A rod bacterium-like magnetic polymer micelle for strongly enhancing selective accumulation and internalization of nanocarriers

2017 ◽  
Vol 5 (25) ◽  
pp. 4943-4954 ◽  
Author(s):  
Yuqian Gao ◽  
Jingya Zhao ◽  
Xiaobin Zhang ◽  
Xiao Wei ◽  
Xiang Xiong ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Therapeutic Agent ◽  
Tumor Site ◽  
Polymer Micelle ◽  
Highly Efficient ◽  
Efficient Delivery ◽  
Selective Accumulation

The precise and highly efficient delivery of a therapeutic agent with nanocarriers to a tumor site to achieve excellent therapeutic efficacy remains a major challenge in cancer chemotherapy.

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for intratumoral administration with improved therapeutic efficacy in tumor-bearing mice

2015 ◽  
Vol 3 (39) ◽  
pp. 7707-7717 ◽  
Author(s):  
Jinyan Lin ◽  
Yanxiu Li ◽  
Yang Li ◽  
Fei Cui ◽  
Fei Yu ◽  
...  
Keyword(s):  
Controlled Release ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Polymeric Nanoparticles ◽  
Intratumoral Administration ◽  
Tumor Bearing ◽  
Highly Efficient

Self-targeted, bacillus-shaped, and controlled-release methotrexate prodrug polymeric nanoparticles for highly efficient cancer chemotherapy: more elongated is better.

Progress in systemic co-delivery of microRNAs and chemotherapeutics for cancer treatment by using lipid-based nanoparticles

2020 ◽  
Vol 11 (9) ◽  
pp. 591-603
Author(s):  
Wei He ◽  
Annie Turkeshi ◽  
Xiaotong Li ◽  
Hongwei Zhang
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Cancer Treatment ◽  
Cancer Chemotherapy ◽  
Therapeutic Efficacy ◽  
Treatment Approach ◽  
Delivery Systems ◽  
Special Report ◽  
Efficient Delivery ◽  
Mirna Therapeutics

MicroRNAs (miRNAs) hold the potential to boost therapeutic efficacy and/or reverse drug resistance associated with traditional cancer chemotherapy. Both miRNA mimics and inhibitors have been explored in cancer therapy. Systemic co-delivery of chemotherapeutics and miRNA therapeutics represents an attractive treatment approach, but safe and efficient delivery systems are greatly needed. The regulatory approval of Onpattro® paved the way for lipid-based nanoparticles to deliver RNA therapeutics in different settings, including in combination with chemotherapeutics to treat cancer. In this Special Report, we discuss the significance of systemic co-delivery of chemotherapeutics and miRNA therapeutics for cancer therapy and highlight the representative examples of this strategy using lipid-based nanoparticles. We also present outstanding roadblocks to clinical translation and provide the latest perspectives.

scholarly journals Preparation of HCPT-Loaded Nanoneedles with Pointed Ends for Highly Efficient Cancer Chemotherapy

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Shichao Wu ◽  
Xiangrui Yang ◽  
Yang Li ◽  
Hongjie Wu ◽  
Yu Huang ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Highly Efficient

Recent advances in the development of metal-organic framework-based gas nanoplatforms for synergistic cancer therapy

2021 ◽  
Author(s):  
Yong Yao ◽  
Danni Jing ◽  
Jianan Zhang ◽  
Youyou Huang ◽  
Xiru Qin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Metal Organic Framework ◽  
Research Field ◽  
Tumor Site ◽  
Recent Advances ◽  
Metal Organic ◽  
Organic Framework

Featuring high therapeutic efficacy, biocompatibility, and biosafety, gas therapy as a burgeoning and promising research field has attracted considerable attention in biomedicine. However, the lack of the tumor site accumulation...

