Multifunctional phase-change hollow mesoporous Prussian blue nanoparticles as a NIR light responsive drug co-delivery system to overcome cancer therapeutic resistance

2017 ◽  
Vol 5 (34) ◽  
pp. 7051-7058 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Zhengbao Zha
Keyword(s):  
Phase Change ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Resistance ◽  
Killing Effect ◽  
Nir Light ◽  
Prussian Blue Nanoparticles ◽  
Delivery Platform ◽  
Cell Killing Effect

A versatile NIR light responsive co-delivery platform of both hydrophobic and hydrophilic anticancer drugs has been developed here for overcoming adaptive therapeutic resistance of cancer cells and enhancing cell-killing effect.

scholarly journals Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

RSC Advances ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2646-2649 ◽  
Author(s):  
Lamiaa M. A. Ali ◽  
Emna Mathlouthi ◽  
Maëlle Cahu ◽  
Saad Sene ◽  
Morgane Daurat ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Prussian Blue ◽  
Cancer Cells ◽  
High Efficiency ◽  
Synergic Effect ◽  
Photon Irradiation ◽  
Two Photon ◽  
Prussian Blue Nanoparticles ◽  
Doxorubicin Release

Mn2+-doped Prussian blue nanoparticles loaded with doxorubicin present high efficiency for combined photothermal and chemotherapy of cancer cells with a synergic effect under two-photon irradiation.

A chloroquine-loaded Prussian blue platform with controllable autophagy inhibition for enhanced photothermal therapy

2018 ◽  
Vol 6 (37) ◽  
pp. 5854-5859 ◽  
Author(s):  
Yan Ma ◽  
Huajian Chen ◽  
Baimei Hao ◽  
Junhong Zhou ◽  
Gang He ◽  
...  
Keyword(s):  
Prussian Blue ◽  
Photothermal Therapy ◽  
Prussian Blue Nanoparticles ◽  
Delivery Platform ◽  
Autophagy Inhibition

A controllable CQ delivery platform consisting of hollow mesoporous Prussian blue nanoparticles and phase changing material was developed here to realize tumor specific autophagy inhibition for enhanced PTT.

scholarly journals CD59 receptor targeted delivery of miRNA-1284 and Cisplatin-loaded liposomes for effective therapeutic efficacy against cervical cancers

2020 ◽  
Author(s):  
Li Wang ◽  
Ting-Ting Liang
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Blood Circulation ◽  
Anticancer Effect ◽  
Killing Effect ◽  
Cervical Cancers ◽  
Cervical Cancer Cells ◽  
Dependent Cell ◽  
Cell Killing Effect

Abstract Co-delivery of two different therapeutics (miRNA-1284 and cisplatin (CDDP)) into the cancer cells in a single nanocarrier provides new dimension to the cancer treatment. In this study, we have designed the CD59sp-conjugated miRNA-1284/cisplatin(CDDP)-loaded liposomes for the enhanced therapeutic effect against cervical cancers. Compared with miRNA-1284/CDDP-loaded liposomes (LP-miCDDP), CD59 antibody-conjugated LP-miCDDP (CD/LP-miCDDP) showed a significantly higher cytotoxicity in HeLa cells. Notably, MiR-1284 showed a typical concentration-dependent cell killing effect in the cervical cancer cells owing to the downregulation of HMGB1. Flow cytometer analysis showed that CD/LP-miCDDP resulted in maximum apoptosis effect (~60%) compared to CDDP (~20%) or miR-1284 (~12%) treated cells indicating the superior anticancer effect in the cancer cells. Importantly, CD/LP-miCDDP significantly prolonged the blood circulation of encapsulated drug in rats with significantly higher AUC (o-t) , t 1/2 and lower CL compared to that of free CDDP. Overall, results demonstrated that targeted and synergistic co-delivery of therapeutic components could be promising in cervical cancer therapy.

scholarly journals Facile synthesis of Prussian blue nanoparticles as pH-responsive drug carriers for combined photothermal-chemo treatment of cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 248-255 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Xiaoyi Wu ◽  
Zhengbao Zha
Keyword(s):  
Drug Delivery ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Drug Carriers ◽  
High Efficacy ◽  
Ph Responsive ◽  
Facile Synthesis ◽  
Drug Delivery Vehicles ◽  
Prussian Blue Nanoparticles ◽  
Delivery Vehicles

Multifunctional PEGylated PB-DOX NPs with a lipid-PEG shell were developed as a gram-scale manner and used as novel pH-responsive drug delivery vehicles for combined photothermal-chemo treatment of cancer cells with high efficacy.

scholarly journals Selective Killing Natural Products and Drugs in Oral Cancer Treatments

2016 ◽  
pp. 1-2
Author(s):  
Hsueh-Wei Chang
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Side Effects ◽  
Oral Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Cancer Treatments ◽  
Normal Cells ◽  
Killing Effect ◽  
Anticancer Drug Discovery

Most cancer drugs are effective to kill cancer cells but also harm normal cells. Drugs and natural products with the selective killing effect may be helpful to solve this problem. The side effects of many anticancer drugs are partly derived from its damage to both cancer and normal cells without selection. This problem raises the need of anticancer drug discovery with the selective killing effect.

Efficient Wormlike Micelles for the Controlled Delivery of Anticancer Drugs

2020 ◽  
Vol 10 ◽  
Author(s):  
P. Sharmiladevi ◽  
M. Breghatha ◽  
K. Dhanavardhini ◽  
R. Priya ◽  
Koyeli Girigoswami ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Sodium Salicylate ◽  
Controlled Delivery ◽  
Self Organization ◽  
Wormlike Micelles ◽  
Delivery Vehicle ◽  
Killing Effect ◽  
Salicylate Concentration ◽  
Doxorubicin Release ◽  
Cell Killing Effect

Background: In order to improve the solubility and carrying capacity of anticancer drugs to the targeted cells a potential nanoformulation is needed Objective: A viscoelastic wormlike micelles (WLM) have been reported in the present study. Methods: The elongated and flexible aggregates of amphiphiles were formed due to the self-organization when the amphiphile concentration was fixed at its CMC and the sodium salicylate concentration was varied for the optimization Results: The stable structure, higher density, higher viscosity and potent cell killing effect at lower concentration of drug were observed at 480 μM concentration of sodium salicylate. The doxorubicin release profile showed a clear sustained release after 20 h and 82% of the drug has been released after 72 h. Conclusion: Therefore, the designed WLMs can be used as efficient drug delivery vehicle for the treatment of cancer

A NIR-light activated nanoplatform for sensitizing triple negative breast cancer against therapeutic resistance to enhance the treatment effect

2018 ◽  
Vol 6 (43) ◽  
pp. 6950-6956 ◽  
Author(s):  
Xiaojing Sun ◽  
Yi Jin ◽  
Hao Wang ◽  
Na Feng ◽  
Zhenhua Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Silencing ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Treatment Effect ◽  
Triple Negative ◽  
Therapeutic Resistance ◽  
Nir Light

A NIR-light activated combination therapeutic nanoplatform is reported to cure TNBC by gene-silencing based sensitization of cancer cells toward treatment.

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