scholarly journals Bacteria killing in ICU associated infections: antibacterial nanosheets as disinfectant

RSC Advances ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. 278-283 ◽  
Author(s):  
Li Zhang ◽  
Jiaming Lou ◽  
Wei Zhang ◽  
Chaoyang Wu ◽  
Zhaocheng Jin
Keyword(s):  
Cell Wall ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Irreversible Damage ◽  
Bacterial Lysis ◽  
Bacteria Killing

Here we propose Zn–CuO@GO nanosheets that induce rapid bacterial lysis via physically penetrating and wrapping into the cell wall. Such an irreversible damage make them promising as ICU disinfectants to combat ICU-associated multidrug resistant bacteria.

C-terminal Lysine-Linked Magainin 2 with Increased Activity Against Multidrug-Resistant Bacteria

2016 ◽  
Vol 23 (8) ◽  
pp. 738-747 ◽  
Author(s):  
Esteban N. Lorenzón ◽  
Norival A. Santos-Filho ◽  
Matheus A. S. Ramos ◽  
Tais M. Bauab ◽  
Ilana L. B. C. Camargo ◽  
...  
Keyword(s):  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Increased Activity

scholarly journals Identification of Aminoglycoside Resistance Genes From Bacteria Isolated From Selected Municipal Drinking Water Distribution Systems in Southwestern Nigeria

2020 ◽  
Vol 41 (S1) ◽  
pp. s255-s255
Author(s):  
Ayodele T. Adesoji ◽  
Adeniyi A. Ogunjobi
Keyword(s):  
Drinking Water ◽  
Distribution Systems ◽  
Water Distribution ◽  
Water Distribution Systems ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Multidrug Resistant Bacteria ◽  
Southwestern Nigeria ◽  
Drinking Water Distribution Systems ◽  
Drinking Water Distribution

Background: Multidrug-resistant bacteria can lead to treatment failure, resulting in infectious diseases being transferred through nonpotable water. Aminoglycosides are an important class of antibiotics that are abused in Nigeria. Few studies have investigated aminoglycoside-modifying genes (AMGs) that are likely responsible for resistance in Nigeria bacteria isolates. Therefore, we aimed to characterize AMGs from isolates in drinking water distribution systems (DWDS) in southwestern Nigeria. Methods: Multidrug-resistant bacteria (n = 181) that had been previously characterized by 16S rDNA sequencing and that were positive for resistance to at least 1 aminoglycoside antibiotic were selected from 6 treated and untreated water distribution systems. Strains were PCR genotyped for 3 AMGs: aph(3)c, ant(3)b and aph(6)-1dd. Results: Of 181 MDR bacteria tested, 69 (38.12%) were positive for at least 1 of the AMGs. The most common was ant(3)c (27.6%), followed by aph(3")c (18.23%). Both aph(3)c and ant(3")b were found in 7.73% of tested isolates, ant(3)b was most commonly found in Alcaligenes spp (50%). Furthermore, aph(3")c was most commonly detected in Proteus spp (50%). Other genera positive for AMGs included Acinetobacter, Aeromonas, Bordetella, Brevundimonas, Chromobacterium, Klebsiella, Leucobacter, Morganella, Pantoae, Proteus, Providencia, Psychrobacter, and Serratia. Conclusions: High occurrence of ant(3)c and aph(3)c among these bacteria call for urgent attention among public health workers because these genes can be easily disseminated to consumers if present on mobile genetic elements like plasmids, integrons, and transposons.Funding: NoneDisclosures: None

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