Biocompatible tumor-targeting nanocomposites based on CuS for tumor imaging and photothermal therapy

Photothermal therapy (PTT) is a minimally invasive tumor treatment method in which photothermal conversion agents (PTAs) can be enriched in tumor tissue by external light stimulation to convert photon energy into thermal energy to induce the temperature of tumor tissue higher than normal physiological, and can effectively kill tumor cells and tissues while avoiding damage to healthy tissue. As a well-known biocompatible nanomaterial, gold-based nanomaterials have high photothermal conversion efficiency and cross section, which can be used in tumor targeting therapy treatment as a potential photothermal conversion agent. Combining PTT and chemotherapy can be achieved by loading a chemotherapeutic drug modified on the surface of a gold nanomaterials. Therefore, this paper first reviews the preparation and surface functionalization of Au-based nanomaterials, such as Au nanorods, Au nanostars, Au nanoshells, and so on. Second, we have also introduced the application of Au-based nanomaterials in PTT, chemotherapy, and combination therapy. Finally, the limitations and challenges of Au-based photothermal conversion agents are summarized and the development prospects in this field are prospected.

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Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy

Journal of Materials Chemistry B ◽

10.1039/d0tb00030b ◽

2020 ◽

Vol 8 (22) ◽

pp. 4738-4747 ◽

Cited By ~ 7

Author(s):

Xue Zhang ◽

Lu An ◽

Qiwei Tian ◽

Jiaomin Lin ◽

Shiping Yang

Keyword(s):

Photodynamic Therapy ◽

Tumor Microenvironment ◽

Fluorescence Imaging ◽

Photothermal Therapy ◽

Tumor Imaging ◽

Photoacoustic Imaging ◽

Tumor Diagnosis ◽

Diagnosis And Treatment ◽

Recent Advances

This review summarizes the recent advances of tumor microenvironment-activated NIR-II agents for tumor diagnosis and treatment, including smart NIR-II fluorescence imaging, photoacoustic imaging, photothermal therapy and photodynamic therapy.

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A tumor microenvironment–induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy

Science Advances ◽

10.1126/sciadv.abe3588 ◽

2021 ◽

Vol 7 (12) ◽

pp. eabe3588

Author(s):

Shulong Wang ◽

Liangliang Zhang ◽

Jingjin Zhao ◽

Min He ◽

Yong Huang ◽

...

Keyword(s):

Absorption Spectrum ◽

Tumor Microenvironment ◽

Redox Reaction ◽

Photothermal Therapy ◽

Near Infrared ◽

Tumor Imaging ◽

Photoacoustic Imaging ◽

Diagnosis And Treatment ◽

Induced Absorption

Tumor microenvironment–responsive therapy has enormous application potential in the diagnosis and treatment of cancer. The glutathione (GSH) level has been shown to be significantly increased in tumor tissues. Thus, GSH can be used as an effective endogenous molecule for diagnosis and tumor microenvironment–activated therapy. In this study, we prepared a tumor microenvironment–induced, absorption spectrum red-shifted, iron-copper co-doped polyaniline nanoparticle (Fe-Cu@PANI). The Cu(II) in this nanoparticle can undergo a redox reaction with GSH in tumors. The redox reaction induces a red shift in the absorption spectrum of the Fe-Cu@PANI nanoparticles from the visible to the near-infrared region accompanying with the etching of this nanoparticle, which simultaneously activates tumor photoacoustic imaging and photothermal therapy, thereby improving the accuracy of in vivo tumor imaging and the efficiency of photothermal therapy. The nanoparticle prepared in this study has broad application prospects in the diagnosis and treatment of cancer.

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Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy

Frontiers in Pharmacology ◽

10.3389/fphar.2021.799588 ◽

2021 ◽

Vol 12 ◽

Author(s):

Man Zhang ◽

Jinti Lin ◽

Jiakang Jin ◽

Wei Yu ◽

Yiying Qi ◽

...

