Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo

2016 ◽  
Vol 4 (33) ◽  
pp. 5608-5620 ◽  
Author(s):  
Pan Li ◽  
Gaona Shi ◽  
Xiuyuan Zhang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Protein Antigen ◽  
Antigen Delivery ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Immune Adjuvants ◽  
Cationic Nanoparticles ◽  
Antigen Delivery Systems

Guanidinylated nanoparticles could act as effective immune adjuvants to elicit both potent antigen-specific cellular and humoral immune responses.

scholarly journals Correction: Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo

2016 ◽  
Vol 4 (41) ◽  
pp. 6746-6747
Author(s):  
Pan Li ◽  
Gaona Shi ◽  
Xiuyuan Zhang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Protein Antigen ◽  
Antigen Delivery ◽  
Cationic Nanoparticles ◽  
Antigen Delivery Systems

Correction for ‘Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo’ by Pan Li et al., J. Mater. Chem. B, 2016, 4, 5608–5620.

In vivo inhibition of cell-mediated and humoral immune responses to cellular antigens by SV-IV, a major protein secreted from the rat seminal vesicle epithelium

1995 ◽  
Vol 28 (1) ◽  
pp. 15-30 ◽  
Author(s):  
Caterina Romano-Carratelli ◽  
Marilena Galdiero ◽  
Immacolata Nuzzo ◽  
Concetta Bentivoglio ◽  
Raffaele Porta ◽  
...  
Keyword(s):  
Immune Responses ◽  
Seminal Vesicle ◽  
Major Protein ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Rat Seminal Vesicle

Chondroitin sulfate activates B cells in vitro, expands CD138+cells in vivo, and interferes with established humoral immune responses

2014 ◽  
Vol 96 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Hilke Brühl ◽  
Josef Cihak ◽  
Nicole Goebel ◽  
Yvonne Talke ◽  
Kerstin Renner ◽  
...  
Keyword(s):  
B Cells ◽  
Immune Responses ◽  
Chondroitin Sulfate ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation

Blood ◽  
2007 ◽  
Vol 110 (1) ◽  
pp. 193-200 ◽  
Author(s):  
Li-Fan Lu ◽  
Cory L. Ahonen ◽  
Evan F. Lind ◽  
Vanitha S. Raman ◽  
W. James Cook ◽  
...  
Keyword(s):  
Immune Responses ◽  
B Cell ◽  
Cell Activation ◽  
Affinity Maturation ◽  
Functional Domain ◽  
Antibody Isotype ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Cell Immunity

The recruitment of tumor necrosis factor receptor–associated factors (TRAFs) 1, 2, 3, 5, and 6 to the CD40 cytoplasmic tail upon CD40 trimerization results in downstream signaling events that ultimately lead to CD40-dependent, thymus-dependent (TD) humoral immune responses. Previously, we have shown signaling through the C-terminal tail of CD40 in the absence of canonical TRAF-binding sites is capable of signaling through an alternative TRAF2-binding site. Here, we demonstrate that B cells from mice harboring CD40 with only the C-terminal tail can activate both canonical and noncanonical NFκB signaling pathways. Moreover, while lacking germinal center formation, several hallmarks of humoral immune responses including clonal B-cell activation/expansion, antibody isotype switching, and affinity maturation remain normal. This study demonstrates a new functional domain in CD40 that controls critical aspects of B-cell immunity in an in vivo setting.

scholarly journals CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

1996 ◽  
Vol 183 (5) ◽  
pp. 2129-2142 ◽  
Author(s):  
P Borrow ◽  
A Tishon ◽  
S Lee ◽  
J Xu ◽  
I S Grewal ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Responses ◽  
Humoral Immunity ◽  
Cd4 T Cells ◽  
Antiviral Immunity ◽  
Ctl Response ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Deficient Mice

The ligand for CD40 (CD40L) is expressed on the surface of activated CD4+ T cells and its role in T-B cell collaborations and thymus-dependent humoral immunity is well established. Recently, by generating CD40L-knockout mice, we have confirmed its previously described role in humoral immunity and defined another important function of this molecule in the in vivo clonal expansion of antigen-specific CD4+ T cells. Here, we investigated the potential in vivo role of CD40L in antiviral immunity by examining the immune response mounted by CD40L-deficient mice following infection with lymphocytic choriomeningitis virus (LCMV), Pichinde virus, or vesicular stomatitis virus. Humoral immune responses of CD40L-deficient mice to these viruses were severely compromised, although moderate titres of antiviral IgM and some IgG2a were produced by virus-infected CD40L-deficient mice by a CD4+ T cell-independent mechanism. By contrast, CD40L-deficient mice made strong primary CTL responses to all three viruses. Interestingly however, although memory CTL activity was detectable in CD40L-deficient mice two months after infection with LCMV, the memory CTL response was much less efficient than in wild-type mice. Together, the results show that CD40-CD40L interactions are required for strong antiviral humoral immune responses, and reveal a novel role for CD40L in the establishment and/or maintenance of CD8+ CTL memory.

A new and versatile virosomal antigen delivery system to induce cellular and humoral immune responses

Vaccine ◽  
2007 ◽  
Vol 25 (41) ◽  
pp. 7065-7074 ◽  
Author(s):  
Andreas R. Kammer ◽  
Mario Amacker ◽  
Silvia Rasi ◽  
Nicole Westerfeld ◽  
Christel Gremion ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery System ◽  
Antigen Delivery ◽  
Humoral Immune ◽  
Humoral Immune Responses
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