Single nanoparticle analysis by ICPMS: a potential tool for bioassay

2018 ◽  
Vol 33 (1) ◽  
pp. 57-67 ◽  
Author(s):  
Jianyu Hu ◽  
Dongyan Deng ◽  
Rui Liu ◽  
Yi Lv
Keyword(s):  
Inductively Coupled Plasma ◽  
High Sensitivity ◽  
Absolute Quantification ◽  
Metallic Nanoparticle ◽  
Promising Technique ◽  
Inductively Coupled ◽  
Single Nanoparticle ◽  
Plasma Mass Spectrometry ◽  
Dynamic Linear Range ◽  
Potential Tool

Inductively coupled plasma mass spectrometry (ICPMS) has already been demonstrated as a promising technique for metallic nanoparticle tagged bioassays due to its high sensitivity, wide dynamic linear range, and more importantly multiplex and absolute quantification ability.

Fluid compositions reveal fluid nature, metal deposition mechanisms, and mineralization potential: An example at the Haobugao Zn-Pb skarn, China

Geology ◽  
2020 ◽  
Author(s):  
Qihai Shu ◽  
Zhaoshan Chang ◽  
John Mavrogenes
Keyword(s):  
Inductively Coupled Plasma ◽  
Isotope Composition ◽  
Northeastern China ◽  
Metal Deposition ◽  
Mass Balance Calculation ◽  
Inductively Coupled ◽  
Mineralization Potential ◽  
Plasma Mass Spectrometry ◽  
Absolute Concentrations ◽  
Potential Tool

Fluid inclusion compositions obtained from laser ablation–inductively coupled plasma–mass spectrometry at the Haobugao Zn-Pb skarn in northeastern China provide constraints on fluid origin, evolution, and metal deposition mechanisms and an example of evaluating mineralization potential. Metal concentrations in the prograde fluids were high (up to 1.4 wt% Zn and 1.8 wt% Pb) but remained in solution, likely due to the high temperatures (440–575 °C) and salinities (35.4–45.3 wt% NaCl equivalent). Absolute concentrations of elements (e.g., Rb and Na) and mass ratios (e.g., Zn/Na and K/Na) reveal that the early, prograde fluids were magmatic, consistent with the oxygen isotope composition of fluids (δ18OH2O = 5.5‰–8.5‰). Later mixing with a meteoric fluid caused dilution and Zn-Pb deposition, as revealed by lowered element concentrations and Pb/(Na + K) and Zn/(Na + K) ratios in the sulfide-stage fluid inclusions. Elevated Ca/K ratios in sphalerite-hosted inclusions indicate fluid-carbonate reactions that buffered fluid pH, also facilitating Zn-Pb precipitation. Although cassiterite and molybdenite occur locally at Haobugao, mass balance calculation shows low metal endowment (maximum 2900 t Sn and 2200 t Mo) of the system. Furthermore, the generally unchanged Sn/(Na + K) and Mo/(Na + K) ratios from pre- to late-mineralization fluids suggest that the fluids were never saturated in Sn and Mo. Therefore, finding much Sn or Mo at Haobugao is unlikely. This demonstrates a potential tool for evaluating the metal endowment of a mineral prospect, which may guide exploration.

scholarly journals Measurement of CeO2 Nanoparticles in Natural Waters Using a High Sensitivity, Single Particle ICP-MS

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5516
Author(s):  
Ibrahim Jreije ◽  
Agil Azimzada ◽  
Madjid Hadioui ◽  
Kevin J. Wilkinson
Keyword(s):  
Single Particle ◽  
Inductively Coupled Plasma ◽  
Natural Waters ◽  
High Sensitivity ◽  
Au Nps ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Mean Diameter ◽  
Plasma Mass Spectrometry ◽  
St Lawrence River

As the production and use of cerium oxide nanoparticles (CeO2 NPs) increases, so does the concern of the scientific community over their release into the environment. Single particle inductively coupled plasma mass spectrometry is emerging as one of the best techniques for NP detection and quantification; however, it is often limited by high size detection limits (SDL). To that end, a high sensitivity sector field ICP-MS (SF-ICP-MS) with microsecond dwell times (50 µs) was used to lower the SDL of CeO2 NPs to below 4.0 nm. Ag and Au NPs were also analyzed for reference. SF-ICP-MS was then used to detect CeO2 NPs in a Montreal rainwater at a concentration of (2.2 ± 0.1) × 108 L−1 with a mean diameter of 10.8 ± 0.2 nm; and in a St. Lawrence River water at a concentration of ((1.6 ± 0.3) × 109 L−1) with a higher mean diameter (21.9 ± 0.8 nm). SF-ICP-MS and single particle time of flight ICP-MS on Ce and La indicated that 36% of the Ce-containing NPs detected in Montreal rainwater were engineered Ce NPs.