Keyword(s):

Gold Nanorods ◽

Photothermal Therapy ◽

Tumor Targeting ◽

Tumor Treatment ◽

Targeting Therapy ◽

Cell Penetrating ◽

Transcription Factor Eb ◽

Membrane Peptide ◽

Targeting Ability ◽

Risk Of Relapse

Gold nanorods (GNRs) are intensively explored for the application in cancer therapy, which has motivated the development of photothermal therapy (PTT) multifunctional nanoplatforms based on GNRs to cure osteosarcoma (OS). However, the major limitations include the toxicity of surface protectants of GNRs, unsatisfactory targeting therapy, and the resistant effects of photothermal-induced autophagy, so the risk of relapse and metastasis of OS increase. In the present study, the GNR multifunctional nanoplatforms were designed and synthesized to deliver transcription factor EB (TFEB)-siRNA–targeting autophagy; then, the resistance of autophagy to PTT and the pH-sensitive cell-penetrating membrane peptide (CPP) was weakened, which could improve the tumor-targeting ability of the GNR nanoplatforms and realize an efficient synergistic effect for tumor treatment. Meanwhile, it is worth noting that the GNR nanoplatform groups have anti-lung metastasis of OS. This study provides a new reference to improve the efficacy of OS clinically.

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Novel albumin-binding photothermal agent ICG-IBA-RGD for targeted fluorescent imaging and photothermal therapy of cancer

RSC Advances ◽

10.1039/d0ra09653a ◽

2021 ◽

Vol 11 (13) ◽

pp. 7226-7230

Author(s):

Cheng Yu ◽

Enhua Xiao ◽

Pengfei Xu ◽

Jingjing Lin ◽

Linan Hu ◽

...

Keyword(s):

Photothermal Therapy ◽

Tumor Targeting ◽

Fluorescent Imaging ◽

Albumin Binding

In this work, we present a novel photothermal agent ICG-IBA-RGD based on albumin-binding strategy for enhanced tumor targeting imaging and photothermal therapy.

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The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies

10.31219/osf.io/rk2bf ◽

2021 ◽

Author(s):

Moataz Dowaidar

Keyword(s):

Treatment Outcome ◽

Gene Silencing ◽

Large Volume ◽

Photothermal Therapy ◽

Tumor Model ◽

Vascular Wall ◽

Tumor Treatment ◽

Physical Methods ◽

Vascular Disruption ◽

Tumor Neovascularization

Customized nanomedicines can be used in a variety of ways, including angiogenesis suppression, vascular disruption, and vascular infarction. In the angiogenesis suppression approach, VEGF, VEGFR, mTOR, EGFR, bFGF, ROS, and other components have become promising therapeutic targets. The nanomedicine system has successfully inhibited tumor neovascularization using gene silencing, chemotherapy, photothermal therapy, and other therapies. In the vascular disruption approach, VDAs supplied by nanomaterials were bonded with the bonding sites of CA4, COL, PTX, and other medications on microtubules to promote rapid disintegration of tumor vascular wall cells. Combining many medicines increased the tumor treatment outcome even more. For example, disruption of tumor blood arteries caused by nanoparticle-mediated physical methods combined with chemotherapy resulted in effective treatment in a large volume tumor model. The vascular infarction methodology uses a variety of carriers, including nanoparticles, DNA nanorobots, platelet membranes, and others, to carry thrombin, tTF, and other drugs to generate local thrombosis and provide safe and effective tumor treatment.

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Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH+ Cancer Cells in MRI

Contrast Media & Molecular Imaging ◽

10.1155/2021/5534848 ◽

2021 ◽

Vol 2021 ◽

pp. 1-10

Author(s):

Milad Yousefvand ◽

Zahra Mohammadi ◽

Farzaneh Ghorbani ◽

Rasoul Irajirad ◽

Hormoz Abedi ◽

...

