scholarly journals Multicomponent polysaccharide–protein bioconjugation in the development of antibacterial glycoconjugate vaccine candidates

2018 ◽  
Vol 9 (9) ◽  
pp. 2581-2588 ◽  
Author(s):  
Yanira Méndez ◽  
Janoi Chang ◽  
Ana R. Humpierre ◽  
Abel Zanuy ◽  
Raine Garrido ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
Vaccine Candidates ◽  
Glycoconjugate Vaccine ◽  
The One

A multicomponent reaction enables the one-pot assembly of immunogenic multivalent glycoconjugates.

scholarly journals A Multicomponent Reaction for the One-Pot Synthesis of 4-Aza-2,3-didehydropodophyllotoxin and Derivatives.

ChemInform ◽  
2003 ◽  
Vol 34 (3) ◽  
Author(s):  
Christophe Tratrat ◽  
Sylviane Giorgi-Renault ◽  
Henri-Philippe Husson
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

Multicomponent Reaction of Aldehydes, Amines and Oxalacetate Analogues Leading to Biologically Attractive Pyrrole Derivatives

2020 ◽  
Vol 20 (10) ◽  
pp. 818-830
Author(s):  
Stella Manta ◽  
Nikolaos Kollatos ◽  
Christos Mitsos ◽  
Georgia-Anna Chatzieffraimidi ◽  
Ioannis Papanastasiou ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Point Of View ◽  
Primary Amines ◽  
One Pot ◽  
Pyrrole Derivatives ◽  
Anti Inflammatory ◽  
The One ◽  
Active Substances

Pyrrole is a very important pharmacophoric moiety. It has been widely incorporated into the skeleton of antitumor, anti-inflammatory, antibacterial, antioxidant and antifungal active substances. Access to this key heterocycle by diverse routes is particularly attractive in terms of chemistry, and also from the environmental point of view. The present minireview summarizes the reported methods for the preparation of highly substituted pyrrole derivatives based on the one-pot multicomponent reaction of aldehydes, primary amines, and oxalacetate analogues as well as their biology.

A Multicomponent Reaction for the One-Pot Synthesis of 4-Aza-2,3-didehydropodophyllotoxin and Derivatives

2002 ◽  
Vol 4 (19) ◽  
pp. 3187-3189 ◽  
Author(s):  
Christophe Tratrat ◽  
Sylviane Giorgi-Renault ◽  
Henri-Philippe Husson
Keyword(s):  
Multicomponent Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One

scholarly journals Graphene Oxide: A Carbocatalyst for the One-Pot Multicomponent Synthesis of 5-Aryl-1H-Indeno[2’,1’:5,6]Pyrido[2,3-d]Pyrimidine-2,4,6(3H)-Trione

2018 ◽  
Vol 42 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Hamid Reza Dehghanpour ◽  
Mohammad H. Mosslemin ◽  
Razieh Mohebat
Keyword(s):  
Graphene Oxide ◽  
Multicomponent Reaction ◽  
Catalytic Amount ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Pyrimidine Synthesis ◽  
Key Features ◽  
The One ◽  
Work Up ◽  
Operational Simplicity

A simple, straightforward and efficient method is described for the synthesis of 5-aryl-1H-indeno[2’,1’:5,6]pyrido[2,3-d]pyrimidine-2,4,6(3H)-trione via one-pot multicomponent reaction of indane-1,3-dione, arylaldehydes and 6-aminopyrimidin-2,4(1H,3H)-dione in presence of catalytic amount of graphene oxide in water. Graphene oxide is a versatile carbocatalyst and this is the first report on its application in a pyrido[2,3-d]pyrimidine synthesis. Good yield, use of readily available starting materials, operational simplicity, easy work-up and eco-friendly re-usable catalyst are the key features of this protocol.

scholarly journals A One-Pot Process for the Synthesis of Alkyne-3-tretrazolyl-tetrazolo [1,5-a] Quinolines

Proceedings ◽  
2018 ◽  
Vol 9 (1) ◽  
pp. 42 ◽  
Author(s):  
Sandra C. Ramírez-López ◽  
M.V. Basavanag Unnamatla ◽  
Rocío Gámez-Montaño
Keyword(s):  
Multicomponent Reaction ◽  
Medicinal Chemistry ◽  
Bioactive Molecules ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
The One ◽  
Preparation And Evaluation ◽  
Privileged Scaffolds

An efficient synthesis of alkyne-3-tetrazolyl-tetrazolo[1,5-a] quinolones via a one-pot isocyanide-based multicomponent reaction (IMCR) process: I-MCR Ugi-azide/SNAr/ring-chain azido tautomerization was performed under eco-friendly conditions. We report the one-pot synthesis of tris-heterocycles containing a tetrazolo[1,5-a] quinoline connected to a 1,5-disubstituted-tetrazole (1,5-DS-T). The synthesis of these compounds is of great interest in synthetic and medicinal chemistry because these heterocycles are considered privileged scaffolds and their preparation and evaluation may lead to the discovery of novel bioactive molecules.