Using Inductively Coupled Plasma Mass Spectrometry to Assess Essential and Performance-Enhancing Metals in the Urine of Racehorses

2020 ◽  
Vol 44 (5) ◽  
pp. 490-498
Author(s):  
Abdul Khader Karakka Kal ◽  
Zubair Perwad ◽  
Tajudheen K Karatt ◽  
Jahfar Nalakath ◽  
Michael Subhahar
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Performance Enhancement ◽  
Research Work ◽  
High Sensitivity ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
And Performance ◽  
Sport Events

Abstract Recently, an increased tendency to use various metals has been observed in the sports competition fields. Many of these metals and their organic complexes reportedly have good pharmacologic, therapeutic and performance-enhancement uses; they are banned or recommended as controlled medications in competitive sports. The objective of this research was to determine the concentration of pharmacologically relevant metals in urine samples collected from racehorses at various sport events, develop a method and assess the concentrations of above metals using inductively coupled plasma mass spectrometry (ICP-MS). Seven alkali–alkaline earth metals (lithium, sodium, potassium, magnesium, calcium, strontium and barium) and six heavy metals (chromium, cobalt, copper, zinc, arsenic and selenium) were studied in detail. To compare and confirm the concentrations of these metals, the screening was carried out on the basis of region and sex of the animal. ICP-MS provides extremely high sensitivity that enables the determination of the metals at very low concentration from complex biological matrices. From the research, it is clear that irrespective of sex and region the concentration of metal is very high in some samples, might be accidental or intentional doping to improve sporting performances. This research work is of significant importance in setting threshold values for screening metals in race day samples in order to avoid potential harmful effects on athletes and the depth of malpractices, it can bring to sports.

scholarly journals Quantitative aspects of inductively coupled plasma mass spectrometry

2016 ◽  
Vol 374 (2079) ◽  
pp. 20150369 ◽  
Author(s):  
Ewa Bulska ◽  
Barbara Wagner
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Environmental Science ◽  
Certified Reference Materials ◽  
Accurate Determination ◽  
High Sensitivity ◽  
Good Precision ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

Accurate determination of elements in various kinds of samples is essential for many areas, including environmental science, medicine, as well as industry. Inductively coupled plasma mass spectrometry (ICP-MS) is a powerful tool enabling multi-elemental analysis of numerous matrices with high sensitivity and good precision. Various calibration approaches can be used to perform accurate quantitative measurements by ICP-MS. They include the use of pure standards, matrix-matched standards, or relevant certified reference materials, assuring traceability of the reported results. This review critically evaluates the advantages and limitations of different calibration approaches, which are used in quantitative analyses by ICP-MS. Examples of such analyses are provided. This article is part of the themed issue ‘Quantitative mass spectrometry’.

scholarly journals Analysis of seven mineral elements in cultivated fruiting bodies of Cordyceps militaris

2020 ◽  
Vol 185 ◽  
pp. 04019
Author(s):  
Li Fenglin ◽  
Li Li ◽  
Jiang Xiaokun ◽  
Liang Yan ◽  
Liu Hengwei
Keyword(s):  
Inductively Coupled Plasma ◽  
Microwave Digestion ◽  
High Sensitivity ◽  
Mineral Elements ◽  
Cordyceps Militaris ◽  
Fruiting Bodies ◽  
Fast Analysis ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

The objective of this study was to investigate the content of main mineral elements in cultivated fruiting bodies of Cordyceps militaris. Microwave digestion was used to pretreat Cordyceps militaris samples, and the content of seven mineral elements in Cordyceps militaris was determined by inductively coupled plasma mass spectrometry (ICP-MS). The results showed that the content of arsenic (As), lead (Pb) , cadmium (Cd), copper (Cu) , silver (Ag), zinc (Zn), and manganese (Mn) in cultivated fruiting bodies of Cordyceps militaris, respectively, is 0.0047 mg/kg, 0.22 mg/kg, 0.0041 mg/kg, 9.1 mg/kg, 0.024mg/kg, 5.2mg/kg, and 1.6 mg/kg. The content of heavy metals such as Pb, Cd and As is within the limits of Chinese national food safety standard. The method used in this study has the advantages of high sensitivity, fast analysis speed, and good reproducibility. It can be used for the determination of mineral elements in cultivated fruiting bodies of Cordyceps militaris.

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