A target-initiated DNA network caged on magnetic particles for amplified chemiluminescence resonance energy transfer imaging of microRNA and targeted drug delivery

2016 ◽  
Vol 52 (87) ◽  
pp. 12841-12844 ◽  
Author(s):  
Sai Bi ◽  
Shuzhen Yue ◽  
Weiling Song ◽  
Shusheng Zhang
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Targeted Drug Delivery ◽  
Magnetic Particles ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Targeted Drug

DNA networks are constructed on magnetic particles by an initiator, which are functionalized for CRET imaging assay and targeted drug delivery.

Fluorescence resonance energy transfer monitoring of pH-responsive doxorubicin release from carbon dots/aptamer functionalized magnetic mesoporous silica

Nanomedicine ◽  
2021 ◽  
Author(s):  
Abolghasem Abbasi Kajani ◽  
Masoud Ayatollahi Mehrgardi
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Carbon Dots ◽  
Drug Loading ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Spectroscopic Techniques ◽  
Ph Responsive ◽  
Fluorescence Resonance

Aim: To develop a novel theranostic nanoplatform for simultaneous fluorescent monitoring and stimuli-triggered drug delivery. Materials & methods: Different microscopic and spectroscopic techniques were used for the characterization of nanocarriers. MCF-7 and human umbilical vein endothelial cell lines were cultured and treated with different doses of doxorubicin-loaded nanocarriers. The cell viability and drug release were studied using MTT assay and fluorescence microscopy. Results: Biocompatible and mono-disperse nanocarriers represent hollow and mesoporous structures with the calculated surface area of 552.83 m2.g-1, high magnetic activity (12.6 emu.g-1), appropriate colloidal stability and high drug loading capacity (up to 61%). Conclusion: Taxane-based carbon dots act as the pH-responsive gatekeepers for the controlled release of doxorubicin into cancer cells and provide a fluorescence resonance energy transfer system for real-time monitoring of drug delivery.

Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy

2020 ◽  
Vol 8 (17) ◽  
pp. 3772-3788 ◽  
Author(s):  
Yu Huang ◽  
Feng Qiu ◽  
Rongjun Chen ◽  
Deyue Yan ◽  
Xinyuan Zhu
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Drug Delivery Systems ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Delivery Systems ◽  
Recent Advances ◽  
Fluorescence Resonance

In this Review, recent advances in fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy are described, and the current challenges and perspectives in this emerging field are also discussed.

scholarly journals FRET Ratiometric Nanoprobes for Nanoparticle Monitoring

Biosensors ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 505
Author(s):  
Guangze Yang ◽  
Yun Liu ◽  
Jisi Teng ◽  
Chun-Xia Zhao
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Drug Release ◽  
Self Assembly ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
The Self ◽  
Fundamental Understanding ◽  
Nanoparticle Drug Delivery

Fluorescence labelling is often used for tracking nanoparticles, providing a convenient assay for monitoring nanoparticle drug delivery. However, it is difficult to be quantitative, as many factors affect the fluorescence intensity. Förster resonance energy transfer (FRET), taking advantage of the energy transfer from a donor fluorophore to an acceptor fluorophore, provides a distance ruler to probe NP drug delivery. This article provides a review of different FRET approaches for the ratiometric monitoring of the self-assembly and formation of nanoparticles, their in vivo fate, integrity and drug release. We anticipate that the fundamental understanding gained from these ratiometric studies will offer new insights into the design of new nanoparticles with improved and better-controlled properties.

Computational Simulation of Magnetic Drug Targeting in Human Body

2011 ◽  
Author(s):  
Reza Kamali ◽  
Gholamreza Keshavarzi
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Human Body ◽  
Targeted Drug Delivery ◽  
Drug Targeting ◽  
Magnetic Particles ◽  
Computational Simulation ◽  
Magnetic Drug Targeting ◽  
Targeted Drug ◽  
Specific Part

Development of novel particle carrier methods has led to enhanced advances in targeted drug delivery. This paper has aimed the investigation of targeting drugs via attached magnetic particles into human body. This goal was approached by inducing a magnetic field near a specific part of the human body to target the drug or as it is called magnetic drug targeting (MDT). Blood flow and magnetic particles are simulated under the presence of the specified properties of a magnetic field. In order to demonstrate a more realistic simulation, the flow was considered pulsatile. Finally, the results provided show valuable information on magnetic drug targeting in human body.

Sign in / Sign up

Export Citation Format

Share Document