A cytochrome c-urea functionalized dipeptide conjugate: an efficient HBD framework to synthesize 4H-pyrans via one-pot multicomponent reaction

2020 ◽  
Vol 22 (3) ◽  
pp. 956-968
Author(s):  
Sanjeev Saini ◽  
Mayank ◽  
Navneet Kaur ◽  
Narinder Singh
Keyword(s):  
Cytochrome C ◽  
Multicomponent Reaction ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Green Protocol ◽  
The One

This work is focused on the development of an efficient and green protocol for the one-pot multicomponent synthesis of a series of 4H-pyran derivatives.

Rust-derived Fe2O3 nanoparticles as a green catalyst for the one-pot synthesis of hydrazinyl thiazole derivatives

2020 ◽  
Vol 18 (24) ◽  
pp. 4575-4582 ◽  
Author(s):  
Rutikesh Gurav ◽  
Santosh Kumar Surve ◽  
Santosh Babar ◽  
Prafulla Choudhari ◽  
Devashree Patil ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Fe2o3 Nanoparticles ◽  
Thiazole Derivatives ◽  
One Pot ◽  
Green Catalyst ◽  
Aryl Aldehydes ◽  
One Pot Synthesis ◽  
The One

A novel route of one-pot multicomponent reaction of tosylates, aryl aldehydes and thiosemicarbazide for the synthesis of hydrazinyl thiazole is reported using Fe2O3 NPs derived from rust iron as a catalyst.

scholarly journals Anionic and neutral 2D indium metal–organic frameworks as catalysts for the Ugi one-pot multicomponent reaction

2019 ◽  
Vol 48 (9) ◽  
pp. 2988-2995 ◽  
Author(s):  
Daniel Reinares-Fisac ◽  
Lina M Aguirre-Díaz ◽  
Marta Iglesias ◽  
Enrique Gutiérrez-Puebla ◽  
Felipe Gándara ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Multicomponent Reaction ◽  
Layered Structure ◽  
Metal Organic Frameworks ◽  
Ugi Reaction ◽  
One Pot ◽  
Metal Organic ◽  
Indium Metal ◽  
The One

Two metal–organic frameworks (MOFs) made of indium and 1,3,5-tris(4-carboxyphenyl)benzene and having a layered structure have been synthesized, showing catalytic activity in the one-pot Ugi reaction.

A Series of Metal-Organic Frameworks for Selective CO2 Capture and Catalytic Oxidative Carboxylation of Olefins

2018 ◽  
Author(s):  
Huong T. D. Nguyen ◽  
Y B. N. Tran ◽  
Hung N. Nguyen ◽  
Tranh C. Nguyen ◽  
Felipe Gándara ◽  
...  
Keyword(s):  
Room Temperature ◽  
Gas Adsorption ◽  
New Materials ◽  
One Pot ◽  
Acid Gas ◽  
Naphthalene Diimide ◽  
Styrene Carbonate ◽  
Metal Organic ◽  
Adsorption Of Co ◽  
The One

<p>Three novel lanthanide metal˗organic frameworks (Ln-MOFs), namely MOF-590, -591, and -592 were constructed from a naphthalene diimide tetracarboxylic acid. Gas adsorption measurements of MOF-591 and -592 revealed good adsorption of CO<sub>2</sub> (low pressure, at room temperature) and moderate CO<sub>2</sub> selectivity over N<sub>2</sub> and CH<sub>4</sub>. Accordingly, breakthrough measurements were performed on a representative MOF-592, in which the separation of CO<sub>2</sub> from binary mixture containing N<sub>2</sub> and CO<sub>2</sub> was demonstrated without any loss in performance over three consecutive cycles. Moreover, MOF-590, MOF-591, and MOF-592 exhibited catalytic activity in the one-pot synthesis of styrene carbonate from styrene and CO<sub>2</sub> under mild conditions (1 atm CO<sub>2</sub>, 80 °C, and solvent-free). Among the new materials, MOF-590 revealed a remarkable efficiency with exceptional conversion (96%), selectivity (95%), and yield (91%). </p><br>

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