scholarly journals Correction: Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo

2016 ◽  
Vol 4 (41) ◽  
pp. 6746-6747
Author(s):  
Pan Li ◽  
Gaona Shi ◽  
Xiuyuan Zhang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Protein Antigen ◽  
Antigen Delivery ◽  
Cationic Nanoparticles ◽  
Antigen Delivery Systems

Correction for ‘Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo’ by Pan Li et al., J. Mater. Chem. B, 2016, 4, 5608–5620.

Guanidinylated cationic nanoparticles as robust protein antigen delivery systems and adjuvants for promoting antigen-specific immune responses in vivo

2016 ◽  
Vol 4 (33) ◽  
pp. 5608-5620 ◽  
Author(s):  
Pan Li ◽  
Gaona Shi ◽  
Xiuyuan Zhang ◽  
Huijuan Song ◽  
Chuangnian Zhang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Protein Antigen ◽  
Antigen Delivery ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Immune Adjuvants ◽  
Cationic Nanoparticles ◽  
Antigen Delivery Systems

Guanidinylated nanoparticles could act as effective immune adjuvants to elicit both potent antigen-specific cellular and humoral immune responses.

scholarly journals A Review of Intra- and Extracellular Antigen Delivery Systems for Virus Vaccines of Finfish

2015 ◽  
Vol 2015 ◽  
pp. 1-19 ◽  
Author(s):  
Hetron Mweemba Munang’andu ◽  
Øystein Evensen
Keyword(s):  
Immune Responses ◽  
Adaptive Immune Response ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Mhc I ◽  
Mhc Ii ◽  
Adaptive Immune ◽  
Long Time ◽  
T Cell Immune Responses ◽  
Antigen Delivery Systems

Vaccine efficacy in aquaculture has for a long time depended on evaluating relative percent survival and antibody responses after vaccination. However, current advances in vaccine immunology show that the route in which antigens are delivered into cells is deterministic of the type of adaptive immune response evoked by vaccination. Antigens delivered by the intracellular route induce MHC-I restricted CD8+ responses while antigens presented through the extracellular route activate MHC-II restricted CD4+ responses implying that the route of antigen delivery is a conduit to induction of B- or T-cell immune responses. In finfish, different antigen delivery systems have been explored that include live, DNA, inactivated whole virus, fusion protein, virus-like particles, and subunit vaccines although mechanisms linking these delivery systems to protective immunity have not been studied in detail. Hence, in this review we provide a synopsis of different strategies used to administer viral antigens via the intra- or extracellular compartments. Further, we highlight the differences in immune responses induced by antigens processed by the endogenous route compared to exogenously processed antigens. Overall, we anticipate that the synopsis put together in this review will shed insights into limitations and successes of the current vaccination strategies used in finfish vaccinology.

scholarly journals Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis

Vaccines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 972
Author(s):  
Abu Salim Mustafa
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Immune Responses ◽  
Pulmonary Disease ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Special Issue ◽  
Subunit Vaccines ◽  
Recombinant Bcg ◽  
New Vaccines ◽  
Antigen Delivery Systems

The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults. Furthermore, the use of BCG is contraindicated in immunocompromised subjects. The research towards the development of new vaccines against TB includes the use of Mycobacterium tuberculosis antigens as subunit vaccines. Such vaccines may be used either alone or in the prime-boost model in BCG-vaccinated people. However, the antigens for subunit vaccines require adjuvants and/or delivery systems to induce appropriate and protective immune responses against tuberculosis and other diseases. Articles published in this Special Issue have studied the pathogenesis of BCG in children and the use of BCG and recombinant BCG as potential vaccines against asthma. Furthermore, the use of different adjuvants and delivery systems in inducing the protective immune responses after immunization with subunit vaccines has been described.

Quaternized Cationic Carbon Dots as Antigen Delivery Systems for Improving Humoral and Cellular Immune Responses

2020 ◽  
Vol 3 (9) ◽  
pp. 9449-9461 ◽  
Author(s):  
Shaomei Huang ◽  
Bowen Li ◽  
Usama Ashraf ◽  
Qi Li ◽  
Xingchang Lu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Carbon Dots ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Cellular Immune Responses ◽  
Cellular Immune ◽  
Antigen Delivery Systems

Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems

2010 ◽  
Vol 147 (3) ◽  
pp. 342-349 ◽  
Author(s):  
Deepa Mohanan ◽  
Bram Slütter ◽  
Malou Henriksen-Lacey ◽  
Wim Jiskoot ◽  
Joke A. Bouwstra ◽  
...  
Keyword(s):  
Immune Responses ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Cross Sectional ◽  
Administration Routes ◽  
Particulate Antigen ◽  
Antigen Delivery Systems

scholarly journals A Novel Recombinant Fcγ Receptor-Targeted Survivin Combines with Chemotherapy for Efficient Cancer Treatment

