Bio-inspired drug delivery systems: an emerging platform for targeted cancer therapy

2018 ◽  
Vol 6 (5) ◽  
pp. 958-973 ◽  
Author(s):  
Gella Maelys Ngandeu Neubi ◽  
Yaw Opoku-Damoah ◽  
Xiaochen Gu ◽  
Yue Han ◽  
Jianping Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Targeted Cancer Therapy ◽  
Anticancer Therapeutics ◽  
Biological Sources

Bio-inspired platforms directly derived from biological sources are becoming a rapidly emerging field in the development of future anticancer therapeutics. The various platforms discussed are bacteria-based, virus-inspired, cell-derived, nanostructured lipid nanoparticles, and biomacromolecular drug delivery systems.

scholarly journals Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles

2019 ◽  
Vol 34 (1) ◽  
Author(s):  
Mehran Alavi ◽  
Mehrdad Hamidi
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Multidrug Resistant ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Active Targeting ◽  
Anticancer Chemotherapy ◽  
Breast And Prostate Cancer ◽  
Poly Ethylene

Abstract Considerable development in the application of injectable drug delivery systems for cancer therapy has occurred in the last few decades. These improvements include liposomes, lipid nanoparticles (LNPs), and other nanoparticles with or without macromolecular conjugates. For example, liposomal doxorubicin modified by poly(ethylene glycol) (Doxil) was the first liposome with anti-cancer effects which was approved by the US Food and Drug Administration, whereas Abraxane (modified albumin nanoparticles loaded by paclitaxel) was recently confirmed for the treatment of breast cancer. Recently, drug delivery systems by LNPs are an emerging technology with numerous advantages over conventional liposomes and chemotherapy using free drug treatment of cancer. These properties are biocompatibility, controlled and sustained release of anti-tumor drugs, and lower toxicity. Valuable experiments on these drug delivery systems offer better treatment of multidrug-resistant cancers and lower cardiotoxicity. LNPs have been presented with high functionality in chemotherapeutic targeting of breast and prostate cancer. The basis for this targeting behavior has been shown to be both passive and active targeting. The main objective of this review was an overview of the current position of the liposome-based drug delivery systems in targeted anticancer chemotherapy.

scholarly journals Current Status and Perspectives of Protease Inhibitors and Their Combination with Nanosized Drug Delivery Systems for Targeted Cancer Therapy

2021 ◽  
Vol Volume 15 ◽  
pp. 9-20
Author(s):  
Magdalena Rudzińska ◽  
Cenk Daglioglu ◽  
Lyudmila V Savvateeva ◽  
Fatma Necmiye Kaci ◽  
Rodolphe Antoine ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Protease Inhibitors ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Current Status ◽  
Targeted Cancer Therapy

Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

2020 ◽  
Vol 21 (11) ◽  
pp. 1084-1098
Author(s):  
Fengqian Chen ◽  
Yunzhen Shi ◽  
Jinming Zhang ◽  
Qi Liu
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Therapeutic Index ◽  
Delivery Systems ◽  
Epigenetic Therapy ◽  
Cancer Therapies ◽  
Therapeutic Benefits ◽  
High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

Development of Gel-Core Solid Lipid Nanoparticles as Drug Delivery Systems for Hydrophilic Molecules

2016 ◽  
Vol 12 (5) ◽  
pp. 598-604 ◽  
Author(s):  
Tatiana N. Pashirova ◽  
Tatiana Andreani ◽  
Ana S. Macedo ◽  
Eliana B. Souto ◽  
Lucia Ya. Zakharova
Keyword(s):  
Drug Delivery ◽  
Solid Lipid Nanoparticles ◽  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Solid Lipid

Stimuli-Responsive Nano-Drug Delivery Systems for Cancer Therapy

2020 ◽  
pp. 151-162
Author(s):  
Sauraj ◽  
Anuj Kumar ◽  
Bijender Kumar ◽  
Ruchir Priyadarshi ◽  
Chhavi Sharma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Nano Drug Delivery
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