Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for intratumoral administration with improved therapeutic efficacy in tumor-bearing mice

2015 ◽  
Vol 3 (39) ◽  
pp. 7707-7717 ◽  
Author(s):  
Jinyan Lin ◽  
Yanxiu Li ◽  
Yang Li ◽  
Fei Cui ◽  
Fei Yu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Polymeric Nanoparticles ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Highly Efficient

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for highly efficient cancer chemotherapy: more elongated is better.

Acetate ions enhance load and stability of doxorubicin onto PEGylated nanodiamond for selective tumor intracellular controlled release and therapy

2016 ◽  
Vol 8 (9) ◽  
pp. 956-967 ◽  
Author(s):  
Lin Li ◽  
Lu Tian ◽  
Wenjing Zhao ◽  
Yingqi Li ◽  
Binsheng Yang
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Tumor Cells ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Normal Tissue ◽  
Delivery Device ◽  
Drug Delivery Device

A successful drug delivery device for cancer chemotherapy should ideally be able to load drugs highly, bring the drug preferentially into tumor cells and reduce its distribution in normal tissue to enhance therapeutic efficacy.

A rod bacterium-like magnetic polymer micelle for strongly enhancing selective accumulation and internalization of nanocarriers

2017 ◽  
Vol 5 (25) ◽  
pp. 4943-4954 ◽  
Author(s):  
Yuqian Gao ◽  
Jingya Zhao ◽  
Xiaobin Zhang ◽  
Xiao Wei ◽  
Xiang Xiong ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Therapeutic Agent ◽  
Tumor Site ◽  
Polymer Micelle ◽  
Highly Efficient ◽  
Efficient Delivery ◽  
Selective Accumulation

The precise and highly efficient delivery of a therapeutic agent with nanocarriers to a tumor site to achieve excellent therapeutic efficacy remains a major challenge in cancer chemotherapy.

Recent Advances in Drug Delivery Strategies for Improved Therapeutic Efficacy of Efavirenz

2020 ◽  
Vol 14 (2) ◽  
pp. 119-127
Author(s):  
Mitali Patel ◽  
Ruhi Shah ◽  
Krutika Sawant
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Therapeutic Efficacy ◽  
Water Solubility ◽  
Polymeric Nanoparticles ◽  
Solid Dispersions ◽  
Engineered Nanoparticles ◽  
Recent Advances ◽  
Hiv Drugs ◽  
Anti Hiv

Background: Efavirenz, an anti-HIV agent, has a noticeable place in the HAART regimen for the treatment and maintenance therapy of AIDS. However, its poor water solubility accounts for hindered absorption and bio-distribution upon administration. This results in its low and variable bioavailability. To circumvent these limitations, various novel formulations of Efavirenz have been investigated in order to mitigate its drawbacks and draw out its maximum therapeutic effect. Methods: Numerous formulations explored to overcome the drawbacks of Efavirenz include modified/ controlled-release tablets, solid dispersions, polymeric nanoparticles, dendrimers, surface-engineered nanoparticles and various other nanoformulations. Moreover, combinatorial formulations of Efavirenz with other Anti-HIV drugs have also been reported to overcome the problem of Drug-Resistance. Results: The nanoformulation based strategies, owing to their ability to provide controlled release profile and targeted drug delivery were found to augment bioavailability, therapeutic efficacy and reduce the side effects of the Efavirenz. Conclusion: This review pivots around the challenges and recent advances in the delivery of Efavirenz with particular emphasis on novel formulations including its patents.

scholarly journals Preparation of HCPT-Loaded Nanoneedles with Pointed Ends for Highly Efficient Cancer Chemotherapy

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Shichao Wu ◽  
Xiangrui Yang ◽  
Yang Li ◽  
Hongjie Wu ◽  
Yu Huang ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Highly Efficient

scholarly journals A Novel Paclitaxel Microemulsion Containing a Reduced Amount of Cremophor EL: Pharmacokinetics, Biodistribution, andIn VivoAntitumor Efficacy and Safety

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Ying Wang ◽  
Ke-Chun Wu ◽  
Bing-Xiang Zhao ◽  
Xin Zhao ◽  
Xin Wang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Therapeutic Efficacy ◽  
Antitumor Efficacy ◽  
Allergic Reactions ◽  
Cremophor El ◽  
Efficacy And Safety ◽  
Tumor Bearing ◽  
Allergic Effect ◽  
Injection Product

The purpose of this study was to prepare a novel paclitaxel (PTX) microemulsion containing a reduced amount of Cremophor EL (CrEL) which had similar pharmacokinetics and antitumor efficacy as the commercially available PTX injection, but a significantly reduced allergic effect due to the CrEL. The pharmacokinetics, biodistribution,in vivoantitumor activity and safety of PTX microemulsion was evaluated. The results of pharmacokinetic and distribution properties of PTX in the microemulsion were similar to those of the PTX injection. The antitumor efficacy of the PTX microemulsion in OVCRA-3 and A 549 tumor-bearing animals was similar to that of PTX injection. The PTX microemulsion did not cause haemolysis, erythrocyte agglutination or simulative reaction. The incidence and degree of allergic reactions exhibited by the PTX microemulsion group, with or without premedication, were significantly lower than those in the PTX injection group (P<.01). In conclusion, the PTX microemulsion had similar pharmacokinetics and anti-tumor efficacy to the PTX injection, but a significantly reduced allergic effect due to CrEL, indicating that the PTX microemulsion overcomes the disadvantages of the conventional PTX injection and is one way of avoiding the limitations of current injection product while providing suitable therapeutic efficacy.

Polymeric nanoparticles as carrier for controlled release

2018 ◽  
pp. 216-244
Author(s):  
Muddana Eswara Bhanoji Rao ◽  
Suryakanta Swain ◽  
Sitty Manohar Babu
Keyword(s):  
Controlled Release ◽  
Polymeric Nanoparticles

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

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