Dissecting extracellular and intracellular distribution of nanoparticles and their contribution to therapeutic response by monochromatic ratiometric imaging

2021 ◽  
Author(s):  
Yue Yan ◽  
Binlong Chen ◽  
Qingqing Yin ◽  
Zenghui Wang ◽  
Ye Yang ◽  
...  
Keyword(s):  
Treatment Outcome ◽  
Therapeutic Efficacy ◽  
Near Infrared ◽  
Therapeutic Response ◽  
Intracellular Distribution ◽  
Infrared Light ◽  
Dual Responsive ◽  
Efficient Delivery ◽  
Ratiometric Imaging ◽  
Intracellular Targets

Abstract Efficient delivery of payload to intracellular targets has been identified as the central principle for nanomedicine development, while the extracellular targets are equally important for cancer treatment. Notably, the contribution of extracellularly distributed nanoparticles to therapeutic outcome is far from being understood. Herein, we develop a pH/light dual-responsive monochromatic ratiometric imaging nanoparticle (MRIN), which functions through sequentially lighting up the intracellular and extracellular fluorescence signals by acidic endocytic pH and near-infrared light. Enabled by MRIN nanotechnology, we accurately quantify the extracellular and intracellular distribution of nanoparticles in several tumor models, which account for 65-80% and 20-35% of total tumor exposure, respectively. Given that the majority of nanoparticles are trapped in extracellular regions, we successfully dissect the contribution of extracellularly distributed nanophotosensitizer to therapeutic efficacy, thereby maximize the treatment outcome. Our study provides key strategies to precisely quantify nanocarrier microdistribtion and engineer multifunctional nanomedicines for efficient theranostics.

Dual-responsive polyphosphazene as a common platform for highly efficient drug self-delivery

2019 ◽  
Vol 7 (27) ◽  
pp. 4319-4327 ◽  
Author(s):  
Sheng-Lei Hou ◽  
Shuang-Shuang Chen ◽  
Zhang-Jun Huang ◽  
Qing-Hua Lu
Keyword(s):  
Drug Release ◽  
Delivery System ◽  
Cancer Chemotherapy ◽  
Stimuli Responsive ◽  
Highly Efficient ◽  
Dual Responsive ◽  
Common Platform

A drug self-framed delivery system (DSFDS) with dual-stimuli-responsive drug release and superhigh drug loaded capacity for efficient cancer chemotherapy is proposed.

Bioreducible poly(urethane amine)s for robust nucleic acid transfection in stem cells

2019 ◽  
Vol 7 (8) ◽  
pp. 3510-3518
Author(s):  
Ying Ye ◽  
Rong Jin ◽  
Xiaoxin Hu ◽  
Juhua Zhuang ◽  
Wei Xia ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Nucleic Acid ◽  
Embryonic Stem ◽  
Highly Efficient ◽  
Efficient Delivery ◽  
Low Cytotoxicity

Bioreducible poly(urethane amine)s can be designed and optimized for highly efficient delivery in vitro of DNA or SiRNA into adult or embryonic stem cells with low cytotoxicity.

scholarly journals Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Jeffrey K. Actor
Keyword(s):  
Therapeutic Efficacy ◽  
Therapeutic Agent ◽  
Iron Binding ◽  
Therapeutic Tool ◽  
Cord Factor ◽  
Pulmonary Pathology ◽  
Mucosal Secretions ◽  
Binding Glycoprotein ◽  
Promising Avenue

There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a “firebreak” to slow transmission. A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or stop development of aggressive destructive pulmonary pathology. Lactoferrin, an iron-binding glycoprotein found in mucosal secretions and granules of neutrophils, is just such a potential adjunct therapeutic agent. The focus of this review is to explore the utility of lactoferrin to serve as a therapeutic tool to investigate “disruption” of the mycobacterial granuloma. Proposed concepts for mechanisms underlying lactoferrin efficacy to control immunopathology are supported by data generated based onin vivomodels using nonpathogenic trehalose 6,6′-dimycolate (TDM, cord factor).

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