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 806
Author(s):  
Chiao-Chieh Wu ◽  
Chen-Yi Chiang ◽  
Shih-Jen Liu ◽  
Hsin-Wei Chen
Keyword(s):  
Immune Responses ◽  
Fusion Protein ◽  
Human Cancer ◽  
Formyl Peptide Receptor ◽  
Antigen Delivery ◽  
Potential Candidate ◽  
Fcγ Receptor ◽  
Formyl Peptide ◽  
Efficient Uptake

Formyl peptide receptor-like 1 inhibitor (FLIPr), an Fcγ receptor (FcγR) antagonist, can be used as a carrier to guide antigen-FLIPr fusion protein to FcγR then enhances antigen-specific immune responses. Survivin, a tumor-associated antigen, is over-expressed in various types of human cancer. In this study, we demonstrate that recombinant survivin-FLIPr fusion protein (rSur-FLIPr) binds to FcγRs, and efficient uptake by dendritic cells in vivo. In addition, rSur-FLIPr alone stimulates survivin-specific immune responses, which effectively suppresses the tumor growth. The antitumor immunities are through TAP-mediated and CD8-dependent pathways. Furthermore, preexisting anti-FLIPr antibody does not abolish antitumor responses induced by rSur-FLIPr immunization. These results suggest that FLIPr is an effective antigen delivery vector and can be repeatedly used. Combination of chemotherapy with rSur-FLIPr treatment reveals a great benefit to tumor-bearing mice. Altogether, these findings suggest that rSur-FLIPr is a potential candidate for efficient cancer therapy.

Cell-Penetrating Peptide-Mediated Nanovaccine Delivery

2021 ◽  
Vol 22 ◽  
Author(s):  
Jizong Jiang
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Cell Penetrating Peptide ◽  
Antigen Delivery ◽  
Efficient Manner ◽  
Antigen Uptake ◽  
Cell Penetrating ◽  
The Stability ◽  
Antigen Presenting

Abstract: Vaccination with small antigens, such as proteins, peptides, or nucleic acids, is used to activate the immune system and trigger the protective immune responses against a pathogen. Currently, nanovaccines are undergoing development instead of conventional vaccines. The size of nanovaccines is in the range of 10–500 nm, which enables them to be readily taken up by cells and exhibit improved safety profiles. However, low-level immune responses, as the removal of redundant pathogens, trigger counter-effective activation of the immune system invalidly and present a challenging obstacle to antigen recognition and its uptake via antigen-presenting cells (APCs). In addition, toxicity can be substantial. To overcome these problems, a variety of cell-penetrating peptide (CPP)-mediated vaccine delivery systems based on nanotechnology have been proposed, most of which are designed to improve the stability of antigens in vivo and their delivery into immune cells. CPPs are particularly attractive components of antigen delivery. Thus, the unique translocation property of CPPs ensures that they remain an attractive carrier with the capacity to deliver cargo in an efficient manner for the application of drugs, gene transfer, protein, and DNA/RNA vaccination delivery. CPP-mediated nanovaccines can enhance antigen uptake, processing, and presentation by APCs, which are the fundamental steps in initiating an immune response. This review describes the different types of CPP-based nanovaccines delivery strategies.

scholarly journals Implantable vaccines: a solution for immune system manipulation to any antigenic stimulus

2020 ◽  
Vol 4 (4) ◽  
pp. 5-11
Author(s):  
Ioanna Zerva ◽  
Vasileia Pateraki ◽  
Irene Athanassakis
Keyword(s):  
Immune Response ◽  
Ex Vivo ◽  
Great Majority ◽  
Delivery Systems ◽  
Antigen Delivery ◽  
Immune Responsiveness ◽  
Antigenic Stimulus ◽  
Human Pathology ◽  
Check Points ◽  
Antigen Delivery Systems

Effective and side-effect-free vaccines are still difficult tasks to achieve for a great majority of antigenic stimuli. Pathogen manipulation to abort infectivity and antigen delivery to ensure immune responsiveness are the major components vaccine technology tries to resolve. However, the development of an immune response is still a complicated matter, lies on hundreds of parameters and any effort towards activation can easily lead to adverse effects, making immunotherapy very difficult to control. The present review attempts to highlight the major parameters affecting immune responsiveness and show that vaccine technology, except from pathogen manipulation and the development of antigen delivery systems, requires attention to additional check-points. Analyzing the recently described personalized implantable vaccine technology, it becomes obvious that the nature of each antigenic stimulus dictates different responsiveness to the organism, which discourages the use of universal adjuvant and antigen-delivery systems. On the contrary, the ex vivo tuning of the immune response proposed by the implantable vaccine technology, allows controllable amendment of the response. The development of personalized technologies is expected to provide valuable tools for the management of human pathology.

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