tumor drug delivery, but the production and purification hinder its application for nanomedicine. Besides, the formation of protein corona (PC) may affect the behaviour of nanocarriers. Here, multifunctional exosomes-mimetics (EM) are developed and decorated with angiopep-2 (Ang) for enhancing GBM drug delivery by manipulating PC. Docetaxel (DTX)-loaded EM with Ang modification (DTX@Ang-EM) show less absorption of serum proteins and phagocytosis by macrophages. Ang-EM show enhanced BBB penetration ability and targeting ability to the GBM. Ang-EM-mediated delivery increase the concentration of DTX in the tumor area. The multifunctional DTX@Ang-EM exhibits significant inhibition effects on orthotopic GBM growth with reduced side effects of the chemotherapeutic. Findings from this study indicate that the developed DTX@Ang-EM provide a new strategy for targeted brain drug delivery and GBM therapy. Graphical abstract

scholarly journals Active Targeted Nanoparticles for Delivery of Poly(ADP-ribose) Polymerase (PARP) Inhibitors: A Preliminary Review

2021 ◽  
Vol 22 (19) ◽  
pp. 10319
Author(s):  
Saman Sargazi ◽  
Mahwash Mukhtar ◽  
Abbas Rahdar ◽  
Mahmood Barani ◽  
Sadanad Pandey ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Dna Repair ◽  
Cancer Cells ◽  
Polymeric Micelles ◽  
Drug Carriers ◽  
Antioxidant Response ◽  
Parp Inhibitors ◽  
Preliminary Review ◽  
Repair Gene ◽  
Dna Repair Gene

Nanotechnology has revolutionized novel drug delivery strategies through establishing nanoscale drug carriers, such as niosomes, liposomes, nanomicelles, dendrimers, polymeric micelles, and nanoparticles (NPs). Owing to their desirable cancer-targeting efficacy and controlled release, these nanotherapeutic modalities are broadly used in clinics to improve the efficacy of small-molecule inhibitors. Poly(ADP-ribose) polymerase (PARP) family members engage in various intracellular processes, including DNA repair, gene transcription, signal transduction, cell cycle regulation, cell division, and antioxidant response. PARP inhibitors are synthetic small-molecules that have emerged as one of the most successful innovative strategies for targeted therapy in cancer cells harboring mutations in DNA repair genes. Despite these advances, drug resistance and unwanted side effects are two significant drawbacks to using PARP inhibitors in the clinic. Recently, the development of practical nanotechnology-based drug delivery systems has tremendously improved the efficacy of PARP inhibitors. NPs can specifically accumulate in the leaky vasculature of the tumor and cancer cells and release the chemotherapeutic moiety in the tumor microenvironment. On the contrary, NPs are usually unable to permeate across the body’s normal organs and tissues; hence the toxicity is zero to none. NPs can modify the release of encapsulated drugs based on the composition of the coating substance. Delivering PARP inhibitors without modulation often leads to the toxic effect; therefore, a delivery vehicle is essential to encapsulate them. Various nanocarriers have been exploited to deliver PARP inhibitors in different cancers. Through this review, we hope to cast light on the most innovative advances in applying PARP inhibitors for therapeutic purposes.

scholarly journals Pectin-Tannic Acid Nano-Complexes Promote the Delivery and Bioactivity of Drugs in Pancreatic Cancer Cells

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 285 ◽  
Author(s):  
Sumeet S. Chauhan ◽  
Advait B. Shetty ◽  
Elham Hatami ◽  
Pallabita Chowdhury ◽  
Murali M. Yallapu
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Tannic Acid ◽  
Pancreatic Cancer Cells ◽  
Drug Treatments ◽  
Ft Ir ◽  
Size And Morphology ◽  
Targeting Ability

Pancreatic cancer (PanCa) is a lethal disease. Conventional chemotherapies for PanCa offer severe systemic toxicities. Thus, the development of a successful nanomedicine-based therapeutic regimen with augmented therapeutic efficacy is highly sought. Naturally occurring pectin and modified pectin-based drug delivery systems exhibit remarkable self-targeting ability via galactose residues to various cancer cells. Herein, we developed and used an innovative approach of highly stable nanocomplexes based on modified pectin and tannic acid (MPT-NCs). The nanocomplex formation was enabled by strong intermolecular interactions between pectin and tannic acid under very mild conditions. These nanocomplexes were characterized by particle size and morphology (DLS, TEM, and SEM), FT-IR spectroscopy, and zeta potential measurements. Additionally, MPT-NCs were capable of encapsulating anticancer drugs (5-fluorouracil, gemcitabine, and irinotecan) through tannic acid binding. The in vitro bioactivity of these drug MPT-NCs were evaluated in pancreatic cancer adenocarcinoma (PDAC) cell lines (HPAF-II and PANC-1). A dose-dependent internalization of nanocomplexes was evident from microscopy and flow cytometry analysis. Both proliferation and colony formation assays indicated the anticancer potential of pectin drug nanocomplexes against PDAC cells compared to that of free drug treatments. Together, the pectin-based nanocomplexes could be a reliable and efficient drug delivery strategy for cancer therapy.