Keyword(s):

Contrast Agent ◽

Cancer Cells ◽

Cellular Uptake ◽

Tumor Targeting ◽

Tumor Imaging ◽

Superparamagnetic Iron Oxide ◽

Gnrh Receptors ◽

Imaging Probes ◽

Magnetic Resonance Imaging Mri ◽

Targeted Contrast Agent

In recent years, the conjugation of superparamagnetic iron oxide nanoparticles (SPIONs), as tumor-imaging probes for magnetic resonance imaging (MRI), with tumor targeting peptides possesses promising advantages for specific delivery of MRI agents. The objective of the current study was to design a targeted contrast agent for MRI based on Fe3O4 nanoparticles conjugated triptorelin (SPION@triptorelin), which has a great affinity to the GnRH receptors. The SPIONs-coated carboxymethyl dextran (SPION@CMD) conjugated triptorelin (SPION@CMD@triptorelin) were synthesized using coprecipitation method and characterized by DLS, TEM, XRD, FTIR, Zeta, and VSM techniques. The relaxivities of synthetized formulations were then calculated using a 1.5 Tesla clinical magnetic field. MRI, quantitative cellular uptake, and cytotoxicity level of them were estimated. The characterization results confirmed that the formation of SPION@CMD@triptorelin has been conjugated with a suitable size. Our results demonstrated the lack of cellular cytotoxicity of SPION@CMD@triptorelin, and it could increase the cellular uptake of SPIONs to MDA-MB-231 cancer cells 6.50-fold greater than to SPION@CMD at the concentration of 75 μM. The relaxivity calculations for SPION@CMD@triptorelin showed a suitable r2 and r2/r1 with values of 31.75 mM−1·s−1 and 10.26, respectively. Our findings confirm that triptorelin-targeted SPIONs could provide a T2-weighted probe contrast agent that has the great potential for the diagnosis of GnRH-positive cancer in MRI.

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Polypyrrole-encapsulated iron tungstate nanocomposites: a versatile platform for multimodal tumor imaging and photothermal therapy

Nanoscale ◽

10.1039/c6nr03336a ◽

2016 ◽

Vol 8 (26) ◽

pp. 12917-12928 ◽

Cited By ~ 18

Author(s):

Zhiyin Xiao ◽

Chen Peng ◽

Xiaohong Jiang ◽

Yuxuan Peng ◽

Xiaojuan Huang ◽

...

Keyword(s):

Photothermal Therapy ◽

Tumor Imaging

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The Evolution of Neuroendocrine Tumor Treatment Reflected by ENETS Guidelines

Neuroendocrinology ◽

10.1159/000486096 ◽

2018 ◽

Vol 106 (4) ◽

pp. 357-365 ◽

Cited By ~ 15

Author(s):

Wouter T. Zandee ◽

Wouter W. de Herder

Keyword(s):

Diagnostic Accuracy ◽

Neuroendocrine Tumor ◽

Unmet Needs ◽

Somatostatin Analogs ◽

Diagnosis And Treatment ◽

Tumor Treatment ◽

Peptide Receptor ◽

The Third ◽

Pet Ct ◽

New Treatments

In 2016, the third version of guidelines for the diagnosis and treatment of neuroendocrine tumors (NETs) has been published by the European Neuroendocrine Tumor Society (ENETS). These guidelines reflect the progress in treatment of NETs, and by comparing the newest guidelines with the first guidelines of 2001, this progress can be clearly recognized. Diagnostic accuracy has been increased by the introduction of PET-CT with Ga-labelled somatostatin analogs, and multiple new treatments and treatment schedules have been developed, like peptide receptor radiotherapy with radiolabeled somatostatin analogs, or targeted therapies. Evidence and indications for these therapies are discussed in the ENETS guidelines. In this review, we aim to show the progress in NET diagnosis and treatment on the basis of the advances in the guidelines, but also to discuss the unsolved questions and unmet needs which still remain.

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