pH-Sensitive degradable polymeric micelles for bio-triggered targeted anti-tumor drug delivery

2017 ◽  
Vol 259 ◽  
pp. e86-e87
Author(s):  
Lipeng Qiu ◽  
Mengqin Zhu ◽  
Kai Gong ◽  
Jinghua Chen
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Ph Sensitive ◽  
Tumor Drug Delivery

EVALUATION OF THE UPTAKE OF CDDP-CONTAINING POLYMERIC MICELLES IN SINGLE PANCREATIC CANCER CELLS

2010 ◽  
Vol 20 (01n02) ◽  
pp. 37-43 ◽  
Author(s):  
K. MIZUNO ◽  
M. UESAKA ◽  
S. MATSUYAMA ◽  
Y. ITO ◽  
K. ISHII ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Polymeric Micelles ◽  
Human Pancreatic Cancer ◽  
Accumulation Rates ◽  
Pancreatic Cancer Cells ◽  
Kinetics Of

Highly functionalized drugs delivered via a drug delivery system are expected to have less side effects and higher accumulation rates compared to conventional anticancer drugs. An understanding of the kinetics of drugs contained within a delivery system is necessary to obtain the maximum therapeutic effect. We performed micro-elemental analysis of human pancreatic cancer cells treated with cis-diamminedichloroplatinum(II) (CDDP)-containing polymeric micelles. The results showed that the platinum signals were distributed inside the cellular nuclei and the cytoplasm indicating that CDDP was delivered into the cells. The results from this study will be useful for designing an optimum carrier for platinum-containing anticancer drugs.

scholarly journals Redox-sensitive polymeric micelles with aggregation-induced emission for bioimaging and delivery of anticancer drugs

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Changzhen Sun ◽  
Ji Lu ◽  
Jun Wang ◽  
Ping Hao ◽  
Chunhong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Background Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject. Results To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells. Conclusions A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

scholarly journals Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform

2016 ◽  
Vol 4 (3) ◽  
pp. 511-521 ◽  
Author(s):  
Vitaliy Kapishon ◽  
Stephanie Allison ◽  
Ralph A. Whitney ◽  
Michael F. Cunningham ◽  
Myron R. Szewczuk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Radical Polymerization ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Living Radical Polymerization ◽  
Delivery Platform

Synthetic steps and subsequent preparation of oseltamivir-conjugated micelles capable of targeting and triggering receptor-induced endocytosis in cancer cells.

MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery

2015 ◽  
Vol 51 (3) ◽  
pp. 465-468 ◽  
Author(s):  
Wei-Hai Chen ◽  
Guo-Feng Luo ◽  
Qi Lei ◽  
Hui-Zhen Jia ◽  
Sheng Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Cells ◽  
Polymeric Micelles ◽  
Intracellular Drug Delivery

Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were demonstrated to selectively eliminate cancer cells with significantly reduced side effects.

scholarly journals Redox-Sensitive Polymeric Micelles with Aggregation-Induced Emission for Bioimaging and Delivery of Anticancer Drugs

2020 ◽  
Author(s):  
Changzhen Sun ◽  
Ji Lu ◽  
Jun Wang ◽  
Ping Hao ◽  
Chunhong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Polymeric Micelles ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Background: Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug delivery system, however, the distribution of micelles and the release of the drug are difficult to trace in cancer cells. Therefore, the construction of a redox-sensitive multifunctional drug delivery system for intelligent release of anticancer drugs and simultaneous diagnostic imaging and therapy remains an attractive research subject.Results: To construct a smart drug delivery system for simultaneous imaging and cancer chemotherapy, mPEG-ss-Tripp was prepared and self-assembled into redox-sensitive polymeric micelles with a diameter of 105 nm that were easily detected within cells using confocal laser scanning microscopy based on aggregation-induced emission. Doxorubicin-loaded micelles rapidly released the drug intracellularly when GSH reduced the disulfide bond. The drug-loaded micelles inhibited tumor xenografts in mice, while this efficacy was lower without the GSH-responsive disulfide bridge. These results establish an innovative multi-functional polymeric micelle for intracellular imaging and redox-triggered drug deliver to cancer cells.Conclusions: A novel redox-sensitive drug delivery system with AIE property was constructed for simultaneous cellular imaging and intelligent drug delivery and release. This smart drug delivery system opens up new possibilities for multifunctional drug delivery systems.

pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery

2017 ◽  
Vol 78 ◽  
pp. 912-922 ◽  
Author(s):  
Lipeng Qiu ◽  
Mengqin Zhu ◽  
Kai Gong ◽  
Huanhuan Peng ◽  
Lu Ge ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Tumor Drug Delivery
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